MLLT3 (MLLT3 super elongation complex subunit)

Gene

• Entrez ID: 4300
• Gene name: MLLT3 super elongation complex subunit
• Gene symbol: MLLT3
• Synonyms (NCBI Gene): AF9, YEATS3
• Chromosome: 9
• Chromosome location: 9p21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022911	hsa-miR-124-3p	Microarray	18668037
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT535872	hsa-miR-5692b	PAR-CLIP	20371350
MIRT535871	hsa-miR-5692c	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508973	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT508972	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT535872	hsa-miR-5692b	PAR-CLIP	22012620
MIRT535871	hsa-miR-5692c	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508973	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT508972	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT508969	hsa-miR-3924	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508973	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT508972	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508969	hsa-miR-3924	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT535872	hsa-miR-5692b	PAR-CLIP	20371350
MIRT535871	hsa-miR-5692c	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508973	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT508972	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508975	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508969	hsa-miR-3924	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT535872	hsa-miR-5692b	PAR-CLIP	22012620
MIRT535871	hsa-miR-5692c	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT508973	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT508972	hsa-miR-223-5p	PAR-CLIP	22012620
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT508969	hsa-miR-3924	PAR-CLIP	22012620
MIRT508975	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508974	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508973	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT508972	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT508971	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508969	hsa-miR-3924	PAR-CLIP	23446348
MIRT508970	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1152149	hsa-miR-1237	CLIP-seq
MIRT1152150	hsa-miR-1248	CLIP-seq
MIRT1152151	hsa-miR-1283	CLIP-seq
MIRT1152152	hsa-miR-1299	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT1152154	hsa-miR-3121-3p	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT1152157	hsa-miR-3653	CLIP-seq
MIRT1152158	hsa-miR-3658	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT1152161	hsa-miR-4328	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT1152163	hsa-miR-4700-3p	CLIP-seq
MIRT1152164	hsa-miR-4709-5p	CLIP-seq
MIRT1152165	hsa-miR-4782-5p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT1152168	hsa-miR-500a	CLIP-seq
MIRT1152169	hsa-miR-516b	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT1152171	hsa-miR-570	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT1152173	hsa-miR-875-3p	CLIP-seq
MIRT2043341	hsa-miR-1253	CLIP-seq
MIRT2043342	hsa-miR-4426	CLIP-seq
MIRT2043343	hsa-miR-4434	CLIP-seq
MIRT2043344	hsa-miR-4516	CLIP-seq
MIRT2043345	hsa-miR-4531	CLIP-seq
MIRT2043346	hsa-miR-4647	CLIP-seq
MIRT2043347	hsa-miR-4662b	CLIP-seq
MIRT2043348	hsa-miR-4802-5p	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT2043351	hsa-miR-603	CLIP-seq
MIRT1152173	hsa-miR-875-3p	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT2571646	hsa-miR-1276	CLIP-seq
MIRT2571647	hsa-miR-1287	CLIP-seq
MIRT2571648	hsa-miR-2277-3p	CLIP-seq
MIRT2571649	hsa-miR-3065-5p	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT2571650	hsa-miR-3135b	CLIP-seq
MIRT2571651	hsa-miR-3148	CLIP-seq
MIRT2571652	hsa-miR-3165	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT2571653	hsa-miR-374a	CLIP-seq
MIRT2571654	hsa-miR-374b	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT2571655	hsa-miR-3978	CLIP-seq
MIRT2571656	hsa-miR-409-3p	CLIP-seq
MIRT2571657	hsa-miR-4320	CLIP-seq
MIRT2571658	hsa-miR-4424	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT2571659	hsa-miR-4502	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT2571660	hsa-miR-4731-3p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT2571661	hsa-miR-4801	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2571662	hsa-miR-548n	CLIP-seq
MIRT2571663	hsa-miR-548t	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT2571664	hsa-miR-654-3p	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT2571665	hsa-miR-890	CLIP-seq
MIRT2571666	hsa-miR-891a	CLIP-seq
MIRT2571646	hsa-miR-1276	CLIP-seq
MIRT2571647	hsa-miR-1287	CLIP-seq
MIRT2571648	hsa-miR-2277-3p	CLIP-seq
MIRT2571649	hsa-miR-3065-5p	CLIP-seq
MIRT1152153	hsa-miR-31	CLIP-seq
MIRT2571650	hsa-miR-3135b	CLIP-seq
MIRT2571651	hsa-miR-3148	CLIP-seq
MIRT2571652	hsa-miR-3165	CLIP-seq
MIRT1152155	hsa-miR-33a	CLIP-seq
MIRT1152156	hsa-miR-33b	CLIP-seq
MIRT1152159	hsa-miR-378g	CLIP-seq
MIRT1152160	hsa-miR-3974	CLIP-seq
MIRT2571655	hsa-miR-3978	CLIP-seq
MIRT2571656	hsa-miR-409-3p	CLIP-seq
MIRT2571657	hsa-miR-4320	CLIP-seq
MIRT2571658	hsa-miR-4424	CLIP-seq
MIRT2272725	hsa-miR-4436a	CLIP-seq
MIRT1152162	hsa-miR-450b-3p	CLIP-seq
MIRT2571660	hsa-miR-4731-3p	CLIP-seq
MIRT1152166	hsa-miR-4796-3p	CLIP-seq
MIRT2571661	hsa-miR-4801	CLIP-seq
MIRT1152167	hsa-miR-488	CLIP-seq
MIRT2043349	hsa-miR-5095	CLIP-seq
MIRT2571662	hsa-miR-548n	CLIP-seq
MIRT2571663	hsa-miR-548t	CLIP-seq
MIRT2043350	hsa-miR-552	CLIP-seq
MIRT1152170	hsa-miR-564	CLIP-seq
MIRT1152172	hsa-miR-769-3p	CLIP-seq
MIRT2571665	hsa-miR-890	CLIP-seq
MIRT2571666	hsa-miR-891a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	25417107, 27105114
GO:0005515	Function	Protein binding	IPI	16189514, 20153263, 20203130, 21729782, 23145062, 23260655, 26496610, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8506309
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0007379	Process	Segment specification	IEA
GO:0008023	Component	Transcription elongation factor complex	IBA
GO:0008023	Component	Transcription elongation factor complex	IDA	22195968, 25417107, 27105114
GO:0008023	Component	Transcription elongation factor complex	IEA
GO:0009952	Process	Anterior/posterior pattern specification	IEA
GO:0010467	Process	Gene expression	IEA
GO:0042393	Function	Histone binding	IDA	27105114, 27545619
GO:0045893	Process	Positive regulation of DNA-templated transcription	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	25417107, 27105114, 31776511
GO:0060090	Function	Molecular adaptor activity	EXP	23260655
GO:0060218	Process	Hematopoietic stem cell differentiation	IDA	31776511
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	19591803
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	19591803
GO:0140030	Function	Modification-dependent protein binding	IDA	27105114, 27545619
GO:0140044	Function	Histone H3K18ac reader activity	IDA	25417107
GO:0140072	Function	Histone H3K9ac reader activity	IDA	25417107
GO:0140119	Function	Histone H3K27ac reader activity	IDA	25417107
GO:1902275	Process	Regulation of chromatin organization	IMP	31776511
GO:2000035	Process	Regulation of stem cell division	IDA	31776511
GO:2000096	Process	Positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI	19591803

Other IDs

• MIM: 159558
• HGNC: 7136
• e!Ensembl: ENSG00000171843

Protein

• UniProt ID: P42568
• Protein name: Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)
• Protein function: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:201
• PDB: 2LM0, 2MV7, 2N4Q, 2NDF, 2NDG, 4TMP, 5HJB, 5HJD, 5YYF, 6B7G, 6L5Z, 6LS6, 6MIL, 6MIM, 7EIC, 7EID, 7VKG, 7VKH, 8PJ7, 8TLV, 8TLW, 8TLX, 9ARO, 9ARR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03366	YEATS	29 → 110	YEATS family	Domain
  PF17793	AHD	503 → 563	ANC1 homology domain (AHD)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Enriched in undifferentiated hematopoietic stem cells in fetal liver, cord blood and bone marrow. {ECO:0000269|PubMed:31776511}.
• Sequence:

  MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP
  RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE
  KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
  SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK
  PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
  SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
  PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD
  EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE
  VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN
  TTFDFDLCSLDKTTVRKLQSYLETSGTS

• Sequence length: 568

Pathways

KEGG:

Viral life cycle - HIV-1
Transcriptional misregulation in cancer

Reactome:

Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation