MGMT (O-6-methylguanine-DNA methyltransferase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4255
Gene name Gene Name - the full gene name approved by the HGNC.
O-6-methylguanine-DNA methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MGMT
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q26.3
Summary Summary of gene provided in NCBI Entrez Gene.
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(45)
miRTarBase ID miRNA Experiments Reference
MIRT006937 hsa-miR-181d-5p Luciferase reporter assay, qRT-PCR, Western blot 22570426
MIRT006937 hsa-miR-181d-5p Luciferase reporter assay, qRT-PCR, Western blot 22570426
MIRT438835 hsa-miR-661 Luciferase reporter assay 23340988
MIRT438835 hsa-miR-661 Luciferase reporter assay 23340988
MIRT438833 hsa-miR-370-3p Luciferase reporter assay 23340988
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
Transcription factor Regulation Reference
DNMT1 Unknown 18555750
EP300 Unknown 22675172
HDAC1 Unknown 18555750
JUN Unknown 9731508
MBD1 Repression 15657354
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding TAS 2188979
GO:0003824 Function Catalytic activity IEA
GO:0003908 Function Methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA
GO:0003908 Function Methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
156569 7059 ENSG00000170430
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P16455
Protein name Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
Protein function Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue
PDB 1EH6 , 1EH7 , 1EH8 , 1QNT , 1T38 , 1T39 , 1YFH , 8RGG , 8RGH , 8RTY , 8RU2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02870 Methyltransf_1N 6 → 90 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Domain
PF01035 DNA_binding_1 93 → 174 6-O-methylguanine DNA methyltransferase, DNA binding domain Domain
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    MGMT-mediated DNA damage reversal
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (8)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anorexia Anorexia nervosa N/A N/A GWAS
Carpal Tunnel Syndrome Carpal tunnel syndrome N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Glioblastoma Glioblastoma N/A N/A GWAS
Show/Hide Text Mining Associations (238)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aberrant Crypt Foci Associate 12000733, 17487400, 38554332
ACTH Secreting Pituitary Adenoma Associate 33480240
Adenocarcinoma Associate 11856482, 15785933, 18831746, 19596925, 21355081, 21457162, 27643594, 31199091, 34092617, 35701814
Adenocarcinoma Mucinous Associate 28429715
Adenocarcinoma of Lung Associate 11856482, 21355081
Adenoma Inhibit 15800999
Adenoma Associate 16891355, 17143260, 20653064, 25092825, 28429715
Adenoma Islet Cell Associate 25028501
Adenoma Villous Associate 20653064
Adenomatous Polyps Associate 21274674