Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4214
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP3K1
Synonyms (NCBI Gene) Gene synonyms aliases	MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
Disease Acronyms (UniProt) Disease acronyms from UniProt database	SRXY6
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requir

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SNP ID	Visualize variation	Clinical significance	Consequence
rs56160159	C>T	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs143853590	G>A,C,T	Likely-benign, pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs387906788	T>A,C,G	Likely-pathogenic, pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs886041049	G>A	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1131692053	T>A	Pathogenic	Intron variant
rs1131692186	T>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1554034036	G>A	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs1561193071	C>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1561198459	C>G	Pathogenic	Coding sequence variant, non coding transcript variant, stop gained
rs1561199329	TTAGAAATGCTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion, non coding transcript variant
rs1561199493	CTTTGGATGGTCAACA>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1561204571	CATCT>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1579750361	A>G	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004142	hsa-miR-192-5p	Microarray	16822819
MIRT031009	hsa-miR-21-5p	Microarray	18591254
MIRT052565	hsa-let-7a-5p	CLASH	23622248
MIRT047383	hsa-miR-34a-5p	CLASH	23622248
MIRT046560	hsa-let-7g-5p	CLASH	23622248
MIRT046560	hsa-let-7g-5p	CLASH	23622248
MIRT045762	hsa-miR-125a-5p	CLASH	23622248
MIRT042622	hsa-miR-423-3p	CLASH	23622248
MIRT702158	hsa-miR-548ac	HITS-CLIP	23313552
MIRT702157	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT702156	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT702155	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT702154	hsa-miR-548z	HITS-CLIP	23313552
MIRT702153	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT702152	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT702151	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT702150	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT702149	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT702148	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT702147	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT702146	hsa-miR-323a-3p	HITS-CLIP	23313552
MIRT702145	hsa-miR-452-5p	HITS-CLIP	23313552
MIRT702144	hsa-miR-4676-3p	HITS-CLIP	23313552
MIRT702143	hsa-miR-892c-3p	HITS-CLIP	23313552
MIRT702142	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT702141	hsa-miR-4703-3p	HITS-CLIP	23313552
MIRT702140	hsa-miR-5585-3p	HITS-CLIP	23313552
MIRT166417	hsa-miR-3646	HITS-CLIP	23824327
MIRT656513	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT166402	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT656512	hsa-miR-4539	HITS-CLIP	23824327
MIRT656511	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT440285	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT440285	ebv-miR-BART13-3p	HITS-CLIP	22473208
MIRT166338	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT166342	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT166399	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT166400	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT731313	hsa-miR-302a-3p	Luciferase reporter assay	26842910
MIRT731313	hsa-miR-302a-3p	Luciferase reporter assay	26842910
MIRT731314	hsa-miR-302b-3p	Luciferase reporter assay	26842910
MIRT731314	hsa-miR-302b-3p	Luciferase reporter assay	26842910
MIRT731315	hsa-miR-302c-3p	Luciferase reporter assay	26842910
MIRT731315	hsa-miR-302c-3p	Luciferase reporter assay	26842910
MIRT731316	hsa-miR-302d-3p	Luciferase reporter assay	26842910
MIRT731316	hsa-miR-302d-3p	Luciferase reporter assay	26842910
MIRT736426	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT736993	hsa-miR-770-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR	34195198
MIRT702158	hsa-miR-548ac	HITS-CLIP	23313552
MIRT702157	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT702156	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT702155	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT702154	hsa-miR-548z	HITS-CLIP	23313552
MIRT702153	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT702152	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT702151	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT702150	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT702149	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT702148	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT702147	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT702146	hsa-miR-323a-3p	HITS-CLIP	23313552
MIRT702145	hsa-miR-452-5p	HITS-CLIP	23313552
MIRT702144	hsa-miR-4676-3p	HITS-CLIP	23313552
MIRT702143	hsa-miR-892c-3p	HITS-CLIP	23313552
MIRT702142	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT702141	hsa-miR-4703-3p	HITS-CLIP	23313552
MIRT702140	hsa-miR-5585-3p	HITS-CLIP	23313552
MIRT166417	hsa-miR-3646	HITS-CLIP	23824327
MIRT656513	hsa-miR-1252-3p	HITS-CLIP	23824327
MIRT166402	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT656512	hsa-miR-4539	HITS-CLIP	23824327
MIRT656511	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT755632	hsa-miR-203a-3p	Luciferase reporter assay, Western blotting	35524422
MIRT755675	hsa-miR-1200	Luciferase reporter assay, qRT-PCR	35230926
MIRT1128197	hsa-let-7a	CLIP-seq
MIRT1128198	hsa-let-7b	CLIP-seq
MIRT1128199	hsa-let-7c	CLIP-seq
MIRT1128200	hsa-let-7d	CLIP-seq
MIRT1128201	hsa-let-7e	CLIP-seq
MIRT1128202	hsa-let-7f	CLIP-seq
MIRT1128203	hsa-let-7g	CLIP-seq
MIRT1128204	hsa-let-7i	CLIP-seq
MIRT1128205	hsa-miR-103b	CLIP-seq
MIRT1128206	hsa-miR-105	CLIP-seq
MIRT1128207	hsa-miR-1197	CLIP-seq
MIRT755675	hsa-miR-1200	CLIP-seq
MIRT1128208	hsa-miR-124	CLIP-seq
MIRT1128209	hsa-miR-1246	CLIP-seq
MIRT1128210	hsa-miR-1257	CLIP-seq
MIRT1128211	hsa-miR-125b	CLIP-seq
MIRT1128212	hsa-miR-1278	CLIP-seq
MIRT1128213	hsa-miR-1283	CLIP-seq
MIRT1128214	hsa-miR-1290	CLIP-seq
MIRT1128215	hsa-miR-129-5p	CLIP-seq
MIRT1128216	hsa-miR-1303	CLIP-seq
MIRT1128217	hsa-miR-1324	CLIP-seq
MIRT1128218	hsa-miR-139-5p	CLIP-seq
MIRT1128219	hsa-miR-145	CLIP-seq
MIRT1128220	hsa-miR-146b-3p	CLIP-seq
MIRT1128221	hsa-miR-186	CLIP-seq
MIRT1128222	hsa-miR-18a	CLIP-seq
MIRT1128223	hsa-miR-18b	CLIP-seq
MIRT1128224	hsa-miR-1911	CLIP-seq
MIRT1128225	hsa-miR-193b	CLIP-seq
MIRT1128226	hsa-miR-194	CLIP-seq
MIRT1128227	hsa-miR-196a	CLIP-seq
MIRT1128228	hsa-miR-196b	CLIP-seq
MIRT1128229	hsa-miR-199a-3p	CLIP-seq
MIRT1128230	hsa-miR-199b-3p	CLIP-seq
MIRT1128231	hsa-miR-200b	CLIP-seq
MIRT1128232	hsa-miR-200c	CLIP-seq
MIRT1128233	hsa-miR-202	CLIP-seq
MIRT1128234	hsa-miR-203	CLIP-seq
MIRT1128235	hsa-miR-205	CLIP-seq
MIRT1128236	hsa-miR-2355-5p	CLIP-seq
MIRT1128237	hsa-miR-23a	CLIP-seq
MIRT1128238	hsa-miR-23b	CLIP-seq
MIRT1128239	hsa-miR-23c	CLIP-seq
MIRT1128240	hsa-miR-31	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128242	hsa-miR-3126-5p	CLIP-seq
MIRT1128243	hsa-miR-3129-5p	CLIP-seq
MIRT1128244	hsa-miR-3130-3p	CLIP-seq
MIRT1128245	hsa-miR-3133	CLIP-seq
MIRT1128246	hsa-miR-3134	CLIP-seq
MIRT1128247	hsa-miR-3140-5p	CLIP-seq
MIRT1128248	hsa-miR-3143	CLIP-seq
MIRT1128249	hsa-miR-3163	CLIP-seq
MIRT1128250	hsa-miR-3167	CLIP-seq
MIRT1128251	hsa-miR-3173-5p	CLIP-seq
MIRT1128252	hsa-miR-3176	CLIP-seq
MIRT1128253	hsa-miR-320a	CLIP-seq
MIRT1128254	hsa-miR-320b	CLIP-seq
MIRT1128255	hsa-miR-320c	CLIP-seq
MIRT1128256	hsa-miR-320d	CLIP-seq
MIRT1128257	hsa-miR-324-5p	CLIP-seq
MIRT1128258	hsa-miR-331-5p	CLIP-seq
MIRT1128259	hsa-miR-342-3p	CLIP-seq
MIRT1128260	hsa-miR-3529	CLIP-seq
MIRT1128261	hsa-miR-3606	CLIP-seq
MIRT1128262	hsa-miR-3609	CLIP-seq
MIRT1128263	hsa-miR-3611	CLIP-seq
MIRT1128264	hsa-miR-3622a-3p	CLIP-seq
MIRT1128265	hsa-miR-3622b-3p	CLIP-seq
MIRT1128266	hsa-miR-3622b-5p	CLIP-seq
MIRT1128267	hsa-miR-3647-3p	CLIP-seq
MIRT1128268	hsa-miR-3662	CLIP-seq
MIRT1128269	hsa-miR-3686	CLIP-seq
MIRT1128270	hsa-miR-376a	CLIP-seq
MIRT1128271	hsa-miR-376b	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128273	hsa-miR-379	CLIP-seq
MIRT1128274	hsa-miR-3920	CLIP-seq
MIRT1128275	hsa-miR-3922-3p	CLIP-seq
MIRT1128276	hsa-miR-3927	CLIP-seq
MIRT1128277	hsa-miR-3941	CLIP-seq
MIRT1128278	hsa-miR-3945	CLIP-seq
MIRT1128279	hsa-miR-3973	CLIP-seq
MIRT1128280	hsa-miR-411	CLIP-seq
MIRT1128281	hsa-miR-4253	CLIP-seq
MIRT1128282	hsa-miR-4277	CLIP-seq
MIRT1128283	hsa-miR-4282	CLIP-seq
MIRT1128284	hsa-miR-4286	CLIP-seq
MIRT1128285	hsa-miR-4289	CLIP-seq
MIRT1128286	hsa-miR-429	CLIP-seq
MIRT1128287	hsa-miR-4319	CLIP-seq
MIRT1128288	hsa-miR-4324	CLIP-seq
MIRT1128289	hsa-miR-4327	CLIP-seq
MIRT1128290	hsa-miR-433	CLIP-seq
MIRT1128291	hsa-miR-4419a	CLIP-seq
MIRT1128292	hsa-miR-4427	CLIP-seq
MIRT1128293	hsa-miR-4429	CLIP-seq
MIRT1128294	hsa-miR-4432	CLIP-seq
MIRT1128295	hsa-miR-4446-5p	CLIP-seq
MIRT1128296	hsa-miR-4451	CLIP-seq
MIRT1128297	hsa-miR-4458	CLIP-seq
MIRT1128298	hsa-miR-4471	CLIP-seq
MIRT1128299	hsa-miR-4500	CLIP-seq
MIRT1128300	hsa-miR-4510	CLIP-seq
MIRT1128301	hsa-miR-4534	CLIP-seq
MIRT1128302	hsa-miR-4640-5p	CLIP-seq
MIRT1128303	hsa-miR-4650-3p	CLIP-seq
MIRT1128304	hsa-miR-4652-3p	CLIP-seq
MIRT1128305	hsa-miR-466	CLIP-seq
MIRT1128306	hsa-miR-4670-3p	CLIP-seq
MIRT1128307	hsa-miR-4672	CLIP-seq
MIRT1128308	hsa-miR-4680-3p	CLIP-seq
MIRT1128309	hsa-miR-4699-3p	CLIP-seq
MIRT1128310	hsa-miR-4705	CLIP-seq
MIRT1128311	hsa-miR-4709-5p	CLIP-seq
MIRT1128312	hsa-miR-4712-3p	CLIP-seq
MIRT1128313	hsa-miR-4712-5p	CLIP-seq
MIRT1128314	hsa-miR-4726-5p	CLIP-seq
MIRT1128315	hsa-miR-4732-3p	CLIP-seq
MIRT1128316	hsa-miR-4735-3p	CLIP-seq
MIRT1128317	hsa-miR-4738-3p	CLIP-seq
MIRT1128318	hsa-miR-4755-5p	CLIP-seq
MIRT1128319	hsa-miR-4757-5p	CLIP-seq
MIRT1128320	hsa-miR-4774-5p	CLIP-seq
MIRT1128321	hsa-miR-4789-5p	CLIP-seq
MIRT1128322	hsa-miR-4790-3p	CLIP-seq
MIRT1128323	hsa-miR-4793-3p	CLIP-seq
MIRT1128324	hsa-miR-488	CLIP-seq
MIRT1128325	hsa-miR-493	CLIP-seq
MIRT1128326	hsa-miR-495	CLIP-seq
MIRT1128327	hsa-miR-501-5p	CLIP-seq
MIRT1128328	hsa-miR-506	CLIP-seq
MIRT1128329	hsa-miR-520d-5p	CLIP-seq
MIRT1128330	hsa-miR-524-5p	CLIP-seq
MIRT1128331	hsa-miR-541	CLIP-seq
MIRT1128332	hsa-miR-543	CLIP-seq
MIRT1128333	hsa-miR-544	CLIP-seq
MIRT1128334	hsa-miR-544b	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT1128336	hsa-miR-548a-5p	CLIP-seq
MIRT1128337	hsa-miR-548aa	CLIP-seq
MIRT1128338	hsa-miR-548ab	CLIP-seq
MIRT1128339	hsa-miR-548ad	CLIP-seq
MIRT1128340	hsa-miR-548ah	CLIP-seq
MIRT1128341	hsa-miR-548ak	CLIP-seq
MIRT1128342	hsa-miR-548an	CLIP-seq
MIRT1128343	hsa-miR-548b-5p	CLIP-seq
MIRT1128344	hsa-miR-548c-3p	CLIP-seq
MIRT1128345	hsa-miR-548c-5p	CLIP-seq
MIRT1128346	hsa-miR-548d-5p	CLIP-seq
MIRT1128347	hsa-miR-548h	CLIP-seq
MIRT1128348	hsa-miR-548i	CLIP-seq
MIRT1128349	hsa-miR-548j	CLIP-seq
MIRT1128350	hsa-miR-548u	CLIP-seq
MIRT1128351	hsa-miR-548w	CLIP-seq
MIRT1128352	hsa-miR-548y	CLIP-seq
MIRT1128353	hsa-miR-559	CLIP-seq
MIRT1128354	hsa-miR-580	CLIP-seq
MIRT1128355	hsa-miR-582-5p	CLIP-seq
MIRT1128356	hsa-miR-590-3p	CLIP-seq
MIRT1128357	hsa-miR-627	CLIP-seq
MIRT1128358	hsa-miR-630	CLIP-seq
MIRT1128359	hsa-miR-634	CLIP-seq
MIRT1128360	hsa-miR-654-5p	CLIP-seq
MIRT1128361	hsa-miR-670	CLIP-seq
MIRT1128362	hsa-miR-874	CLIP-seq
MIRT1128363	hsa-miR-876-5p	CLIP-seq
MIRT1128364	hsa-miR-888	CLIP-seq
MIRT1128365	hsa-miR-9	CLIP-seq
MIRT1128366	hsa-miR-924	CLIP-seq
MIRT1128367	hsa-miR-98	CLIP-seq
MIRT1128237	hsa-miR-23a	CLIP-seq
MIRT1128238	hsa-miR-23b	CLIP-seq
MIRT1128239	hsa-miR-23c	CLIP-seq
MIRT1128269	hsa-miR-3686	CLIP-seq
MIRT1128304	hsa-miR-4652-3p	CLIP-seq
MIRT1128197	hsa-let-7a	CLIP-seq
MIRT1128198	hsa-let-7b	CLIP-seq
MIRT1128199	hsa-let-7c	CLIP-seq
MIRT1128200	hsa-let-7d	CLIP-seq
MIRT1128201	hsa-let-7e	CLIP-seq
MIRT1128202	hsa-let-7f	CLIP-seq
MIRT1128203	hsa-let-7g	CLIP-seq
MIRT1128204	hsa-let-7i	CLIP-seq
MIRT1128207	hsa-miR-1197	CLIP-seq
MIRT2036471	hsa-miR-137	CLIP-seq
MIRT1128219	hsa-miR-145	CLIP-seq
MIRT1128227	hsa-miR-196a	CLIP-seq
MIRT1128228	hsa-miR-196b	CLIP-seq
MIRT1128229	hsa-miR-199a-3p	CLIP-seq
MIRT1128230	hsa-miR-199b-3p	CLIP-seq
MIRT1128233	hsa-miR-202	CLIP-seq
MIRT1128234	hsa-miR-203	CLIP-seq
MIRT1128235	hsa-miR-205	CLIP-seq
MIRT1128236	hsa-miR-2355-5p	CLIP-seq
MIRT1128237	hsa-miR-23a	CLIP-seq
MIRT1128238	hsa-miR-23b	CLIP-seq
MIRT1128239	hsa-miR-23c	CLIP-seq
MIRT2036472	hsa-miR-2681	CLIP-seq
MIRT1128240	hsa-miR-31	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128243	hsa-miR-3129-5p	CLIP-seq
MIRT1128249	hsa-miR-3163	CLIP-seq
MIRT1128257	hsa-miR-324-5p	CLIP-seq
MIRT1128258	hsa-miR-331-5p	CLIP-seq
MIRT2036473	hsa-miR-33a	CLIP-seq
MIRT2036474	hsa-miR-33b	CLIP-seq
MIRT1128260	hsa-miR-3529	CLIP-seq
MIRT2036475	hsa-miR-3591-3p	CLIP-seq
MIRT1128262	hsa-miR-3609	CLIP-seq
MIRT1128263	hsa-miR-3611	CLIP-seq
MIRT2036476	hsa-miR-3613-3p	CLIP-seq
MIRT1128264	hsa-miR-3622a-3p	CLIP-seq
MIRT1128265	hsa-miR-3622b-3p	CLIP-seq
MIRT1128268	hsa-miR-3662	CLIP-seq
MIRT2036477	hsa-miR-371-5p	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128273	hsa-miR-379	CLIP-seq
MIRT2036478	hsa-miR-409-3p	CLIP-seq
MIRT1128280	hsa-miR-411	CLIP-seq
MIRT2036479	hsa-miR-4256	CLIP-seq
MIRT2036480	hsa-miR-4275	CLIP-seq
MIRT2036481	hsa-miR-4276	CLIP-seq
MIRT1128283	hsa-miR-4282	CLIP-seq
MIRT1128284	hsa-miR-4286	CLIP-seq
MIRT1128285	hsa-miR-4289	CLIP-seq
MIRT1128292	hsa-miR-4427	CLIP-seq
MIRT1128296	hsa-miR-4451	CLIP-seq
MIRT1128297	hsa-miR-4458	CLIP-seq
MIRT1128299	hsa-miR-4500	CLIP-seq
MIRT2036482	hsa-miR-4642	CLIP-seq
MIRT1128303	hsa-miR-4650-3p	CLIP-seq
MIRT1128306	hsa-miR-4670-3p	CLIP-seq
MIRT1128313	hsa-miR-4712-5p	CLIP-seq
MIRT1128317	hsa-miR-4738-3p	CLIP-seq
MIRT2036483	hsa-miR-4764-3p	CLIP-seq
MIRT1128326	hsa-miR-495	CLIP-seq
MIRT2036484	hsa-miR-499-3p	CLIP-seq
MIRT2036485	hsa-miR-499a-3p	CLIP-seq
MIRT1128327	hsa-miR-501-5p	CLIP-seq
MIRT1128334	hsa-miR-544b	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT1128340	hsa-miR-548ah	CLIP-seq
MIRT1128344	hsa-miR-548c-3p	CLIP-seq
MIRT2036486	hsa-miR-570	CLIP-seq
MIRT1128355	hsa-miR-582-5p	CLIP-seq
MIRT2036487	hsa-miR-618	CLIP-seq
MIRT2036488	hsa-miR-664	CLIP-seq
MIRT1128364	hsa-miR-888	CLIP-seq
MIRT1128365	hsa-miR-9	CLIP-seq
MIRT1128367	hsa-miR-98	CLIP-seq
MIRT1128197	hsa-let-7a	CLIP-seq
MIRT1128198	hsa-let-7b	CLIP-seq
MIRT1128199	hsa-let-7c	CLIP-seq
MIRT1128200	hsa-let-7d	CLIP-seq
MIRT1128201	hsa-let-7e	CLIP-seq
MIRT1128202	hsa-let-7f	CLIP-seq
MIRT1128203	hsa-let-7g	CLIP-seq
MIRT1128204	hsa-let-7i	CLIP-seq
MIRT1128205	hsa-miR-103b	CLIP-seq
MIRT2266719	hsa-miR-1183	CLIP-seq
MIRT1128207	hsa-miR-1197	CLIP-seq
MIRT1128209	hsa-miR-1246	CLIP-seq
MIRT1128211	hsa-miR-125b	CLIP-seq
MIRT2266720	hsa-miR-1276	CLIP-seq
MIRT2266721	hsa-miR-129-3p	CLIP-seq
MIRT2266722	hsa-miR-1322	CLIP-seq
MIRT1128217	hsa-miR-1324	CLIP-seq
MIRT2266723	hsa-miR-143	CLIP-seq
MIRT2266724	hsa-miR-144	CLIP-seq
MIRT1128219	hsa-miR-145	CLIP-seq
MIRT2266725	hsa-miR-1537	CLIP-seq
MIRT2266726	hsa-miR-191	CLIP-seq
MIRT1128225	hsa-miR-193b	CLIP-seq
MIRT1128227	hsa-miR-196a	CLIP-seq
MIRT1128228	hsa-miR-196b	CLIP-seq
MIRT1128229	hsa-miR-199a-3p	CLIP-seq
MIRT1128230	hsa-miR-199b-3p	CLIP-seq
MIRT2266727	hsa-miR-19a	CLIP-seq
MIRT2266728	hsa-miR-19b	CLIP-seq
MIRT1128233	hsa-miR-202	CLIP-seq
MIRT1128234	hsa-miR-203	CLIP-seq
MIRT1128235	hsa-miR-205	CLIP-seq
MIRT1128236	hsa-miR-2355-5p	CLIP-seq
MIRT2036472	hsa-miR-2681	CLIP-seq
MIRT2266729	hsa-miR-2964a-3p	CLIP-seq
MIRT2266730	hsa-miR-298	CLIP-seq
MIRT1128240	hsa-miR-31	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128242	hsa-miR-3126-5p	CLIP-seq
MIRT1128243	hsa-miR-3129-5p	CLIP-seq
MIRT1128247	hsa-miR-3140-5p	CLIP-seq
MIRT1128249	hsa-miR-3163	CLIP-seq
MIRT1128252	hsa-miR-3176	CLIP-seq
MIRT1128253	hsa-miR-320a	CLIP-seq
MIRT1128254	hsa-miR-320b	CLIP-seq
MIRT1128255	hsa-miR-320c	CLIP-seq
MIRT1128256	hsa-miR-320d	CLIP-seq
MIRT1128257	hsa-miR-324-5p	CLIP-seq
MIRT2266731	hsa-miR-330-3p	CLIP-seq
MIRT1128258	hsa-miR-331-5p	CLIP-seq
MIRT2266732	hsa-miR-34c-3p	CLIP-seq
MIRT1128260	hsa-miR-3529	CLIP-seq
MIRT2266733	hsa-miR-3591-5p	CLIP-seq
MIRT2266734	hsa-miR-3607-3p	CLIP-seq
MIRT1128262	hsa-miR-3609	CLIP-seq
MIRT1128263	hsa-miR-3611	CLIP-seq
MIRT2266735	hsa-miR-3613-5p	CLIP-seq
MIRT1128264	hsa-miR-3622a-3p	CLIP-seq
MIRT1128265	hsa-miR-3622b-3p	CLIP-seq
MIRT2266736	hsa-miR-3653	CLIP-seq
MIRT2266737	hsa-miR-3658	CLIP-seq
MIRT1128268	hsa-miR-3662	CLIP-seq
MIRT2266738	hsa-miR-3678-3p	CLIP-seq
MIRT2266739	hsa-miR-3691-3p	CLIP-seq
MIRT2036477	hsa-miR-371-5p	CLIP-seq
MIRT1128270	hsa-miR-376a	CLIP-seq
MIRT1128271	hsa-miR-376b	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128273	hsa-miR-379	CLIP-seq
MIRT1128275	hsa-miR-3922-3p	CLIP-seq
MIRT2266740	hsa-miR-3978	CLIP-seq
MIRT1128280	hsa-miR-411	CLIP-seq
MIRT2036479	hsa-miR-4256	CLIP-seq
MIRT2266741	hsa-miR-4261	CLIP-seq
MIRT2036480	hsa-miR-4275	CLIP-seq
MIRT2036481	hsa-miR-4276	CLIP-seq
MIRT2266742	hsa-miR-4280	CLIP-seq
MIRT1128283	hsa-miR-4282	CLIP-seq
MIRT1128284	hsa-miR-4286	CLIP-seq
MIRT1128285	hsa-miR-4289	CLIP-seq
MIRT2266743	hsa-miR-4308	CLIP-seq
MIRT2266744	hsa-miR-4311	CLIP-seq
MIRT1128287	hsa-miR-4319	CLIP-seq
MIRT1128289	hsa-miR-4327	CLIP-seq
MIRT1128290	hsa-miR-433	CLIP-seq
MIRT1128291	hsa-miR-4419a	CLIP-seq
MIRT1128292	hsa-miR-4427	CLIP-seq
MIRT1128293	hsa-miR-4429	CLIP-seq
MIRT1128295	hsa-miR-4446-5p	CLIP-seq
MIRT1128296	hsa-miR-4451	CLIP-seq
MIRT1128297	hsa-miR-4458	CLIP-seq
MIRT1128298	hsa-miR-4471	CLIP-seq
MIRT2266745	hsa-miR-4495	CLIP-seq
MIRT1128299	hsa-miR-4500	CLIP-seq
MIRT2266746	hsa-miR-451	CLIP-seq
MIRT1128300	hsa-miR-4510	CLIP-seq
MIRT2266747	hsa-miR-4640-3p	CLIP-seq
MIRT1128302	hsa-miR-4640-5p	CLIP-seq
MIRT2036482	hsa-miR-4642	CLIP-seq
MIRT1128303	hsa-miR-4650-3p	CLIP-seq
MIRT2266748	hsa-miR-4660	CLIP-seq
MIRT2266749	hsa-miR-4668-3p	CLIP-seq
MIRT1128306	hsa-miR-4670-3p	CLIP-seq
MIRT1128308	hsa-miR-4680-3p	CLIP-seq
MIRT2266750	hsa-miR-4687-5p	CLIP-seq
MIRT1128309	hsa-miR-4699-3p	CLIP-seq
MIRT1128310	hsa-miR-4705	CLIP-seq
MIRT1128312	hsa-miR-4712-3p	CLIP-seq
MIRT1128313	hsa-miR-4712-5p	CLIP-seq
MIRT1128314	hsa-miR-4726-5p	CLIP-seq
MIRT1128315	hsa-miR-4732-3p	CLIP-seq
MIRT1128317	hsa-miR-4738-3p	CLIP-seq
MIRT1128318	hsa-miR-4755-5p	CLIP-seq
MIRT1128319	hsa-miR-4757-5p	CLIP-seq
MIRT2266751	hsa-miR-4770	CLIP-seq
MIRT1128321	hsa-miR-4789-5p	CLIP-seq
MIRT1128326	hsa-miR-495	CLIP-seq
MIRT1128327	hsa-miR-501-5p	CLIP-seq
MIRT1128334	hsa-miR-544b	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT1128337	hsa-miR-548aa	CLIP-seq
MIRT1128340	hsa-miR-548ah	CLIP-seq
MIRT1128344	hsa-miR-548c-3p	CLIP-seq
MIRT2266752	hsa-miR-568	CLIP-seq
MIRT1128355	hsa-miR-582-5p	CLIP-seq
MIRT2266753	hsa-miR-583	CLIP-seq
MIRT1128359	hsa-miR-634	CLIP-seq
MIRT2266754	hsa-miR-643	CLIP-seq
MIRT2036488	hsa-miR-664	CLIP-seq
MIRT1128361	hsa-miR-670	CLIP-seq
MIRT2266755	hsa-miR-875-3p	CLIP-seq
MIRT2266756	hsa-miR-885-3p	CLIP-seq
MIRT2266757	hsa-miR-887	CLIP-seq
MIRT1128364	hsa-miR-888	CLIP-seq
MIRT2266758	hsa-miR-890	CLIP-seq
MIRT1128365	hsa-miR-9	CLIP-seq
MIRT2266759	hsa-miR-938	CLIP-seq
MIRT1128367	hsa-miR-98	CLIP-seq
MIRT1128197	hsa-let-7a	CLIP-seq
MIRT1128198	hsa-let-7b	CLIP-seq
MIRT1128199	hsa-let-7c	CLIP-seq
MIRT1128200	hsa-let-7d	CLIP-seq
MIRT1128201	hsa-let-7e	CLIP-seq
MIRT1128202	hsa-let-7f	CLIP-seq
MIRT1128203	hsa-let-7g	CLIP-seq
MIRT1128204	hsa-let-7i	CLIP-seq
MIRT1128206	hsa-miR-105	CLIP-seq
MIRT1128207	hsa-miR-1197	CLIP-seq
MIRT1128212	hsa-miR-1278	CLIP-seq
MIRT1128227	hsa-miR-196a	CLIP-seq
MIRT1128228	hsa-miR-196b	CLIP-seq
MIRT1128233	hsa-miR-202	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128264	hsa-miR-3622a-3p	CLIP-seq
MIRT1128265	hsa-miR-3622b-3p	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128276	hsa-miR-3927	CLIP-seq
MIRT1128280	hsa-miR-411	CLIP-seq
MIRT1128285	hsa-miR-4289	CLIP-seq
MIRT1128297	hsa-miR-4458	CLIP-seq
MIRT1128299	hsa-miR-4500	CLIP-seq
MIRT1128334	hsa-miR-544b	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT2390559	hsa-miR-767-5p	CLIP-seq
MIRT1128364	hsa-miR-888	CLIP-seq
MIRT1128367	hsa-miR-98	CLIP-seq
MIRT1128221	hsa-miR-186	CLIP-seq
MIRT1128240	hsa-miR-31	CLIP-seq
MIRT1128245	hsa-miR-3133	CLIP-seq
MIRT1128249	hsa-miR-3163	CLIP-seq
MIRT1128253	hsa-miR-320a	CLIP-seq
MIRT1128254	hsa-miR-320b	CLIP-seq
MIRT1128255	hsa-miR-320c	CLIP-seq
MIRT1128256	hsa-miR-320d	CLIP-seq
MIRT1128257	hsa-miR-324-5p	CLIP-seq
MIRT1128268	hsa-miR-3662	CLIP-seq
MIRT1128280	hsa-miR-411	CLIP-seq
MIRT1128293	hsa-miR-4429	CLIP-seq
MIRT1128313	hsa-miR-4712-5p	CLIP-seq
MIRT1128327	hsa-miR-501-5p	CLIP-seq
MIRT1128344	hsa-miR-548c-3p	CLIP-seq
MIRT1128221	hsa-miR-186	CLIP-seq
MIRT1128245	hsa-miR-3133	CLIP-seq
MIRT1128344	hsa-miR-548c-3p	CLIP-seq
MIRT2266721	hsa-miR-129-3p	CLIP-seq
MIRT2266724	hsa-miR-144	CLIP-seq
MIRT1128222	hsa-miR-18a	CLIP-seq
MIRT1128223	hsa-miR-18b	CLIP-seq
MIRT1128234	hsa-miR-203	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128260	hsa-miR-3529	CLIP-seq
MIRT1128262	hsa-miR-3609	CLIP-seq
MIRT1128263	hsa-miR-3611	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128273	hsa-miR-379	CLIP-seq
MIRT1128277	hsa-miR-3941	CLIP-seq
MIRT2036479	hsa-miR-4256	CLIP-seq
MIRT1128285	hsa-miR-4289	CLIP-seq
MIRT2266743	hsa-miR-4308	CLIP-seq
MIRT1128296	hsa-miR-4451	CLIP-seq
MIRT1128303	hsa-miR-4650-3p	CLIP-seq
MIRT1128305	hsa-miR-466	CLIP-seq
MIRT1128306	hsa-miR-4670-3p	CLIP-seq
MIRT1128307	hsa-miR-4672	CLIP-seq
MIRT2266750	hsa-miR-4687-5p	CLIP-seq
MIRT1128316	hsa-miR-4735-3p	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT1128340	hsa-miR-548ah	CLIP-seq
MIRT2036488	hsa-miR-664	CLIP-seq
MIRT2266755	hsa-miR-875-3p	CLIP-seq
MIRT1128365	hsa-miR-9	CLIP-seq
MIRT2266759	hsa-miR-938	CLIP-seq
MIRT2266721	hsa-miR-129-3p	CLIP-seq
MIRT1128222	hsa-miR-18a	CLIP-seq
MIRT1128223	hsa-miR-18b	CLIP-seq
MIRT1128241	hsa-miR-3120-3p	CLIP-seq
MIRT1128272	hsa-miR-377	CLIP-seq
MIRT1128277	hsa-miR-3941	CLIP-seq
MIRT2266743	hsa-miR-4308	CLIP-seq
MIRT1128305	hsa-miR-466	CLIP-seq
MIRT1128306	hsa-miR-4670-3p	CLIP-seq
MIRT1128307	hsa-miR-4672	CLIP-seq
MIRT2266750	hsa-miR-4687-5p	CLIP-seq
MIRT1128316	hsa-miR-4735-3p	CLIP-seq
MIRT1128335	hsa-miR-545	CLIP-seq
MIRT2266755	hsa-miR-875-3p	CLIP-seq
MIRT2266759	hsa-miR-938	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ATF2	Unknown	9710625
JUN	Unknown	9710625

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000186	Process	Activation of MAPKK activity	IEA
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004672	Function	Protein kinase activity	IDA	15001576
GO:0004672	Function	Protein kinase activity	TAS
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	7997270, 9639556
GO:0004709	Function	MAP kinase kinase kinase activity	NAS	9808624
GO:0005515	Function	Protein binding	IPI	9808624, 11784851, 14743216, 16636664, 16810323, 16888650, 17620599, 19270716, 20940704, 25241761
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	NAS	9808624
GO:0008270	Function	Zinc ion binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	17906693
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

MIM	HGNC	e!Ensembl
600982	6848	ENSG00000095015

Protein

UniProt ID

Q13233

Protein name

Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)

Protein function

Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates

PDB

6WHB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	1243 → 1508	Protein kinase domain	Domain

Sequence

MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG
GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP
EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA
ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS
PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF
VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT
LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR
RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN
LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG
ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA
MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG
REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD
VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM
LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS
SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG
RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ
TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS
MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM
PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD
ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA
QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN
LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST
GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR
ELLKHPVFRTTW

Sequence length

1512

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction RIG-I-like receptor signaling pathway Neurotrophin signaling pathway GnRH signaling pathway Growth hormone synthesis, secretion and action Hepatitis B Human T-cell leukemia virus 1 infection		MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane

Show/Hide Causal Diseases (13)

Disease term	Disease name	dbSNP ID	References
Causal
46, xy partial gonadal dysgenesis	46,XY partial gonadal dysgenesis	rs193922688	21129722
46, xy sex reversal	46,XY SEX REVERSAL 6	rs111033589, rs1592184934, rs121908255, rs121908256, rs606231178, rs104894956, rs104894957, rs104894958, rs104894959, rs104894964, rs606231179, rs104894966, rs104894967, rs104894968, rs104894969 View all (54 more)	12476449, 21129722
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	17529967
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	24493630, 17529967
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Dysgerminoma	Dysgerminoma	rs121913506, rs80357888
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	17529967
Nephroblastoma	Nephroblastoma	rs1553551874, rs1555913934, rs769116796
Nephrotic syndrome	Nephrotic Syndrome	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910 View all (152 more)
Osteoporosis	Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29662167

Show/Hide Unknown Diseases (10)

Disease term	Disease name	Evidence	Source
Unknown
Ambiguous genitalia	Ambiguous Genitalia		ClinVar
Breast Cancer	breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GenCC, CBGDA
46, XY complete gonadal dysgenesis	46,XY complete gonadal dysgenesis		GenCC
46, XY partial gonadal dysgenesis	46,XY partial gonadal dysgenesis		GenCC
Endometriosis	Endometriosis		GWAS
Diabetes	Diabetes		GWAS
Coronary artery disease	Coronary artery disease		GWAS
Metabolic Syndrome	Metabolic Syndrome		GWAS
Dementia	Dementia		GWAS
Psoriasis	Psoriasis		GWAS

Show/Hide Text Mining Associations (52)

Disease Name	Relationship Type	References
Associations from Text Mining
3 methylcrotonyl CoA carboxylase 1 deficiency	Associate	26655088
46 XY female	Associate	34112222, 36088066
Adenocarcinoma	Associate	28581676
Allanson Pantzar McLeod syndrome	Associate	33060765
Amyotrophic Lateral Sclerosis	Associate	31575382
Androgen Insensitivity Syndrome	Associate	32338288, 33060765
Autoimmune Diseases	Associate	29339359
Breast Carcinoma In Situ	Associate	24743323
Breast Neoplasms	Associate	17529967, 17997823, 18355772, 18437204, 18973230, 19028704, 19094228, 19656774, 19843670, 20605201, 21118973, 21194473, 21475998, 22452962, 22532573 View all (34 more)
Breast Neoplasms	Inhibit	38003265
Carcinoma Adenosquamous	Associate	31958074
Carcinoma Intraductal Noninfiltrating	Associate	38523186
Carcinoma Ovarian Epithelial	Associate	32660222
Carcinoma Renal Cell	Stimulate	34331411
Cataract	Associate	25352737
Choriocarcinoma	Associate	30889489
Colorectal Neoplasms	Associate	29458332, 35230926, 37314251
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	29458332
Cytomegalovirus Infections	Associate	23376463
Disorder of Sex Development 46 XY	Associate	28504475, 33060765, 34112222, 36088066, 36102299, 39285472
Disorders of Sex Development	Associate	28504475, 34112222
Dwarfism Pituitary	Associate	36102299
Endometrial Neoplasms	Associate	18785201
Esophageal Neoplasms	Associate	26019450
Fibroadenoma	Associate	33727697
Gestational Trophoblastic Disease	Associate	31998776
Glaucoma Open Angle	Associate	29452408
Glioblastoma	Associate	31318172
Glioma	Associate	31318172
Gonadal Dysgenesis	Associate	28504475, 36088066
Gonadal Dysgenesis 46 XY	Associate	28504475, 36088066, 40290305
Hereditary Angioedema Type III	Associate	29339359
Hydatidiform Mole	Associate	30889489
Hypertrophy	Associate	28504475
Hypoxia	Stimulate	27486656
Infections	Associate	23797008
Inflammation	Associate	26308008, 28858533
Leukemia Myeloid Acute	Associate	32811810
Leukemia Promyelocytic Acute	Associate	34404765
Neoplasms	Associate	19028704, 22722201, 23577780, 25529635, 28029147, 29339359, 29559730, 31318172, 32429412, 32591342, 32817551, 33149122, 34331411, 37145128, 37314251, 37454130 View all (1 more)
Neuroblastoma	Associate	24253178, 32295184
Pancreatic Neoplasms	Associate	19843670, 35476515
Penile Diseases	Associate	36102299
Prostate cancer familial	Associate	18785201
Recombinant chromosome 8 syndrome	Associate	36709040
Respiratory Distress Syndrome	Associate	28858533
Rhabdomyosarcoma	Associate	23797008
Simpson Golabi Behmel syndrome	Associate	31739742
Stomach Neoplasms	Associate	24759887, 36510163
Tertiary Lymphoid Structures	Associate	17997823
Thyroid Cancer Papillary	Associate	35524422
Triple Negative Breast Neoplasms	Associate	36788078

MAP3K1 (mitogen-activated protein kinase kinase kinase 1)