MIF (macrophage migration inhibitory factor)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4282
Gene name Gene Name - the full gene name approved by the HGNC.
Macrophage migration inhibitory factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MIF
Synonyms (NCBI Gene) Gene synonyms aliases
GIF, GLIF, MMIF
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This l
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT000664 hsa-miR-338-3p Review 19935707
MIRT000046 hsa-miR-451a Review 20026422
MIRT000046 hsa-miR-451a ELISA, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19318487
MIRT000046 hsa-miR-451a ELISA, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19318487
MIRT044670 hsa-miR-320a CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
Transcription factor Regulation Reference
HBP1 Repression 20383199
HIF1A Activation 20727156
NFKB1 Unknown 18710704
RELA Unknown 18710704
SP1 Activation 18034423
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(73)
GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IDA 12782713
GO:0001819 Process Positive regulation of cytokine production IDA 19602265
GO:0002020 Function Protease binding IEA
GO:0002376 Process Immune system process IEA
GO:0002906 Process Negative regulation of mature B cell apoptotic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
153620 7097 ENSG00000240972
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14174
Protein name Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
Protein function Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of
PDB 1CA7 , 1CGQ , 1GCZ , 1GD0 , 1GIF , 1LJT , 1MIF , 1P1G , 2OOH , 2OOW , 2OOZ , 3B9S , 3CE4 , 3DJH , 3DJI , 3HOF , 3IJG , 3IJJ , 3JSF , 3JSG , 3JTU , 3L5P , 3L5R , 3L5S , 3L5T , 3L5U , 3L5V , 3SMB , 3SMC , 3U18 , 3WNR , 3WNS , 3WNT , 4ETG , 4EUI , 4EVG , 4F2K , 4GRN , 4GRO , 4GRP , 4GRQ , 4GRR , 4GRU , 4GUM , 4K9G , 4OSF , 4OYQ , 4P01 , 4P0H , 4PKK , 4PKZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01187 MIF 2 → 115 Macrophage migration inhibitory factor (MIF) Domain
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Tyrosine metabolism
Phenylalanine metabolism
Metabolic pathways 		  Cell surface interactions at the vascular wall
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Cystic Fibrosis cystic fibrosis N/A N/A GenCC
Show/Hide Text Mining Associations (304)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Stimulate 14769218, 22693633
Acute Coronary Syndrome Associate 25105152, 27101443, 31924846
Adenocarcinoma Associate 15248897, 18820669, 25716200
Adenocarcinoma Inhibit 18751381
Adenocarcinoma Stimulate 26530123
Adenocarcinoma of Lung Associate 17709373, 24932684, 30070326, 37783508, 37784249, 39735553
Alzheimer Disease Associate 28005991, 28230058, 31611872, 37147668, 38178159
Anemia Associate 19591577
Anemia Aplastic Associate 40406144
Aneurysm Associate 12618703