Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4216
Gene name	Mitogen-activated protein kinase kinase kinase 4
Gene symbol	MAP3K4
Synonyms (NCBI Gene)	MAPKKK4MEKK 4MEKK4MTK1PRO0412
Chromosome	6
Chromosome location	6q26
Summary	The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAP

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022893	hsa-miR-124-3p	Microarray	18668037
MIRT049769	hsa-miR-92a-3p	CLASH	23622248
MIRT048846	hsa-miR-93-5p	CLASH	23622248
MIRT048040	hsa-miR-148a-3p	CLASH	23622248
MIRT099168	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT099169	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT099174	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493268	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT099173	hsa-miR-3123	PAR-CLIP	23592263
MIRT099172	hsa-miR-1245a	PAR-CLIP	23592263
MIRT099181	hsa-miR-8079	PAR-CLIP	23592263
MIRT099180	hsa-miR-8062	PAR-CLIP	23592263
MIRT099176	hsa-miR-3691-3p	PAR-CLIP	23592263
MIRT099178	hsa-miR-6073	PAR-CLIP	23592263
MIRT048040	hsa-miR-148a-3p	Luciferase reporter assayqRT-PCRWestern blot	26253263
MIRT099168	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT099169	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT099174	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493269	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT493268	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT099173	hsa-miR-3123	PAR-CLIP	23592263
MIRT099172	hsa-miR-1245a	PAR-CLIP	23592263
MIRT099181	hsa-miR-8079	PAR-CLIP	23592263
MIRT099180	hsa-miR-8062	PAR-CLIP	23592263
MIRT099176	hsa-miR-3691-3p	PAR-CLIP	23592263
MIRT099178	hsa-miR-6073	PAR-CLIP	23592263
MIRT1128996	hsa-miR-128	CLIP-seq
MIRT1128997	hsa-miR-148a	CLIP-seq
MIRT1128998	hsa-miR-148b	CLIP-seq
MIRT1128999	hsa-miR-152	CLIP-seq
MIRT1129000	hsa-miR-27a	CLIP-seq
MIRT1129001	hsa-miR-27b	CLIP-seq
MIRT1129002	hsa-miR-3065-5p	CLIP-seq
MIRT1129003	hsa-miR-4697-3p	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1129005	hsa-miR-495	CLIP-seq
MIRT1129006	hsa-miR-513a-5p	CLIP-seq
MIRT1129007	hsa-miR-548ac	CLIP-seq
MIRT1129008	hsa-miR-548ae	CLIP-seq
MIRT1129009	hsa-miR-548aj	CLIP-seq
MIRT1129010	hsa-miR-548am	CLIP-seq
MIRT1129011	hsa-miR-548d-3p	CLIP-seq
MIRT1129012	hsa-miR-548m	CLIP-seq
MIRT1129013	hsa-miR-548x	CLIP-seq
MIRT1129014	hsa-miR-548z	CLIP-seq
MIRT1129015	hsa-miR-624	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1128996	hsa-miR-128	CLIP-seq
MIRT2266906	hsa-miR-1324	CLIP-seq
MIRT1128997	hsa-miR-148a	CLIP-seq
MIRT1128998	hsa-miR-148b	CLIP-seq
MIRT1128999	hsa-miR-152	CLIP-seq
MIRT2266907	hsa-miR-15a	CLIP-seq
MIRT2266908	hsa-miR-15b	CLIP-seq
MIRT2266909	hsa-miR-16	CLIP-seq
MIRT2266910	hsa-miR-195	CLIP-seq
MIRT2266911	hsa-miR-214	CLIP-seq
MIRT1129000	hsa-miR-27a	CLIP-seq
MIRT1129001	hsa-miR-27b	CLIP-seq
MIRT1129002	hsa-miR-3065-5p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2266913	hsa-miR-3619-5p	CLIP-seq
MIRT2266914	hsa-miR-424	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT1129003	hsa-miR-4697-3p	CLIP-seq
MIRT2266917	hsa-miR-4722-5p	CLIP-seq
MIRT1129004	hsa-miR-4768-3p	CLIP-seq
MIRT1129005	hsa-miR-495	CLIP-seq
MIRT2266918	hsa-miR-497	CLIP-seq
MIRT1129006	hsa-miR-513a-5p	CLIP-seq
MIRT1129007	hsa-miR-548ac	CLIP-seq
MIRT1129008	hsa-miR-548ae	CLIP-seq
MIRT1129009	hsa-miR-548aj	CLIP-seq
MIRT1129010	hsa-miR-548am	CLIP-seq
MIRT1129011	hsa-miR-548d-3p	CLIP-seq
MIRT1129012	hsa-miR-548m	CLIP-seq
MIRT1129013	hsa-miR-548x	CLIP-seq
MIRT1129014	hsa-miR-548z	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq
MIRT2266920	hsa-miR-761	CLIP-seq
MIRT2566450	hsa-miR-1914	CLIP-seq
MIRT2566451	hsa-miR-3065-3p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2566452	hsa-miR-3622a-3p	CLIP-seq
MIRT2566453	hsa-miR-3622b-3p	CLIP-seq
MIRT2566454	hsa-miR-380	CLIP-seq
MIRT2566455	hsa-miR-3924	CLIP-seq
MIRT2566456	hsa-miR-3944-5p	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2566457	hsa-miR-4495	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq
MIRT2566450	hsa-miR-1914	CLIP-seq
MIRT2566451	hsa-miR-3065-3p	CLIP-seq
MIRT2266912	hsa-miR-3202	CLIP-seq
MIRT2566452	hsa-miR-3622a-3p	CLIP-seq
MIRT2566453	hsa-miR-3622b-3p	CLIP-seq
MIRT2566456	hsa-miR-3944-5p	CLIP-seq
MIRT2266915	hsa-miR-432	CLIP-seq
MIRT2266916	hsa-miR-4533	CLIP-seq
MIRT2266919	hsa-miR-622	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IDA	9305639, 9827804
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001890	Process	Placenta development	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	9305639, 9827804
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	12052864, 16157600, 16256071, 19270716, 20221403, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	9827804
GO:0005737	Component	Cytoplasm	IEA
GO:0010225	Process	Response to UV-C	IMP	9305639
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019100	Process	Male germ-line sex determination	IEA
GO:0032206	Process	Positive regulation of telomere maintenance	IMP	21531765
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0038066	Process	P38MAPK cascade	IBA
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	9305639
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060718	Process	Chorionic trophoblast cell differentiation	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IDA	9305639

MIM	HGNC	e!Ensembl
602425	6856	ENSG00000085511

Q9Y6R4

Protein name

Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)

Protein function

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:930

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	1343 → 1601	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}.

Sequence

MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA
CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP
NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP
DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK
KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT
FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL
LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS
DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN
SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR
KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS
WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK
GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH
SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS
ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD
LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY
LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK
AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV
DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK
CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL
YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV
AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP
AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ
VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND
HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI
RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN
STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM
GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE

Sequence length

1608

Interactions

View interactions

	KEGG
	MAPK signaling pathway GnRH signaling pathway

MAP3K4 (mitogen-activated protein kinase kinase kinase 4)