Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4319
Gene name Gene Name - the full gene name approved by the HGNC.	Matrix metallopeptidase 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MMP10
Synonyms (NCBI Gene) Gene synonyms aliases	SL-2, STMY2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006040	hsa-miR-203a-3p	Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	21159887
MIRT006040	hsa-miR-203a-3p	Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	21159887
MIRT006040	hsa-miR-203a-3p	Immunoblot, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	21159887
MIRT028865	hsa-miR-26b-5p	Microarray	19088304
MIRT1153132	hsa-miR-1229	CLIP-seq
MIRT1153133	hsa-miR-1286	CLIP-seq
MIRT1153134	hsa-miR-181a	CLIP-seq
MIRT1153135	hsa-miR-181b	CLIP-seq
MIRT1153136	hsa-miR-181c	CLIP-seq
MIRT1153137	hsa-miR-181d	CLIP-seq
MIRT1153138	hsa-miR-24	CLIP-seq
MIRT1153139	hsa-miR-3148	CLIP-seq
MIRT1153140	hsa-miR-323-3p	CLIP-seq
MIRT1153141	hsa-miR-3647-3p	CLIP-seq
MIRT1153142	hsa-miR-369-3p	CLIP-seq
MIRT1153143	hsa-miR-374c	CLIP-seq
MIRT1153144	hsa-miR-4262	CLIP-seq
MIRT1153145	hsa-miR-4284	CLIP-seq
MIRT1153146	hsa-miR-4704-3p	CLIP-seq
MIRT1153147	hsa-miR-4722-5p	CLIP-seq
MIRT1153148	hsa-miR-4768-5p	CLIP-seq
MIRT1153149	hsa-miR-655	CLIP-seq
MIRT1153132	hsa-miR-1229	CLIP-seq
MIRT1153134	hsa-miR-181a	CLIP-seq
MIRT1153135	hsa-miR-181b	CLIP-seq
MIRT1153136	hsa-miR-181c	CLIP-seq
MIRT1153137	hsa-miR-181d	CLIP-seq
MIRT1153141	hsa-miR-3647-3p	CLIP-seq
MIRT1153144	hsa-miR-4262	CLIP-seq
MIRT1153148	hsa-miR-4768-5p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
ETS1	Unknown	20432469
HDAC7	Repression	16873063;20693714
MEF2A	Activation	19935709
NCOA3	Activation	18162290
STAT3	Unknown	16205632
ZNF267	Repression	16054593

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	2844164
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	TAS	2844164
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	2844164
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	2844164
GO:0016787	Function	Hydrolase activity	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0030574	Process	Collagen catabolic process	TAS
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	TAS	2844164
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
185260	7156	ENSG00000166670

Protein

UniProt ID

P09238

Protein name

Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2)

Protein function

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

PDB

1Q3A , 3V96 , 4ILW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	28 → 86	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	107 → 263	Matrixin	Domain
PF00045	Hemopexin	295 → 337	Hemopexin	Repeat
PF00045	Hemopexin	339 → 382	Hemopexin	Repeat
PF00045	Hemopexin	387 → 434	Hemopexin	Repeat
PF00045	Hemopexin	436 → 476	Hemopexin	Repeat

Sequence

MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV
KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY
TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL
AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN
SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST
LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW
AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG
FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC

Sequence length

476

Interactions

View interactions

	Reactome
			Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases

MMP10 (matrix metallopeptidase 10)