Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4221
Gene name Gene Name - the full gene name approved by the HGNC.	Menin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MEN1
Synonyms (NCBI Gene) Gene synonyms aliases	MEAI, SCG2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathw

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SNP ID	Visualize variation	Clinical significance	Consequence
rs607969	C>G,T	Benign, benign-likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs28931612	C>A,T	Pathogenic, uncertain-significance, likely-pathogenic	Coding sequence variant, stop gained, missense variant
rs77461664	G>A,C,T	Uncertain-significance, benign, likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs104894256	A>C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs104894257	C>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs104894258	C>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs104894262	A>T	Pathogenic	Splice donor variant, coding sequence variant, missense variant
rs104894263	G>C	Pathogenic	Missense variant, coding sequence variant
rs104894265	G>A,T	Pathogenic, likely-benign	Stop gained, coding sequence variant, synonymous variant
rs104894266	G>A	Pathogenic	Coding sequence variant, stop gained
rs104894268	C>G,T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant
rs121913034	T>A,G	Uncertain-significance, pathogenic	Coding sequence variant, stop gained, missense variant
rs143329068	G>A,C	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs267607234	CC>TT	Pathogenic	Coding sequence variant, missense variant
rs371192390	C>A	Likely-benign, conflicting-interpretations-of-pathogenicity, benign-likely-benign	Synonymous variant, coding sequence variant
rs374749001	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs376872829	C>A,G,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs386134245	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs386134246	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs386134247	C>-,CC	Pathogenic, likely-pathogenic	Coding sequence variant, frameshift variant
rs386134250	T>A,C,G	Pathogenic-likely-pathogenic, pathogenic, likely-pathogenic	Missense variant, initiator codon variant
rs386134251	GG>-	Pathogenic	Coding sequence variant, frameshift variant
rs386134253	->A,AA	Pathogenic, likely-pathogenic	Coding sequence variant, frameshift variant
rs386134254	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs386134255	->AATT	Likely-pathogenic	Coding sequence variant, frameshift variant
rs386134256	A>G	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs386134258	CCCGCTCA>-	Likely-pathogenic	Coding sequence variant, splice donor variant, intron variant
rs386134259	G>A,C,T	Uncertain-significance, likely-pathogenic	Missense variant, stop gained, coding sequence variant
rs386134260	G>C	Pathogenic, not-provided	Stop gained, coding sequence variant
rs386134261	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs397515385	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs398124437	C>G,T	Pathogenic, likely-pathogenic	Splice donor variant
rs587776841	ACAG>-	Pathogenic	Coding sequence variant, frameshift variant
rs730882136	->GGGGC	Pathogenic	Coding sequence variant, frameshift variant
rs747851909	C>A	Pathogenic	Coding sequence variant, missense variant
rs750904332	G>A,C,T	Pathogenic	Stop gained, synonymous variant, coding sequence variant
rs767078097	G>A,C	Pathogenic	Coding sequence variant, stop gained, synonymous variant
rs772588551	C>A,T	Pathogenic	Coding sequence variant, stop gained, missense variant
rs778670301	C>G,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant, synonymous variant
rs778921501	G>A,T	Pathogenic	Stop gained, coding sequence variant, synonymous variant
rs786204242	C>T	Pathogenic-likely-pathogenic	Missense variant, initiator codon variant
rs794728614	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs794728615	G>A,C	Pathogenic	Stop gained, missense variant, coding sequence variant
rs794728616	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs794728618	T>A	Likely-pathogenic	Missense variant, coding sequence variant
rs794728622	C>A,T	Pathogenic	Splice donor variant, intron variant
rs794728624	C>T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs794728625	C>T	Pathogenic	Intron variant
rs794728627	G>A,C	Likely-pathogenic	Missense variant, coding sequence variant
rs794728636	->A	Pathogenic	Frameshift variant, coding sequence variant
rs794728637	CCAGCTCGGC>-	Pathogenic	Frameshift variant, coding sequence variant
rs794728638	->A	Pathogenic	Frameshift variant, coding sequence variant
rs794728639	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs794728640	TCTG>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant
rs794728641	AGATGTGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs794728647	G>A,C	Pathogenic, uncertain-significance	Stop gained, missense variant, coding sequence variant
rs794728648	C>A,T	Pathogenic, uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs794728650	C>T	Pathogenic	Stop gained, coding sequence variant
rs794728652	C>A,G,T	Pathogenic, likely-pathogenic	Splice donor variant
rs794728655	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs794728656	->G	Pathogenic	Frameshift variant, coding sequence variant
rs794728657	TTC>-	Pathogenic	Inframe deletion, coding sequence variant
rs794728658	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs869025185	CCT>-	Pathogenic	Inframe deletion, coding sequence variant
rs869312167	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs878855191	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs878855192	T>A	Pathogenic	Stop gained, coding sequence variant
rs878855196	G>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant
rs886039413	G>A	Pathogenic	Stop gained, coding sequence variant
rs886039414	C>A,T	Pathogenic, uncertain-significance	Missense variant, coding sequence variant, stop gained
rs886039415	A>G	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs886039416	G>A,C	Pathogenic, uncertain-significance	Stop gained, missense variant, coding sequence variant
rs886039553	G>A	Pathogenic	Stop gained, coding sequence variant
rs886041213	->T	Pathogenic	Frameshift variant, coding sequence variant
rs886041634	GC>A	Pathogenic	Frameshift variant, coding sequence variant
rs886042035	T>C,G	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1057517760	->TGC	Likely-pathogenic	Inframe insertion, coding sequence variant
rs1057517902	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1057518572	C>T	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1057518903	C>-	Pathogenic	Intron variant, coding sequence variant, splice donor variant
rs1057520733	G>A	Pathogenic	Stop gained, coding sequence variant
rs1057521110	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057524571	A>C	Likely-pathogenic	Splice donor variant
rs1060499971	CTC>-	Conflicting-interpretations-of-pathogenicity	Inframe deletion, coding sequence variant
rs1060499973	G>A,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1060499976	C>A,G,T	Pathogenic, likely-pathogenic	Splice donor variant
rs1060499984	G>A,C	Pathogenic, uncertain-significance	Missense variant, stop gained, coding sequence variant
rs1060499987	A>T	Pathogenic	Stop gained, coding sequence variant
rs1060499990	G>-	Pathogenic, likely-pathogenic	Coding sequence variant, frameshift variant
rs1060499992	C>A,T	Pathogenic	Missense variant, stop gained, coding sequence variant
rs1060503789	G>A,T	Likely-benign, pathogenic	Stop gained, coding sequence variant, synonymous variant
rs1064792906	TGAAGCGGGCATAGAGGGCGG>-	Uncertain-significance, likely-pathogenic	Inframe deletion, coding sequence variant
rs1064793167	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1064793169	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1064793398	C>T	Likely-pathogenic	Intron variant
rs1064793613	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064793672	C>G,T	Pathogenic	Splice acceptor variant
rs1064795635	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1085307471	C>G,T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1085307971	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167469	G>A	Pathogenic	Missense variant, coding sequence variant
rs1114167470	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167471	A>C,G	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1114167472	T>C	Pathogenic	Splice acceptor variant
rs1114167473	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167474	C>T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1114167478	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167480	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167481	GAAG>AAT	Pathogenic	Coding sequence variant, frameshift variant
rs1114167482	C>T	Pathogenic	Stop gained, coding sequence variant
rs1114167483	->CGCAC	Pathogenic	Coding sequence variant, frameshift variant
rs1114167485	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167486	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167488	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167489	C>G,T	Pathogenic, likely-pathogenic	Splice donor variant
rs1114167490	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167491	C>T	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1114167492	C>-	Pathogenic	Stop gained, coding sequence variant
rs1114167493	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167494	C>A	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs1114167495	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1114167498	T>C	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1114167499	T>A	Pathogenic	Stop gained, coding sequence variant
rs1114167502	A>G	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1114167503	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167505	C>T	Likely-pathogenic	Splice acceptor variant
rs1114167506	C>AA	Pathogenic	Coding sequence variant, frameshift variant
rs1114167508	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167511	GA>TT	Pathogenic	Stop gained, coding sequence variant
rs1114167515	T>C	Pathogenic	Missense variant, coding sequence variant
rs1114167516	GGGC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167519	->CATG	Pathogenic	Coding sequence variant, frameshift variant
rs1114167523	CG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167527	A>T	Pathogenic	Stop gained, coding sequence variant
rs1114167532	GTTGATGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167534	->CACC	Pathogenic	Coding sequence variant, frameshift variant
rs1114167538	G>-	Pathogenic	Intron variant, coding sequence variant, frameshift variant
rs1114167540	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167541	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1114167543	A>C	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1187634059	C>T	Pathogenic	Missense variant, coding sequence variant
rs1555164707	G>T	Pathogenic	Coding sequence variant, missense variant
rs1555164946	A>G	Likely-pathogenic	Splice donor variant
rs1555164986	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555165008	CCCGCACATTGCGGTTGCGACAGTGG>-	Likely-pathogenic	Coding sequence variant, inframe indel, stop gained
rs1555165128	A>C	Pathogenic	Coding sequence variant, stop gained
rs1555165256	A>G	Pathogenic	Splice donor variant
rs1555165360	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555165377	C>G	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1555165488	->AGCTCCA	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1555165503	TCAATGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555165565	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1555165570	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1555165597	G>C,T	Pathogenic	Coding sequence variant, stop gained
rs1555165756	GG>-	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1555166365	C>T	Pathogenic	Coding sequence variant, stop gained
rs1555166368	GA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555166387	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555166435	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1555166466	TA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555166494	->CGGTG	Pathogenic	Coding sequence variant, frameshift variant
rs1555166508	ATGATAGACAGGTCG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1555166567	G>C	Pathogenic	Coding sequence variant, stop gained
rs1555166609	->GCTGG	Pathogenic	Coding sequence variant, frameshift variant
rs1555166681	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1555166695	AGGAAAGGAGCACCA>-,AGGAAAGGAGCACCAAGGAAAGGAGCACCA	Uncertain-significance, likely-pathogenic	Coding sequence variant, inframe deletion, inframe insertion
rs1555166711	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1565642765	T>A,C	Pathogenic	Splice acceptor variant
rs1565644366	G>T	Pathogenic	Coding sequence variant, stop gained
rs1565645563	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1565646772	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1565647197	C>T	Pathogenic	Coding sequence variant, stop gained
rs1565647767	G>A	Pathogenic	Coding sequence variant, intron variant, stop gained
rs1565648511	G>A	Pathogenic	Coding sequence variant, stop gained
rs1565648656	C>G	Pathogenic	Coding sequence variant, missense variant
rs1565651223	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1565651568	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1565652689	C>A,G	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1592640081	->GC	Pathogenic	Frameshift variant, coding sequence variant
rs1592640181	->G	Pathogenic	Frameshift variant, coding sequence variant
rs1592640213	GCAGGTTGGGGATGACATCATTGGCTACTTCA>-	Pathogenic	Frameshift variant, coding sequence variant
rs1592643178	G>A	Pathogenic	Coding sequence variant, stop gained
rs1592646211	C>T	Likely-pathogenic, uncertain-significance	Synonymous variant, coding sequence variant
rs1592646226	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1592646831	GTACC>AACCTCTAGGTA	Pathogenic	Coding sequence variant, splice acceptor variant
rs1592647398	C>T	Pathogenic	Coding sequence variant, stop gained
rs1592648765	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1592648830	->TGCA	Pathogenic	Frameshift variant, coding sequence variant
rs1592649069	AC>-	Pathogenic	Frameshift variant, coding sequence variant
rs1592649108	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1592649598	AGCTCTTAGGGGGGGATGA>-	Likely-pathogenic	Intron variant, coding sequence variant, splice acceptor variant
rs1592649615	C>G,T	Pathogenic	Splice acceptor variant
rs1592650986	T>-	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs1592651767	G>T	Pathogenic	Coding sequence variant, stop gained
rs1592657785	GGGCCCGATC>AGGGA	Pathogenic	Frameshift variant, coding sequence variant
rs1592658517	->GGGA	Pathogenic	Frameshift variant, coding sequence variant
rs1592659414	GC>-	Pathogenic	Frameshift variant, coding sequence variant
rs1592660057	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1592660101	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1592660983	->GC	Pathogenic	Frameshift variant, coding sequence variant
rs1592661082	A>-	Pathogenic	Frameshift variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050813	hsa-miR-17-5p	CLASH	23622248
MIRT049455	hsa-miR-92a-3p	CLASH	23622248
MIRT040940	hsa-miR-18a-3p	CLASH	23622248
MIRT054288	hsa-miR-24-3p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	22761894
MIRT455061	hsa-miR-3141	PAR-CLIP	23592263
MIRT455060	hsa-miR-4259	PAR-CLIP	23592263
MIRT455059	hsa-miR-589-3p	PAR-CLIP	23592263
MIRT455058	hsa-miR-759	PAR-CLIP	23592263
MIRT455057	hsa-miR-571	PAR-CLIP	23592263
MIRT455056	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT054288	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT455055	hsa-miR-4437	PAR-CLIP	23592263
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT455054	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT455052	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT455051	hsa-miR-5698	PAR-CLIP	23592263
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT455047	hsa-miR-4525	PAR-CLIP	23592263
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT455045	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT455044	hsa-miR-4488	PAR-CLIP	23592263
MIRT455043	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT455042	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT455041	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT455040	hsa-miR-4674	PAR-CLIP	23592263
MIRT455039	hsa-miR-1275	PAR-CLIP	23592263
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT455045	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT455045	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT455045	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT455039	hsa-miR-1275	PAR-CLIP	26701625
MIRT455039	hsa-miR-1275	PAR-CLIP	26701625
MIRT455039	hsa-miR-1275	PAR-CLIP	26701625
MIRT455039	hsa-miR-1275	PAR-CLIP	26701625
MIRT054288	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT054288	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT054288	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT054288	hsa-miR-24-3p	PAR-CLIP	26701625
MIRT455056	hsa-miR-25-5p	PAR-CLIP	26701625
MIRT455056	hsa-miR-25-5p	PAR-CLIP	26701625
MIRT455056	hsa-miR-25-5p	PAR-CLIP	26701625
MIRT455061	hsa-miR-3141	PAR-CLIP	26701625
MIRT455061	hsa-miR-3141	PAR-CLIP	26701625
MIRT455061	hsa-miR-3141	PAR-CLIP	26701625
MIRT455060	hsa-miR-4259	PAR-CLIP	26701625
MIRT455060	hsa-miR-4259	PAR-CLIP	26701625
MIRT455060	hsa-miR-4259	PAR-CLIP	26701625
MIRT455060	hsa-miR-4259	PAR-CLIP	26701625
MIRT455055	hsa-miR-4437	PAR-CLIP	26701625
MIRT455055	hsa-miR-4437	PAR-CLIP	26701625
MIRT455055	hsa-miR-4437	PAR-CLIP	26701625
MIRT455055	hsa-miR-4437	PAR-CLIP	26701625
MIRT455044	hsa-miR-4488	PAR-CLIP	26701625
MIRT455044	hsa-miR-4488	PAR-CLIP	26701625
MIRT455044	hsa-miR-4488	PAR-CLIP	26701625
MIRT455047	hsa-miR-4525	PAR-CLIP	26701625
MIRT455047	hsa-miR-4525	PAR-CLIP	26701625
MIRT455047	hsa-miR-4525	PAR-CLIP	26701625
MIRT455047	hsa-miR-4525	PAR-CLIP	26701625
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	26701625
MIRT455040	hsa-miR-4674	PAR-CLIP	26701625
MIRT455040	hsa-miR-4674	PAR-CLIP	26701625
MIRT455040	hsa-miR-4674	PAR-CLIP	26701625
MIRT455040	hsa-miR-4674	PAR-CLIP	26701625
MIRT455043	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT455043	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT455043	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT455054	hsa-miR-486-3p	PAR-CLIP	26701625
MIRT455054	hsa-miR-486-3p	PAR-CLIP	26701625
MIRT455054	hsa-miR-486-3p	PAR-CLIP	26701625
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	26701625
MIRT455051	hsa-miR-5698	PAR-CLIP	26701625
MIRT455051	hsa-miR-5698	PAR-CLIP	26701625
MIRT455051	hsa-miR-5698	PAR-CLIP	26701625
MIRT455051	hsa-miR-5698	PAR-CLIP	26701625
MIRT455057	hsa-miR-571	PAR-CLIP	26701625
MIRT455057	hsa-miR-571	PAR-CLIP	26701625
MIRT455057	hsa-miR-571	PAR-CLIP	26701625
MIRT455057	hsa-miR-571	PAR-CLIP	26701625
MIRT455059	hsa-miR-589-3p	PAR-CLIP	26701625
MIRT455059	hsa-miR-589-3p	PAR-CLIP	26701625
MIRT455059	hsa-miR-589-3p	PAR-CLIP	26701625
MIRT455059	hsa-miR-589-3p	PAR-CLIP	26701625
MIRT455052	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT455052	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT455052	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT455052	hsa-miR-625-5p	PAR-CLIP	26701625
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT455042	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT455042	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT455042	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT455041	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT455041	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT455041	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT455058	hsa-miR-759	PAR-CLIP	26701625
MIRT455058	hsa-miR-759	PAR-CLIP	26701625
MIRT455058	hsa-miR-759	PAR-CLIP	26701625
MIRT455058	hsa-miR-759	PAR-CLIP	26701625
MIRT455061	hsa-miR-3141	PAR-CLIP	23592263
MIRT455060	hsa-miR-4259	PAR-CLIP	23592263
MIRT455059	hsa-miR-589-3p	PAR-CLIP	23592263
MIRT455058	hsa-miR-759	PAR-CLIP	23592263
MIRT455057	hsa-miR-571	PAR-CLIP	23592263
MIRT455056	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT054288	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT455055	hsa-miR-4437	PAR-CLIP	23592263
MIRT455053	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT455054	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT455052	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT455050	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT455051	hsa-miR-5698	PAR-CLIP	23592263
MIRT455049	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT455048	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT455047	hsa-miR-4525	PAR-CLIP	23592263
MIRT455046	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT455045	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT455044	hsa-miR-4488	PAR-CLIP	23592263
MIRT455043	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT455042	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT455041	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT455040	hsa-miR-4674	PAR-CLIP	23592263
MIRT455039	hsa-miR-1275	PAR-CLIP	23592263
MIRT455038	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT455037	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT455036	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT455035	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT1142911	hsa-miR-1207-5p	CLIP-seq
MIRT1142912	hsa-miR-1587	CLIP-seq
MIRT1142913	hsa-miR-24	CLIP-seq
MIRT1142914	hsa-miR-4260	CLIP-seq
MIRT1142915	hsa-miR-4270	CLIP-seq
MIRT1142916	hsa-miR-4300	CLIP-seq
MIRT1142917	hsa-miR-4320	CLIP-seq
MIRT1142918	hsa-miR-4441	CLIP-seq
MIRT1142919	hsa-miR-4453	CLIP-seq
MIRT1142920	hsa-miR-4492	CLIP-seq
MIRT1142921	hsa-miR-4498	CLIP-seq
MIRT1142922	hsa-miR-4505	CLIP-seq
MIRT1142923	hsa-miR-4538	CLIP-seq
MIRT1142924	hsa-miR-4656	CLIP-seq
MIRT1142925	hsa-miR-4670-3p	CLIP-seq
MIRT1142926	hsa-miR-4675	CLIP-seq
MIRT1142927	hsa-miR-4731-5p	CLIP-seq
MIRT1142928	hsa-miR-4741	CLIP-seq
MIRT1142929	hsa-miR-4763-3p	CLIP-seq
MIRT1142930	hsa-miR-625	CLIP-seq
MIRT1142931	hsa-miR-637	CLIP-seq
MIRT1142932	hsa-miR-762	CLIP-seq
MIRT1142933	hsa-miR-920	CLIP-seq
MIRT1142911	hsa-miR-1207-5p	CLIP-seq
MIRT1142934	hsa-miR-1286	CLIP-seq
MIRT1142935	hsa-miR-1321	CLIP-seq
MIRT1142936	hsa-miR-1914	CLIP-seq
MIRT1142937	hsa-miR-3135b	CLIP-seq
MIRT1142938	hsa-miR-3169	CLIP-seq
MIRT1142939	hsa-miR-3194-3p	CLIP-seq
MIRT1142940	hsa-miR-3202	CLIP-seq
MIRT1142941	hsa-miR-3545-5p	CLIP-seq
MIRT1142942	hsa-miR-3616-5p	CLIP-seq
MIRT1142943	hsa-miR-3647-5p	CLIP-seq
MIRT1142944	hsa-miR-3649	CLIP-seq
MIRT1142945	hsa-miR-3652	CLIP-seq
MIRT1142946	hsa-miR-3688-3p	CLIP-seq
MIRT1142947	hsa-miR-3689d	CLIP-seq
MIRT1142948	hsa-miR-370	CLIP-seq
MIRT1142914	hsa-miR-4260	CLIP-seq
MIRT1142915	hsa-miR-4270	CLIP-seq
MIRT1142916	hsa-miR-4300	CLIP-seq
MIRT1142917	hsa-miR-4320	CLIP-seq
MIRT1142949	hsa-miR-4430	CLIP-seq
MIRT1142918	hsa-miR-4441	CLIP-seq
MIRT1142919	hsa-miR-4453	CLIP-seq
MIRT1142950	hsa-miR-4454	CLIP-seq
MIRT1142951	hsa-miR-4481	CLIP-seq
MIRT1142920	hsa-miR-4492	CLIP-seq
MIRT1142921	hsa-miR-4498	CLIP-seq
MIRT1142952	hsa-miR-4532	CLIP-seq
MIRT1142923	hsa-miR-4538	CLIP-seq
MIRT1142953	hsa-miR-4640-5p	CLIP-seq
MIRT1142954	hsa-miR-4648	CLIP-seq
MIRT1142924	hsa-miR-4656	CLIP-seq
MIRT1142925	hsa-miR-4670-3p	CLIP-seq
MIRT1142955	hsa-miR-4688	CLIP-seq
MIRT1142956	hsa-miR-4698	CLIP-seq
MIRT1142957	hsa-miR-4726-5p	CLIP-seq
MIRT1142958	hsa-miR-4739	CLIP-seq
MIRT1142959	hsa-miR-4740-5p	CLIP-seq
MIRT1142960	hsa-miR-4745-5p	CLIP-seq
MIRT1142961	hsa-miR-4756-5p	CLIP-seq
MIRT1142962	hsa-miR-4758-5p	CLIP-seq
MIRT1142929	hsa-miR-4763-3p	CLIP-seq
MIRT1142963	hsa-miR-4795-5p	CLIP-seq
MIRT1142964	hsa-miR-492	CLIP-seq
MIRT1142965	hsa-miR-495	CLIP-seq
MIRT1142966	hsa-miR-573	CLIP-seq
MIRT1142967	hsa-miR-630	CLIP-seq
MIRT1142968	hsa-miR-645	CLIP-seq
MIRT1142969	hsa-miR-664	CLIP-seq
MIRT1142932	hsa-miR-762	CLIP-seq
MIRT1142933	hsa-miR-920	CLIP-seq
MIRT1142970	hsa-miR-1225-5p	CLIP-seq
MIRT1142934	hsa-miR-1286	CLIP-seq
MIRT1142971	hsa-miR-1299	CLIP-seq
MIRT1142972	hsa-miR-296-3p	CLIP-seq
MIRT1142973	hsa-miR-3132	CLIP-seq
MIRT1142974	hsa-miR-3159	CLIP-seq
MIRT1142975	hsa-miR-3167	CLIP-seq
MIRT1142938	hsa-miR-3169	CLIP-seq
MIRT1142914	hsa-miR-4260	CLIP-seq
MIRT1142976	hsa-miR-4316	CLIP-seq
MIRT1142977	hsa-miR-4451	CLIP-seq
MIRT1142978	hsa-miR-4494	CLIP-seq
MIRT1142979	hsa-miR-4496	CLIP-seq
MIRT1142925	hsa-miR-4670-3p	CLIP-seq
MIRT1142980	hsa-miR-4710	CLIP-seq
MIRT1142959	hsa-miR-4740-5p	CLIP-seq
MIRT1142981	hsa-miR-4782-5p	CLIP-seq
MIRT1142982	hsa-miR-516b	CLIP-seq
MIRT1142983	hsa-miR-876-5p	CLIP-seq
MIRT1142974	hsa-miR-3159	CLIP-seq
MIRT1142975	hsa-miR-3167	CLIP-seq
MIRT1142917	hsa-miR-4320	CLIP-seq
MIRT1142922	hsa-miR-4505	CLIP-seq
MIRT2040675	hsa-miR-4743	CLIP-seq
MIRT2040676	hsa-miR-587	CLIP-seq
MIRT1142983	hsa-miR-876-5p	CLIP-seq
MIRT1142913	hsa-miR-24	CLIP-seq
MIRT2270392	hsa-miR-1233	CLIP-seq
MIRT1142934	hsa-miR-1286	CLIP-seq
MIRT1142971	hsa-miR-1299	CLIP-seq
MIRT2270393	hsa-miR-1908	CLIP-seq
MIRT1142913	hsa-miR-24	CLIP-seq
MIRT1142937	hsa-miR-3135b	CLIP-seq
MIRT1142974	hsa-miR-3159	CLIP-seq
MIRT2270394	hsa-miR-3160-3p	CLIP-seq
MIRT1142975	hsa-miR-3167	CLIP-seq
MIRT2270395	hsa-miR-3180	CLIP-seq
MIRT2270396	hsa-miR-3180-3p	CLIP-seq
MIRT2270397	hsa-miR-3192	CLIP-seq
MIRT2270398	hsa-miR-3196	CLIP-seq
MIRT1142941	hsa-miR-3545-5p	CLIP-seq
MIRT1142942	hsa-miR-3616-5p	CLIP-seq
MIRT1142943	hsa-miR-3647-5p	CLIP-seq
MIRT2270399	hsa-miR-3664-3p	CLIP-seq
MIRT2270400	hsa-miR-3929	CLIP-seq
MIRT2270401	hsa-miR-4283	CLIP-seq
MIRT2270402	hsa-miR-4292	CLIP-seq
MIRT2270403	hsa-miR-4303	CLIP-seq
MIRT2270404	hsa-miR-4314	CLIP-seq
MIRT1142917	hsa-miR-4320	CLIP-seq
MIRT2270405	hsa-miR-4419b	CLIP-seq
MIRT2270406	hsa-miR-4434	CLIP-seq
MIRT2270407	hsa-miR-4478	CLIP-seq
MIRT1142951	hsa-miR-4481	CLIP-seq
MIRT2270408	hsa-miR-4487	CLIP-seq
MIRT1142922	hsa-miR-4505	CLIP-seq
MIRT2270409	hsa-miR-4508	CLIP-seq
MIRT2270410	hsa-miR-4516	CLIP-seq
MIRT2270411	hsa-miR-4531	CLIP-seq
MIRT2270412	hsa-miR-4646-5p	CLIP-seq
MIRT1142924	hsa-miR-4656	CLIP-seq
MIRT1142955	hsa-miR-4688	CLIP-seq
MIRT1142927	hsa-miR-4731-5p	CLIP-seq
MIRT1142960	hsa-miR-4745-5p	CLIP-seq
MIRT1142962	hsa-miR-4758-5p	CLIP-seq
MIRT1142981	hsa-miR-4782-5p	CLIP-seq
MIRT1142963	hsa-miR-4795-5p	CLIP-seq
MIRT1142982	hsa-miR-516b	CLIP-seq
MIRT2270413	hsa-miR-558	CLIP-seq
MIRT1142966	hsa-miR-573	CLIP-seq
MIRT1142931	hsa-miR-637	CLIP-seq
MIRT2270414	hsa-miR-663	CLIP-seq
MIRT2270415	hsa-miR-744	CLIP-seq
MIRT2270416	hsa-miR-873	CLIP-seq
MIRT1142983	hsa-miR-876-5p	CLIP-seq
MIRT1142937	hsa-miR-3135b	CLIP-seq
MIRT1142944	hsa-miR-3649	CLIP-seq
MIRT1142945	hsa-miR-3652	CLIP-seq
MIRT1142947	hsa-miR-3689d	CLIP-seq
MIRT1142949	hsa-miR-4430	CLIP-seq
MIRT1142920	hsa-miR-4492	CLIP-seq
MIRT1142921	hsa-miR-4498	CLIP-seq
MIRT1142952	hsa-miR-4532	CLIP-seq
MIRT1142954	hsa-miR-4648	CLIP-seq
MIRT1142932	hsa-miR-762	CLIP-seq
MIRT2270392	hsa-miR-1233	CLIP-seq
MIRT2569591	hsa-miR-125a-5p	CLIP-seq
MIRT2569592	hsa-miR-125b	CLIP-seq
MIRT2569593	hsa-miR-149	CLIP-seq
MIRT2569594	hsa-miR-151-5p	CLIP-seq
MIRT2569595	hsa-miR-151b	CLIP-seq
MIRT2569596	hsa-miR-28-5p	CLIP-seq
MIRT2569597	hsa-miR-3064-5p	CLIP-seq
MIRT2569598	hsa-miR-3139	CLIP-seq
MIRT2270397	hsa-miR-3192	CLIP-seq
MIRT2569599	hsa-miR-320e	CLIP-seq
MIRT2569600	hsa-miR-3689a-3p	CLIP-seq
MIRT2569601	hsa-miR-3689c	CLIP-seq
MIRT2569602	hsa-miR-4319	CLIP-seq
MIRT1142919	hsa-miR-4453	CLIP-seq
MIRT1142920	hsa-miR-4492	CLIP-seq
MIRT1142921	hsa-miR-4498	CLIP-seq
MIRT1142922	hsa-miR-4505	CLIP-seq
MIRT2569603	hsa-miR-4527	CLIP-seq
MIRT1142923	hsa-miR-4538	CLIP-seq
MIRT2569604	hsa-miR-4728-5p	CLIP-seq
MIRT2569605	hsa-miR-4792	CLIP-seq
MIRT2569606	hsa-miR-4794	CLIP-seq
MIRT2569607	hsa-miR-708	CLIP-seq
MIRT2569608	hsa-miR-760	CLIP-seq
MIRT1142932	hsa-miR-762	CLIP-seq
MIRT2569609	hsa-miR-765	CLIP-seq
MIRT2270392	hsa-miR-1233	CLIP-seq
MIRT2569591	hsa-miR-125a-5p	CLIP-seq
MIRT2569592	hsa-miR-125b	CLIP-seq
MIRT2270397	hsa-miR-3192	CLIP-seq
MIRT2569599	hsa-miR-320e	CLIP-seq
MIRT2569600	hsa-miR-3689a-3p	CLIP-seq
MIRT2569601	hsa-miR-3689c	CLIP-seq
MIRT2569602	hsa-miR-4319	CLIP-seq
MIRT2569604	hsa-miR-4728-5p	CLIP-seq
MIRT2569609	hsa-miR-765	CLIP-seq

Show/Hide all(54)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	9989505, 12837246, 22327296, 23784080
GO:0000165	Process	MAPK cascade	IDA	12226747
GO:0000400	Function	Four-way junction DNA binding	IDA	15331604
GO:0000403	Function	Y-form DNA binding	IBA
GO:0000403	Function	Y-form DNA binding	IDA	15331604
GO:0000781	Component	Chromosome, telomeric region	ISS
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	12837246, 12874027
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	20484083
GO:0001933	Process	Negative regulation of protein phosphorylation	IDA	12226747
GO:0002076	Process	Osteoblast development	IGI	15563473
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003690	Function	Double-stranded DNA binding	IDA	15331604
GO:0005515	Function	Protein binding	IPI	9989505, 11302744, 11500056, 11526476, 12509449, 12874027, 14508515, 14992727, 15199122, 15960975, 16951149, 20484083, 22327296, 22936661, 23784080, 24981860, 25305204, 27705803, 35512704
GO:0005634	Component	Nucleus	IDA	9465067, 14508515, 15199122, 15640349, 17500065
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	11500056
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005829	Component	Cytosol	IDA	14508515
GO:0005829	Component	Cytosol	TAS
GO:0006281	Process	DNA repair	NAS	12874027
GO:0006325	Process	Chromatin organization	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006974	Process	DNA damage response	IDA	16690369
GO:0008285	Process	Negative regulation of cell population proliferation	IBA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	15331604
GO:0009411	Process	Response to UV	IDA	16690369
GO:0010332	Process	Response to gamma radiation	IDA	12874027
GO:0016363	Component	Nuclear matrix	IDA	12874027
GO:0017053	Component	Transcription repressor complex	IPI	22327296
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IMP	11274402
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	20484083
GO:0032154	Component	Cleavage furrow	IDA	14508515
GO:0032991	Component	Protein-containing complex	IDA	15199122
GO:0035097	Component	Histone methyltransferase complex	IBA
GO:0035097	Component	Histone methyltransferase complex	IDA	17500065
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	IDA	11526476, 12226747
GO:0044665	Component	MLL1/2 complex	IPI	23508102
GO:0045064	Process	T-helper 2 cell differentiation	IDA	20484083
GO:0045668	Process	Negative regulation of osteoblast differentiation	IGI	15563473
GO:0045736	Process	Negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	15640349
GO:0045786	Process	Negative regulation of cell cycle	IBA
GO:0045786	Process	Negative regulation of cell cycle	IDA	15331604
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IMP	14992727
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12226747
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	15199122
GO:0046329	Process	Negative regulation of JNK cascade	IDA	12226747
GO:0051219	Function	Phosphoprotein binding	IPI	14992727
GO:0070412	Function	R-SMAD binding	IPI	11274402
GO:0071339	Component	MLL1 complex	IPI	23508102

MIM	HGNC	e!Ensembl
613733	7010	ENSG00000133895

Protein

UniProt ID

O00255

Protein name

Menin

Protein function

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase express

PDB

3U84 , 3U85 , 3U86 , 3U88 , 4GPQ , 4GQ3 , 4GQ4 , 4GQ6 , 4I80 , 4OG3 , 4OG4 , 4OG5 , 4OG6 , 4OG7 , 4OG8 , 4X5Y , 4X5Z , 5DB0 , 5DB1 , 5DB2 , 5DB3 , 5DD9 , 5DDA , 5DDB , 5DDC , 5DDD , 5DDE , 5DDF , 6B41 , 6BXH , 6BXY , 6BY8 , 6E1A , 6O5I , 6OPJ , 6PKC , 6S2K , 6WNH , 7M4T , 7O9T , 7O9X , 7O9Z , 7OA9 , 7UJ4 , 8E90 , 8GPN , 8IG0 , 8VA5 , 8VA6 , 9C92 , 9C93

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05053	Menin	1 → 516	Menin	Family
PF05053	Menin	526 → 613	Menin	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHL
ALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKME
VAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGR
PDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCR
EDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR
FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEA
REGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTA
QVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTP
SDYTLSFLKRQRKGL

Sequence length

615

Interactions

View interactions

	KEGG		Reactome
	Cushing syndrome Transcriptional misregulation in cancer		Formation of the beta-catenin:TCF transactivating complex SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Deactivation of the beta-catenin transactivating complex Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate IQGAPs Post-translational protein phosphorylation

Show/Hide Causal Diseases (7)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Hyperparathyroidism	hyperparathyroidism 1	rs863223311	N/A
Hyperthyroidism	Primary hyperparathyroidism	rs869312167	N/A
Multiple Endocrine Neoplasia	Multiple endocrine neoplasia, type 1, multiple endocrine neoplasia	rs386134250, rs1114167519, rs1060499974, rs1555163780, rs1592643178, rs794728647, rs1555166365, rs1565651223, rs398124435, rs104894261, rs1064793613, rs1941733228, rs878855196, rs1060499984, rs886039413 View all (190 more)	N/A
somatotroph adenoma	Somatotroph adenoma	rs1565635212, rs972128957	N/A
adrenocortical adenoma	Adrenocortical adenoma	rs121913035	N/A
Angiofibroma	Angiofibroma, somatic	rs121913034, rs267607234	N/A
Ependymoma	ependymoma	rs1555165565	N/A

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
hereditary cancer	Hereditary cancer	N/A	N/A	ClinVar
Hereditary Pheochromocytoma-Paraganglioma	hereditary pheochromocytoma-paraganglioma	N/A	N/A	GenCC
Neuroblastoma	neuroblastoma	N/A	N/A	ClinVar
ovarian cancer	Ovarian cancer	N/A	N/A	ClinVar
Pituitary adenoma	pituitary adenoma 5, multiple types	N/A	N/A	ClinVar
pituitary dependent hypercortisolism	Pituitary dependent hypercortisolism	N/A	N/A	ClinVar
Pituitary Gigantism	pituitary gigantism	N/A	N/A	GenCC

Show/Hide Text Mining Associations (128)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acromegaly	Associate	20454499, 33125695, 9709921
Acth Independent Macronodular Adrenal Hyperplasia	Associate	19509103
ACTH Secreting Pituitary Adenoma	Associate	29927501
Adenocarcinoma Follicular	Associate	34171097
Adenoma	Associate	23321498, 32759398
Adenoma Islet Cell	Associate	20616437
Adrenal Cortex Neoplasms	Associate	21655742
Adrenocortical Carcinoma	Associate	21655742, 25034529, 25078331
Alopecia Neurologic Defects and Endocrinopathy Syndrome	Associate	28066056
Angiofibroma	Associate	11200937, 37484956
Breast Neoplasms	Associate	15168774, 26732163, 28273452, 33370954, 35850772, 37437063, 37484956
Breast Neoplasms	Inhibit	35317849
Carcinogenesis	Associate	16604156, 19528440, 25625803, 26732163, 28701629, 31211356, 35014621, 9681840
Carcinoid Tumor	Associate	22825745, 24276465, 24670920, 26960398, 27873319, 31085341, 31300474, 38159439, 38237798
Carcinoma Hepatocellular	Associate	10674843, 26732163
Carcinoma Large Cell	Associate	10760691, 31085341, 35696052
Carcinoma Neuroendocrine	Inhibit	24276465
Carcinoma Non Small Cell Lung	Inhibit	20639902
Cardiomyopathy infantile histiocytoid	Associate	25625803
Cardiovascular Diseases	Associate	9681844
Cell Transformation Viral	Associate	20484370
Cholangiocarcinoma	Inhibit	36782257
Cleft Palate	Associate	37449924
Colorectal Neoplasms	Associate	34237211, 37484956
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	28701629
Congenital Hyperinsulinism	Associate	27247513
Consciousness Disorders	Associate	32759398
Constipation	Associate	32759398
Coronary Disease	Associate	36221106
Cushing Syndrome	Associate	37405461
Deglutition Disorders	Associate	32759398
Dystonic Disorders	Associate	35941657
Ectodermal Dysplasia	Associate	35563746
Endocrine Gland Neoplasms	Associate	10993646, 16604156, 20616437, 35268848, 35856247
Endocrine Gland Neoplasms	Inhibit	18310293
Endocrine System Diseases	Associate	19528440, 26732163
Esophageal Squamous Cell Carcinoma	Associate	33457096
Esophageal Stenosis	Associate	28270118
Familial medullary thyroid carcinoma	Associate	26530882
Farber Lipogranulomatosis	Associate	27873319
Fibrosis	Associate	36782257
Gastrinoma	Associate	21852362, 38229586
Gastro enteropancreatic neuroendocrine tumor	Associate	31044390, 36969744
Gastrointestinal Neoplasms	Associate	12973852
Gastrointestinal Stromal Tumors	Associate	28130400, 35499757
Genetic Diseases Inborn	Stimulate	2565085
Genetic Diseases Inborn	Associate	9709921
Glucagonoma	Associate	10993646, 19525592
Glutaric Acidemia I	Associate	30373905
Growth Hormone Secreting Pituitary Adenoma	Associate	20454499
Hereditary Breast and Ovarian Cancer Syndrome	Associate	28273452
Hyperparathyroidism	Associate	15635078, 17065424, 19461164, 9681844
Hyperparathyroidism 1	Associate	16995822, 22187299, 35856247, 9709921
Hyperparathyroidism Primary	Associate	15168774, 17065424, 19309299, 19461164, 22447146, 23547958, 24121387, 28663159, 29408534, 29927501, 32808116, 33125695, 33233395, 35856247, 37449924, 37465121 View all (1 more)
Hyperplasia	Associate	15635078
Hyperplasia	Stimulate	2565085
Hyperprolactinemia	Associate	29927501
Hyperthyroidism	Associate	37876543
Hypoglycemia	Associate	28395809
Hypoxia	Associate	28126478, 34237211
Insulinoma	Associate	25034529, 26307114, 26756113, 28663159
Leiomyoma	Associate	37484956
Leukemia	Associate	15199122, 16604156, 20558618, 22936661, 31253180, 34196551, 35534777, 35938317, 38003662, 38048400
Leukemia	Inhibit	36455613
Leukemia Biphenotypic Acute	Associate	20484083, 20484370, 22936661
Leukemia Lymphocytic Chronic B Cell	Associate	12973852
Leukemia Myeloid Acute	Associate	22936661, 27535106, 27760321, 31855575, 35017466, 35534777, 35938317, 36455613, 37055414, 38003662, 38096371
Leukemia T Cell	Associate	36922593
Li Fraumeni Syndrome	Associate	32191290
Lipoma	Associate	21078971, 37484956
Lung Neoplasms	Associate	20639902, 27873319, 35477182, 37484956
Lymphatic Metastasis	Inhibit	20639902
Lymphatic Metastasis	Associate	30787304
Lymphoma	Associate	37460547
Lymphoma Non Hodgkin	Associate	32883742
MASS syndrome	Associate	32808116
Melanoma	Inhibit	23648481
Melanoma	Associate	26732163, 28186096
Mouth Diseases	Associate	37484956
Multiple Endocrine Neoplasia	Associate	25153502, 27247513
Multiple Endocrine Neoplasia	Stimulate	30428914, 32570972
Multiple Endocrine Neoplasia Type 1	Associate	10395230, 10760691, 10993646, 1362397, 15082967, 15635078, 15640349, 1680115, 17050672, 17356705, 18310293, 19461164, 19564705, 20464709, 20616437 View all (41 more)
Multiple Endocrine Neoplasia Type 1	Inhibit	15691381, 23648481, 32278331
Multiple Endocrine Neoplasia Type 1	Stimulate	16604156, 2565085, 31044390
Multiple Endocrine Neoplasia Type 2a	Associate	10993647, 9681840
Multiple Myeloma	Associate	38003662
Neoplasm Metastasis	Associate	24276465, 29486199, 34183353, 35014621
Neoplasm Metastasis	Inhibit	29092957, 35179814
Neoplasm Recurrence Local	Associate	34326338
Neoplasms	Inhibit	10389976, 12755955, 15082967, 15199122, 15640349, 15691381, 16604156, 17050672, 17065424, 17671196, 21264250, 22447146, 23188049, 25012242, 25034529 View all (16 more)
Neoplasms	Associate	10433956, 12368203, 15168774, 15383867, 18310293, 1968641, 21252315, 22447146, 22740705, 22825745, 23676460, 24293293, 26732163, 27175596, 28126478 View all (22 more)
Neoplastic Syndromes Hereditary	Associate	21078971, 30580288, 7911003
Neuroblastoma	Associate	25012242
Neuroectodermal Tumors Primitive	Associate	29092957, 36604142
Neuroendocrine Tumors	Associate	15691381, 21252315, 22575867, 23676460, 25210493, 26678657, 27994516, 28130400, 28591701, 29092957, 30315258, 32345369, 33536587, 35171113, 35739266 View all (7 more)
Non functioning pancreatic endocrine tumor	Associate	12940462, 26732163
Oncocytoma renal	Associate	27175596
Osteosarcoma	Inhibit	25034529
Ovarian Neoplasms	Associate	33560870
Pancreatic Neoplasms	Associate	10993646, 23745036, 24293293, 28199314, 28663159, 32278331, 35179814, 36835048, 40421248
Parathyroid Diseases	Associate	10993646, 1968641
Parathyroid Diseases	Stimulate	2565085
Parathyroid Neoplasms	Associate	15168774, 20208994, 22207168, 22454399, 22740705, 25034529, 28066056, 30373905, 34054720, 35856247, 36611251, 9681842
Periventricular Nodular Heterotopia	Associate	31489630
Pheochromocytoma	Associate	25494863
Pituitary ACTH Hypersecretion	Associate	20507346, 29927501
Pituitary Neoplasms	Associate	12755955, 15635078, 20507346, 21078971, 21917868, 25494863, 28663159, 28701629, 31665029
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	38003662
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	33741715, 38003662
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	36922593
Prolactinoma	Associate	19391077
Prostate Cancer Hereditary 7	Associate	25131421
Prostatic Neoplasms	Associate	18779856, 26732163, 35014621
Prostatitis	Associate	18779856
Sarcoma Ewing	Associate	33741715
Seizures	Associate	27247513
Small Cell Lung Carcinoma	Associate	10760691, 38237798
Stomach Diseases	Associate	12973852
Syndrome	Associate	17065424
Taste Disorders	Associate	32759398
Thymoma	Associate	37749819
Thymus Neoplasms	Associate	10395230, 16594911, 37749819
Thyroid Adenoma Hyperfunctioning	Associate	32808116
Thyroid cancer Hurthle cell	Associate	25625803
Thyroid Neoplasms	Associate	32737449, 34972706, 37484956
Turcot syndrome	Associate	28701629
Vitamin D Deficiency	Associate	30315258
Zollinger Ellison Syndrome	Associate	28270118

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