Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4335
Gene name Gene Name - the full gene name approved by the HGNC.
MAX network transcriptional repressor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MNT
Synonyms (NCBI Gene) Gene synonyms aliases
MAD6, MXD6, ROX, bHLHd3, lncRNA-HAL
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Heli
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004672 hsa-miR-210-3p Luciferase reporter assay, qRT-PCR, Western blot 19652553
MIRT004672 hsa-miR-210-3p Luciferase reporter assay, qRT-PCR, Western blot 19652553
MIRT050948 hsa-miR-17-5p CLASH 23622248
MIRT043556 hsa-miR-331-3p CLASH 23622248
MIRT004672 hsa-miR-210-3p QRTPCR, Western blot 23618526
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 9184233
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 9598315
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 9184233
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603039 7188 ENSG00000070444
Protein
UniProt ID Q99583
Protein name Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)
Protein function Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 221 272 Helix-loop-helix DNA-binding domain Domain
Sequence
MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRM
EAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQ
PALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLPTPVLTIAPHP
GVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECF
ETLKRNIPNVDDKKTSNLSVLRTALRYIQSLK
RKEKEYEHEMERLAREKIATQQRLAELK
HELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQ
PELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPA
QTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQ
LAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPAT
VMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
Sequence length 582
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lissencephaly Classical Lissencephaly rs137853043, rs137853044, rs137853045, rs137853046, rs137853047, rs137853048, rs137853049, rs137853050, rs121434482, rs121434483, rs1567561137, rs121434485, rs121434486, rs121434487, rs121434489
View all (183 more)
15028671
Lissencephaly, x-linked Lissencephaly, X-Linked, 1, X-Linked Lissencephaly rs387906492, rs2147324181, rs111033612, rs104894740, rs1328291159, rs104894741, rs267606666, rs398124510, rs587783183, rs587783184, rs587783187, rs587783189, rs587783191, rs587783199, rs587783202
View all (11 more)
15028671
Subcortical band heterotopia Subcortical Band Heterotopia rs121434484, rs121434488, rs121434489 15028671
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autism Spectrum Disorder Associate 26398136
Breast Neoplasms Associate 34460331
Carcinogenesis Associate 26506232
Carcinoma Hepatocellular Associate 32735635
Hypoxia Associate 19652553, 24951777
Hypoxia Brain Associate 24951777
Idiopathic Pulmonary Fibrosis Associate 24951777
Leukemia Lymphocytic Chronic B Cell Associate 23047824
Neoplasms Inhibit 29596783
Uremia Associate 27018948