Gene Gene information from NCBI Gene database.
Entrez ID 4277
Gene name MHC class I polypeptide-related sequence B
Gene symbol MICB
Synonyms (NCBI Gene)
PERB11.2
Chromosome 6
Chromosome location 6p21.33
Summary This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the recepto
miRNA miRNA information provided by mirtarbase database.
380
miRTarBase ID miRNA Experiments Reference
MIRT001999 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT001999 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT001999 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT691422 hsa-miR-6856-3p HITS-CLIP 23313552
MIRT691421 hsa-miR-129-1-3p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
6
Transcription factor Regulation Reference
ESR1 Unknown 23527639
HDAC1 Unknown 17625602
HSF1 Activation 19139882
SP1 Activation 19139882
SP1 Unknown 23527639
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002429 Process Immune response-activating cell surface receptor signaling pathway IDA 11491531
GO:0005615 Component Extracellular space IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602436 7091 ENSG00000204516
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q29980
Protein name MHC class I polypeptide-related sequence B (MIC-B)
Protein function Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubM
PDB 1JE6 , 2WY3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I 24 201 Class I Histocompatibility antigen, domains alpha 1 and 2 Domain
PF07654 C1-set 208 289 Immunoglobulin C1-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumo
Sequence
Sequence length 383
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Natural killer cell mediated cytotoxicity
Kaposi sarcoma-associated herpesvirus infection
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell