MIF (macrophage migration inhibitory factor)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 4282
Gene name Macrophage migration inhibitory factor
Gene symbol MIF
Synonyms (NCBI Gene)
GIFGLIFMMIF
Chromosome 22
Chromosome location 22q11.23
Summary This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This l
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT000664 hsa-miR-338-3p Review 19935707
MIRT000046 hsa-miR-451a Review 20026422
MIRT000046 hsa-miR-451a ELISALuciferase reporter assayMicroarrayqRT-PCRWestern blot 19318487
MIRT000046 hsa-miR-451a ELISALuciferase reporter assayMicroarrayqRT-PCRWestern blot 19318487
MIRT044670 hsa-miR-320a CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Transcription factor Regulation Reference
HBP1 Repression 20383199
HIF1A Activation 20727156
NFKB1 Unknown 18710704
RELA Unknown 18710704
SP1 Activation 18034423
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IDA 12782713
GO:0001819 Process Positive regulation of cytokine production IDA 19602265
GO:0002020 Function Protease binding IEA
GO:0002376 Process Immune system process IEA
GO:0002906 Process Negative regulation of mature B cell apoptotic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
153620 7097 ENSG00000240972
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14174
Protein name Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
Protein function Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (PubMed:15908412, PubMed:17443469, PubMed:23776208). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of
PDB 1CA7 , 1CGQ , 1GCZ , 1GD0 , 1GIF , 1LJT , 1MIF , 1P1G , 2OOH , 2OOW , 2OOZ , 3B9S , 3CE4 , 3DJH , 3DJI , 3HOF , 3IJG , 3IJJ , 3JSF , 3JSG , 3JTU , 3L5P , 3L5R , 3L5S , 3L5T , 3L5U , 3L5V , 3SMB , 3SMC , 3U18 , 3WNR , 3WNS , 3WNT , 4ETG , 4EUI , 4EVG , 4F2K , 4GRN , 4GRO , 4GRP , 4GRQ , 4GRR , 4GRU , 4GUM , 4K9G , 4OSF , 4OYQ , 4P01 , 4P0H , 4PKK , 4PKZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01187 MIF 2 → 115 Macrophage migration inhibitory factor (MIF) Domain
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Tyrosine metabolism
Phenylalanine metabolism
Metabolic pathways 		  Cell surface interactions at the vascular wall
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (14)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
- risk factor rs755622 RCV000015433
Familial cancer of breast Benign rs2070766 RCV005937217
Glioma susceptibility 1 Benign rs2070766 RCV005937218
Hepatocellular carcinoma Benign rs2070766 RCV005937219
Show/Hide Text Mining Associations (304)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Stimulate 14769218, 22693633
Acute Coronary Syndrome Associate 25105152, 27101443, 31924846
Adenocarcinoma Associate 15248897, 18820669, 25716200
Adenocarcinoma Inhibit 18751381
Adenocarcinoma Stimulate 26530123
Adenocarcinoma of Lung Associate 17709373, 24932684, 30070326, 37783508, 37784249, 39735553
Alzheimer Disease Associate 28005991, 28230058, 31611872, 37147668, 38178159
Anemia Associate 19591577
Anemia Aplastic Associate 40406144
Aneurysm Associate 12618703