MICB (MHC class I polypeptide-related sequence B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4277 |
| Gene name | MHC class I polypeptide-related sequence B |
| Gene symbol | MICB |
| Synonyms (NCBI Gene) |
PERB11.2
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| Chromosome | 6 |
| Chromosome location | 6p21.33 |
| Summary | This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the recepto |
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miRNA
miRNA information provided by mirtarbase database.
380
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
6
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q29980 | |||||||||||||||
| Protein name | MHC class I polypeptide-related sequence B (MIC-B) | |||||||||||||||
| Protein function | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells (PubMed:11491531, PubM | |||||||||||||||
| PDB | 1JE6 , 2WY3 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumo | |||||||||||||||
| Sequence |
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| Sequence length | 383 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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