MMP16 (matrix metallopeptidase 16)

Gene

• Entrez ID: 4325
• Gene name: Matrix metallopeptidase 16
• Gene symbol: MMP16
• Synonyms (NCBI Gene): C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP
• Chromosome: 8
• Chromosome location: 8q21.3
• Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004887	hsa-miR-146b-5p	U138	19265686
MIRT004978	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	19524507
MIRT004978	hsa-miR-31-5p	Luciferase reporter assay, qRT-PCR, Western blot	19524507
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT004887	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21823013
MIRT052989	hsa-miR-328-3p	Luciferase reporter assay, qRT-PCR, Western blot	22453125
MIRT052989	hsa-miR-328-3p	Luciferase reporter assay, qRT-PCR, Western blot	22453125
MIRT053318	hsa-miR-155-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot, Zymography	22348515
MIRT053318	hsa-miR-155-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot, Zymography	22348515
MIRT053318	hsa-miR-155-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot, Zymography	22348515
MIRT004887	hsa-miR-146b-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	23796692
MIRT004887	hsa-miR-146b-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	23796692
MIRT724192	hsa-miR-99a-3p	HITS-CLIP	19536157
MIRT724191	hsa-miR-99b-3p	HITS-CLIP	19536157
MIRT724190	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT724189	hsa-miR-4318	HITS-CLIP	19536157
MIRT724188	hsa-miR-892a	HITS-CLIP	19536157
MIRT724187	hsa-miR-4693-5p	HITS-CLIP	19536157
MIRT629031	hsa-miR-4502	HITS-CLIP	19536157
MIRT629030	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT629028	hsa-miR-3171	HITS-CLIP	19536157
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	19536157
MIRT629026	hsa-let-7c-3p	HITS-CLIP	19536157
MIRT522465	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522463	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT522461	hsa-miR-628-3p	HITS-CLIP	21572407
MIRT522460	hsa-miR-325	HITS-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522457	hsa-miR-3924	HITS-CLIP	21572407
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522463	hsa-miR-154-3p	PAR-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	21572407
MIRT522461	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT522460	hsa-miR-325	PAR-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT522457	hsa-miR-3924	PAR-CLIP	21572407
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522463	hsa-miR-154-3p	PAR-CLIP	23446348
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	23446348
MIRT522461	hsa-miR-628-3p	PAR-CLIP	23446348
MIRT522460	hsa-miR-325	PAR-CLIP	23446348
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT522457	hsa-miR-3924	PAR-CLIP	23446348
MIRT443658	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT443657	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT440224	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440224	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT734091	hsa-miR-377-3p	Luciferase reporter assay, Western blotting	33569426
MIRT735294	hsa-let-7g-5p	Western blotting, Microarray, qRT-PCR, Immunocytochemistry (ICC)	33352502
MIRT724192	hsa-miR-99a-3p	HITS-CLIP	19536157
MIRT724191	hsa-miR-99b-3p	HITS-CLIP	19536157
MIRT724190	hsa-miR-6796-3p	HITS-CLIP	19536157
MIRT724189	hsa-miR-4318	HITS-CLIP	19536157
MIRT724188	hsa-miR-892a	HITS-CLIP	19536157
MIRT724187	hsa-miR-4693-5p	HITS-CLIP	19536157
MIRT629031	hsa-miR-4502	HITS-CLIP	19536157
MIRT629030	hsa-miR-767-3p	HITS-CLIP	19536157
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT629028	hsa-miR-3171	HITS-CLIP	19536157
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	19536157
MIRT629026	hsa-let-7c-3p	HITS-CLIP	19536157
MIRT522465	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT522463	hsa-miR-154-3p	HITS-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	HITS-CLIP	21572407
MIRT522461	hsa-miR-628-3p	HITS-CLIP	21572407
MIRT522460	hsa-miR-325	HITS-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT522457	hsa-miR-3924	HITS-CLIP	21572407
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT629031	hsa-miR-4502	HITS-CLIP	23824327
MIRT629030	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT629029	hsa-miR-29b-1-5p	HITS-CLIP	23824327
MIRT629028	hsa-miR-3171	HITS-CLIP	23824327
MIRT629027	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT629026	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT522463	hsa-miR-154-3p	PAR-CLIP	21572407
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	21572407
MIRT522461	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT522460	hsa-miR-325	PAR-CLIP	21572407
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT522457	hsa-miR-3924	PAR-CLIP	21572407
MIRT522465	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522464	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522463	hsa-miR-154-3p	PAR-CLIP	23446348
MIRT522462	hsa-miR-487a-3p	PAR-CLIP	23446348
MIRT522461	hsa-miR-628-3p	PAR-CLIP	23446348
MIRT522460	hsa-miR-325	PAR-CLIP	23446348
MIRT522459	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT522457	hsa-miR-3924	PAR-CLIP	23446348
MIRT443658	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT443657	hsa-miR-4712-3p	PAR-CLIP	22100165
MIRT1153208	hsa-miR-1184	CLIP-seq
MIRT1153209	hsa-miR-1197	CLIP-seq
MIRT1153210	hsa-miR-1205	CLIP-seq
MIRT1153211	hsa-miR-1206	CLIP-seq
MIRT1153212	hsa-miR-1224-3p	CLIP-seq
MIRT1153213	hsa-miR-1227	CLIP-seq
MIRT1153214	hsa-miR-1258	CLIP-seq
MIRT1153215	hsa-miR-1260	CLIP-seq
MIRT1153216	hsa-miR-1260b	CLIP-seq
MIRT1153217	hsa-miR-1280	CLIP-seq
MIRT1153218	hsa-miR-129-5p	CLIP-seq
MIRT1153219	hsa-miR-1297	CLIP-seq
MIRT1153220	hsa-miR-1303	CLIP-seq
MIRT1153221	hsa-miR-1304	CLIP-seq
MIRT1153222	hsa-miR-138	CLIP-seq
MIRT1153223	hsa-miR-150	CLIP-seq
MIRT1153224	hsa-miR-1909	CLIP-seq
MIRT1153225	hsa-miR-193a-3p	CLIP-seq
MIRT1153226	hsa-miR-193b	CLIP-seq
MIRT1153227	hsa-miR-200b	CLIP-seq
MIRT1153228	hsa-miR-200c	CLIP-seq
MIRT1153229	hsa-miR-205	CLIP-seq
MIRT1153230	hsa-miR-2053	CLIP-seq
MIRT1153231	hsa-miR-2113	CLIP-seq
MIRT1153232	hsa-miR-2681	CLIP-seq
MIRT1153233	hsa-miR-26a	CLIP-seq
MIRT1153234	hsa-miR-26b	CLIP-seq
MIRT1153235	hsa-miR-298	CLIP-seq
MIRT1153236	hsa-miR-3074-3p	CLIP-seq
MIRT1153237	hsa-miR-3117-3p	CLIP-seq
MIRT1153238	hsa-miR-3119	CLIP-seq
MIRT1153239	hsa-miR-3123	CLIP-seq
MIRT1153240	hsa-miR-3129-3p	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT1153242	hsa-miR-3158-5p	CLIP-seq
MIRT1153243	hsa-miR-3163	CLIP-seq
MIRT1153244	hsa-miR-3177-5p	CLIP-seq
MIRT1153245	hsa-miR-3187-3p	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153251	hsa-miR-320e	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT1153253	hsa-miR-338-5p	CLIP-seq
MIRT1153254	hsa-miR-3591-3p	CLIP-seq
MIRT1153255	hsa-miR-3622a-3p	CLIP-seq
MIRT1153256	hsa-miR-3622b-3p	CLIP-seq
MIRT1153257	hsa-miR-3646	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT1153259	hsa-miR-3662	CLIP-seq
MIRT1153260	hsa-miR-3665	CLIP-seq
MIRT1153261	hsa-miR-3672	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153266	hsa-miR-377	CLIP-seq
MIRT1153267	hsa-miR-382	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT1153269	hsa-miR-3922-5p	CLIP-seq
MIRT1153270	hsa-miR-3925-5p	CLIP-seq
MIRT1153271	hsa-miR-425	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153274	hsa-miR-4289	CLIP-seq
MIRT1153275	hsa-miR-429	CLIP-seq
MIRT1153276	hsa-miR-4310	CLIP-seq
MIRT1153277	hsa-miR-4326	CLIP-seq
MIRT1153278	hsa-miR-4328	CLIP-seq
MIRT1153279	hsa-miR-4428	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT1153281	hsa-miR-4434	CLIP-seq
MIRT1153282	hsa-miR-4446-5p	CLIP-seq
MIRT1153283	hsa-miR-4465	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT1153285	hsa-miR-450b-5p	CLIP-seq
MIRT1153286	hsa-miR-4516	CLIP-seq
MIRT1153287	hsa-miR-4528	CLIP-seq
MIRT1153288	hsa-miR-4529-5p	CLIP-seq
MIRT1153289	hsa-miR-4531	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT1153291	hsa-miR-4645-3p	CLIP-seq
MIRT1153292	hsa-miR-4653-3p	CLIP-seq
MIRT1153293	hsa-miR-4672	CLIP-seq
MIRT1153294	hsa-miR-4694-3p	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT1153296	hsa-miR-4711-5p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT1153298	hsa-miR-4717-3p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT1153300	hsa-miR-4762-5p	CLIP-seq
MIRT1153301	hsa-miR-4773	CLIP-seq
MIRT1153302	hsa-miR-4778-3p	CLIP-seq
MIRT1153303	hsa-miR-490-5p	CLIP-seq
MIRT1153304	hsa-miR-507	CLIP-seq
MIRT1153305	hsa-miR-513b	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT1153307	hsa-miR-532-3p	CLIP-seq
MIRT1153308	hsa-miR-539	CLIP-seq
MIRT1153309	hsa-miR-548c-3p	CLIP-seq
MIRT1153310	hsa-miR-557	CLIP-seq
MIRT1153311	hsa-miR-569	CLIP-seq
MIRT1153312	hsa-miR-607	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT1153314	hsa-miR-630	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT1153316	hsa-miR-657	CLIP-seq
MIRT1153317	hsa-miR-659	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT1153321	hsa-miR-922	CLIP-seq
MIRT1153322	hsa-miR-944	CLIP-seq
MIRT2043890	hsa-miR-204	CLIP-seq
MIRT2043891	hsa-miR-2052	CLIP-seq
MIRT2043892	hsa-miR-211	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT2043895	hsa-miR-328	CLIP-seq
MIRT1153253	hsa-miR-338-5p	CLIP-seq
MIRT2043896	hsa-miR-33a	CLIP-seq
MIRT2043897	hsa-miR-33b	CLIP-seq
MIRT2043898	hsa-miR-34b	CLIP-seq
MIRT2043899	hsa-miR-34c-3p	CLIP-seq
MIRT2043900	hsa-miR-3545-3p	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT1153259	hsa-miR-3662	CLIP-seq
MIRT2043901	hsa-miR-3678-3p	CLIP-seq
MIRT2043902	hsa-miR-3688-3p	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153282	hsa-miR-4446-5p	CLIP-seq
MIRT2043903	hsa-miR-455-5p	CLIP-seq
MIRT2043904	hsa-miR-4637	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2043906	hsa-miR-4755-5p	CLIP-seq
MIRT2043907	hsa-miR-4778-5p	CLIP-seq
MIRT2043908	hsa-miR-5096	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT2043910	hsa-miR-544	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT2043911	hsa-miR-623	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT1153225	hsa-miR-193a-3p	CLIP-seq
MIRT1153226	hsa-miR-193b	CLIP-seq
MIRT2273252	hsa-miR-21	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT2273253	hsa-miR-3140-3p	CLIP-seq
MIRT1153243	hsa-miR-3163	CLIP-seq
MIRT1153245	hsa-miR-3187-3p	CLIP-seq
MIRT2273254	hsa-miR-361-3p	CLIP-seq
MIRT1153258	hsa-miR-3647-3p	CLIP-seq
MIRT2043902	hsa-miR-3688-3p	CLIP-seq
MIRT2273255	hsa-miR-410	CLIP-seq
MIRT1153273	hsa-miR-4282	CLIP-seq
MIRT1153278	hsa-miR-4328	CLIP-seq
MIRT1153285	hsa-miR-450b-5p	CLIP-seq
MIRT1153288	hsa-miR-4529-5p	CLIP-seq
MIRT2273256	hsa-miR-4700-3p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT2043908	hsa-miR-5096	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT2273257	hsa-miR-590-5p	CLIP-seq
MIRT2273258	hsa-miR-760	CLIP-seq
MIRT1153210	hsa-miR-1205	CLIP-seq
MIRT2273253	hsa-miR-3140-3p	CLIP-seq
MIRT2273254	hsa-miR-361-3p	CLIP-seq
MIRT1153297	hsa-miR-4713-5p	CLIP-seq
MIRT1153236	hsa-miR-3074-3p	CLIP-seq
MIRT1153262	hsa-miR-369-3p	CLIP-seq
MIRT1153263	hsa-miR-374a	CLIP-seq
MIRT1153264	hsa-miR-374b	CLIP-seq
MIRT1153276	hsa-miR-4310	CLIP-seq
MIRT1153313	hsa-miR-618	CLIP-seq
MIRT1153320	hsa-miR-889	CLIP-seq
MIRT2454276	hsa-miR-144	CLIP-seq
MIRT2454277	hsa-miR-203	CLIP-seq
MIRT2454278	hsa-miR-3926	CLIP-seq
MIRT1153293	hsa-miR-4672	CLIP-seq
MIRT2454279	hsa-miR-548s	CLIP-seq
MIRT2572031	hsa-miR-1200	CLIP-seq
MIRT2572032	hsa-miR-1270	CLIP-seq
MIRT2572033	hsa-miR-1298	CLIP-seq
MIRT2572034	hsa-miR-2276	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT2572035	hsa-miR-3202	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT2572036	hsa-miR-342-5p	CLIP-seq
MIRT2572037	hsa-miR-3607-3p	CLIP-seq
MIRT2572038	hsa-miR-3660	CLIP-seq
MIRT2572039	hsa-miR-3675-3p	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT2572040	hsa-miR-4252	CLIP-seq
MIRT2572041	hsa-miR-4256	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT2572042	hsa-miR-4420	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT2572043	hsa-miR-4436b-5p	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT2572044	hsa-miR-4493	CLIP-seq
MIRT2572045	hsa-miR-4526	CLIP-seq
MIRT1153289	hsa-miR-4531	CLIP-seq
MIRT2572046	hsa-miR-4533	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT2572047	hsa-miR-4651	CLIP-seq
MIRT2572048	hsa-miR-4660	CLIP-seq
MIRT2572049	hsa-miR-4664-5p	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2572050	hsa-miR-4690-3p	CLIP-seq
MIRT2572051	hsa-miR-4696	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT2572052	hsa-miR-4699-5p	CLIP-seq
MIRT2572053	hsa-miR-4747-5p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT1153302	hsa-miR-4778-3p	CLIP-seq
MIRT2572054	hsa-miR-4802-5p	CLIP-seq
MIRT2572055	hsa-miR-486-3p	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT1153309	hsa-miR-548c-3p	CLIP-seq
MIRT2572056	hsa-miR-591	CLIP-seq
MIRT2572057	hsa-miR-608	CLIP-seq
MIRT2572058	hsa-miR-620	CLIP-seq
MIRT2572059	hsa-miR-646	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT2572060	hsa-miR-661	CLIP-seq
MIRT2572061	hsa-miR-664	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT2572062	hsa-miR-765	CLIP-seq
MIRT2572063	hsa-miR-9	CLIP-seq
MIRT2572031	hsa-miR-1200	CLIP-seq
MIRT2572033	hsa-miR-1298	CLIP-seq
MIRT2685127	hsa-miR-18a	CLIP-seq
MIRT2685128	hsa-miR-18b	CLIP-seq
MIRT2572034	hsa-miR-2276	CLIP-seq
MIRT2043893	hsa-miR-27a	CLIP-seq
MIRT2043894	hsa-miR-27b	CLIP-seq
MIRT1153241	hsa-miR-3134	CLIP-seq
MIRT2685129	hsa-miR-3154	CLIP-seq
MIRT2685130	hsa-miR-3179	CLIP-seq
MIRT1153246	hsa-miR-3194-3p	CLIP-seq
MIRT2572035	hsa-miR-3202	CLIP-seq
MIRT1153247	hsa-miR-320a	CLIP-seq
MIRT1153248	hsa-miR-320b	CLIP-seq
MIRT1153249	hsa-miR-320c	CLIP-seq
MIRT1153250	hsa-miR-320d	CLIP-seq
MIRT1153252	hsa-miR-330-3p	CLIP-seq
MIRT2572036	hsa-miR-342-5p	CLIP-seq
MIRT2572037	hsa-miR-3607-3p	CLIP-seq
MIRT2572038	hsa-miR-3660	CLIP-seq
MIRT2572039	hsa-miR-3675-3p	CLIP-seq
MIRT1153265	hsa-miR-374c	CLIP-seq
MIRT1153268	hsa-miR-3919	CLIP-seq
MIRT2685131	hsa-miR-3936	CLIP-seq
MIRT2685132	hsa-miR-3978	CLIP-seq
MIRT2572040	hsa-miR-4252	CLIP-seq
MIRT2572041	hsa-miR-4256	CLIP-seq
MIRT1153272	hsa-miR-4274	CLIP-seq
MIRT2572042	hsa-miR-4420	CLIP-seq
MIRT1153280	hsa-miR-4429	CLIP-seq
MIRT2572043	hsa-miR-4436b-5p	CLIP-seq
MIRT1153284	hsa-miR-4466	CLIP-seq
MIRT2572044	hsa-miR-4493	CLIP-seq
MIRT2572045	hsa-miR-4526	CLIP-seq
MIRT2572046	hsa-miR-4533	CLIP-seq
MIRT1153290	hsa-miR-4534	CLIP-seq
MIRT2572047	hsa-miR-4651	CLIP-seq
MIRT2572049	hsa-miR-4664-5p	CLIP-seq
MIRT2043905	hsa-miR-4687-3p	CLIP-seq
MIRT2572050	hsa-miR-4690-3p	CLIP-seq
MIRT2572051	hsa-miR-4696	CLIP-seq
MIRT1153295	hsa-miR-4698	CLIP-seq
MIRT2572052	hsa-miR-4699-5p	CLIP-seq
MIRT2685133	hsa-miR-4735-3p	CLIP-seq
MIRT2572053	hsa-miR-4747-5p	CLIP-seq
MIRT1153299	hsa-miR-4756-3p	CLIP-seq
MIRT2572054	hsa-miR-4802-5p	CLIP-seq
MIRT2572055	hsa-miR-486-3p	CLIP-seq
MIRT2043909	hsa-miR-513a-5p	CLIP-seq
MIRT1153306	hsa-miR-522	CLIP-seq
MIRT2572056	hsa-miR-591	CLIP-seq
MIRT2572057	hsa-miR-608	CLIP-seq
MIRT2685134	hsa-miR-629	CLIP-seq
MIRT2572059	hsa-miR-646	CLIP-seq
MIRT1153315	hsa-miR-655	CLIP-seq
MIRT2572060	hsa-miR-661	CLIP-seq
MIRT2572061	hsa-miR-664	CLIP-seq
MIRT1153318	hsa-miR-671-5p	CLIP-seq
MIRT1153319	hsa-miR-675	CLIP-seq
MIRT2572062	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0001503	Process	Ossification	IEA
GO:0001958	Process	Endochondral ossification	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	27229514
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	7559440
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	7559440
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IDA	24970228
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	14645246
GO:0008047	Function	Enzyme activator activity	TAS	7559440
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IDA	27229514
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	7559440
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IDA	27229514
GO:0016485	Process	Protein processing	TAS	21768085
GO:0016787	Function	Hydrolase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0035988	Process	Chondrocyte proliferation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048701	Process	Embryonic cranial skeleton morphogenesis	IEA
GO:0060348	Process	Bone development	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IDA	24970228
GO:0070006	Function	Metalloaminopeptidase activity	TAS	14645246
GO:0097094	Process	Craniofacial suture morphogenesis	IEA

Other IDs

• MIM: 602262
• HGNC: 7162
• e!Ensembl: ENSG00000156103

Protein

• UniProt ID: P51512
• Protein name: Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
• Protein function: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also coll
• PDB: 1RM8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01471	PG_binding_1	38 → 96	Putative peptidoglycan binding domain	Domain
  PF00413	Peptidase_M10	126 → 291	Matrixin	Domain
  PF00045	Hemopexin	349 → 390	Hemopexin	Repeat
  PF00045	Hemopexin	392 → 436	Hemopexin	Repeat
  PF00045	Hemopexin	439 → 485	Hemopexin	Repeat
  PF00045	Hemopexin	487 → 532	Hemopexin	Repeat
  PF11857	DUF3377	537 → 607	Domain of unknown function (DUF3377)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.
• Sequence:

  MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM
  SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY
  ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR
  DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL
  FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT
  RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF
  KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ
  PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW
  KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK
  EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK
  RSMQEWV

• Sequence length: 607

Pathways

KEGG:

Parathyroid hormone synthesis, secretion and action
MicroRNAs in cancer

Reactome:

Activation of Matrix Metalloproteinases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANOREXIA NERVOSA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Aortic Valve Stenosis	Inhibit	33129260	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	10857781	★☆☆☆☆ Found in Text Mining only
Asthma	Associate	34448644	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Associate	10027400	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Inhibit	33129260	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	30468477	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	27292876	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	34730679	★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	34747300	★☆☆☆☆ Found in Text Mining only
Cataract	Associate	32572898	★☆☆☆☆ Found in Text Mining only
Cicatrix Hypertrophic	Associate	30320389	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Associate	32813775	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	28422174	★☆☆☆☆ Found in Text Mining only
Dental Caries	Associate	32398053	★☆☆☆☆ Found in Text Mining only
Dupuytren Contracture	Associate	23554969	★☆☆☆☆ Found in Text Mining only
Ehlers Danlos syndrome type 3	Associate	27518164	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	28871006	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	27292876	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	31385537	★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Associate	29351188	★☆☆☆☆ Found in Text Mining only
Hypoxia	Associate	29351188	★☆☆☆☆ Found in Text Mining only
IgA Vasculitis	Associate	10830778	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	34448644	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Inhibit	27292876	★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	22164270	★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Associate	28796414	★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Associate	26231841	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	22164270	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	26605780, 30874288, 33407764	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	22164270, 24553122, 25158190, 28422174, 28871006, 33853673	★☆☆☆☆ Found in Text Mining only
Odontogenic Tumors	Associate	25158190	★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Stimulate	14730609	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	26605780	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	31515968	★☆☆☆☆ Found in Text Mining only
Plaque Atherosclerotic	Associate	12473546	★☆☆☆☆ Found in Text Mining only
Prostate Cancer Hereditary 7	Associate	23593148, 28039167	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	30874288	★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Associate	24755270	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	36941602	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	12174360, 22677901, 27340864	★☆☆☆☆ Found in Text Mining only
Tongue Neoplasms	Associate	28939077	★☆☆☆☆ Found in Text Mining only
Tooth Eruption Ectopic	Associate	18452654	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	32317088	★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Associate	34587931	★☆☆☆☆ Found in Text Mining only