Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4218
Gene name Gene Name - the full gene name approved by the HGNC.
RAB8A, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB8A
Synonyms (NCBI Gene) Gene synonyms aliases
MEL, RAB8
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MEL
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endo
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023153 hsa-miR-124-3p Microarray 18668037
MIRT030290 hsa-miR-26b-5p Microarray 19088304
MIRT049530 hsa-miR-92a-3p CLASH 23622248
MIRT664342 hsa-miR-6892-3p HITS-CLIP 23824327
MIRT664341 hsa-miR-2276-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0003924 Function GTPase activity IDA 17646400
GO:0005515 Function Protein binding IPI 15207266, 15837803, 16541104, 16902405, 17646400, 18329369, 19864458, 20308558, 20388642, 20643351, 21273506, 21378754, 22011575, 22159412, 22543976, 22854040, 26258637, 26824392, 27103069, 27173435, 29125462, 32017888
GO:0005525 Function GTP binding IDA 20937701
GO:0005768 Component Endosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165040 7007 ENSG00000167461
Protein
UniProt ID P61006
Protein name Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 3QBT , 3TNF , 4LHV , 4LHW , 4LHX , 4LHY , 4LHZ , 4LI0 , 5SZI , 6RIR , 6SQ2 , 6STF , 6STG , 6WHE , 6YX5 , 6ZSI , 6ZSJ , 7BWT , 7LWB , 9IKQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 10 171 Ras family Domain
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Autophagy - animal
Endocytosis
AMPK signaling pathway
Tight junction
Pancreatic secretion
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
  Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 12833524
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 36815135
Cleft Palate Associate 34242216
Endometrial Neoplasms Associate 25477298
Esophageal Neoplasms Associate 36815135
Hirschsprung Disease Associate 33561610
Microvillus inclusion disease Associate 24892806, 26553929, 28407399
Neoplasms Associate 25477298
Parkinson Disease Associate 29357897
Respiratory Tract Diseases Associate 34004362
Uterine Cervical Neoplasms Associate 35435110