Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4312
Gene name Gene Name - the full gene name approved by the HGNC.
Matrix metallopeptidase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MMP1
Synonyms (NCBI Gene) Gene synonyms aliases
CLG, CLGN
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and t
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000136 hsa-miR-222-3p Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19487542
MIRT006062 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006062 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006062 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
MIRT006062 hsa-miR-203a-3p ELISA, qRT-PCR 21279994
Transcription factors
Transcription factor Regulation Reference
BACH1 Activation 21873975
CEBPB Unknown 19723873
CITED2 Repression 12960175
ETS1 Activation 15972796;16278291;17283078
ETS1 Unknown 10949659;11556732;21244711
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IDA 19022250
GO:0004222 Function Metalloendopeptidase activity IBA 21873635
GO:0004222 Function Metalloendopeptidase activity IDA 9920899
GO:0004222 Function Metalloendopeptidase activity TAS
GO:0004252 Function Serine-type endopeptidase activity TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
120353 7155 ENSG00000196611
Protein
UniProt ID P03956
Protein name Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Protein function Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat prote
PDB 1AYK , 1CGE , 1CGF , 1CGL , 1HFC , 1SU3 , 2AYK , 2CLT , 2J0T , 2TCL , 3AYK , 3SHI , 4AUO , 4AYK , 966C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01471 PG_binding_1 27 87 Putative peptidoglycan binding domain Domain
PF00413 Peptidase_M10 108 261 Matrixin Domain
PF00045 Hemopexin 284 326 Hemopexin Repeat
PF00045 Hemopexin 328 372 Hemopexin Repeat
PF00045 Hemopexin 377 424 Hemopexin Repeat
PF00045 Hemopexin 426 466 Hemopexin Repeat
Sequence
Sequence length 469
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  PPAR signaling pathway
IL-17 signaling pathway
Relaxin signaling pathway
Coronavirus disease - COVID-19
Pathways in cancer
Bladder cancer
Rheumatoid arthritis
Lipid and atherosclerosis
  Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia, Refractory anemias rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
23548910
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
23548910
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 24469321 ClinVar
Atherosclerosis Atherosclerosis 21742783 ClinVar
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Achondrogenesis type 2 Associate 31277141
Acidosis Stimulate 35414794
Acne Vulgaris Associate 16528362, 18563181
Actinic cheilitis Associate 26515234
Acute Coronary Syndrome Associate 29044936
Adenocarcinoma Associate 19321798, 20946664, 21143918, 27460729, 30670912, 33905434
Adenocarcinoma Stimulate 22422400
Adenocarcinoma Mucinous Associate 29463039
Adenocarcinoma of Lung Associate 29463039, 33487115
Adenocarcinoma Scirrhous Associate 8766524