Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4237
Gene name Gene Name - the full gene name approved by the HGNC.	Microfibril associated protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MFAP2
Synonyms (NCBI Gene) Gene synonyms aliases	MAGP, MAGP-1, MAGP1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.13
Summary Summary of gene provided in NCBI Entrez Gene.	Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for

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miRTarBase ID	miRNA	Experiments	Reference
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT515930	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT515929	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT515928	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT515927	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT515926	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT515925	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT515924	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT515923	hsa-miR-302e	HITS-CLIP	23824327
MIRT515922	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT515921	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT515920	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT515919	hsa-miR-520b	HITS-CLIP	23824327
MIRT515918	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT515917	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT515916	hsa-miR-520e	HITS-CLIP	23824327
MIRT515914	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT667426	hsa-miR-4454	HITS-CLIP	23824327
MIRT667425	hsa-miR-4707-3p	HITS-CLIP	23824327
MIRT667424	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT515910	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT515930	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT515929	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT515928	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT515927	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT515926	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT515925	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT515924	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT515923	hsa-miR-302e	PAR-CLIP	23446348
MIRT515922	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT515921	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT515920	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT515919	hsa-miR-520b	PAR-CLIP	23446348
MIRT515918	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT515917	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT515916	hsa-miR-520e	PAR-CLIP	23446348
MIRT515915	hsa-miR-2114-5p	PAR-CLIP	23446348
MIRT515914	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT515913	hsa-miR-6128	PAR-CLIP	23446348
MIRT515912	hsa-miR-3135b	PAR-CLIP	23446348
MIRT515911	hsa-miR-1287-5p	PAR-CLIP	23446348
MIRT515910	hsa-miR-18a-3p	PAR-CLIP	23446348
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2390837	hsa-miR-1207-3p	CLIP-seq
MIRT2390838	hsa-miR-342-5p	CLIP-seq
MIRT2390839	hsa-miR-4447	CLIP-seq
MIRT2390840	hsa-miR-4472	CLIP-seq
MIRT2390841	hsa-miR-4525	CLIP-seq
MIRT2390842	hsa-miR-4651	CLIP-seq
MIRT2390843	hsa-miR-4664-5p	CLIP-seq
MIRT2390844	hsa-miR-4731-5p	CLIP-seq
MIRT2390845	hsa-miR-608	CLIP-seq
MIRT2570088	hsa-miR-1915	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2570090	hsa-miR-4446-3p	CLIP-seq
MIRT2570091	hsa-miR-4685-5p	CLIP-seq
MIRT2041426	hsa-miR-1285	CLIP-seq
MIRT2684873	hsa-miR-188-3p	CLIP-seq
MIRT2041427	hsa-miR-3184	CLIP-seq
MIRT2041428	hsa-miR-3187-5p	CLIP-seq
MIRT2684874	hsa-miR-34a	CLIP-seq
MIRT2684875	hsa-miR-34c-5p	CLIP-seq
MIRT2570089	hsa-miR-361-3p	CLIP-seq
MIRT2041429	hsa-miR-423-5p	CLIP-seq
MIRT2041430	hsa-miR-4463	CLIP-seq
MIRT2041431	hsa-miR-4494	CLIP-seq
MIRT2684876	hsa-miR-449a	CLIP-seq
MIRT2684877	hsa-miR-449b	CLIP-seq
MIRT2041432	hsa-miR-4688	CLIP-seq
MIRT2041433	hsa-miR-4771	CLIP-seq
MIRT2041434	hsa-miR-486-3p	CLIP-seq
MIRT2684878	hsa-miR-491-5p	CLIP-seq
MIRT2041435	hsa-miR-612	CLIP-seq
MIRT2684879	hsa-miR-661	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001527	Component	Microfibril	IBA
GO:0001527	Component	Microfibril	IDA	24353434
GO:0001527	Component	Microfibril	IEA
GO:0001968	Function	Fibronectin binding	IEA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	25037231, 28327460, 28675934
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0030220	Process	Platelet formation	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28327460, 28675934
GO:0048048	Process	Embryonic eye morphogenesis	IBA
GO:0048048	Process	Embryonic eye morphogenesis	IEP	25406291
GO:0048050	Process	Post-embryonic eye morphogenesis	IEP	25406291
GO:0070051	Function	Fibrinogen binding	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	24458361

MIM	HGNC	e!Ensembl
156790	7033	ENSG00000117122

Protein

UniProt ID

P55001

Protein name

Microfibrillar-associated protein 2 (MFAP-2) (Microfibril-associated glycoprotein 1) (MAGP) (MAGP-1)

Protein function

Component of the elastin-associated microfibrils.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05507	MAGP	1 → 151	Microfibril-associated glycoprotein (MAGP)	Family
PF01549	ShK	152 → 183	ShK domain-like	Domain

Sequence

MRAAYLFLLFLPAGLLAQGQYDLDPLPPFPDHVQYTHYSDQIDNPDYYDYQEVTPRPSEE
QFQFQSQQQVQQEVIPAPTPEPGNAELEPTEPGPLDCREEQYPCTRLYSIHRPCKQCLNE
VCFYSLRRVYVINKEICVRTVCAHEELLRADLCRDKFSKCGVMASSGLCQSVAASCARSC
GSC

Sequence length

183

Interactions

View interactions

	Reactome
			Elastic fibre formation Molecules associated with elastic fibres

MFAP2 (microfibril associated protein 2)