Gene Gene information from NCBI Gene database.
Entrez ID 4218
Gene name RAB8A, member RAS oncogene family
Gene symbol RAB8A
Synonyms (NCBI Gene)
MELRAB8
Chromosome 19
Chromosome location 19p13.11
Summary The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endo
miRNA miRNA information provided by mirtarbase database.
514
miRTarBase ID miRNA Experiments Reference
MIRT023153 hsa-miR-124-3p Microarray 18668037
MIRT030290 hsa-miR-26b-5p Microarray 19088304
MIRT049530 hsa-miR-92a-3p CLASH 23622248
MIRT664342 hsa-miR-6892-3p HITS-CLIP 23824327
MIRT664341 hsa-miR-2276-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
96
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 17646400
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
165040 7007 ENSG00000167461
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61006
Protein name Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 3QBT , 3TNF , 4LHV , 4LHW , 4LHX , 4LHY , 4LHZ , 4LI0 , 5SZI , 6RIR , 6SQ2 , 6STF , 6STG , 6WHE , 6YX5 , 6ZSI , 6ZSJ , 7BWT , 7LWB , 9IKQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 10 171 Ras family Domain
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Autophagy - animal
Endocytosis
AMPK signaling pathway
Tight junction
Pancreatic secretion
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
  Regulation of PLK1 Activity at G2/M Transition
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs