Gene Gene information from NCBI Gene database.
Entrez ID 4233
Gene name MET proto-oncogene, receptor tyrosine kinase
Gene symbol MET
Synonyms (NCBI Gene)
AUTS9DA11DFNB97HGFRRCCP2c-Met
Chromosome 7
Chromosome location 7q31.2
Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form
SNPs SNP information provided by dbSNP.
37
SNP ID Visualize variation Clinical significance Consequence
rs34589476 C>T Likely-pathogenic, conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
rs35776110 C>T Conflicting-interpretations-of-pathogenicity, likely-benign, benign-likely-benign Non coding transcript variant, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs45520237 C>T Conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, synonymous variant, coding sequence variant
rs56311081 C>A,T Conflicting-interpretations-of-pathogenicity, likely-benign Non coding transcript variant, stop gained, genic upstream transcript variant, missense variant, intron variant, coding sequence variant
rs56391007 C>T Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-pathogenic, benign-likely-benign Non coding transcript variant, missense variant, genic downstream transcript variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
637
miRTarBase ID miRNA Experiments Reference
MIRT001969 hsa-miR-199a-3p Luciferase reporter assayWestern blot 18456660
MIRT004292 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
MIRT004292 hsa-miR-23b-3p Luciferase reporter assayqRT-PCRWestern blot 19490101
Transcription factors Transcription factors information provided by TRRUST V2 database.
12
Transcription factor Regulation Reference
FOXP2 Repression 21832174
HIF1A Activation 16099863
MITF Unknown 17371876
PAX3 Unknown 8633043
PAX5 Activation 24628993
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001886 Process Endothelial cell morphogenesis IDA 14500721
GO:0001889 Process Liver development IBA
GO:0004672 Function Protein kinase activity IEA
GO:0004713 Function Protein tyrosine kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164860 7029 ENSG00000105976
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08581
Protein name Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Protein function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and su
PDB 1FYR , 1R0P , 1R1W , 1SHY , 1SSL , 2G15 , 2RFN , 2RFS , 2UZX , 2UZY , 2WD1 , 2WGJ , 2WKM , 3A4P , 3BUX , 3C1X , 3CCN , 3CD8 , 3CE3 , 3CTH , 3CTJ , 3DKC , 3DKF , 3DKG , 3EFJ , 3EFK , 3F66 , 3F82 , 3I5N , 3L8V , 3LQ8 , 3Q6U , 3Q6W , 3QTI , 3R7O , 3RHK , 3U6H , 3U6I , 3VW8 , 3ZBX , 3ZC5 , 3ZCL , 3ZXZ , 3ZZE , 4AOI , 4AP7 , 4DEG , 4DEH , 4DEI , 4EEV , 4GG5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01403 Sema 54 493 Sema domain Family
PF01437 PSI 519 562 Plexin repeat Family
PF01833 TIG 563 654 IPT/TIG domain Domain
PF01833 TIG 657 738 IPT/TIG domain Domain
PF01833 TIG 742 832 IPT/TIG domain Domain
PF07714 PK_Tyr_Ser-Thr 1078 1337 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyr
Sequence
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVE
HTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICL
PAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSY
VDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSY
REDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFD
LIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRI
SAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS
Sequence length 1390
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - reactive oxygen species
Renal cell carcinoma
Melanoma
Non-small cell lung cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
  PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
MECP2 regulates neuronal receptors and channels
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
7793
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Arthrogryposis, distal, IIa 11 Likely pathogenic; Pathogenic rs121913243, rs1554400286 RCV005394153
RCV002279723
Arthrogryposis, distal, type 1A Pathogenic rs1554400286 RCV000626485
Autosomal recessive nonsyndromic hearing loss 97 Pathogenic; Likely pathogenic rs794728016, rs121913243 RCV000202585
RCV005394153
Colorectal cancer Pathogenic rs1794836064 RCV001293831
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism, susceptibility to, 9 Uncertain significance rs1858830 RCV000014905
Breast carcinoma Conflicting classifications of pathogenicity rs45602940, rs199701987 RCV005429001
RCV001262296
Cervical cancer Benign; Likely benign rs1584947055 RCV005907054
Cholangiocarcinoma Benign; Likely benign rs146651797, rs12540703 RCV005889558
RCV005899173
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 30149144
Adenocarcinoma Associate 15720819, 22198430, 28859123, 8097369, 8440743, 8957065, 9876767
Adenocarcinoma Mucinous Associate 30638462
Adenocarcinoma of Lung Associate 11290563, 17459054, 23919423, 25278243, 25902175, 27496196, 29400000, 30615629, 31711449, 32395869, 36544145, 36640859
Adenoma Stimulate 10944610
Adenoma Associate 20200025
Adenoma Liver Cell Associate 29256857
Adenoma Pleomorphic Associate 21626008
Androgen Insensitivity Syndrome Associate 28859123
Apraxia Ideomotor Associate 22180430