ADAM11 (ADAM metallopeptidase domain 11)

Gene

• Entrez ID: 4185
• Gene name: ADAM metallopeptidase domain 11
• Gene symbol: ADAM11
• Synonyms (NCBI Gene): MDC
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT765889	hsa-miR-1470	CLIP-seq
MIRT765890	hsa-miR-19a	CLIP-seq
MIRT765891	hsa-miR-19b	CLIP-seq
MIRT765892	hsa-miR-3173-3p	CLIP-seq
MIRT765893	hsa-miR-3184	CLIP-seq
MIRT765894	hsa-miR-34a	CLIP-seq
MIRT765895	hsa-miR-34c-5p	CLIP-seq
MIRT765896	hsa-miR-3617	CLIP-seq
MIRT765897	hsa-miR-423-5p	CLIP-seq
MIRT765898	hsa-miR-4455	CLIP-seq
MIRT765899	hsa-miR-4469	CLIP-seq
MIRT765900	hsa-miR-449a	CLIP-seq
MIRT765901	hsa-miR-449b	CLIP-seq
MIRT765902	hsa-miR-4529-5p	CLIP-seq
MIRT765903	hsa-miR-4645-5p	CLIP-seq
MIRT765904	hsa-miR-4667-3p	CLIP-seq
MIRT765905	hsa-miR-4673	CLIP-seq
MIRT765906	hsa-miR-4684-3p	CLIP-seq
MIRT765907	hsa-miR-4708-3p	CLIP-seq
MIRT765908	hsa-miR-4779	CLIP-seq
MIRT765909	hsa-miR-486-3p	CLIP-seq
MIRT765910	hsa-miR-602	CLIP-seq
MIRT765911	hsa-miR-609	CLIP-seq
MIRT765912	hsa-miR-641	CLIP-seq
MIRT1925677	hsa-miR-1827	CLIP-seq
MIRT1925678	hsa-miR-3622a-5p	CLIP-seq
MIRT1925679	hsa-miR-4292	CLIP-seq
MIRT1925680	hsa-miR-4308	CLIP-seq
MIRT1925681	hsa-miR-4423-3p	CLIP-seq
MIRT765903	hsa-miR-4645-5p	CLIP-seq
MIRT765905	hsa-miR-4673	CLIP-seq
MIRT1925682	hsa-miR-4685-5p	CLIP-seq
MIRT1925683	hsa-miR-4727-5p	CLIP-seq
MIRT1925684	hsa-miR-4755-3p	CLIP-seq
MIRT1925685	hsa-miR-4769-3p	CLIP-seq
MIRT1925686	hsa-miR-483-3p	CLIP-seq
MIRT2167085	hsa-miR-1202	CLIP-seq
MIRT2167086	hsa-miR-1207-3p	CLIP-seq
MIRT2167087	hsa-miR-147	CLIP-seq
MIRT2167088	hsa-miR-3135b	CLIP-seq
MIRT2167089	hsa-miR-3194-5p	CLIP-seq
MIRT2167090	hsa-miR-3670	CLIP-seq
MIRT2167091	hsa-miR-3911	CLIP-seq
MIRT2167092	hsa-miR-3972	CLIP-seq
MIRT2167093	hsa-miR-4302	CLIP-seq
MIRT2167094	hsa-miR-4633-3p	CLIP-seq
MIRT2167095	hsa-miR-644	CLIP-seq
MIRT2383877	hsa-miR-1291	CLIP-seq
MIRT2383878	hsa-miR-3173-5p	CLIP-seq
MIRT2383879	hsa-miR-328	CLIP-seq
MIRT2383880	hsa-miR-4268	CLIP-seq
MIRT2383881	hsa-miR-4286	CLIP-seq
MIRT2383882	hsa-miR-4448	CLIP-seq
MIRT2443120	hsa-miR-361-3p	CLIP-seq
MIRT2383881	hsa-miR-4286	CLIP-seq
MIRT2443121	hsa-miR-4690-3p	CLIP-seq
MIRT2443122	hsa-miR-4726-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005178	Function	Integrin binding	TAS	9693107
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9693107
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	TAS	8252040
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	9693107
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0031012	Component	Extracellular matrix	ISS	22261194
GO:0033555	Process	Multicellular organismal response to stress	ISS
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0045184	Process	Establishment of protein localization	ISS
GO:0045202	Component	Synapse	IEA
GO:0061367	Process	Behavioral response to acetic acid induced pain	ISS
GO:0061368	Process	Behavioral response to formalin induced pain	ISS

Other IDs

• MIM: 155120
• HGNC: 189
• e!Ensembl: ENSG00000073670

Protein

• UniProt ID: O75078
• Protein name: Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)
• Protein function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, i
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	46 → 189	Reprolysin family propeptide	Family
  PF01421	Reprolysin	239 → 438	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	453 → 526	Disintegrin	Domain
  PF08516	ADAM_CR	531 → 647	ADAM cysteine-rich	Family
  PF07974	EGF_2	677 → 709	EGF-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in brain. Slightly detected or not at all in other tissues.
• Sequence:

  MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG
  EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE
  GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP
  QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY
  VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ
  VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY
  GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID
  EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT
  HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG
  RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF
  LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML
  CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP
  TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA

• Sequence length: 769

Pathways

Reactome:

LGI-ADAM interactions

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Oligodendroglioma	Oligodendroglioma	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Lichen Planus Oral	Associate	28278185