MMP10 (matrix metallopeptidase 10)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4319
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP10
Synonyms (NCBI Gene) Gene synonyms aliases
SL-2, STMY2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(30)
miRTarBase ID miRNA Experiments Reference
MIRT006040 hsa-miR-203a-3p Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 21159887
MIRT006040 hsa-miR-203a-3p Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 21159887
MIRT006040 hsa-miR-203a-3p Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 21159887
MIRT028865 hsa-miR-26b-5p Microarray 19088304
MIRT1153132 hsa-miR-1229 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
ETS1 Unknown 20432469
HDAC7 Repression 16873063;20693714
MEF2A Activation 19935709
NCOA3 Activation 18162290
STAT3 Unknown 16205632
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity IBA 21873635
GO:0004222 Function Metalloendopeptidase activity TAS
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space TAS 2844164
GO:0006508 Process Proteolysis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
185260 7156 ENSG00000166670
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09238
Protein name Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2)
Protein function Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
PDB 1Q3A , 3V96 , 4ILW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 28 → 86 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 107 → 263 Matrixin Domain
PF00045 Hemopexin 295 → 337 Hemopexin Repeat
PF00045 Hemopexin 339 → 382 Hemopexin Repeat
PF00045 Hemopexin 387 → 434 Hemopexin Repeat
PF00045 Hemopexin 436 → 476 Hemopexin Repeat
Sequence
Sequence length 476
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (5)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 22285823
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 22022614
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 16926187 ClinVar
Show/Hide Text Mining Associations (112)
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Stimulate 33436543
Adenocarcinoma Associate 33126685
Adenocarcinoma Stimulate 33436543
Adenocarcinoma of Lung Associate 20032397
Adrenoleukodystrophy Stimulate 23185624
Alzheimer Disease Stimulate 34440700
Alzheimer Disease Associate 36504281, 37348871
Aortic Valve Stenosis Associate 32188274
Arthritis Rheumatoid Associate 12379519
Asthma Associate 19710636, 35000533, 40464643