CXCL9 (C-X-C motif chemokine ligand 9)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4283
Gene name C-X-C motif chemokine ligand 9
Gene symbol CXCL9
Synonyms (NCBI Gene)
CMKHumigMIGSCYB9crg-10
Chromosome 4
Chromosome location 4q21.1
Summary This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C moti
miRNA miRNA information provided by mirtarbase database.
46
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (46)
miRTarBase ID miRNA Experiments Reference
MIRT016944 hsa-miR-335-5p Microarray 18185580
MIRT025283 hsa-miR-34a-5p Proteomics 21566225
MIRT028888 hsa-miR-26b-5p Microarray 19088304
MIRT736789 hsa-miR-588 Western blottingImmunohistochemistry (IHC)qRT-PCR 33323542
MIRT918121 hsa-miR-1251 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (40)
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity TAS 2115167
GO:0005515 Function Protein binding IPI 18275857, 21314817, 25416956, 28381538, 31515488, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601704 7098 ENSG00000138755
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q07325
Protein name C-X-C motif chemokine 9 (Gamma-interferon-induced monokine) (Monokine induced by interferon-gamma) (HuMIG) (MIG) (Small-inducible cytokine B9)
Protein function Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 29 → 89 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence 
MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEK
IEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSR
QKKTT
Sequence length 125
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway
Toll-like receptor signaling pathway 		  Chemokine receptors bind chemokines
G alpha (i) signalling events
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (13)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BILIARY CIRRHOSIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CAROTID STENOSIS — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CELIAC DISEASE — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (255)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acrodermatitis Stimulate 17606602
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Kidney Injury Stimulate 32165324
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Stimulate 22247499
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 31960110, 32509861
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Mucinous Associate 32840168
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 36991099
★★★★★
★☆☆☆☆
Found in Text Mining only
Allergic Fungal Sinusitis Associate 26047816
★★★★★
★☆☆☆☆
Found in Text Mining only
Alopecia Areata Stimulate 23502337
★★★★★
★☆☆☆☆
Found in Text Mining only
Aneurysm Associate 23887838
★★★★★
★☆☆☆☆
Found in Text Mining only
Appendicitis Associate 30918467
★★★★★
★☆☆☆☆
Found in Text Mining only