MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Gene

• Entrez ID: 4215
• Gene name: Mitogen-activated protein kinase kinase kinase 3
• Gene symbol: MAP3K3
• Synonyms (NCBI Gene): CCM5, MAPKKK3, MEKK3
• Chromosome: 17
• Chromosome location: 17q23.3
• Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003519	hsa-miR-145-5p	Review	20144549
MIRT021476	hsa-miR-9-5p	Microarray	17612493
MIRT021851	hsa-miR-132-3p	Microarray	17612493
MIRT023113	hsa-miR-124-3p	Microarray	18668037
MIRT041562	hsa-miR-193b-3p	CLASH	23622248
MIRT003519	hsa-miR-145-5p	Microarray	22942087
MIRT053682	hsa-miR-181a-5p	Microarray	22942087
MIRT053697	hsa-miR-188-5p	Microarray	22942087
MIRT556302	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT078464	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT078466	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT556301	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT556300	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT078467	hsa-miR-1178-5p	PAR-CLIP	21572407
MIRT078468	hsa-miR-1182	PAR-CLIP	21572407
MIRT078471	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT078470	hsa-miR-4328	PAR-CLIP	21572407
MIRT556299	hsa-miR-3140-3p	PAR-CLIP	21572407
MIRT078474	hsa-miR-6753-3p	PAR-CLIP	21572407
MIRT078476	hsa-miR-7107-3p	PAR-CLIP	21572407
MIRT556298	hsa-miR-2052	PAR-CLIP	21572407
MIRT078461	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT078462	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT078463	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT078475	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT147124	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT147118	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT147124	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT147117	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT147128	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT147119	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT147133	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT053682	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT147121	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT147122	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT147129	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT727250	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT041562	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT147118	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT734113	hsa-miR-212-3p	Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	32269720
MIRT556302	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT078464	hsa-miR-96-5p	PAR-CLIP	21572407
MIRT078466	hsa-miR-1271-5p	PAR-CLIP	21572407
MIRT556301	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT556300	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT078467	hsa-miR-1178-5p	PAR-CLIP	21572407
MIRT078468	hsa-miR-1182	PAR-CLIP	21572407
MIRT078471	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT078470	hsa-miR-4328	PAR-CLIP	21572407
MIRT556299	hsa-miR-3140-3p	PAR-CLIP	21572407
MIRT078474	hsa-miR-6753-3p	PAR-CLIP	21572407
MIRT078476	hsa-miR-7107-3p	PAR-CLIP	21572407
MIRT556298	hsa-miR-2052	PAR-CLIP	21572407
MIRT078461	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT078462	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT078463	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT078475	hsa-miR-6885-3p	PAR-CLIP	21572407
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128849	hsa-miR-106a	CLIP-seq
MIRT1128850	hsa-miR-106b	CLIP-seq
MIRT1128851	hsa-miR-1185	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT1128853	hsa-miR-1207-5p	CLIP-seq
MIRT1128854	hsa-miR-1243	CLIP-seq
MIRT1128855	hsa-miR-1254	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT1128857	hsa-miR-1271	CLIP-seq
MIRT1128858	hsa-miR-1294	CLIP-seq
MIRT1128859	hsa-miR-1305	CLIP-seq
MIRT1128860	hsa-miR-1323	CLIP-seq
MIRT1128861	hsa-miR-150	CLIP-seq
MIRT1128862	hsa-miR-17	CLIP-seq
MIRT1128863	hsa-miR-181a	CLIP-seq
MIRT1128864	hsa-miR-181b	CLIP-seq
MIRT1128865	hsa-miR-181c	CLIP-seq
MIRT1128866	hsa-miR-181d	CLIP-seq
MIRT1128867	hsa-miR-182	CLIP-seq
MIRT1128868	hsa-miR-1909	CLIP-seq
MIRT1128869	hsa-miR-1915	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128871	hsa-miR-20a	CLIP-seq
MIRT1128872	hsa-miR-20b	CLIP-seq
MIRT1128873	hsa-miR-217	CLIP-seq
MIRT1128874	hsa-miR-22	CLIP-seq
MIRT1128875	hsa-miR-2276	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT1128877	hsa-miR-23a	CLIP-seq
MIRT1128878	hsa-miR-23b	CLIP-seq
MIRT1128879	hsa-miR-23c	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT1128881	hsa-miR-3116	CLIP-seq
MIRT1128882	hsa-miR-3136-3p	CLIP-seq
MIRT1128883	hsa-miR-320e	CLIP-seq
MIRT1128884	hsa-miR-323-3p	CLIP-seq
MIRT1128885	hsa-miR-330-3p	CLIP-seq
MIRT1128886	hsa-miR-338-3p	CLIP-seq
MIRT1128887	hsa-miR-33a	CLIP-seq
MIRT1128888	hsa-miR-33b	CLIP-seq
MIRT1128889	hsa-miR-3605-5p	CLIP-seq
MIRT1128890	hsa-miR-3607-3p	CLIP-seq
MIRT1128891	hsa-miR-3652	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128893	hsa-miR-3679-5p	CLIP-seq
MIRT1128894	hsa-miR-3686	CLIP-seq
MIRT1128895	hsa-miR-3926	CLIP-seq
MIRT1128896	hsa-miR-3929	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT1128898	hsa-miR-4262	CLIP-seq
MIRT1128899	hsa-miR-4273	CLIP-seq
MIRT1128900	hsa-miR-432	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128902	hsa-miR-4419b	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT1128904	hsa-miR-4430	CLIP-seq
MIRT1128905	hsa-miR-4446-3p	CLIP-seq
MIRT1128906	hsa-miR-4455	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128908	hsa-miR-4478	CLIP-seq
MIRT1128909	hsa-miR-4496	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128911	hsa-miR-4505	CLIP-seq
MIRT1128912	hsa-miR-4531	CLIP-seq
MIRT1128913	hsa-miR-4633-3p	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT1128915	hsa-miR-4651	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT1128917	hsa-miR-4663	CLIP-seq
MIRT1128918	hsa-miR-4666-5p	CLIP-seq
MIRT1128919	hsa-miR-4677-5p	CLIP-seq
MIRT1128920	hsa-miR-4683	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT1128923	hsa-miR-4728-3p	CLIP-seq
MIRT1128924	hsa-miR-4736	CLIP-seq
MIRT1128925	hsa-miR-4738-3p	CLIP-seq
MIRT1128926	hsa-miR-4738-5p	CLIP-seq
MIRT1128927	hsa-miR-4760-3p	CLIP-seq
MIRT1128928	hsa-miR-4763-3p	CLIP-seq
MIRT1128929	hsa-miR-4772-3p	CLIP-seq
MIRT1128930	hsa-miR-505	CLIP-seq
MIRT1128931	hsa-miR-519a	CLIP-seq
MIRT1128932	hsa-miR-519b-3p	CLIP-seq
MIRT1128933	hsa-miR-519c-3p	CLIP-seq
MIRT1128934	hsa-miR-519d	CLIP-seq
MIRT1128935	hsa-miR-544	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128937	hsa-miR-548a-3p	CLIP-seq
MIRT1128938	hsa-miR-548aa	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128944	hsa-miR-548e	CLIP-seq
MIRT1128945	hsa-miR-548f	CLIP-seq
MIRT1128946	hsa-miR-548n	CLIP-seq
MIRT1128947	hsa-miR-548o	CLIP-seq
MIRT1128948	hsa-miR-548s	CLIP-seq
MIRT1128949	hsa-miR-548t	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128952	hsa-miR-549	CLIP-seq
MIRT1128953	hsa-miR-558	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT1128955	hsa-miR-579	CLIP-seq
MIRT1128956	hsa-miR-603	CLIP-seq
MIRT1128957	hsa-miR-607	CLIP-seq
MIRT1128958	hsa-miR-608	CLIP-seq
MIRT1128959	hsa-miR-609	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT1128961	hsa-miR-618	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT1128965	hsa-miR-664	CLIP-seq
MIRT1128966	hsa-miR-885-3p	CLIP-seq
MIRT1128967	hsa-miR-93	CLIP-seq
MIRT1128968	hsa-miR-96	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128970	hsa-miR-103a	CLIP-seq
MIRT1128849	hsa-miR-106a	CLIP-seq
MIRT1128850	hsa-miR-106b	CLIP-seq
MIRT1128971	hsa-miR-107	CLIP-seq
MIRT1128851	hsa-miR-1185	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT1128972	hsa-miR-1225-5p	CLIP-seq
MIRT1128973	hsa-miR-124	CLIP-seq
MIRT1128974	hsa-miR-125a-5p	CLIP-seq
MIRT1128975	hsa-miR-125b	CLIP-seq
MIRT1128976	hsa-miR-141	CLIP-seq
MIRT1128862	hsa-miR-17	CLIP-seq
MIRT1128863	hsa-miR-181a	CLIP-seq
MIRT1128864	hsa-miR-181b	CLIP-seq
MIRT1128865	hsa-miR-181c	CLIP-seq
MIRT1128866	hsa-miR-181d	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT1128977	hsa-miR-200a	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128871	hsa-miR-20a	CLIP-seq
MIRT1128872	hsa-miR-20b	CLIP-seq
MIRT1128873	hsa-miR-217	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT1128979	hsa-miR-3140-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT1128883	hsa-miR-320e	CLIP-seq
MIRT1128886	hsa-miR-338-3p	CLIP-seq
MIRT1128887	hsa-miR-33a	CLIP-seq
MIRT1128888	hsa-miR-33b	CLIP-seq
MIRT1128889	hsa-miR-3605-5p	CLIP-seq
MIRT1128893	hsa-miR-3679-5p	CLIP-seq
MIRT1128981	hsa-miR-3714	CLIP-seq
MIRT1128982	hsa-miR-3910	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT1128895	hsa-miR-3926	CLIP-seq
MIRT1128896	hsa-miR-3929	CLIP-seq
MIRT1128984	hsa-miR-3977	CLIP-seq
MIRT1128898	hsa-miR-4262	CLIP-seq
MIRT1128985	hsa-miR-4319	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128986	hsa-miR-4325	CLIP-seq
MIRT1128902	hsa-miR-4419b	CLIP-seq
MIRT1128987	hsa-miR-4427	CLIP-seq
MIRT1128988	hsa-miR-4450	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128908	hsa-miR-4478	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT1128917	hsa-miR-4663	CLIP-seq
MIRT1128923	hsa-miR-4728-3p	CLIP-seq
MIRT1128990	hsa-miR-4732-3p	CLIP-seq
MIRT1128925	hsa-miR-4738-3p	CLIP-seq
MIRT1128926	hsa-miR-4738-5p	CLIP-seq
MIRT1128991	hsa-miR-4743	CLIP-seq
MIRT1128930	hsa-miR-505	CLIP-seq
MIRT1128992	hsa-miR-506	CLIP-seq
MIRT1128993	hsa-miR-507	CLIP-seq
MIRT1128931	hsa-miR-519a	CLIP-seq
MIRT1128932	hsa-miR-519b-3p	CLIP-seq
MIRT1128933	hsa-miR-519c-3p	CLIP-seq
MIRT1128934	hsa-miR-519d	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128946	hsa-miR-548n	CLIP-seq
MIRT1128948	hsa-miR-548s	CLIP-seq
MIRT1128949	hsa-miR-548t	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128952	hsa-miR-549	CLIP-seq
MIRT1128994	hsa-miR-557	CLIP-seq
MIRT1128961	hsa-miR-618	CLIP-seq
MIRT1128995	hsa-miR-670	CLIP-seq
MIRT1128967	hsa-miR-93	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT738730	hsa-miR-1972	CLIP-seq
MIRT738734	hsa-miR-3127-5p	CLIP-seq
MIRT738735	hsa-miR-3918	CLIP-seq
MIRT738732	hsa-miR-4435	CLIP-seq
MIRT738739	hsa-miR-450b-3p	CLIP-seq
MIRT738737	hsa-miR-4713-3p	CLIP-seq
MIRT738731	hsa-miR-4755-3p	CLIP-seq
MIRT738736	hsa-miR-4772-5p	CLIP-seq
MIRT738740	hsa-miR-638	CLIP-seq
MIRT738738	hsa-miR-769-3p	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT2036669	hsa-miR-1251	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2036671	hsa-miR-132	CLIP-seq
MIRT2036672	hsa-miR-1321	CLIP-seq
MIRT1128976	hsa-miR-141	CLIP-seq
MIRT738733	hsa-miR-193b	CLIP-seq
MIRT2036673	hsa-miR-194	CLIP-seq
MIRT1128977	hsa-miR-200a	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT2036674	hsa-miR-212	CLIP-seq
MIRT2036675	hsa-miR-28-5p	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT2036676	hsa-miR-3139	CLIP-seq
MIRT2036677	hsa-miR-3151	CLIP-seq
MIRT2036678	hsa-miR-3160-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT2036679	hsa-miR-3184	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2036681	hsa-miR-3202	CLIP-seq
MIRT2036682	hsa-miR-323-5p	CLIP-seq
MIRT2036683	hsa-miR-3616-3p	CLIP-seq
MIRT2036684	hsa-miR-3622a-3p	CLIP-seq
MIRT2036685	hsa-miR-3622b-3p	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT2036686	hsa-miR-3670	CLIP-seq
MIRT2036687	hsa-miR-3671	CLIP-seq
MIRT2036688	hsa-miR-3908	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT2036689	hsa-miR-3925-3p	CLIP-seq
MIRT2036690	hsa-miR-3942-5p	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT2036691	hsa-miR-423-5p	CLIP-seq
MIRT2036692	hsa-miR-4300	CLIP-seq
MIRT2036693	hsa-miR-4302	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT2036694	hsa-miR-4329	CLIP-seq
MIRT2036695	hsa-miR-4419a	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT2036696	hsa-miR-4443	CLIP-seq
MIRT2036697	hsa-miR-4447	CLIP-seq
MIRT1128988	hsa-miR-4450	CLIP-seq
MIRT2036698	hsa-miR-4456	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT2036699	hsa-miR-4472	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT2036700	hsa-miR-4510	CLIP-seq
MIRT2036701	hsa-miR-4533	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT2036703	hsa-miR-4656	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT2036704	hsa-miR-4690-3p	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT2036705	hsa-miR-4703-5p	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT2036707	hsa-miR-4728-5p	CLIP-seq
MIRT2036708	hsa-miR-4739	CLIP-seq
MIRT1128991	hsa-miR-4743	CLIP-seq
MIRT2036709	hsa-miR-4756-3p	CLIP-seq
MIRT2036710	hsa-miR-4756-5p	CLIP-seq
MIRT2036711	hsa-miR-4766-3p	CLIP-seq
MIRT2036712	hsa-miR-4768-5p	CLIP-seq
MIRT2036713	hsa-miR-4769-3p	CLIP-seq
MIRT2036714	hsa-miR-491-5p	CLIP-seq
MIRT1128939	hsa-miR-548ac	CLIP-seq
MIRT1128940	hsa-miR-548ae	CLIP-seq
MIRT1128941	hsa-miR-548aj	CLIP-seq
MIRT1128942	hsa-miR-548am	CLIP-seq
MIRT1128943	hsa-miR-548d-3p	CLIP-seq
MIRT1128950	hsa-miR-548x	CLIP-seq
MIRT1128951	hsa-miR-548z	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT1128955	hsa-miR-579	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT2036716	hsa-miR-624	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT2036717	hsa-miR-708	CLIP-seq
MIRT2036718	hsa-miR-765	CLIP-seq
MIRT2036719	hsa-miR-876-3p	CLIP-seq
MIRT2036720	hsa-miR-920	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128841	hsa-let-7a	CLIP-seq
MIRT1128842	hsa-let-7b	CLIP-seq
MIRT1128843	hsa-let-7c	CLIP-seq
MIRT1128844	hsa-let-7d	CLIP-seq
MIRT1128845	hsa-let-7e	CLIP-seq
MIRT1128846	hsa-let-7f	CLIP-seq
MIRT1128847	hsa-let-7g	CLIP-seq
MIRT1128848	hsa-let-7i	CLIP-seq
MIRT1128970	hsa-miR-103a	CLIP-seq
MIRT1128971	hsa-miR-107	CLIP-seq
MIRT2266882	hsa-miR-1197	CLIP-seq
MIRT1128852	hsa-miR-1200	CLIP-seq
MIRT2266883	hsa-miR-1225-3p	CLIP-seq
MIRT2266884	hsa-miR-1250	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2266885	hsa-miR-1304	CLIP-seq
MIRT2036671	hsa-miR-132	CLIP-seq
MIRT2266886	hsa-miR-1825	CLIP-seq
MIRT2036673	hsa-miR-194	CLIP-seq
MIRT2266887	hsa-miR-199a-5p	CLIP-seq
MIRT2266888	hsa-miR-199b-5p	CLIP-seq
MIRT1128870	hsa-miR-202	CLIP-seq
MIRT2036674	hsa-miR-212	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT2266889	hsa-miR-3186-5p	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2266890	hsa-miR-3197	CLIP-seq
MIRT2266891	hsa-miR-326	CLIP-seq
MIRT2266892	hsa-miR-330-5p	CLIP-seq
MIRT2266893	hsa-miR-342-5p	CLIP-seq
MIRT2036684	hsa-miR-3622a-3p	CLIP-seq
MIRT2036685	hsa-miR-3622b-3p	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT2266894	hsa-miR-378g	CLIP-seq
MIRT2036689	hsa-miR-3925-3p	CLIP-seq
MIRT1128897	hsa-miR-3944-5p	CLIP-seq
MIRT2266895	hsa-miR-4283	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT1128901	hsa-miR-4324	CLIP-seq
MIRT1128903	hsa-miR-4426	CLIP-seq
MIRT2266897	hsa-miR-4436a	CLIP-seq
MIRT1128907	hsa-miR-4458	CLIP-seq
MIRT2266898	hsa-miR-4466	CLIP-seq
MIRT2266899	hsa-miR-4486	CLIP-seq
MIRT1128910	hsa-miR-4500	CLIP-seq
MIRT1128911	hsa-miR-4505	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128914	hsa-miR-4647	CLIP-seq
MIRT1128916	hsa-miR-4662b	CLIP-seq
MIRT2266900	hsa-miR-4664-5p	CLIP-seq
MIRT1128921	hsa-miR-4691-3p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT2266901	hsa-miR-4767	CLIP-seq
MIRT2036714	hsa-miR-491-5p	CLIP-seq
MIRT2266902	hsa-miR-526b	CLIP-seq
MIRT1128936	hsa-miR-544b	CLIP-seq
MIRT1128954	hsa-miR-574-5p	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128960	hsa-miR-615-5p	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT2266903	hsa-miR-637	CLIP-seq
MIRT1128963	hsa-miR-648	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2266904	hsa-miR-675	CLIP-seq
MIRT2266905	hsa-miR-767-3p	CLIP-seq
MIRT1128969	hsa-miR-98	CLIP-seq
MIRT1128892	hsa-miR-3667-5p	CLIP-seq
MIRT1128980	hsa-miR-3176	CLIP-seq
MIRT1128983	hsa-miR-3922-3p	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT2438506	hsa-miR-4308	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2442342	hsa-miR-3199	CLIP-seq
MIRT2442343	hsa-miR-490-3p	CLIP-seq
MIRT2453685	hsa-miR-3064-5p	CLIP-seq
MIRT2453686	hsa-miR-3915	CLIP-seq
MIRT2453687	hsa-miR-3928	CLIP-seq
MIRT2453688	hsa-miR-4487	CLIP-seq
MIRT2453689	hsa-miR-4773	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT2566406	hsa-miR-1207-3p	CLIP-seq
MIRT2566407	hsa-miR-1260	CLIP-seq
MIRT2566408	hsa-miR-1260b	CLIP-seq
MIRT1128856	hsa-miR-1270	CLIP-seq
MIRT2566409	hsa-miR-1273c	CLIP-seq
MIRT2036670	hsa-miR-1285	CLIP-seq
MIRT2566410	hsa-miR-133a	CLIP-seq
MIRT2566411	hsa-miR-133b	CLIP-seq
MIRT2566412	hsa-miR-138	CLIP-seq
MIRT2566413	hsa-miR-188-3p	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT1128876	hsa-miR-2355-5p	CLIP-seq
MIRT2566414	hsa-miR-296-5p	CLIP-seq
MIRT1128880	hsa-miR-3064-3p	CLIP-seq
MIRT2453685	hsa-miR-3064-5p	CLIP-seq
MIRT1128978	hsa-miR-3120-3p	CLIP-seq
MIRT2566415	hsa-miR-3127-3p	CLIP-seq
MIRT1128882	hsa-miR-3136-3p	CLIP-seq
MIRT2566416	hsa-miR-3156-3p	CLIP-seq
MIRT2566417	hsa-miR-3177-3p	CLIP-seq
MIRT2036680	hsa-miR-3187-5p	CLIP-seq
MIRT2566418	hsa-miR-3190	CLIP-seq
MIRT2036682	hsa-miR-323-5p	CLIP-seq
MIRT2036683	hsa-miR-3616-3p	CLIP-seq
MIRT2566419	hsa-miR-3620	CLIP-seq
MIRT2566420	hsa-miR-3646	CLIP-seq
MIRT2566421	hsa-miR-3683	CLIP-seq
MIRT2453686	hsa-miR-3915	CLIP-seq
MIRT2453687	hsa-miR-3928	CLIP-seq
MIRT2566422	hsa-miR-4254	CLIP-seq
MIRT2566423	hsa-miR-4267	CLIP-seq
MIRT2266895	hsa-miR-4283	CLIP-seq
MIRT2266896	hsa-miR-4292	CLIP-seq
MIRT2438506	hsa-miR-4308	CLIP-seq
MIRT2566424	hsa-miR-4446-5p	CLIP-seq
MIRT2036698	hsa-miR-4456	CLIP-seq
MIRT2453688	hsa-miR-4487	CLIP-seq
MIRT2566425	hsa-miR-4489	CLIP-seq
MIRT2566426	hsa-miR-4520a-3p	CLIP-seq
MIRT2566427	hsa-miR-4520b-3p	CLIP-seq
MIRT2566428	hsa-miR-4529-3p	CLIP-seq
MIRT2566429	hsa-miR-4536	CLIP-seq
MIRT2036702	hsa-miR-4640-5p	CLIP-seq
MIRT1128989	hsa-miR-4641	CLIP-seq
MIRT2566430	hsa-miR-4645-5p	CLIP-seq
MIRT2566431	hsa-miR-4649-5p	CLIP-seq
MIRT2566432	hsa-miR-4673	CLIP-seq
MIRT1128920	hsa-miR-4683	CLIP-seq
MIRT1128922	hsa-miR-4708-5p	CLIP-seq
MIRT2566433	hsa-miR-4721	CLIP-seq
MIRT2566434	hsa-miR-4722-5p	CLIP-seq
MIRT2566435	hsa-miR-4726-3p	CLIP-seq
MIRT2036706	hsa-miR-4726-5p	CLIP-seq
MIRT738731	hsa-miR-4755-3p	CLIP-seq
MIRT2566436	hsa-miR-4755-5p	CLIP-seq
MIRT2566437	hsa-miR-4758-3p	CLIP-seq
MIRT2036712	hsa-miR-4768-5p	CLIP-seq
MIRT2453689	hsa-miR-4773	CLIP-seq
MIRT2566438	hsa-miR-4786-3p	CLIP-seq
MIRT2566439	hsa-miR-4786-5p	CLIP-seq
MIRT2566440	hsa-miR-485-5p	CLIP-seq
MIRT2566441	hsa-miR-511	CLIP-seq
MIRT2566442	hsa-miR-564	CLIP-seq
MIRT1128956	hsa-miR-603	CLIP-seq
MIRT2036715	hsa-miR-612	CLIP-seq
MIRT1128962	hsa-miR-620	CLIP-seq
MIRT2566443	hsa-miR-623	CLIP-seq
MIRT2566444	hsa-miR-646	CLIP-seq
MIRT1128964	hsa-miR-661	CLIP-seq
MIRT2566445	hsa-miR-671-5p	CLIP-seq
MIRT2566446	hsa-miR-769-5p	CLIP-seq
MIRT2566447	hsa-miR-873	CLIP-seq
MIRT2036719	hsa-miR-876-3p	CLIP-seq
MIRT2566448	hsa-miR-9	CLIP-seq
MIRT2566449	hsa-miR-938	CLIP-seq
MIRT2566445	hsa-miR-671-5p	CLIP-seq
MIRT2566404	hsa-miR-204	CLIP-seq
MIRT2566405	hsa-miR-211	CLIP-seq
MIRT2566420	hsa-miR-3646	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS	9006902
GO:0000166	Function	Nucleotide binding	IEA
GO:0001568	Process	Blood vessel development	IEA
GO:0004672	Function	Protein kinase activity	IDA	15001576
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	IMP	33729480, 33891857
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	TAS	9006902
GO:0005515	Function	Protein binding	IPI	12392720, 14743216, 15001576, 16407301, 18308725, 25241761, 25982527, 27027284, 28514442, 32707033, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	15001576
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0046777	Process	Protein autophosphorylation	IDA	15001576
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA

Other IDs

• MIM: 602539
• HGNC: 6855
• e!Ensembl: ENSG00000198909

Protein

• UniProt ID: Q99759
• Protein name: Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
• Protein function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMe
• PDB: 2C60, 2JRH, 2O2V, 2PPH, 4Y5O, 4YL6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00564	PB1	44 → 123	PB1 domain	Domain
  PF00069	Pkinase	362 → 622	Protein kinase domain	Domain

• Sequence:

  MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
  SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
  LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
  YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
  RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
  HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
  NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
  HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
  HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
  GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
  RRIFVEARQRPSAEELLTHHFAQLMY

• Sequence length: 626

Pathways

KEGG:

MAPK signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Human T-cell leukemia virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer

Reactome:

Interleukin-1 signaling

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
CEREBRAL CAVERNOUS MALFORMATIONS 5, SOMATIC	Likely pathogenic; Pathogenic	rs2143631386	RCV004799648
Verrucous hemangioma	Likely pathogenic; Pathogenic	rs2143631386	RCV002254484

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
MAP3K3-related disorder	Likely benign	rs775721157	RCV003896749

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	26088427, 31898160
Arthritis Psoriatic	Associate	16622521
Arthritis Rheumatoid	Associate	16622521
Carcinogenesis	Associate	24383423
Carcinoma Renal Cell	Associate	25388155
Carcinoma Renal Cell	Stimulate	25824786
Carcinoma Squamous Cell	Associate	31898160
Carcinoma Verrucous	Associate	25728774, 37658401
Esophageal Squamous Cell Carcinoma	Stimulate	24383423
Esophagitis	Stimulate	24383423
Hemangioma Cavernous Central Nervous System	Associate	33891857, 40401429
Hemorrhage	Associate	33891857
Hereditary Breast and Ovarian Cancer Syndrome	Stimulate	14662759
Lung Neoplasms	Associate	26088427
Lymphatic Metastasis	Associate	25040987
Melanoma	Associate	38622197
Mouth Diseases	Associate	33891857
Nasopharyngeal Carcinoma	Associate	30652073
Neoplasms	Associate	14662759, 19517469, 24383423, 25388155, 25824786, 26088427, 30652073, 32812852, 38622197
Nevus Epithelioid and Spindle Cell	Associate	35319526
Ovarian Neoplasms	Associate	19517469, 34027641, 34887384
Prostatic Hyperplasia	Associate	24474452
Sarcopenia	Associate	38644354
Stomach Neoplasms	Associate	35637410
Tertiary Lymphoid Structures	Associate	24383423
Thoracic Neoplasms	Associate	35688571
Thoracic Outlet Syndrome	Associate	35688571
Thyroid Neoplasms	Associate	32812852
Uterine Cervical Dysplasia	Associate	25040987
Uterine Cervical Neoplasms	Associate	25040987
Uterine Cervicitis	Associate	25040987
Venous Malformations Multiple Cutaneous and Mucosal	Associate	35688571