MELTF (melanotransferrin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4241
Gene name Gene Name - the full gene name approved by the HGNC.
Melanotransferrin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MELTF
Synonyms (NCBI Gene) Gene synonyms aliases
CD228, MAP97, MFI2, MTF1, MTf
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not ye
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
miRTarBase ID miRNA Experiments Reference
MIRT490254 hsa-miR-3940-3p PAR-CLIP 23592263
MIRT490253 hsa-miR-6499-5p PAR-CLIP 23592263
MIRT490252 hsa-miR-3960 PAR-CLIP 23592263
MIRT490250 hsa-miR-8072 PAR-CLIP 23592263
MIRT490251 hsa-miR-4767 PAR-CLIP 23592263
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
FOS Unknown 8836133
JUN Unknown 8836133
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth IMP 7556058
GO:0005506 Function Iron ion binding IMP 7556058
GO:0005515 Function Protein binding IPI 19815549
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
155750 7037 ENSG00000163975
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08582
Protein name Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Protein function Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
PDB 6XR0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00405 Transferrin 23 → 357 Transferrin Domain
PF00405 Transferrin 366 → 706 Transferrin Domain
Tissue specificity TISSUE SPECIFICITY: Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
Sequence
Sequence length 738
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)		 16704991
Show/Hide Text Mining Associations (25)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 25830243, 29667179, 33287749, 38594917
Breast Neoplasms Associate 26766492
Carcinoma Non Small Cell Lung Associate 36800443
Carcinoma Renal Cell Associate 28819235, 34040677
Carcinoma Squamous Cell Associate 26655237, 37966613
Colorectal Neoplasms Associate 31094023, 31724326, 36032659, 36800443
Distal myopathy Nonaka type Associate 19923742, 20414249, 24196964
Frontotemporal Dementia Associate 19923742, 24196964
Heredodegenerative Disorders Nervous System Associate 30584095, 31701538
Inclusion Body Myopathy With Early Onset Paget Disease And Frontotemporal Dementia Associate 19923742, 20414249