MMP7 (matrix metallopeptidase 7)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4316
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP7
Synonyms (NCBI Gene) Gene synonyms aliases
MMP-7, MPSL1, PUMP-1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007268 hsa-miR-126-5p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT007269 hsa-miR-126-3p Luciferase reporter assay 23437250
MIRT052917 hsa-miR-148a-3p In situ hybridization, Microarray, qRT-PCR, Western blot 24283384
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
Transcription factor Regulation Reference
CTNNB1 Activation 11158322;15000152
ETV4 Activation 11158322
ETV4 Unknown 12851697
FOS Unknown 11774399
FOXA2 Activation 22268124
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(38)
GO ID Ontology Definition Evidence Reference
GO:0002779 Process Antibacterial peptide secretion IEA
GO:0002780 Process Antibacterial peptide biosynthetic process IEA
GO:0004175 Function Endopeptidase activity IDA 23845380
GO:0004175 Function Endopeptidase activity IEA
GO:0004222 Function Metalloendopeptidase activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
178990 7174 ENSG00000137673
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09237
Protein name Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP-7) (Pump-1 protease) (Uterine metalloproteinase)
Protein function Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
PDB 1MMP , 1MMQ , 1MMR , 2DDY , 2MZE , 2MZH , 2MZI , 2Y6C , 2Y6D , 5UE2 , 5UE5 , 7WXX , 8JUD , 8JUF , 8JUG , 8K4Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 28 → 82 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 103 → 259 Matrixin Domain
Sequence
Sequence length 267
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Wnt signaling pathway
Human T-cell leukemia virus 1 infection 		  Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Extra-nuclear estrogen signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Neuroblastoma Neuroblastoma N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Show/Hide Text Mining Associations (224)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 11487270, 17695477, 29845775, 9137088
Adenocarcinoma Stimulate 18823373
Adenocarcinoma Bronchiolo Alveolar Associate 12707032
Adenocarcinoma Follicular Associate 37203104
Adenocarcinoma of Lung Associate 24704993, 34236827
Adenoma Stimulate 11371737
Adenoma Associate 17125518, 23319034, 23682078, 32258125, 37203104
Adenoma Liver Cell Inhibit 19465902
Adenomatous Polyposis Coli Inhibit 10514384
Adenomatous Polyps Associate 23319034