Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4216
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP3K4
Synonyms (NCBI Gene) Gene synonyms aliases	MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q26
Summary Summary of gene provided in NCBI Entrez Gene.	The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAP

Show/Hide all(105)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022893	hsa-miR-124-3p	Microarray	18668037
MIRT049769	hsa-miR-92a-3p	CLASH	23622248
MIRT048846	hsa-miR-93-5p	CLASH	23622248
MIRT048040	hsa-miR-148a-3p	CLASH	23622248
MIRT099168	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT099169	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT099174	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493268	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT099173	hsa-miR-3123	PAR-CLIP	23592263
MIRT099172	hsa-miR-1245a	PAR-CLIP	23592263
MIRT099181	hsa-miR-8079	PAR-CLIP	23592263
MIRT099180	hsa-miR-8062	PAR-CLIP	23592263
MIRT099176	hsa-miR-3691-3p	PAR-CLIP	23592263
MIRT099178	hsa-miR-6073	PAR-CLIP	23592263
MIRT048040	hsa-miR-148a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26253263
MIRT099168	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT099169	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT099174	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493268	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT099173	hsa-miR-3123	PAR-CLIP	23592263
MIRT099172	hsa-miR-1245a	PAR-CLIP	23592263
MIRT099181	hsa-miR-8079	PAR-CLIP	23592263
MIRT099180	hsa-miR-8062	PAR-CLIP	23592263
MIRT099176	hsa-miR-3691-3p	PAR-CLIP	23592263
MIRT099178	hsa-miR-6073	PAR-CLIP	23592263
MIRT1128996	hsa-miR-128	CLIP-seq
MIRT1128997	hsa-miR-148a	CLIP-seq
MIRT1128998	hsa-miR-148b	CLIP-seq
MIRT1128999	hsa-miR-152	CLIP-seq
MIRT1129000	hsa-miR-27a	CLIP-seq
MIRT1129001	hsa-miR-27b	CLIP-seq
MIRT1129002	hsa-miR-3065-5p	CLIP-seq
MIRT1129003	hsa-miR-4697-3p	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1129005	hsa-miR-495	CLIP-seq
MIRT1129006	hsa-miR-513a-5p	CLIP-seq
MIRT1129007	hsa-miR-548ac	CLIP-seq
MIRT1129008	hsa-miR-548ae	CLIP-seq
MIRT1129009	hsa-miR-548aj	CLIP-seq
MIRT1129010	hsa-miR-548am	CLIP-seq
MIRT1129011	hsa-miR-548d-3p	CLIP-seq
MIRT1129012	hsa-miR-548m	CLIP-seq
MIRT1129013	hsa-miR-548x	CLIP-seq
MIRT1129014	hsa-miR-548z	CLIP-seq
MIRT1129015	hsa-miR-624	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1128996	hsa-miR-128	CLIP-seq
MIRT2266906	hsa-miR-1324	CLIP-seq
MIRT1128997	hsa-miR-148a	CLIP-seq
MIRT1128998	hsa-miR-148b	CLIP-seq
MIRT1128999	hsa-miR-152	CLIP-seq
MIRT2266907	hsa-miR-15a	CLIP-seq
MIRT2266908	hsa-miR-15b	CLIP-seq
MIRT2266909	hsa-miR-16	CLIP-seq
MIRT2266910	hsa-miR-195	CLIP-seq
MIRT2266911	hsa-miR-214	CLIP-seq
MIRT1129000	hsa-miR-27a	CLIP-seq
MIRT1129001	hsa-miR-27b	CLIP-seq
MIRT1129002	hsa-miR-3065-5p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2266913	hsa-miR-3619-5p	CLIP-seq
MIRT2266914	hsa-miR-424	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT1129003	hsa-miR-4697-3p	CLIP-seq
MIRT2266917	hsa-miR-4722-5p	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1129005	hsa-miR-495	CLIP-seq
MIRT2266918	hsa-miR-497	CLIP-seq
MIRT1129006	hsa-miR-513a-5p	CLIP-seq
MIRT1129007	hsa-miR-548ac	CLIP-seq
MIRT1129008	hsa-miR-548ae	CLIP-seq
MIRT1129009	hsa-miR-548aj	CLIP-seq
MIRT1129010	hsa-miR-548am	CLIP-seq
MIRT1129011	hsa-miR-548d-3p	CLIP-seq
MIRT1129012	hsa-miR-548m	CLIP-seq
MIRT1129013	hsa-miR-548x	CLIP-seq
MIRT1129014	hsa-miR-548z	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq
MIRT2266920	hsa-miR-761	CLIP-seq
MIRT2566450	hsa-miR-1914	CLIP-seq
MIRT2566451	hsa-miR-3065-3p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2566452	hsa-miR-3622a-3p	CLIP-seq
MIRT2566453	hsa-miR-3622b-3p	CLIP-seq
MIRT2566454	hsa-miR-380	CLIP-seq
MIRT2566455	hsa-miR-3924	CLIP-seq
MIRT2566456	hsa-miR-3944-5p	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2566457	hsa-miR-4495	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq
MIRT2566450	hsa-miR-1914	CLIP-seq
MIRT2566451	hsa-miR-3065-3p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2566452	hsa-miR-3622a-3p	CLIP-seq
MIRT2566453	hsa-miR-3622b-3p	CLIP-seq
MIRT2566456	hsa-miR-3944-5p	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000186	Process	Activation of MAPKK activity	IDA	9305639, 9827804
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	9305639, 9827804
GO:0005515	Function	Protein binding	IPI	12052864, 16157600, 16256071, 19270716, 20221403, 25241761
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	9827804
GO:0006468	Process	Protein phosphorylation	IEA
GO:0010225	Process	Response to UV-C	IMP	9305639
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	21531765
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	9305639
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051973	Process	Positive regulation of telomerase activity	IMP	21531765
GO:1900745	Process	Positive regulation of p38MAPK cascade	IDA	9305639
GO:1904355	Process	Positive regulation of telomere capping	IMP	21531765

MIM	HGNC	e!Ensembl
602425	6856	ENSG00000085511

Protein

UniProt ID

Q9Y6R4

Protein name

Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)

Protein function

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:930

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	1343 → 1601	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.

Sequence

MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE

Sequence length

1608

Interactions

View interactions

	KEGG
	MAPK signaling pathway GnRH signaling pathway

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077 View all (247 more)	23104009
Nephroblastoma	Nephroblastoma	rs1553551874, rs1555913934, rs769116796	28825729
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	22491018
Wilms tumor	Bilateral Wilms Tumor	rs121918261, rs2116574924, rs587776573, rs587776574, rs121907900, rs121907901, rs587776576, rs121907909, rs121907906, rs587776577, rs121907911, rs80359604, rs80358785, rs104894855, rs122453119 View all (13 more)	28825729

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Evidence	References	Source
Unknown
Endometriosis	Endometriosis		28333195	ClinVar
Coronary artery disease	Coronary artery disease			GWAS
Periodontitis	Periodontitis			GWAS
Coronary Heart Disease	Coronary Heart Disease			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma			GWAS
Insomnia	Insomnia			GWAS
Myocardial Infarction	Myocardial Infarction			GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	27869167
Carcinogenesis	Associate	33149122
Cataract Age Related Nuclear	Associate	36071682
Developmental Disabilities	Associate	31694657
Endometrial Neoplasms	Associate	23104009
Endometriosis	Associate	28333195
Glycogen Storage Disease Type II	Associate	23940728
Intellectual Disability	Associate	31694657
Leukemia Lymphocytic Chronic B Cell	Associate	31142279
Lung Neoplasms	Associate	33853833
Melanoma	Associate	22589389
Neoplasm Metastasis	Associate	30285791
Neoplasms	Associate	25198898, 27356755, 27869167, 33853833, 34728787
Neoplasms Cystic Mucinous and Serous	Associate	23104009
Neuroendocrine Tumors	Associate	34728787
Non alcoholic Fatty Liver Disease	Associate	36376950
Ovarian Neoplasms	Associate	24448499
Pituitary Neoplasms	Associate	36750863
Pneumonia Lipid	Associate	36376950
Polycystic Ovary Syndrome	Inhibit	26459919
Stomach Neoplasms	Associate	25173755
Urinary Bladder Neoplasms	Associate	27440446
Wilms Tumor	Associate	28825729

MAP3K4 (mitogen-activated protein kinase kinase kinase 4)