MMP11 (matrix metallopeptidase 11)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4320
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP11
Synonyms (NCBI Gene) Gene synonyms aliases
SL-3, ST3, STMY3
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
miRTarBase ID miRNA Experiments Reference
MIRT006905 hsa-miR-125a-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 22768249
MIRT732735 hsa-miR-139-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 27355528
MIRT732735 hsa-miR-139-3p Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting 31595150
MIRT756084 hsa-miR-202-3p Luciferase reporter assay, Western blotting, qRT-PCR 37226011
MIRT1153150 hsa-miR-1251 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
SP1 Activation 22227581
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity IBA 21873635
GO:0005576 Component Extracellular region TAS
GO:0005796 Component Golgi lumen TAS
GO:0006508 Process Proteolysis IEA
GO:0007275 Process Multicellular organism development IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
185261 7157 ENSG00000099953
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P24347
Protein name Stromelysin-3 (SL-3) (ST3) (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11)
Protein function May play an important role in the progression of epithelial malignancies.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00413 Peptidase_M10 104 → 258 Matrixin Domain
PF00045 Hemopexin 298 → 341 Hemopexin Repeat
PF00045 Hemopexin 343 → 383 Hemopexin Repeat
PF00045 Hemopexin 387 → 434 Hemopexin Repeat
PF00045 Hemopexin 436 → 480 Hemopexin Repeat
Tissue specificity TISSUE SPECIFICITY: Specifically expressed in stromal cells of breast carcinomas.
Sequence
Sequence length 488
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)		 10741738
Show/Hide Text Mining Associations (79)
Associations from Text Mining
Disease Name Relationship Type References
Acute Lung Injury Associate 19159011
Adenocarcinoma Associate 22927434, 23803125, 26434888, 27460729
Allergic Fungal Sinusitis Associate 33005006
Aortic Dissection Associate 21276682
Arthritis Juvenile Associate 26510114
Arthritis Rheumatoid Associate 17594488
Ataxia Telangiectasia Associate 8995642
Breast Neoplasms Associate 1469302, 17473389, 19243594, 19531263, 21344163, 22842186, 22927434, 23145063, 24564996, 26084486, 26456994, 27340107, 28409241, 30236106, 31292488
View all (13 more)
Breast Neoplasms Stimulate 23568046
Calcinosis Associate 15001838