Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4240
Gene name Gene Name - the full gene name approved by the HGNC.
Milk fat globule EGF and factor V/VIII domain containing
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MFGE8
Synonyms (NCBI Gene) Gene synonyms aliases
BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q26.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been imp
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017018 hsa-miR-335-5p Microarray 18185580
MIRT038170 hsa-miR-423-5p CLASH 23622248
MIRT1551273 hsa-miR-1 CLIP-seq
MIRT1551274 hsa-miR-1207-5p CLIP-seq
MIRT1551275 hsa-miR-185 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001786 Function Phosphatidylserine binding IPI 21196491
GO:0005178 Function Integrin binding IEA
GO:0005201 Function Extracellular matrix structural constituent RCA 20551380, 27068509, 27559042, 28327460
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602281 7036 ENSG00000140545
Protein
UniProt ID Q08431
Protein name Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]
Protein function Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissue
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00008 EGF 27 65 EGF-like domain Domain
PF00754 F5_F8_type_C 85 222 F5/8 type C domain Domain
PF00754 F5_F8_type_C 245 384 F5/8 type C domain Domain
Tissue specificity TISSUE SPECIFICITY: Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Sequence
Sequence length 387
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Efferocytosis   Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Amyloid fiber formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
21127199
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
21127199
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
21127199
Unknown
Disease term Disease name Evidence References Source
Giant Cell Arteritis Giant Cell Arteritis GWAS
Associations from Text Mining
Disease Name Relationship Type References
AA amyloidosis Associate 24602872, 25614623, 36433666
Acute Lung Injury Inhibit 25936372, 37774691
Alopecia Associate 31811237
Alzheimer Disease Associate 25614623, 37914766
Aortic Aneurysm Abdominal Associate 22797469
Arthritis Infectious Associate 23324439
Ascites Associate 36484512
Atherosclerosis Associate 30861420
Brain Ischemia Associate 35005020
Breast Neoplasms Associate 37704733