Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4237
Gene name Gene Name - the full gene name approved by the HGNC.	Microfibril associated protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MFAP2
Synonyms (NCBI Gene) Gene synonyms aliases	MAGP, MAGP-1, MAGP1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.13
Summary Summary of gene provided in NCBI Entrez Gene.	Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for

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miRTarBase ID	miRNA	Experiments	Reference
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2390837	hsa-miR-1207-3p	CLIP-seq
MIRT2390838	hsa-miR-342-5p	CLIP-seq
MIRT2390839	hsa-miR-4447	CLIP-seq
MIRT2390840	hsa-miR-4472	CLIP-seq
MIRT2390841	hsa-miR-4525	CLIP-seq
MIRT2390842	hsa-miR-4651	CLIP-seq
MIRT2390843	hsa-miR-4664-5p	CLIP-seq
MIRT2390844	hsa-miR-4731-5p	CLIP-seq
MIRT2390845	hsa-miR-608	CLIP-seq
MIRT2570088	hsa-miR-1915	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2570090	hsa-miR-4446-3p	CLIP-seq
MIRT2570091	hsa-miR-4685-5p	CLIP-seq
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2684873	hsa-miR-188-3p	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2684874	hsa-miR-34a	CLIP-seq
MIRT2684875	hsa-miR-34c-5p	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2684876	hsa-miR-449a	CLIP-seq
MIRT2684877	hsa-miR-449b	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2684878	hsa-miR-491-5p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2684879	hsa-miR-661	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001527	Component	Microfibril	IBA	21873635
GO:0001527	Component	Microfibril	IDA	24353434
GO:0005201	Function	Extracellular matrix structural constituent	RCA	25037231, 28327460, 28675934
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	TAS
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0048048	Process	Embryonic eye morphogenesis	IBA	21873635
GO:0048048	Process	Embryonic eye morphogenesis	IEP	25406291
GO:0048050	Process	Post-embryonic eye morphogenesis	IEP	25406291
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28327460, 28675934
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24458361

MIM	HGNC	e!Ensembl
156790	7033	ENSG00000117122

Protein

UniProt ID

P55001

Protein name

Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)

Protein function

Component of the elastin-associated microfibrils.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05507	MAGP	1 → 151	Microfibril-associated glycoprotein (MAGP)	Family
PF01549	ShK	152 → 183	ShK domain-like	Domain

Sequence

MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDNPDYYDYQEVTPRPSEE
QFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQYPCTRLYSIHRPCKQCLNE
VCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKCGVMASSGLCQSVAASCARSC
GSC

Sequence length

183

Interactions

View interactions

	Reactome
			Elastic fibre formation Molecules associated with elastic fibres

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		30804561	ClinVar

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Borderline Personality Disorder	Associate	25612291
Carcinogenesis	Associate	34445187
Carcinoma Hepatocellular	Stimulate	33280519
Carcinoma Ovarian Epithelial	Associate	33246661
Colorectal Neoplasms	Inhibit	34445187
Colorectal Neoplasms	Associate	39844333
Hypoxia	Inhibit	34445187
Metabolic Diseases	Associate	33280519, 37592847
Neoplasms	Associate	33280519, 35356627
Neoplasms	Stimulate	37592847
Obesity	Inhibit	34445187
Obesity	Associate	39844333
Ovarian Neoplasms	Stimulate	39972314
Pediatric Obesity	Associate	25612291
Polycystic Ovary Syndrome	Associate	39754246
Squamous Cell Carcinoma of Head and Neck	Stimulate	33280519
Squamous Cell Carcinoma of Head and Neck	Associate	37592847
Stomach Neoplasms	Stimulate	31894266
Stomach Neoplasms	Associate	33758160, 34868341, 35356627, 37304872

MFAP2 (microfibril associated protein 2)