MMP8 (matrix metallopeptidase 8)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4317
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP8
Synonyms (NCBI Gene) Gene synonyms aliases
CLG1, HNC, MMP-8, PMNL-CL
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(33)
miRTarBase ID miRNA Experiments Reference
MIRT028875 hsa-miR-26b-5p Microarray 19088304
MIRT1153518 hsa-miR-1237 CLIP-seq
MIRT1153519 hsa-miR-1248 CLIP-seq
MIRT1153520 hsa-miR-1343 CLIP-seq
MIRT1153521 hsa-miR-3124-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(40)
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IEA
GO:0004175 Function Endopeptidase activity IMP 25049354
GO:0004222 Function Metalloendopeptidase activity IBA
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
120355 7175 ENSG00000118113
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P22894
Protein name Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
Protein function Can degrade fibrillar type I, II, and III collagens.
PDB 1A85 , 1A86 , 1BZS , 1I73 , 1I76 , 1JAN , 1JAO , 1JAP , 1JAQ , 1JH1 , 1JJ9 , 1KBC , 1MMB , 1MNC , 1ZP5 , 1ZS0 , 1ZVX , 2OY2 , 2OY4 , 3DNG , 3DPE , 3DPF , 3TT4 , 4QKZ , 5H8X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 26 → 86 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 107 → 262 Matrixin Domain
PF00045 Hemopexin 285 → 327 Hemopexin Repeat
PF00045 Hemopexin 329 → 372 Hemopexin Repeat
PF00045 Hemopexin 377 → 422 Hemopexin Repeat
Tissue specificity TISSUE SPECIFICITY: Neutrophils.
Sequence
Sequence length 467
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Epilepsy Epilepsy N/A N/A GWAS
Show/Hide Text Mining Associations (145)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 22098946
Acute Lung Injury Associate 19159011
Adenocarcinoma of Lung Associate 34356991
Airway Obstruction Associate 12429813
Alveolar Bone Loss Associate 35315933
Amniotic Band Syndrome Associate 38098237
Ankyloblepharon filiforme adnatum Associate 27876897
Aortic Aneurysm Abdominal Associate 14522424, 17322367
Aortic Aneurysm Abdominal Stimulate 16432074, 28209269
Arterial Occlusive Diseases Associate 14522424