MICB (MHC class I polypeptide-related sequence B)

Gene

• Entrez ID: 4277
• Gene name: MHC class I polypeptide-related sequence B
• Gene symbol: MICB
• Synonyms (NCBI Gene): PERB11.2
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the recepto

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001999	hcmv-miR-UL112-3p	Luciferase reporter assay	17641203
MIRT001999	hcmv-miR-UL112-3p	Luciferase reporter assay	17641203
MIRT001999	hcmv-miR-UL112-3p	Luciferase reporter assay	17641203
MIRT691422	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT691421	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT691420	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT683791	hsa-miR-5088-5p	HITS-CLIP	23313552
MIRT683789	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT691419	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT683787	hsa-miR-3151-3p	HITS-CLIP	23313552
MIRT691418	hsa-miR-6886-3p	HITS-CLIP	23313552
MIRT683785	hsa-miR-760	HITS-CLIP	23313552
MIRT683781	hsa-miR-3192-3p	HITS-CLIP	23313552
MIRT683779	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT683791	hsa-miR-5088-5p	HITS-CLIP	23313552
MIRT683790	hsa-miR-6805-5p	HITS-CLIP	23313552
MIRT683789	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT683788	hsa-miR-6798-5p	HITS-CLIP	23313552
MIRT683787	hsa-miR-3151-3p	HITS-CLIP	23313552
MIRT683786	hsa-miR-103a-2-5p	HITS-CLIP	23313552
MIRT683785	hsa-miR-760	HITS-CLIP	23313552
MIRT683784	hsa-miR-6815-3p	HITS-CLIP	23313552
MIRT683783	hsa-miR-6846-5p	HITS-CLIP	23313552
MIRT683782	hsa-miR-6848-5p	HITS-CLIP	23313552
MIRT683781	hsa-miR-3192-3p	HITS-CLIP	23313552
MIRT683780	hsa-miR-3977	HITS-CLIP	23313552
MIRT683779	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT100281	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT100277	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439155	hsa-let-7c-5p	3'LIFE	25074381
MIRT100281	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT100276	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT100288	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT100278	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT100297	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT100277	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439155	hsa-let-7c-5p	3'LIFE	25074381
MIRT753612	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT753613	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT753612	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT753613	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT691422	hsa-miR-6856-3p	HITS-CLIP	23313552
MIRT691421	hsa-miR-129-1-3p	HITS-CLIP	23313552
MIRT691420	hsa-miR-129-2-3p	HITS-CLIP	23313552
MIRT683791	hsa-miR-5088-5p	HITS-CLIP	23313552
MIRT683789	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT691419	hsa-miR-140-3p	HITS-CLIP	23313552
MIRT683787	hsa-miR-3151-3p	HITS-CLIP	23313552
MIRT691418	hsa-miR-6886-3p	HITS-CLIP	23313552
MIRT683785	hsa-miR-760	HITS-CLIP	23313552
MIRT683781	hsa-miR-3192-3p	HITS-CLIP	23313552
MIRT683779	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT683791	hsa-miR-5088-5p	HITS-CLIP	23313552
MIRT683790	hsa-miR-6805-5p	HITS-CLIP	23313552
MIRT683789	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT683788	hsa-miR-6798-5p	HITS-CLIP	23313552
MIRT683787	hsa-miR-3151-3p	HITS-CLIP	23313552
MIRT683786	hsa-miR-103a-2-5p	HITS-CLIP	23313552
MIRT683785	hsa-miR-760	HITS-CLIP	23313552
MIRT683784	hsa-miR-6815-3p	HITS-CLIP	23313552
MIRT683783	hsa-miR-6846-5p	HITS-CLIP	23313552
MIRT683782	hsa-miR-6848-5p	HITS-CLIP	23313552
MIRT683781	hsa-miR-3192-3p	HITS-CLIP	23313552
MIRT683780	hsa-miR-3977	HITS-CLIP	23313552
MIRT683779	hsa-miR-3692-3p	HITS-CLIP	23313552
MIRT1148282	hsa-let-7a	CLIP-seq
MIRT1148283	hsa-let-7b	CLIP-seq
MIRT1148284	hsa-let-7c	CLIP-seq
MIRT1148285	hsa-let-7d	CLIP-seq
MIRT1148286	hsa-let-7e	CLIP-seq
MIRT1148287	hsa-let-7f	CLIP-seq
MIRT1148288	hsa-let-7g	CLIP-seq
MIRT1148289	hsa-let-7i	CLIP-seq
MIRT1148290	hsa-miR-103a	CLIP-seq
MIRT1148291	hsa-miR-107	CLIP-seq
MIRT1148292	hsa-miR-1184	CLIP-seq
MIRT1148293	hsa-miR-1207-3p	CLIP-seq
MIRT1148294	hsa-miR-122	CLIP-seq
MIRT1148295	hsa-miR-1228	CLIP-seq
MIRT1148296	hsa-miR-1237	CLIP-seq
MIRT1148297	hsa-miR-1257	CLIP-seq
MIRT1148298	hsa-miR-1262	CLIP-seq
MIRT1148299	hsa-miR-1269	CLIP-seq
MIRT1148300	hsa-miR-1269b	CLIP-seq
MIRT1148301	hsa-miR-1273e	CLIP-seq
MIRT1148302	hsa-miR-1276	CLIP-seq
MIRT1148303	hsa-miR-1288	CLIP-seq
MIRT1148304	hsa-miR-129-3p	CLIP-seq
MIRT1148305	hsa-miR-1301	CLIP-seq
MIRT1148306	hsa-miR-141	CLIP-seq
MIRT1148307	hsa-miR-198	CLIP-seq
MIRT1148308	hsa-miR-200a	CLIP-seq
MIRT1148309	hsa-miR-202	CLIP-seq
MIRT1148310	hsa-miR-2054	CLIP-seq
MIRT1148311	hsa-miR-217	CLIP-seq
MIRT1148312	hsa-miR-24	CLIP-seq
MIRT1148313	hsa-miR-29a	CLIP-seq
MIRT1148314	hsa-miR-29b	CLIP-seq
MIRT1148315	hsa-miR-29c	CLIP-seq
MIRT1148316	hsa-miR-302a	CLIP-seq
MIRT1148317	hsa-miR-302b	CLIP-seq
MIRT1148318	hsa-miR-302c	CLIP-seq
MIRT1148319	hsa-miR-302d	CLIP-seq
MIRT1148320	hsa-miR-302e	CLIP-seq
MIRT1148321	hsa-miR-30a	CLIP-seq
MIRT1148322	hsa-miR-30b	CLIP-seq
MIRT1148323	hsa-miR-30c	CLIP-seq
MIRT1148324	hsa-miR-30d	CLIP-seq
MIRT1148325	hsa-miR-30e	CLIP-seq
MIRT1148326	hsa-miR-3120-5p	CLIP-seq
MIRT1148327	hsa-miR-3122	CLIP-seq
MIRT1148328	hsa-miR-3163	CLIP-seq
MIRT1148329	hsa-miR-3182	CLIP-seq
MIRT1148330	hsa-miR-3185	CLIP-seq
MIRT1148331	hsa-miR-3190	CLIP-seq
MIRT1148332	hsa-miR-3192	CLIP-seq
MIRT1148333	hsa-miR-3545-3p	CLIP-seq
MIRT1148334	hsa-miR-3613-3p	CLIP-seq
MIRT1148335	hsa-miR-3622a-5p	CLIP-seq
MIRT1148336	hsa-miR-365	CLIP-seq
MIRT1148337	hsa-miR-3663-3p	CLIP-seq
MIRT1148338	hsa-miR-3664-5p	CLIP-seq
MIRT1148339	hsa-miR-3672	CLIP-seq
MIRT1148340	hsa-miR-3692	CLIP-seq
MIRT1148341	hsa-miR-3714	CLIP-seq
MIRT1148342	hsa-miR-371-5p	CLIP-seq
MIRT1148343	hsa-miR-371b-5p	CLIP-seq
MIRT1148344	hsa-miR-372	CLIP-seq
MIRT1148345	hsa-miR-373	CLIP-seq
MIRT1148346	hsa-miR-3913-5p	CLIP-seq
MIRT1148347	hsa-miR-411	CLIP-seq
MIRT1148348	hsa-miR-4269	CLIP-seq
MIRT1148349	hsa-miR-4284	CLIP-seq
MIRT1148350	hsa-miR-4290	CLIP-seq
MIRT1148351	hsa-miR-4294	CLIP-seq
MIRT1148352	hsa-miR-4311	CLIP-seq
MIRT1148353	hsa-miR-4418	CLIP-seq
MIRT1148354	hsa-miR-4432	CLIP-seq
MIRT1148355	hsa-miR-4433	CLIP-seq
MIRT1148356	hsa-miR-4458	CLIP-seq
MIRT1148357	hsa-miR-4480	CLIP-seq
MIRT1148358	hsa-miR-4500	CLIP-seq
MIRT1148359	hsa-miR-450b-3p	CLIP-seq
MIRT1148360	hsa-miR-4514	CLIP-seq
MIRT1148361	hsa-miR-4515	CLIP-seq
MIRT1148362	hsa-miR-4522	CLIP-seq
MIRT1148363	hsa-miR-4529-3p	CLIP-seq
MIRT1148364	hsa-miR-4637	CLIP-seq
MIRT1148365	hsa-miR-4645-5p	CLIP-seq
MIRT1148366	hsa-miR-4649-3p	CLIP-seq
MIRT1148367	hsa-miR-4673	CLIP-seq
MIRT1148368	hsa-miR-4692	CLIP-seq
MIRT1148369	hsa-miR-4701-3p	CLIP-seq
MIRT1148370	hsa-miR-4717-5p	CLIP-seq
MIRT1148371	hsa-miR-4724-5p	CLIP-seq
MIRT1148372	hsa-miR-4731-5p	CLIP-seq
MIRT1148373	hsa-miR-4740-5p	CLIP-seq
MIRT1148374	hsa-miR-4755-3p	CLIP-seq
MIRT1148375	hsa-miR-4789-3p	CLIP-seq
MIRT1148376	hsa-miR-4797-5p	CLIP-seq
MIRT1148377	hsa-miR-491-3p	CLIP-seq
MIRT1148378	hsa-miR-499-5p	CLIP-seq
MIRT1148379	hsa-miR-501-3p	CLIP-seq
MIRT1148380	hsa-miR-502-3p	CLIP-seq
MIRT1148381	hsa-miR-5047	CLIP-seq
MIRT1148382	hsa-miR-509-3-5p	CLIP-seq
MIRT1148383	hsa-miR-509-5p	CLIP-seq
MIRT1148384	hsa-miR-520a-3p	CLIP-seq
MIRT1148385	hsa-miR-520a-5p	CLIP-seq
MIRT1148386	hsa-miR-520b	CLIP-seq
MIRT1148387	hsa-miR-520c-3p	CLIP-seq
MIRT1148388	hsa-miR-520d-3p	CLIP-seq
MIRT1148389	hsa-miR-520e	CLIP-seq
MIRT1148390	hsa-miR-520f	CLIP-seq
MIRT1148391	hsa-miR-525-5p	CLIP-seq
MIRT1148392	hsa-miR-542-3p	CLIP-seq
MIRT1148393	hsa-miR-545	CLIP-seq
MIRT1148394	hsa-miR-564	CLIP-seq
MIRT1148395	hsa-miR-578	CLIP-seq
MIRT1148396	hsa-miR-583	CLIP-seq
MIRT1148397	hsa-miR-633	CLIP-seq
MIRT1148398	hsa-miR-636	CLIP-seq
MIRT1148399	hsa-miR-643	CLIP-seq
MIRT1148400	hsa-miR-661	CLIP-seq
MIRT1148401	hsa-miR-7	CLIP-seq
MIRT1148402	hsa-miR-759	CLIP-seq
MIRT1148403	hsa-miR-767-5p	CLIP-seq
MIRT1148404	hsa-miR-769-3p	CLIP-seq
MIRT1148405	hsa-miR-940	CLIP-seq
MIRT1148406	hsa-miR-98	CLIP-seq
MIRT2042205	hsa-miR-1207-5p	CLIP-seq
MIRT2042206	hsa-miR-1283	CLIP-seq
MIRT2042207	hsa-miR-138	CLIP-seq
MIRT1148311	hsa-miR-217	CLIP-seq
MIRT1148316	hsa-miR-302a	CLIP-seq
MIRT1148317	hsa-miR-302b	CLIP-seq
MIRT1148318	hsa-miR-302c	CLIP-seq
MIRT1148319	hsa-miR-302d	CLIP-seq
MIRT1148320	hsa-miR-302e	CLIP-seq
MIRT1148332	hsa-miR-3192	CLIP-seq
MIRT1148334	hsa-miR-3613-3p	CLIP-seq
MIRT2042208	hsa-miR-3680	CLIP-seq
MIRT1148344	hsa-miR-372	CLIP-seq
MIRT1148345	hsa-miR-373	CLIP-seq
MIRT2042209	hsa-miR-376a	CLIP-seq
MIRT2042210	hsa-miR-376b	CLIP-seq
MIRT2042211	hsa-miR-380	CLIP-seq
MIRT2042212	hsa-miR-4270	CLIP-seq
MIRT2042213	hsa-miR-4299	CLIP-seq
MIRT1148353	hsa-miR-4418	CLIP-seq
MIRT1148355	hsa-miR-4433	CLIP-seq
MIRT2042214	hsa-miR-4441	CLIP-seq
MIRT2042215	hsa-miR-4496	CLIP-seq
MIRT1148360	hsa-miR-4514	CLIP-seq
MIRT1148365	hsa-miR-4645-5p	CLIP-seq
MIRT1148367	hsa-miR-4673	CLIP-seq
MIRT2042216	hsa-miR-4684-5p	CLIP-seq
MIRT1148368	hsa-miR-4692	CLIP-seq
MIRT2042217	hsa-miR-4710	CLIP-seq
MIRT2042218	hsa-miR-4735-5p	CLIP-seq
MIRT2042219	hsa-miR-4763-3p	CLIP-seq
MIRT2042220	hsa-miR-4792	CLIP-seq
MIRT2042221	hsa-miR-4798-3p	CLIP-seq
MIRT1148382	hsa-miR-509-3-5p	CLIP-seq
MIRT1148383	hsa-miR-509-5p	CLIP-seq
MIRT2042222	hsa-miR-512-3p	CLIP-seq
MIRT1148384	hsa-miR-520a-3p	CLIP-seq
MIRT1148386	hsa-miR-520b	CLIP-seq
MIRT1148387	hsa-miR-520c-3p	CLIP-seq
MIRT1148388	hsa-miR-520d-3p	CLIP-seq
MIRT1148389	hsa-miR-520e	CLIP-seq
MIRT2042223	hsa-miR-561	CLIP-seq
MIRT2042224	hsa-miR-765	CLIP-seq
MIRT2042225	hsa-miR-873	CLIP-seq
MIRT1148405	hsa-miR-940	CLIP-seq
MIRT1148290	hsa-miR-103a	CLIP-seq
MIRT1148291	hsa-miR-107	CLIP-seq
MIRT1148295	hsa-miR-1228	CLIP-seq
MIRT1148301	hsa-miR-1273e	CLIP-seq
MIRT1148305	hsa-miR-1301	CLIP-seq
MIRT1148306	hsa-miR-141	CLIP-seq
MIRT1148308	hsa-miR-200a	CLIP-seq
MIRT1148311	hsa-miR-217	CLIP-seq
MIRT1148316	hsa-miR-302a	CLIP-seq
MIRT1148317	hsa-miR-302b	CLIP-seq
MIRT1148318	hsa-miR-302c	CLIP-seq
MIRT1148319	hsa-miR-302d	CLIP-seq
MIRT1148320	hsa-miR-302e	CLIP-seq
MIRT1148327	hsa-miR-3122	CLIP-seq
MIRT1148332	hsa-miR-3192	CLIP-seq
MIRT1148333	hsa-miR-3545-3p	CLIP-seq
MIRT1148341	hsa-miR-3714	CLIP-seq
MIRT1148344	hsa-miR-372	CLIP-seq
MIRT1148345	hsa-miR-373	CLIP-seq
MIRT1148346	hsa-miR-3913-5p	CLIP-seq
MIRT1148353	hsa-miR-4418	CLIP-seq
MIRT1148354	hsa-miR-4432	CLIP-seq
MIRT1148355	hsa-miR-4433	CLIP-seq
MIRT1148357	hsa-miR-4480	CLIP-seq
MIRT1148359	hsa-miR-450b-3p	CLIP-seq
MIRT1148360	hsa-miR-4514	CLIP-seq
MIRT1148368	hsa-miR-4692	CLIP-seq
MIRT1148378	hsa-miR-499-5p	CLIP-seq
MIRT1148381	hsa-miR-5047	CLIP-seq
MIRT1148382	hsa-miR-509-3-5p	CLIP-seq
MIRT1148383	hsa-miR-509-5p	CLIP-seq
MIRT1148384	hsa-miR-520a-3p	CLIP-seq
MIRT1148386	hsa-miR-520b	CLIP-seq
MIRT1148387	hsa-miR-520c-3p	CLIP-seq
MIRT1148388	hsa-miR-520d-3p	CLIP-seq
MIRT1148389	hsa-miR-520e	CLIP-seq
MIRT1148390	hsa-miR-520f	CLIP-seq
MIRT1148398	hsa-miR-636	CLIP-seq
MIRT1148404	hsa-miR-769-3p	CLIP-seq
MIRT1148405	hsa-miR-940	CLIP-seq
MIRT1148301	hsa-miR-1273e	CLIP-seq
MIRT2390877	hsa-miR-15a	CLIP-seq
MIRT2390878	hsa-miR-15b	CLIP-seq
MIRT2390879	hsa-miR-16	CLIP-seq
MIRT2390880	hsa-miR-195	CLIP-seq
MIRT2390881	hsa-miR-2278	CLIP-seq
MIRT1148316	hsa-miR-302a	CLIP-seq
MIRT1148317	hsa-miR-302b	CLIP-seq
MIRT1148318	hsa-miR-302c	CLIP-seq
MIRT1148319	hsa-miR-302d	CLIP-seq
MIRT1148320	hsa-miR-302e	CLIP-seq
MIRT1148332	hsa-miR-3192	CLIP-seq
MIRT1148344	hsa-miR-372	CLIP-seq
MIRT1148345	hsa-miR-373	CLIP-seq
MIRT2390882	hsa-miR-424	CLIP-seq
MIRT2390883	hsa-miR-497	CLIP-seq
MIRT1148384	hsa-miR-520a-3p	CLIP-seq
MIRT1148386	hsa-miR-520b	CLIP-seq
MIRT1148387	hsa-miR-520c-3p	CLIP-seq
MIRT1148388	hsa-miR-520d-3p	CLIP-seq
MIRT1148389	hsa-miR-520e	CLIP-seq
MIRT1148390	hsa-miR-520f	CLIP-seq
MIRT1148393	hsa-miR-545	CLIP-seq
MIRT1148398	hsa-miR-636	CLIP-seq
MIRT1148290	hsa-miR-103a	CLIP-seq
MIRT1148291	hsa-miR-107	CLIP-seq
MIRT1148305	hsa-miR-1301	CLIP-seq
MIRT1148306	hsa-miR-141	CLIP-seq
MIRT1148308	hsa-miR-200a	CLIP-seq
MIRT1148381	hsa-miR-5047	CLIP-seq
MIRT2042206	hsa-miR-1283	CLIP-seq
MIRT1148326	hsa-miR-3120-5p	CLIP-seq
MIRT1148334	hsa-miR-3613-3p	CLIP-seq
MIRT1148338	hsa-miR-3664-5p	CLIP-seq
MIRT1148339	hsa-miR-3672	CLIP-seq
MIRT1148342	hsa-miR-371-5p	CLIP-seq
MIRT1148343	hsa-miR-371b-5p	CLIP-seq
MIRT1148362	hsa-miR-4522	CLIP-seq
MIRT2042216	hsa-miR-4684-5p	CLIP-seq
MIRT1148290	hsa-miR-103a	CLIP-seq
MIRT1148291	hsa-miR-107	CLIP-seq
MIRT2570766	hsa-miR-10a	CLIP-seq
MIRT2570767	hsa-miR-10b	CLIP-seq
MIRT2570768	hsa-miR-1208	CLIP-seq
MIRT1148299	hsa-miR-1269	CLIP-seq
MIRT1148300	hsa-miR-1269b	CLIP-seq
MIRT2042206	hsa-miR-1283	CLIP-seq
MIRT1148303	hsa-miR-1288	CLIP-seq
MIRT1148305	hsa-miR-1301	CLIP-seq
MIRT1148306	hsa-miR-141	CLIP-seq
MIRT2570769	hsa-miR-183	CLIP-seq
MIRT1148308	hsa-miR-200a	CLIP-seq
MIRT2570770	hsa-miR-296-5p	CLIP-seq
MIRT1148326	hsa-miR-3120-5p	CLIP-seq
MIRT1148334	hsa-miR-3613-3p	CLIP-seq
MIRT1148338	hsa-miR-3664-5p	CLIP-seq
MIRT1148339	hsa-miR-3672	CLIP-seq
MIRT1148342	hsa-miR-371-5p	CLIP-seq
MIRT1148343	hsa-miR-371b-5p	CLIP-seq
MIRT1148361	hsa-miR-4515	CLIP-seq
MIRT2570771	hsa-miR-4517	CLIP-seq
MIRT1148362	hsa-miR-4522	CLIP-seq
MIRT1148363	hsa-miR-4529-3p	CLIP-seq
MIRT2042216	hsa-miR-4684-5p	CLIP-seq
MIRT1148371	hsa-miR-4724-5p	CLIP-seq
MIRT1148373	hsa-miR-4740-5p	CLIP-seq
MIRT2570772	hsa-miR-4742-3p	CLIP-seq
MIRT2570773	hsa-miR-4758-3p	CLIP-seq
MIRT1148381	hsa-miR-5047	CLIP-seq
MIRT2570774	hsa-miR-889	CLIP-seq
MIRT1148290	hsa-miR-103a	CLIP-seq
MIRT1148291	hsa-miR-107	CLIP-seq
MIRT2570766	hsa-miR-10a	CLIP-seq
MIRT2570767	hsa-miR-10b	CLIP-seq
MIRT2570768	hsa-miR-1208	CLIP-seq
MIRT1148299	hsa-miR-1269	CLIP-seq
MIRT1148300	hsa-miR-1269b	CLIP-seq
MIRT2042206	hsa-miR-1283	CLIP-seq
MIRT1148303	hsa-miR-1288	CLIP-seq
MIRT1148305	hsa-miR-1301	CLIP-seq
MIRT1148306	hsa-miR-141	CLIP-seq
MIRT2570769	hsa-miR-183	CLIP-seq
MIRT1148308	hsa-miR-200a	CLIP-seq
MIRT2570770	hsa-miR-296-5p	CLIP-seq
MIRT1148326	hsa-miR-3120-5p	CLIP-seq
MIRT2685014	hsa-miR-323-5p	CLIP-seq
MIRT1148334	hsa-miR-3613-3p	CLIP-seq
MIRT1148338	hsa-miR-3664-5p	CLIP-seq
MIRT1148339	hsa-miR-3672	CLIP-seq
MIRT1148342	hsa-miR-371-5p	CLIP-seq
MIRT1148343	hsa-miR-371b-5p	CLIP-seq
MIRT2685015	hsa-miR-4455	CLIP-seq
MIRT1148361	hsa-miR-4515	CLIP-seq
MIRT2570771	hsa-miR-4517	CLIP-seq
MIRT1148362	hsa-miR-4522	CLIP-seq
MIRT1148363	hsa-miR-4529-3p	CLIP-seq
MIRT2042216	hsa-miR-4684-5p	CLIP-seq
MIRT1148371	hsa-miR-4724-5p	CLIP-seq
MIRT1148373	hsa-miR-4740-5p	CLIP-seq
MIRT2570772	hsa-miR-4742-3p	CLIP-seq
MIRT2570773	hsa-miR-4758-3p	CLIP-seq
MIRT1148381	hsa-miR-5047	CLIP-seq
MIRT2685016	hsa-miR-609	CLIP-seq
MIRT2685017	hsa-miR-876-3p	CLIP-seq
MIRT2570774	hsa-miR-889	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ESR1	Unknown	23527639
HDAC1	Unknown	17625602
HSF1	Activation	19139882
SP1	Activation	19139882
SP1	Unknown	23527639
SP3	Unknown	23527639

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002429	Process	Immune response-activating cell surface receptor signaling pathway	IDA	11491531
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA	21873635
GO:0006979	Process	Response to oxidative stress	IDA	11287116
GO:0009408	Process	Response to heat	IDA	9497295
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0016032	Process	Viral process	IEA
GO:0019835	Process	Cytolysis	IEA
GO:0032526	Process	Response to retinoic acid	IDA	12569559
GO:0046629	Process	Gamma-delta T cell activation	IDA	9497295
GO:0046703	Function	Natural killer cell lectin-like receptor binding	IDA	11491531
GO:0050689	Process	Negative regulation of defense response to virus by host	IDA	11239445, 12782710
GO:0050776	Process	Regulation of immune response	TAS

Other IDs

• MIM: 602436
• HGNC: 7091
• e!Ensembl: ENSG00000204516

Protein

• UniProt ID: Q29980
• Protein name: MHC class I polypeptide-related sequence B (MIC-B)
• Protein function: Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubM
• PDB: 1JE6, 2WY3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00129	MHC_I	24 → 201	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
  PF07654	C1-set	208 → 289	Immunoglobulin C1-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumo
• Sequence:

  MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYD
  RQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCE
  IHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHY
  RAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWR
  QDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKA
  LVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHR
  DAAQLGFQPLMSATGSTGSTEGT

• Sequence length: 383

Pathways

KEGG:

Natural killer cell mediated cytotoxicity
Kaposi sarcoma-associated herpesvirus infection

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Behcet syndrome	Behcet Syndrome	rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741	23001997
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	17632545
Myasthenia gravis	Myasthenia Gravis	rs5030818, rs121912815, rs121912817, rs121912818, rs121912821, rs75466054, rs121912822, rs121912823, rs794727516, rs764497513, rs376808313, rs1279554995, rs1554802792, rs369251527, rs372760913, rs1554802808, rs769234940, rs201439531, rs1272947184, rs757303526, rs760936252, rs1590576560, rs1838635262	23055271
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	17561376

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma, Childhood asthma		29273806, 31619474	ClinVar, GWAS
Mental depression	Major Depressive Disorder		31619474	ClinVar
Dermatitis	Dermatitis			GWAS
Myositis	Myositis			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA
Coronary artery disease	Coronary artery disease			GWAS
Eczema	Eczema			GWAS
Neuroticism	Neuroticism			GWAS
Psoriasis	Psoriasis			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Ulcerative colitis	Ulcerative colitis			GWAS
Insomnia	Insomnia			GWAS
Dental caries	Dental caries			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Acute Lung Injury	Associate	37878820
Adenocarcinoma	Associate	33832101
Alzheimer Disease	Associate	31504236
Arthritis Juvenile	Associate	37741520
Autoimmune Diseases	Associate	17557375, 19662431, 26569110, 36958849
Barrett Esophagus	Associate	35437997
Breast Neoplasms	Associate	22301547, 27026046, 31603112, 40108523
Chemical and Drug Induced Liver Injury	Associate	21948571
Colitis Ulcerative	Associate	19662431
Colorectal Neoplasms	Associate	19353249, 32306128, 36958849, 38049731
Communicable Diseases	Associate	26569110
Crohn Disease	Associate	28684217
Cytomegalovirus Infections	Associate	32286503
Death	Associate	37878820
Dermatomyositis	Associate	39447013
Diabetic Nephropathies	Associate	37492198
Disease	Associate	16636811
Eosinophilic Esophagitis	Associate	29691386, 35437997
Glaucoma	Associate	25549595
Glycogen Storage Disease Type IV	Associate	32306128
Graft vs Host Disease	Associate	32286503
Hodgkin Disease	Associate	22286212
Hypoxia	Inhibit	29693186
Infections	Associate	19380116, 21857986, 34650566
Inflammation	Associate	21948571, 36754452
Inflammatory Bowel Diseases	Associate	19230040
Intracranial Aneurysm	Associate	36451838
Intraocular Lymphoma	Associate	25549595
Leukemia	Associate	21477352
Lung Neoplasms	Associate	37307368
Lung Neoplasms	Inhibit	37679517
Lupus Erythematosus Systemic	Associate	19851445, 27433477, 34012432
Melioidosis	Associate	28628607
Multiple Myeloma	Associate	19748980, 34482362, 37460534
Multiple Sclerosis	Associate	22184268, 36548255
Myelodysplastic Syndromes	Associate	17341666
Neoplasm Metastasis	Stimulate	16636811
Neoplasm Metastasis	Associate	32306128
Neoplasms	Associate	10359807, 15548365, 16636811, 17557375, 17635809, 17641203, 18569641, 19048252, 19124832, 19353249, 21477352, 24359553, 25393367, 25426550, 26569110, 26708143, 26745675, 28334733, 29496042, 30742113, 31435903, 31603112, 32306128, 36754452, 36958849
Neoplasms Glandular and Epithelial	Associate	32214110
Neuroblastoma	Associate	36521927
Ovarian Neoplasms	Associate	30926680
Parkinson Disease	Associate	31504236
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	30867508
Prodromal Symptoms	Associate	32306128
Prostatic Neoplasms Castration Resistant	Associate	29693186
Pulmonary Disease Chronic Obstructive	Associate	37307368
Schizophrenia	Associate	31504236
Schizophrenia	Stimulate	36482464
Sepsis	Associate	28628607
Somatosensory Disorders	Stimulate	26745675
Squamous Cell Carcinoma of Head and Neck	Associate	19414815
Stevens Johnson Syndrome	Associate	15743917
Stomach Neoplasms	Associate	26708143
Uterine Cervical Neoplasms	Associate	18505429, 21477352
Uveal melanoma	Inhibit	15381927
Virus Diseases	Associate	26982091
Vitiligo	Associate	31877315