Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4249
Gene name Gene Name - the full gene name approved by the HGNC.
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MGAT5
Synonyms (NCBI Gene) Gene synonyms aliases
GNT-V, GNT-VA, MGAT5A, glcNAc-T V
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q21.2-q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It i
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047339 hsa-miR-181a-5p CLASH 23622248
MIRT039157 hsa-miR-769-5p CLASH 23622248
MIRT037984 hsa-miR-502-3p CLASH 23622248
MIRT712416 hsa-miR-4695-5p HITS-CLIP 19536157
MIRT712415 hsa-miR-4459 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 10438459
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane ISS
GO:0000139 Component Golgi membrane TAS
GO:0004864 Function Protein phosphatase inhibitor activity IDA 24846175
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601774 7049 ENSG00000152127
Protein
UniProt ID Q09328
Protein name Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V) [Clea
Protein function Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, comp
PDB 5ZIB , 5ZIC , 6YJQ , 6YJR , 6YJS , 6YJT , 6YJU , 6YJV , 7YYI , 7Z07 , 7Z08 , 7Z0B , 8CE3 , 9F5H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15027 DUF4525 3 138 Domain of unknown function (DUF4525) Family
PF15024 Glyco_transf_18 172 726 Glycosyltransferase family 18 Family
Sequence
Sequence length 741
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  N-Glycan biosynthesis
Metabolic pathways
  N-Glycan antennae elongation
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma (childhood onset) N/A N/A GWAS
Breast Cancer Breast cancer (early onset) N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24913443
Adenoma Associate 10673297
Autoimmune Diseases Associate 32352685
Bile Duct Neoplasms Associate 8900148
Breast Neoplasms Associate 17537730, 18271524, 38254997
Carcinoma Hepatocellular Associate 15044007
Colitis Ulcerative Associate 32352685
Colorectal Neoplasms Associate 10673297, 17878270
Depressive Disorder Associate 22628180
Diabetes Mellitus Type 1 Associate 23266418