MMP7 (matrix metallopeptidase 7)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4316
Gene name Matrix metallopeptidase 7
Gene symbol MMP7
Synonyms (NCBI Gene)
MMP-7MPSL1PUMP-1
Chromosome 11
Chromosome location 11q22.2
Summary This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT052917 hsa-miR-148a-3p In situ hybridizationMicroarrayqRT-PCRWestern blot 24283384
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CTNNB1 Activation 11158322;15000152
ETV4 Activation 11158322
ETV4 Unknown 12851697
FOS Unknown 11774399
FOXA2 Activation 22268124
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002779 Process Antibacterial peptide secretion IEA
GO:0002780 Process Antibacterial peptide biosynthetic process IEA
GO:0004175 Function Endopeptidase activity IDA 23845380
GO:0004175 Function Endopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
178990 7174 ENSG00000137673
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09237
Protein name Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)
Protein function Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
PDB 1MMP , 1MMQ , 1MMR , 2DDY , 2MZE , 2MZH , 2MZI , 2Y6C , 2Y6D , 5UE2 , 5UE5 , 7WXX , 8JUD , 8JUF , 8JUG , 8K4Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 28 → 82 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 103 → 259 Matrixin Domain
Sequence
Sequence length 267
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Wnt signaling pathway
Human T-cell leukemia virus 1 infection 		  Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Extra-nuclear estrogen signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Uncertain significance rs149061598 RCV005929147
Malignant tumor of urinary bladder Uncertain significance rs149061598 RCV005929146
Show/Hide Text Mining Associations (224)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11487270, 17695477, 29845775, 9137088
Adenocarcinoma Stimulate 18823373
Adenocarcinoma Bronchiolo Alveolar Associate 12707032
Adenocarcinoma Follicular Associate 37203104
Adenocarcinoma of Lung Associate 24704993, 34236827
Adenoma Stimulate 11371737
Adenoma Associate 17125518, 23319034, 23682078, 32258125, 37203104
Adenoma Liver Cell Inhibit 19465902
Adenomatous Polyposis Coli Inhibit 10514384
Adenomatous Polyps Associate 23319034