Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4176
Gene name Gene Name - the full gene name approved by the HGNC.
Minichromosome maintenance complex component 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MCM7
Synonyms (NCBI Gene) Gene synonyms aliases
CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016521 hsa-miR-193b-3p Proteomics 21512034
MIRT016521 hsa-miR-193b-3p Microarray 20304954
MIRT022853 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023890 hsa-miR-1-3p Proteomics 18668040
MIRT025469 hsa-miR-34a-5p Proteomics 21566225
Transcription factors
Transcription factor Regulation Reference
MSC Repression 15213307
MYCN Activation 17826980
MYCN Unknown 15668898
TP53 Repression 15899946
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000727 Process Double-strand break repair via break-induced replication IBA
GO:0000781 Component Chromosome, telomeric region HDA 19135898
GO:0000785 Component Chromatin TAS 8798650
GO:0003677 Function DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600592 6950 ENSG00000166508
Protein
UniProt ID P33993
Protein name DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Protein function Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the mol
PDB 6XTX , 6XTY , 7PFO , 7PLO , 7W1Y , 7W68 , 8B9D , 8RWV , 8S09 , 8S0A , 8S0B , 8S0D , 8S0E , 8S0F , 8W0E , 8W0F , 8W0G , 8W0I , 9CAQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14551 MCM_N 10 140 MCM N-terminal domain Domain
PF17207 MCM_OB 148 281 MCM OB domain Domain
PF00493 MCM 320 541 MCM P-loop domain Domain
PF17855 MCM_lid 557 641 MCM AAA-lid domain Domain
Sequence
Sequence length 719
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  DNA replication
Cell cycle
  Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
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