Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4215
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP3K3
Synonyms (NCBI Gene) Gene synonyms aliases	CCM5, MAPKKK3, MEKK3
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003519	hsa-miR-145-5p	Review	20144549
MIRT021476	hsa-miR-9-5p	Microarray	17612493
MIRT021851	hsa-miR-132-3p	Microarray	17612493
MIRT023113	hsa-miR-124-3p	Microarray	18668037
MIRT041562	hsa-miR-193b-3p	CLASH	23622248
MIRT003519	hsa-miR-145-5p	Microarray	22942087
MIRT053682	hsa-miR-181a-5p	Microarray	22942087
MIRT053697	hsa-miR-188-5p	Microarray	22942087
MIRT556302	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT078464	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT078466	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT556301	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT556300	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT078467	hsa-miR-1178-5p	PAR-CLIP	21572407
MIRT078468	hsa-miR-1182	PAR-CLIP	21572407
MIRT078471	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT078470	hsa-miR-4328	PAR-CLIP	21572407
MIRT556299	hsa-miR-3140-3p	PAR-CLIP	21572407
MIRT078474	hsa-miR-6753-3p	PAR-CLIP	21572407
MIRT078476	hsa-miR-7107-3p	PAR-CLIP	21572407
MIRT556298	hsa-miR-2052	PAR-CLIP	21572407
MIRT078461	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT078462	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT078463	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT078475	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT147124	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT147118	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT147124	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT147117	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT147128	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT147119	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT147133	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT053682	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT147121	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT147122	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT147129	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT727250	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT041562	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT147118	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT734113	hsa-miR-212-3p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	32269720
MIRT556302	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT078464	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT078466	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT556301	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT556300	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT078467	hsa-miR-1178-5p	PAR-CLIP	21572407
MIRT078468	hsa-miR-1182	PAR-CLIP	21572407
MIRT078471	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT078470	hsa-miR-4328	PAR-CLIP	21572407
MIRT556299	hsa-miR-3140-3p	PAR-CLIP	21572407
MIRT078474	hsa-miR-6753-3p	PAR-CLIP	21572407
MIRT078476	hsa-miR-7107-3p	PAR-CLIP	21572407
MIRT556298	hsa-miR-2052	PAR-CLIP	21572407
MIRT078461	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT078462	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT078463	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT078475	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128849	hsa-miR-106a	CLIP-seq
MIRT1128850	hsa-miR-106b	CLIP-seq
MIRT1128851	hsa-miR-1185	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT1128853	hsa-miR-1207-5p	CLIP-seq
MIRT1128854	hsa-miR-1243	CLIP-seq
MIRT1128855	hsa-miR-1254	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT1128857	hsa-miR-1271	CLIP-seq
MIRT1128858	hsa-miR-1294	CLIP-seq
MIRT1128859	hsa-miR-1305	CLIP-seq
MIRT1128860	hsa-miR-1323	CLIP-seq
MIRT1128861	hsa-miR-150	CLIP-seq
MIRT1128862	hsa-miR-17	CLIP-seq
MIRT1128863	hsa-miR-181a	CLIP-seq
MIRT1128864	hsa-miR-181b	CLIP-seq
MIRT1128865	hsa-miR-181c	CLIP-seq
MIRT1128866	hsa-miR-181d	CLIP-seq
MIRT1128867	hsa-miR-182	CLIP-seq
MIRT1128868	hsa-miR-1909	CLIP-seq
MIRT1128869	hsa-miR-1915	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128871	hsa-miR-20a	CLIP-seq
MIRT1128872	hsa-miR-20b	CLIP-seq
MIRT1128873	hsa-miR-217	CLIP-seq
MIRT1128874	hsa-miR-22	CLIP-seq
MIRT1128875	hsa-miR-2276	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT1128877	hsa-miR-23a	CLIP-seq
MIRT1128878	hsa-miR-23b	CLIP-seq
MIRT1128879	hsa-miR-23c	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT1128881	hsa-miR-3116	CLIP-seq
MIRT1128882	hsa-miR-3136-3p	CLIP-seq
MIRT1128883	hsa-miR-320e	CLIP-seq
MIRT1128884	hsa-miR-323-3p	CLIP-seq
MIRT1128885	hsa-miR-330-3p	CLIP-seq
MIRT1128886	hsa-miR-338-3p	CLIP-seq
MIRT1128887	hsa-miR-33a	CLIP-seq
MIRT1128888	hsa-miR-33b	CLIP-seq
MIRT1128889	hsa-miR-3605-5p	CLIP-seq
MIRT1128890	hsa-miR-3607-3p	CLIP-seq
MIRT1128891	hsa-miR-3652	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128893	hsa-miR-3679-5p	CLIP-seq
MIRT1128894	hsa-miR-3686	CLIP-seq
MIRT1128895	hsa-miR-3926	CLIP-seq
MIRT1128896	hsa-miR-3929	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT1128898	hsa-miR-4262	CLIP-seq
MIRT1128899	hsa-miR-4273	CLIP-seq
MIRT1128900	hsa-miR-432	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128902	hsa-miR-4419b	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT1128904	hsa-miR-4430	CLIP-seq
MIRT1128905	hsa-miR-4446-3p	CLIP-seq
MIRT1128906	hsa-miR-4455	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128908	hsa-miR-4478	CLIP-seq
MIRT1128909	hsa-miR-4496	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128911	hsa-miR-4505	CLIP-seq
MIRT1128912	hsa-miR-4531	CLIP-seq
MIRT1128913	hsa-miR-4633-3p	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT1128915	hsa-miR-4651	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT1128917	hsa-miR-4663	CLIP-seq
MIRT1128918	hsa-miR-4666-5p	CLIP-seq
MIRT1128919	hsa-miR-4677-5p	CLIP-seq
MIRT1128920	hsa-miR-4683	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT1128923	hsa-miR-4728-3p	CLIP-seq
MIRT1128924	hsa-miR-4736	CLIP-seq
MIRT1128925	hsa-miR-4738-3p	CLIP-seq
MIRT1128926	hsa-miR-4738-5p	CLIP-seq
MIRT1128927	hsa-miR-4760-3p	CLIP-seq
MIRT1128928	hsa-miR-4763-3p	CLIP-seq
MIRT1128929	hsa-miR-4772-3p	CLIP-seq
MIRT1128930	hsa-miR-505	CLIP-seq
MIRT1128931	hsa-miR-519a	CLIP-seq
MIRT1128932	hsa-miR-519b-3p	CLIP-seq
MIRT1128933	hsa-miR-519c-3p	CLIP-seq
MIRT1128934	hsa-miR-519d	CLIP-seq
MIRT1128935	hsa-miR-544	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128937	hsa-miR-548a-3p	CLIP-seq
MIRT1128938	hsa-miR-548aa	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128944	hsa-miR-548e	CLIP-seq
MIRT1128945	hsa-miR-548f	CLIP-seq
MIRT1128946	hsa-miR-548n	CLIP-seq
MIRT1128947	hsa-miR-548o	CLIP-seq
MIRT1128948	hsa-miR-548s	CLIP-seq
MIRT1128949	hsa-miR-548t	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128952	hsa-miR-549	CLIP-seq
MIRT1128953	hsa-miR-558	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT1128955	hsa-miR-579	CLIP-seq
MIRT1128956	hsa-miR-603	CLIP-seq
MIRT1128957	hsa-miR-607	CLIP-seq
MIRT1128958	hsa-miR-608	CLIP-seq
MIRT1128959	hsa-miR-609	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT1128961	hsa-miR-618	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT1128965	hsa-miR-664	CLIP-seq
MIRT1128966	hsa-miR-885-3p	CLIP-seq
MIRT1128967	hsa-miR-93	CLIP-seq
MIRT1128968	hsa-miR-96	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128970	hsa-miR-103a	CLIP-seq
MIRT1128849	hsa-miR-106a	CLIP-seq
MIRT1128850	hsa-miR-106b	CLIP-seq
MIRT1128971	hsa-miR-107	CLIP-seq
MIRT1128851	hsa-miR-1185	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT1128972	hsa-miR-1225-5p	CLIP-seq
MIRT1128973	hsa-miR-124	CLIP-seq
MIRT1128974	hsa-miR-125a-5p	CLIP-seq
MIRT1128975	hsa-miR-125b	CLIP-seq
MIRT1128976	hsa-miR-141	CLIP-seq
MIRT1128862	hsa-miR-17	CLIP-seq
MIRT1128863	hsa-miR-181a	CLIP-seq
MIRT1128864	hsa-miR-181b	CLIP-seq
MIRT1128865	hsa-miR-181c	CLIP-seq
MIRT1128866	hsa-miR-181d	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT1128977	hsa-miR-200a	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128871	hsa-miR-20a	CLIP-seq
MIRT1128872	hsa-miR-20b	CLIP-seq
MIRT1128873	hsa-miR-217	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT1128979	hsa-miR-3140-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT1128883	hsa-miR-320e	CLIP-seq
MIRT1128886	hsa-miR-338-3p	CLIP-seq
MIRT1128887	hsa-miR-33a	CLIP-seq
MIRT1128888	hsa-miR-33b	CLIP-seq
MIRT1128889	hsa-miR-3605-5p	CLIP-seq
MIRT1128893	hsa-miR-3679-5p	CLIP-seq
MIRT1128981	hsa-miR-3714	CLIP-seq
MIRT1128982	hsa-miR-3910	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT1128895	hsa-miR-3926	CLIP-seq
MIRT1128896	hsa-miR-3929	CLIP-seq
MIRT1128984	hsa-miR-3977	CLIP-seq
MIRT1128898	hsa-miR-4262	CLIP-seq
MIRT1128985	hsa-miR-4319	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128986	hsa-miR-4325	CLIP-seq
MIRT1128902	hsa-miR-4419b	CLIP-seq
MIRT1128987	hsa-miR-4427	CLIP-seq
MIRT1128988	hsa-miR-4450	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128908	hsa-miR-4478	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT1128917	hsa-miR-4663	CLIP-seq
MIRT1128923	hsa-miR-4728-3p	CLIP-seq
MIRT1128990	hsa-miR-4732-3p	CLIP-seq
MIRT1128925	hsa-miR-4738-3p	CLIP-seq
MIRT1128926	hsa-miR-4738-5p	CLIP-seq
MIRT1128991	hsa-miR-4743	CLIP-seq
MIRT1128930	hsa-miR-505	CLIP-seq
MIRT1128992	hsa-miR-506	CLIP-seq
MIRT1128993	hsa-miR-507	CLIP-seq
MIRT1128931	hsa-miR-519a	CLIP-seq
MIRT1128932	hsa-miR-519b-3p	CLIP-seq
MIRT1128933	hsa-miR-519c-3p	CLIP-seq
MIRT1128934	hsa-miR-519d	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128946	hsa-miR-548n	CLIP-seq
MIRT1128948	hsa-miR-548s	CLIP-seq
MIRT1128949	hsa-miR-548t	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128952	hsa-miR-549	CLIP-seq
MIRT1128994	hsa-miR-557	CLIP-seq
MIRT1128961	hsa-miR-618	CLIP-seq
MIRT1128995	hsa-miR-670	CLIP-seq
MIRT1128967	hsa-miR-93	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT738730	hsa-miR-1972	CLIP-seq
MIRT738734	hsa-miR-3127-5p	CLIP-seq
MIRT738735	hsa-miR-3918	CLIP-seq
MIRT738732	hsa-miR-4435	CLIP-seq
MIRT738739	hsa-miR-450b-3p	CLIP-seq
MIRT738737	hsa-miR-4713-3p	CLIP-seq
MIRT738731	hsa-miR-4755-3p	CLIP-seq
MIRT738736	hsa-miR-4772-5p	CLIP-seq
MIRT738740	hsa-miR-638	CLIP-seq
MIRT738738	hsa-miR-769-3p	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT2036669	hsa-miR-1251	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2036671	hsa-miR-132	CLIP-seq
MIRT2036672	hsa-miR-1321	CLIP-seq
MIRT1128976	hsa-miR-141	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT2036673	hsa-miR-194	CLIP-seq
MIRT1128977	hsa-miR-200a	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT2036674	hsa-miR-212	CLIP-seq
MIRT2036675	hsa-miR-28-5p	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT2036676	hsa-miR-3139	CLIP-seq
MIRT2036677	hsa-miR-3151	CLIP-seq
MIRT2036678	hsa-miR-3160-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT2036679	hsa-miR-3184	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2036681	hsa-miR-3202	CLIP-seq
MIRT2036682	hsa-miR-323-5p	CLIP-seq
MIRT2036683	hsa-miR-3616-3p	CLIP-seq
MIRT2036684	hsa-miR-3622a-3p	CLIP-seq
MIRT2036685	hsa-miR-3622b-3p	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT2036686	hsa-miR-3670	CLIP-seq
MIRT2036687	hsa-miR-3671	CLIP-seq
MIRT2036688	hsa-miR-3908	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT2036689	hsa-miR-3925-3p	CLIP-seq
MIRT2036690	hsa-miR-3942-5p	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT2036691	hsa-miR-423-5p	CLIP-seq
MIRT2036692	hsa-miR-4300	CLIP-seq
MIRT2036693	hsa-miR-4302	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT2036694	hsa-miR-4329	CLIP-seq
MIRT2036695	hsa-miR-4419a	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT2036696	hsa-miR-4443	CLIP-seq
MIRT2036697	hsa-miR-4447	CLIP-seq
MIRT1128988	hsa-miR-4450	CLIP-seq
MIRT2036698	hsa-miR-4456	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT2036699	hsa-miR-4472	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT2036700	hsa-miR-4510	CLIP-seq
MIRT2036701	hsa-miR-4533	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT2036703	hsa-miR-4656	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT2036704	hsa-miR-4690-3p	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT2036705	hsa-miR-4703-5p	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT2036707	hsa-miR-4728-5p	CLIP-seq
MIRT2036708	hsa-miR-4739	CLIP-seq
MIRT1128991	hsa-miR-4743	CLIP-seq
MIRT2036709	hsa-miR-4756-3p	CLIP-seq
MIRT2036710	hsa-miR-4756-5p	CLIP-seq
MIRT2036711	hsa-miR-4766-3p	CLIP-seq
MIRT2036712	hsa-miR-4768-5p	CLIP-seq
MIRT2036713	hsa-miR-4769-3p	CLIP-seq
MIRT2036714	hsa-miR-491-5p	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT1128955	hsa-miR-579	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT2036716	hsa-miR-624	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT2036717	hsa-miR-708	CLIP-seq
MIRT2036718	hsa-miR-765	CLIP-seq
MIRT2036719	hsa-miR-876-3p	CLIP-seq
MIRT2036720	hsa-miR-920	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128970	hsa-miR-103a	CLIP-seq
MIRT1128971	hsa-miR-107	CLIP-seq
MIRT2266882	hsa-miR-1197	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT2266883	hsa-miR-1225-3p	CLIP-seq
MIRT2266884	hsa-miR-1250	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2266885	hsa-miR-1304	CLIP-seq
MIRT2036671	hsa-miR-132	CLIP-seq
MIRT2266886	hsa-miR-1825	CLIP-seq
MIRT2036673	hsa-miR-194	CLIP-seq
MIRT2266887	hsa-miR-199a-5p	CLIP-seq
MIRT2266888	hsa-miR-199b-5p	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT2036674	hsa-miR-212	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT2266889	hsa-miR-3186-5p	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2266890	hsa-miR-3197	CLIP-seq
MIRT2266891	hsa-miR-326	CLIP-seq
MIRT2266892	hsa-miR-330-5p	CLIP-seq
MIRT2266893	hsa-miR-342-5p	CLIP-seq
MIRT2036684	hsa-miR-3622a-3p	CLIP-seq
MIRT2036685	hsa-miR-3622b-3p	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT2266894	hsa-miR-378g	CLIP-seq
MIRT2036689	hsa-miR-3925-3p	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT2266895	hsa-miR-4283	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT2266897	hsa-miR-4436a	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT2266898	hsa-miR-4466	CLIP-seq
MIRT2266899	hsa-miR-4486	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128911	hsa-miR-4505	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT2266900	hsa-miR-4664-5p	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT2266901	hsa-miR-4767	CLIP-seq
MIRT2036714	hsa-miR-491-5p	CLIP-seq
MIRT2266902	hsa-miR-526b	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT2266903	hsa-miR-637	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2266904	hsa-miR-675	CLIP-seq
MIRT2266905	hsa-miR-767-3p	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT2438506	hsa-miR-4308	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2442342	hsa-miR-3199	CLIP-seq
MIRT2442343	hsa-miR-490-3p	CLIP-seq
MIRT2453685	hsa-miR-3064-5p	CLIP-seq
MIRT2453686	hsa-miR-3915	CLIP-seq
MIRT2453687	hsa-miR-3928	CLIP-seq
MIRT2453688	hsa-miR-4487	CLIP-seq
MIRT2453689	hsa-miR-4773	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT2566406	hsa-miR-1207-3p	CLIP-seq
MIRT2566407	hsa-miR-1260	CLIP-seq
MIRT2566408	hsa-miR-1260b	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT2566409	hsa-miR-1273c	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2566410	hsa-miR-133a	CLIP-seq
MIRT2566411	hsa-miR-133b	CLIP-seq
MIRT2566412	hsa-miR-138	CLIP-seq
MIRT2566413	hsa-miR-188-3p	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT2566414	hsa-miR-296-5p	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT2453685	hsa-miR-3064-5p	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT2566415	hsa-miR-3127-3p	CLIP-seq
MIRT1128882	hsa-miR-3136-3p	CLIP-seq
MIRT2566416	hsa-miR-3156-3p	CLIP-seq
MIRT2566417	hsa-miR-3177-3p	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2566418	hsa-miR-3190	CLIP-seq
MIRT2036682	hsa-miR-323-5p	CLIP-seq
MIRT2036683	hsa-miR-3616-3p	CLIP-seq
MIRT2566419	hsa-miR-3620	CLIP-seq
MIRT2566420	hsa-miR-3646	CLIP-seq
MIRT2566421	hsa-miR-3683	CLIP-seq
MIRT2453686	hsa-miR-3915	CLIP-seq
MIRT2453687	hsa-miR-3928	CLIP-seq
MIRT2566422	hsa-miR-4254	CLIP-seq
MIRT2566423	hsa-miR-4267	CLIP-seq
MIRT2266895	hsa-miR-4283	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT2438506	hsa-miR-4308	CLIP-seq
MIRT2566424	hsa-miR-4446-5p	CLIP-seq
MIRT2036698	hsa-miR-4456	CLIP-seq
MIRT2453688	hsa-miR-4487	CLIP-seq
MIRT2566425	hsa-miR-4489	CLIP-seq
MIRT2566426	hsa-miR-4520a-3p	CLIP-seq
MIRT2566427	hsa-miR-4520b-3p	CLIP-seq
MIRT2566428	hsa-miR-4529-3p	CLIP-seq
MIRT2566429	hsa-miR-4536	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT2566430	hsa-miR-4645-5p	CLIP-seq
MIRT2566431	hsa-miR-4649-5p	CLIP-seq
MIRT2566432	hsa-miR-4673	CLIP-seq
MIRT1128920	hsa-miR-4683	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT2566433	hsa-miR-4721	CLIP-seq
MIRT2566434	hsa-miR-4722-5p	CLIP-seq
MIRT2566435	hsa-miR-4726-3p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT738731	hsa-miR-4755-3p	CLIP-seq
MIRT2566436	hsa-miR-4755-5p	CLIP-seq
MIRT2566437	hsa-miR-4758-3p	CLIP-seq
MIRT2036712	hsa-miR-4768-5p	CLIP-seq
MIRT2453689	hsa-miR-4773	CLIP-seq
MIRT2566438	hsa-miR-4786-3p	CLIP-seq
MIRT2566439	hsa-miR-4786-5p	CLIP-seq
MIRT2566440	hsa-miR-485-5p	CLIP-seq
MIRT2566441	hsa-miR-511	CLIP-seq
MIRT2566442	hsa-miR-564	CLIP-seq
MIRT1128956	hsa-miR-603	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT2566443	hsa-miR-623	CLIP-seq
MIRT2566444	hsa-miR-646	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2566445	hsa-miR-671-5p	CLIP-seq
MIRT2566446	hsa-miR-769-5p	CLIP-seq
MIRT2566447	hsa-miR-873	CLIP-seq
MIRT2036719	hsa-miR-876-3p	CLIP-seq
MIRT2566448	hsa-miR-9	CLIP-seq
MIRT2566449	hsa-miR-938	CLIP-seq
MIRT2566445	hsa-miR-671-5p	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT2566420	hsa-miR-3646	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS	9006902
GO:0000166	Function	Nucleotide binding	IEA
GO:0001568	Process	Blood vessel development	IEA
GO:0004672	Function	Protein kinase activity	IDA	15001576
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	IMP	33729480, 33891857
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	TAS	9006902
GO:0005515	Function	Protein binding	IPI	12392720, 14743216, 15001576, 16407301, 18308725, 25241761, 25982527, 27027284, 28514442, 32707033, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	15001576
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0046777	Process	Protein autophosphorylation	IDA	15001576
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA

MIM	HGNC	e!Ensembl
602539	6855	ENSG00000198909

Protein

UniProt ID

Q99759

Protein name

Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)

Protein function

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMe

PDB

2C60 , 2JRH , 2O2V , 2PPH , 4Y5O , 4YL6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00564	PB1	44 → 123	PB1 domain	Domain
PF00069	Pkinase	362 → 622	Protein kinase domain	Domain

Sequence

MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
RRIFVEARQRPSAEELLTHHFAQLMY

Sequence length

626

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Human T-cell leukemia virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer		Interleukin-1 signaling

MAP3K3 (mitogen-activated protein kinase kinase kinase 3)