Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4296
Gene name	Mitogen-activated protein kinase kinase kinase 11
Gene symbol	MAP3K11
Synonyms (NCBI Gene)	MEKK11MLK-3MLK3PTK1SPRK
Chromosome	11
Chromosome location	11q13.1
Summary	The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK sig

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Show/Hide all (194)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assayqRT-PCRWestern blot	21048306
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assayqRT-PCRWestern blot	21048306
MIRT053660	hsa-miR-145-5p	Microarray	22942087
MIRT438462	hsa-miR-138-5p	Luciferase reporter assay	24211202
MIRT438462	hsa-miR-138-5p	Luciferase reporter assay	24211202
MIRT438462	hsa-miR-138-5p	Luciferase reporter assay	24211202
MIRT438462	hsa-miR-138-5p	Luciferase reporter assay	24211202
MIRT440288	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440288	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26885275
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26885275
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26885275
MIRT731595	hsa-miR-125b-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	26138442
MIRT731595	hsa-miR-125b-5p	Luciferase reporter assayqRT-PCRWestern blot	27613090
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26717044
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26717044
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26717044
MIRT005873	hsa-miR-199a-5p	Luciferase reporter assay	26717044
MIRT1128130	hsa-miR-106a	CLIP-seq
MIRT1128131	hsa-miR-106b	CLIP-seq
MIRT1128132	hsa-miR-1207-5p	CLIP-seq
MIRT1128133	hsa-miR-1243	CLIP-seq
MIRT1128134	hsa-miR-1245b-3p	CLIP-seq
MIRT1128135	hsa-miR-1286	CLIP-seq
MIRT1128136	hsa-miR-138	CLIP-seq
MIRT1128137	hsa-miR-149	CLIP-seq
MIRT1128138	hsa-miR-17	CLIP-seq
MIRT1128139	hsa-miR-1827	CLIP-seq
MIRT1128140	hsa-miR-1909	CLIP-seq
MIRT1128141	hsa-miR-20a	CLIP-seq
MIRT1128142	hsa-miR-20b	CLIP-seq
MIRT1128143	hsa-miR-2110	CLIP-seq
MIRT1128144	hsa-miR-2277-3p	CLIP-seq
MIRT1128145	hsa-miR-299-3p	CLIP-seq
MIRT1128146	hsa-miR-302a	CLIP-seq
MIRT1128147	hsa-miR-302b	CLIP-seq
MIRT1128148	hsa-miR-302c	CLIP-seq
MIRT1128149	hsa-miR-302d	CLIP-seq
MIRT1128150	hsa-miR-302e	CLIP-seq
MIRT1128151	hsa-miR-3064-5p	CLIP-seq
MIRT1128152	hsa-miR-3151	CLIP-seq
MIRT1128153	hsa-miR-372	CLIP-seq
MIRT1128154	hsa-miR-373	CLIP-seq
MIRT1128155	hsa-miR-3942-3p	CLIP-seq
MIRT1128156	hsa-miR-4271	CLIP-seq
MIRT1128157	hsa-miR-4292	CLIP-seq
MIRT1128158	hsa-miR-4299	CLIP-seq
MIRT1128159	hsa-miR-4308	CLIP-seq
MIRT1128160	hsa-miR-4420	CLIP-seq
MIRT1128161	hsa-miR-4436b-3p	CLIP-seq
MIRT1128162	hsa-miR-4447	CLIP-seq
MIRT1128163	hsa-miR-4472	CLIP-seq
MIRT1128164	hsa-miR-4488	CLIP-seq
MIRT1128165	hsa-miR-4649-3p	CLIP-seq
MIRT1128166	hsa-miR-4667-5p	CLIP-seq
MIRT1128167	hsa-miR-4690-5p	CLIP-seq
MIRT1128168	hsa-miR-4697-5p	CLIP-seq
MIRT1128169	hsa-miR-4700-5p	CLIP-seq
MIRT1128170	hsa-miR-4725-3p	CLIP-seq
MIRT1128171	hsa-miR-4738-3p	CLIP-seq
MIRT1128172	hsa-miR-4740-3p	CLIP-seq
MIRT1128173	hsa-miR-4761-3p	CLIP-seq
MIRT1128174	hsa-miR-4763-3p	CLIP-seq
MIRT1128175	hsa-miR-4794	CLIP-seq
MIRT1128176	hsa-miR-491-5p	CLIP-seq
MIRT1128177	hsa-miR-512-3p	CLIP-seq
MIRT1128178	hsa-miR-519d	CLIP-seq
MIRT1128179	hsa-miR-520a-3p	CLIP-seq
MIRT1128180	hsa-miR-520b	CLIP-seq
MIRT1128181	hsa-miR-520c-3p	CLIP-seq
MIRT1128182	hsa-miR-520d-3p	CLIP-seq
MIRT1128183	hsa-miR-520e	CLIP-seq
MIRT1128184	hsa-miR-542-3p	CLIP-seq
MIRT1128185	hsa-miR-548t	CLIP-seq
MIRT1128186	hsa-miR-576-3p	CLIP-seq
MIRT1128187	hsa-miR-93	CLIP-seq
MIRT2036456	hsa-miR-1236	CLIP-seq
MIRT1128136	hsa-miR-138	CLIP-seq
MIRT2036457	hsa-miR-145	CLIP-seq
MIRT1128137	hsa-miR-149	CLIP-seq
MIRT2036458	hsa-miR-1915	CLIP-seq
MIRT1128144	hsa-miR-2277-3p	CLIP-seq
MIRT1128145	hsa-miR-299-3p	CLIP-seq
MIRT1128151	hsa-miR-3064-5p	CLIP-seq
MIRT2036459	hsa-miR-3130-3p	CLIP-seq
MIRT2036460	hsa-miR-361-3p	CLIP-seq
MIRT1128158	hsa-miR-4299	CLIP-seq
MIRT1128161	hsa-miR-4436b-3p	CLIP-seq
MIRT2036461	hsa-miR-4459	CLIP-seq
MIRT1128165	hsa-miR-4649-3p	CLIP-seq
MIRT2036462	hsa-miR-4667-3p	CLIP-seq
MIRT2036463	hsa-miR-4685-5p	CLIP-seq
MIRT2036464	hsa-miR-4711-5p	CLIP-seq
MIRT2036465	hsa-miR-4722-5p	CLIP-seq
MIRT2036466	hsa-miR-4749-3p	CLIP-seq
MIRT1128175	hsa-miR-4794	CLIP-seq
MIRT1128184	hsa-miR-542-3p	CLIP-seq
MIRT2036467	hsa-miR-670	CLIP-seq
MIRT2036457	hsa-miR-145	CLIP-seq
MIRT2266702	hsa-miR-1825	CLIP-seq
MIRT2266703	hsa-miR-199b-5p	CLIP-seq
MIRT2266704	hsa-miR-214	CLIP-seq
MIRT1128151	hsa-miR-3064-5p	CLIP-seq
MIRT2266705	hsa-miR-3619-5p	CLIP-seq
MIRT2266706	hsa-miR-3652	CLIP-seq
MIRT2266707	hsa-miR-3910	CLIP-seq
MIRT2266708	hsa-miR-4267	CLIP-seq
MIRT1128157	hsa-miR-4292	CLIP-seq
MIRT1128159	hsa-miR-4308	CLIP-seq
MIRT2266709	hsa-miR-4430	CLIP-seq
MIRT1128161	hsa-miR-4436b-3p	CLIP-seq
MIRT2266710	hsa-miR-4476	CLIP-seq
MIRT2266711	hsa-miR-4505	CLIP-seq
MIRT2266712	hsa-miR-4651	CLIP-seq
MIRT2266713	hsa-miR-4728-3p	CLIP-seq
MIRT2266714	hsa-miR-4731-5p	CLIP-seq
MIRT1128173	hsa-miR-4761-3p	CLIP-seq
MIRT2266715	hsa-miR-486-3p	CLIP-seq
MIRT2266716	hsa-miR-608	CLIP-seq
MIRT2266717	hsa-miR-615-5p	CLIP-seq
MIRT2266718	hsa-miR-761	CLIP-seq
MIRT2438486	hsa-miR-1207-3p	CLIP-seq
MIRT2438487	hsa-miR-1225-5p	CLIP-seq
MIRT2438488	hsa-miR-150	CLIP-seq
MIRT2266704	hsa-miR-214	CLIP-seq
MIRT2438489	hsa-miR-3155	CLIP-seq
MIRT2438490	hsa-miR-3155b	CLIP-seq
MIRT2266705	hsa-miR-3619-5p	CLIP-seq
MIRT2438491	hsa-miR-3663-5p	CLIP-seq
MIRT2266707	hsa-miR-3910	CLIP-seq
MIRT2438492	hsa-miR-4438	CLIP-seq
MIRT2266710	hsa-miR-4476	CLIP-seq
MIRT2266714	hsa-miR-4731-5p	CLIP-seq
MIRT2438493	hsa-miR-484	CLIP-seq
MIRT2266715	hsa-miR-486-3p	CLIP-seq
MIRT2438494	hsa-miR-520a-5p	CLIP-seq
MIRT2438495	hsa-miR-525-5p	CLIP-seq
MIRT2438496	hsa-miR-760	CLIP-seq
MIRT2266718	hsa-miR-761	CLIP-seq
MIRT2438486	hsa-miR-1207-3p	CLIP-seq
MIRT2438487	hsa-miR-1225-5p	CLIP-seq
MIRT2438488	hsa-miR-150	CLIP-seq
MIRT2438489	hsa-miR-3155	CLIP-seq
MIRT2438490	hsa-miR-3155b	CLIP-seq
MIRT2438491	hsa-miR-3663-5p	CLIP-seq
MIRT2438492	hsa-miR-4438	CLIP-seq
MIRT2438493	hsa-miR-484	CLIP-seq
MIRT2438496	hsa-miR-760	CLIP-seq
MIRT1128130	hsa-miR-106a	CLIP-seq
MIRT1128131	hsa-miR-106b	CLIP-seq
MIRT1128135	hsa-miR-1286	CLIP-seq
MIRT1128138	hsa-miR-17	CLIP-seq
MIRT1128141	hsa-miR-20a	CLIP-seq
MIRT1128142	hsa-miR-20b	CLIP-seq
MIRT1128146	hsa-miR-302a	CLIP-seq
MIRT1128147	hsa-miR-302b	CLIP-seq
MIRT1128148	hsa-miR-302c	CLIP-seq
MIRT1128149	hsa-miR-302d	CLIP-seq
MIRT1128150	hsa-miR-302e	CLIP-seq
MIRT1128153	hsa-miR-372	CLIP-seq
MIRT1128154	hsa-miR-373	CLIP-seq
MIRT1128167	hsa-miR-4690-5p	CLIP-seq
MIRT1128177	hsa-miR-512-3p	CLIP-seq
MIRT1128178	hsa-miR-519d	CLIP-seq
MIRT1128179	hsa-miR-520a-3p	CLIP-seq
MIRT1128180	hsa-miR-520b	CLIP-seq
MIRT1128181	hsa-miR-520c-3p	CLIP-seq
MIRT1128182	hsa-miR-520d-3p	CLIP-seq
MIRT1128183	hsa-miR-520e	CLIP-seq
MIRT1128185	hsa-miR-548t	CLIP-seq
MIRT1128187	hsa-miR-93	CLIP-seq
MIRT1128130	hsa-miR-106a	CLIP-seq
MIRT1128131	hsa-miR-106b	CLIP-seq
MIRT1128135	hsa-miR-1286	CLIP-seq
MIRT1128138	hsa-miR-17	CLIP-seq
MIRT1128141	hsa-miR-20a	CLIP-seq
MIRT1128142	hsa-miR-20b	CLIP-seq
MIRT1128146	hsa-miR-302a	CLIP-seq
MIRT1128147	hsa-miR-302b	CLIP-seq
MIRT1128148	hsa-miR-302c	CLIP-seq
MIRT1128149	hsa-miR-302d	CLIP-seq
MIRT1128150	hsa-miR-302e	CLIP-seq
MIRT1128153	hsa-miR-372	CLIP-seq
MIRT1128154	hsa-miR-373	CLIP-seq
MIRT1128167	hsa-miR-4690-5p	CLIP-seq
MIRT1128177	hsa-miR-512-3p	CLIP-seq
MIRT1128178	hsa-miR-519d	CLIP-seq
MIRT1128179	hsa-miR-520a-3p	CLIP-seq
MIRT1128180	hsa-miR-520b	CLIP-seq
MIRT1128181	hsa-miR-520c-3p	CLIP-seq
MIRT1128182	hsa-miR-520d-3p	CLIP-seq
MIRT1128183	hsa-miR-520e	CLIP-seq
MIRT1128185	hsa-miR-548t	CLIP-seq
MIRT1128187	hsa-miR-93	CLIP-seq

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IMP	15258589
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	8183572, 10799501
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	8195146
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	10799501
GO:0004706	Function	JUN kinase kinase kinase activity	IBA
GO:0004706	Function	JUN kinase kinase kinase activity	IEA
GO:0004706	Function	JUN kinase kinase kinase activity	IMP	15258589
GO:0004706	Function	JUN kinase kinase kinase activity	ISS
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IMP	15258589
GO:0005515	Function	Protein binding	IPI	9003777, 20890305, 23857585, 25241761
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	12529434
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	12529434
GO:0006468	Process	Protein phosphorylation	IDA	11053428
GO:0007017	Process	Microtubule-based process	IBA
GO:0007017	Process	Microtubule-based process	IMP	12529434
GO:0007254	Process	JNK cascade	IBA
GO:0007254	Process	JNK cascade	IEA
GO:0007254	Process	JNK cascade	IMP	15258589
GO:0007254	Process	JNK cascade	TAS	10799501
GO:0016020	Component	Membrane	HDA	19946888
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031434	Function	Mitogen-activated protein kinase kinase binding	IEA
GO:0031435	Function	Mitogen-activated protein kinase kinase kinase binding	IPI	17584736
GO:0042802	Function	Identical protein binding	IPI	9829970
GO:0042803	Function	Protein homodimerization activity	IPI	9829970
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043507	Process	Positive regulation of JUN kinase activity	IMP	17584736
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0044843	Process	Cell cycle G1/S phase transition	IMP	15258589
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IMP	17584736
GO:0046777	Process	Protein autophosphorylation	IDA	8195146
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
600050	6850	ENSG00000173327

Q16584

Protein name

Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)

Protein function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. P

PDB

5K26 , 5K28 , 6AQB , 6CQ7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	48 → 101	Variant SH3 domain	Domain
PF07714	PK_Tyr_Ser-Thr	117 → 376	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. {ECO:0000269|PubMed:8183572, ECO:0000269|P

Sequence

MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP

Sequence length

847

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Non-alcoholic fatty liver disease		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Moyamoya angiopathy	Likely pathogenic	rs746476599	RCV004704487

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Lung cancer	Uncertain significance	rs1218144252	RCV005927287

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	36969166
Asthma	Associate	28479334
Breast Neoplasms	Associate	15001580, 26152725, 28388540
Carcinogenesis	Associate	19567454, 24912674
Carcinoma Hepatocellular	Associate	32214367
Colorectal Neoplasms	Associate	24628919, 29084209
Coronary Artery Disease	Associate	35246263
Encephalitis Herpes Simplex	Associate	21880738
Esophageal Neoplasms	Associate	26717044
Gastrointestinal Neoplasms	Associate	24628919
Glioblastoma	Associate	28487380
Hippocampal Sclerosis	Associate	32189710
HIV Infections	Associate	17257639
Hypertrophy Left Ventricular	Associate	29506515
Infections	Stimulate	17257639
Infections	Associate	23797008
Inflammation	Associate	19586614
Keratoacanthoma	Associate	27788211
Leiomyoma	Associate	19567454
Melanoma	Associate	35307409
Neoplasms	Inhibit	21048306, 28388540
Neoplasms	Associate	21880738, 24628919, 29084209, 33875576
Obesity	Stimulate	28479334
Ovarian Neoplasms	Associate	22652451, 24912674, 28757353, 33875576, 35843311
Prostatic Neoplasms	Associate	21880738, 22761715
Prostatic Neoplasms Castration Resistant	Associate	33298586
Pterygium	Associate	32867783
Rhabdomyosarcoma	Associate	23797008
Stomach Neoplasms	Associate	20150185, 21048306
Triple Negative Breast Neoplasms	Associate	32235890

MAP3K11 (mitogen-activated protein kinase kinase kinase 11)