Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4200
Gene name Gene Name - the full gene name approved by the HGNC.
Malic enzyme 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ME2
Synonyms (NCBI Gene) Gene synonyms aliases
ODS1
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been s
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049487 hsa-miR-92a-3p CLASH 23622248
MIRT1139632 hsa-miR-1228 CLIP-seq
MIRT1139633 hsa-miR-124 CLIP-seq
MIRT1139634 hsa-miR-1247 CLIP-seq
MIRT1139635 hsa-miR-1827 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003824 Function Catalytic activity IEA
GO:0004470 Function Malic enzyme activity IEA
GO:0004470 Function Malic enzyme activity IMP 23334421
GO:0004471 Function Malate dehydrogenase (decarboxylating) (NAD+) activity IEA
GO:0004471 Function Malate dehydrogenase (decarboxylating) (NAD+) activity TAS 1993674
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
154270 6984 ENSG00000082212
Protein
UniProt ID P23368
Protein name NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2)
Protein function NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.
PDB 1DO8 , 1EFK , 1EFL , 1GZ3 , 1GZ4 , 1PJ2 , 1PJ3 , 1PJ4 , 1PJL , 1QR6 , 7BSJ , 7BSK , 7BSL , 7XDE , 7XDF , 7XDG , 9AYI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00390 malic 89 270 Malic enzyme, N-terminal domain Domain
PF03949 Malic_M 280 535 Malic enzyme, NAD binding domain Domain
Sequence
Sequence length 584
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pyruvate metabolism
Carbon metabolism
  Citric acid cycle (TCA cycle)
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