Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4162
Gene name Gene Name - the full gene name approved by the HGNC.	Melanoma cell adhesion molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MCAM
Synonyms (NCBI Gene) Gene synonyms aliases	CD146, HEMCAM, METCAM, MUC18, MelCAM
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q23.3

Show/Hide all(310)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020604	hsa-miR-155-5p	Proteomics	18668040
MIRT022381	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT023581	hsa-miR-1-3p	Proteomics	18668040
MIRT024589	hsa-miR-215-5p	Microarray	19074876
MIRT026263	hsa-miR-192-5p	Microarray	19074876
MIRT437805	hsa-miR-573	Luciferase reporter assay, Western blot	23670160
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT438650	hsa-miR-329-3p	ChIP-seq, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23878390
MIRT708051	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT708050	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT708049	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT708048	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT708047	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT708046	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT708045	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT708044	hsa-miR-5007-3p	HITS-CLIP	21572407
MIRT708043	hsa-miR-335-3p	HITS-CLIP	21572407
MIRT708042	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT536070	hsa-miR-5693	PAR-CLIP	22012620
MIRT522562	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT522561	hsa-miR-3135b	PAR-CLIP	22012620
MIRT522560	hsa-miR-4294	PAR-CLIP	22012620
MIRT522559	hsa-miR-504-3p	PAR-CLIP	22012620
MIRT522558	hsa-miR-122-5p	PAR-CLIP	22012620
MIRT536068	hsa-miR-564	PAR-CLIP	22012620
MIRT522557	hsa-miR-3652	PAR-CLIP	22012620
MIRT522556	hsa-miR-4430	PAR-CLIP	22012620
MIRT522555	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536067	hsa-miR-891a-3p	PAR-CLIP	22012620
MIRT522554	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT522553	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT522552	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT522549	hsa-miR-5698	PAR-CLIP	22012620
MIRT522562	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT522561	hsa-miR-3135b	PAR-CLIP	23446348
MIRT522560	hsa-miR-4294	PAR-CLIP	23446348
MIRT522559	hsa-miR-504-3p	PAR-CLIP	23446348
MIRT522558	hsa-miR-122-5p	PAR-CLIP	23446348
MIRT522557	hsa-miR-3652	PAR-CLIP	23446348
MIRT522556	hsa-miR-4430	PAR-CLIP	23446348
MIRT522555	hsa-miR-143-5p	PAR-CLIP	23446348
MIRT522554	hsa-miR-6501-5p	PAR-CLIP	23446348
MIRT522553	hsa-miR-4423-5p	PAR-CLIP	23446348
MIRT522552	hsa-miR-744-3p	PAR-CLIP	23446348
MIRT522551	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT522550	hsa-miR-1238-3p	PAR-CLIP	23446348
MIRT522549	hsa-miR-5698	PAR-CLIP	23446348
MIRT708051	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT708050	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT708049	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT708048	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT708047	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT708046	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT708045	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT708044	hsa-miR-5007-3p	HITS-CLIP	21572407
MIRT708043	hsa-miR-335-3p	HITS-CLIP	21572407
MIRT708042	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT536070	hsa-miR-5693	PAR-CLIP	22012620
MIRT522562	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT522561	hsa-miR-3135b	PAR-CLIP	22012620
MIRT522560	hsa-miR-4294	PAR-CLIP	22012620
MIRT522559	hsa-miR-504-3p	PAR-CLIP	22012620
MIRT522558	hsa-miR-122-5p	PAR-CLIP	22012620
MIRT536068	hsa-miR-564	PAR-CLIP	22012620
MIRT522557	hsa-miR-3652	PAR-CLIP	22012620
MIRT522556	hsa-miR-4430	PAR-CLIP	22012620
MIRT522555	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536067	hsa-miR-891a-3p	PAR-CLIP	22012620
MIRT522554	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT522553	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT522552	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT522549	hsa-miR-5698	PAR-CLIP	22012620
MIRT522562	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT522561	hsa-miR-3135b	PAR-CLIP	23446348
MIRT522560	hsa-miR-4294	PAR-CLIP	23446348
MIRT522559	hsa-miR-504-3p	PAR-CLIP	23446348
MIRT522558	hsa-miR-122-5p	PAR-CLIP	23446348
MIRT522557	hsa-miR-3652	PAR-CLIP	23446348
MIRT522556	hsa-miR-4430	PAR-CLIP	23446348
MIRT522555	hsa-miR-143-5p	PAR-CLIP	23446348
MIRT522554	hsa-miR-6501-5p	PAR-CLIP	23446348
MIRT522553	hsa-miR-4423-5p	PAR-CLIP	23446348
MIRT522552	hsa-miR-744-3p	PAR-CLIP	23446348
MIRT522551	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT522550	hsa-miR-1238-3p	PAR-CLIP	23446348
MIRT522549	hsa-miR-5698	PAR-CLIP	23446348
MIRT1136319	hsa-miR-1203	CLIP-seq
MIRT1136320	hsa-miR-1207-5p	CLIP-seq
MIRT1136321	hsa-miR-129-5p	CLIP-seq
MIRT1136322	hsa-miR-3149	CLIP-seq
MIRT1136323	hsa-miR-3656	CLIP-seq
MIRT1136324	hsa-miR-411	CLIP-seq
MIRT1136325	hsa-miR-4455	CLIP-seq
MIRT1136326	hsa-miR-4678	CLIP-seq
MIRT1136327	hsa-miR-4699-3p	CLIP-seq
MIRT1136328	hsa-miR-4722-5p	CLIP-seq
MIRT1136329	hsa-miR-4735-5p	CLIP-seq
MIRT1136330	hsa-miR-4736	CLIP-seq
MIRT1136331	hsa-miR-4763-3p	CLIP-seq
MIRT1136332	hsa-miR-4775	CLIP-seq
MIRT1136333	hsa-miR-5096	CLIP-seq
MIRT1136334	hsa-miR-590-3p	CLIP-seq
MIRT1136335	hsa-miR-720	CLIP-seq
MIRT1556657	hsa-miR-1184	CLIP-seq
MIRT1556658	hsa-miR-1293	CLIP-seq
MIRT1556659	hsa-miR-1301	CLIP-seq
MIRT1556660	hsa-miR-141	CLIP-seq
MIRT1556661	hsa-miR-200a	CLIP-seq
MIRT1556662	hsa-miR-296-3p	CLIP-seq
MIRT1556663	hsa-miR-4260	CLIP-seq
MIRT1556664	hsa-miR-4418	CLIP-seq
MIRT1556665	hsa-miR-4459	CLIP-seq
MIRT1556666	hsa-miR-4483	CLIP-seq
MIRT1556667	hsa-miR-4660	CLIP-seq
MIRT1556668	hsa-miR-4768-5p	CLIP-seq
MIRT1556669	hsa-miR-4779	CLIP-seq
MIRT1556670	hsa-miR-5047	CLIP-seq
MIRT1556671	hsa-miR-509-3-5p	CLIP-seq
MIRT1556672	hsa-miR-509-5p	CLIP-seq
MIRT1556673	hsa-miR-885-3p	CLIP-seq
MIRT2038806	hsa-miR-106a	CLIP-seq
MIRT2038807	hsa-miR-106b	CLIP-seq
MIRT1556657	hsa-miR-1184	CLIP-seq
MIRT2038808	hsa-miR-1193	CLIP-seq
MIRT2038809	hsa-miR-122	CLIP-seq
MIRT2038810	hsa-miR-1228	CLIP-seq
MIRT2038811	hsa-miR-1234	CLIP-seq
MIRT2038812	hsa-miR-1299	CLIP-seq
MIRT1556659	hsa-miR-1301	CLIP-seq
MIRT2038813	hsa-miR-1307	CLIP-seq
MIRT2038814	hsa-miR-150	CLIP-seq
MIRT2038815	hsa-miR-17	CLIP-seq
MIRT2038816	hsa-miR-20a	CLIP-seq
MIRT2038817	hsa-miR-20b	CLIP-seq
MIRT2038818	hsa-miR-2276	CLIP-seq
MIRT2038819	hsa-miR-2392	CLIP-seq
MIRT2038820	hsa-miR-302a	CLIP-seq
MIRT2038821	hsa-miR-302b	CLIP-seq
MIRT2038822	hsa-miR-302c	CLIP-seq
MIRT2038823	hsa-miR-302d	CLIP-seq
MIRT2038824	hsa-miR-302e	CLIP-seq
MIRT2038825	hsa-miR-3152-3p	CLIP-seq
MIRT2038826	hsa-miR-372	CLIP-seq
MIRT2038827	hsa-miR-373	CLIP-seq
MIRT2038828	hsa-miR-3907	CLIP-seq
MIRT2038829	hsa-miR-410	CLIP-seq
MIRT2038830	hsa-miR-4284	CLIP-seq
MIRT1556664	hsa-miR-4418	CLIP-seq
MIRT2038831	hsa-miR-4638-5p	CLIP-seq
MIRT1556667	hsa-miR-4660	CLIP-seq
MIRT2038832	hsa-miR-4662a-5p	CLIP-seq
MIRT2038833	hsa-miR-4676-5p	CLIP-seq
MIRT2038834	hsa-miR-4707-3p	CLIP-seq
MIRT2038835	hsa-miR-4731-5p	CLIP-seq
MIRT2038836	hsa-miR-4782-5p	CLIP-seq
MIRT1556670	hsa-miR-5047	CLIP-seq
MIRT1556671	hsa-miR-509-3-5p	CLIP-seq
MIRT1556672	hsa-miR-509-5p	CLIP-seq
MIRT2038837	hsa-miR-512-3p	CLIP-seq
MIRT2038838	hsa-miR-516b	CLIP-seq
MIRT2038839	hsa-miR-519d	CLIP-seq
MIRT2038840	hsa-miR-520a-3p	CLIP-seq
MIRT2038841	hsa-miR-520b	CLIP-seq
MIRT2038842	hsa-miR-520c-3p	CLIP-seq
MIRT2038843	hsa-miR-520d-3p	CLIP-seq
MIRT2038844	hsa-miR-520e	CLIP-seq
MIRT2038845	hsa-miR-520g	CLIP-seq
MIRT2038846	hsa-miR-520h	CLIP-seq
MIRT2038847	hsa-miR-575	CLIP-seq
MIRT2038848	hsa-miR-93	CLIP-seq
MIRT2038806	hsa-miR-106a	CLIP-seq
MIRT2038807	hsa-miR-106b	CLIP-seq
MIRT2038810	hsa-miR-1228	CLIP-seq
MIRT2038811	hsa-miR-1234	CLIP-seq
MIRT2038813	hsa-miR-1307	CLIP-seq
MIRT2268803	hsa-miR-1324	CLIP-seq
MIRT2038814	hsa-miR-150	CLIP-seq
MIRT2038815	hsa-miR-17	CLIP-seq
MIRT2038816	hsa-miR-20a	CLIP-seq
MIRT2038817	hsa-miR-20b	CLIP-seq
MIRT2038818	hsa-miR-2276	CLIP-seq
MIRT2038820	hsa-miR-302a	CLIP-seq
MIRT2038821	hsa-miR-302b	CLIP-seq
MIRT2038822	hsa-miR-302c	CLIP-seq
MIRT2038823	hsa-miR-302d	CLIP-seq
MIRT2038824	hsa-miR-302e	CLIP-seq
MIRT2038825	hsa-miR-3152-3p	CLIP-seq
MIRT2268804	hsa-miR-329	CLIP-seq
MIRT2268805	hsa-miR-362-3p	CLIP-seq
MIRT2038826	hsa-miR-372	CLIP-seq
MIRT2038827	hsa-miR-373	CLIP-seq
MIRT2268806	hsa-miR-3941	CLIP-seq
MIRT1136324	hsa-miR-411	CLIP-seq
MIRT2038830	hsa-miR-4284	CLIP-seq
MIRT2268807	hsa-miR-4438	CLIP-seq
MIRT2268808	hsa-miR-4454	CLIP-seq
MIRT2038831	hsa-miR-4638-5p	CLIP-seq
MIRT2038832	hsa-miR-4662a-5p	CLIP-seq
MIRT2038833	hsa-miR-4676-5p	CLIP-seq
MIRT2038834	hsa-miR-4707-3p	CLIP-seq
MIRT2038835	hsa-miR-4731-5p	CLIP-seq
MIRT2268809	hsa-miR-5095	CLIP-seq
MIRT1136333	hsa-miR-5096	CLIP-seq
MIRT2038837	hsa-miR-512-3p	CLIP-seq
MIRT2038839	hsa-miR-519d	CLIP-seq
MIRT2038840	hsa-miR-520a-3p	CLIP-seq
MIRT2038841	hsa-miR-520b	CLIP-seq
MIRT2038842	hsa-miR-520c-3p	CLIP-seq
MIRT2038843	hsa-miR-520d-3p	CLIP-seq
MIRT2038844	hsa-miR-520e	CLIP-seq
MIRT2038845	hsa-miR-520g	CLIP-seq
MIRT2038846	hsa-miR-520h	CLIP-seq
MIRT2038847	hsa-miR-575	CLIP-seq
MIRT2268810	hsa-miR-603	CLIP-seq
MIRT2268811	hsa-miR-758	CLIP-seq
MIRT2038848	hsa-miR-93	CLIP-seq
MIRT1556658	hsa-miR-1293	CLIP-seq
MIRT2038813	hsa-miR-1307	CLIP-seq
MIRT1556660	hsa-miR-141	CLIP-seq
MIRT1556661	hsa-miR-200a	CLIP-seq
MIRT2038818	hsa-miR-2276	CLIP-seq
MIRT2038830	hsa-miR-4284	CLIP-seq
MIRT1556665	hsa-miR-4459	CLIP-seq
MIRT1556666	hsa-miR-4483	CLIP-seq
MIRT2038831	hsa-miR-4638-5p	CLIP-seq
MIRT1556669	hsa-miR-4779	CLIP-seq
MIRT2038809	hsa-miR-122	CLIP-seq
MIRT1136335	hsa-miR-720	CLIP-seq
MIRT2568149	hsa-miR-1251	CLIP-seq
MIRT2568150	hsa-miR-125a-5p	CLIP-seq
MIRT2568151	hsa-miR-125b	CLIP-seq
MIRT2568152	hsa-miR-1291	CLIP-seq
MIRT1556658	hsa-miR-1293	CLIP-seq
MIRT2268803	hsa-miR-1324	CLIP-seq
MIRT2568153	hsa-miR-1343	CLIP-seq
MIRT2568154	hsa-miR-1827	CLIP-seq
MIRT1556662	hsa-miR-296-3p	CLIP-seq
MIRT2568155	hsa-miR-296-5p	CLIP-seq
MIRT2568156	hsa-miR-3166	CLIP-seq
MIRT2268804	hsa-miR-329	CLIP-seq
MIRT2268805	hsa-miR-362-3p	CLIP-seq
MIRT2568157	hsa-miR-3674	CLIP-seq
MIRT2568158	hsa-miR-4256	CLIP-seq
MIRT1556663	hsa-miR-4260	CLIP-seq
MIRT2568159	hsa-miR-4319	CLIP-seq
MIRT2568160	hsa-miR-4453	CLIP-seq
MIRT1556665	hsa-miR-4459	CLIP-seq
MIRT1556666	hsa-miR-4483	CLIP-seq
MIRT2568161	hsa-miR-4538	CLIP-seq
MIRT2038833	hsa-miR-4676-5p	CLIP-seq
MIRT2568162	hsa-miR-4709-3p	CLIP-seq
MIRT2568163	hsa-miR-4747-3p	CLIP-seq
MIRT2568164	hsa-miR-4755-3p	CLIP-seq
MIRT2568165	hsa-miR-4768-3p	CLIP-seq
MIRT1556668	hsa-miR-4768-5p	CLIP-seq
MIRT1556669	hsa-miR-4779	CLIP-seq
MIRT2568166	hsa-miR-513a-5p	CLIP-seq
MIRT2038847	hsa-miR-575	CLIP-seq
MIRT2568167	hsa-miR-579	CLIP-seq
MIRT2568168	hsa-miR-587	CLIP-seq
MIRT1136335	hsa-miR-720	CLIP-seq
MIRT1556673	hsa-miR-885-3p	CLIP-seq
MIRT2038809	hsa-miR-122	CLIP-seq
MIRT2568149	hsa-miR-1251	CLIP-seq
MIRT2568150	hsa-miR-125a-5p	CLIP-seq
MIRT2568151	hsa-miR-125b	CLIP-seq
MIRT2568152	hsa-miR-1291	CLIP-seq
MIRT1556658	hsa-miR-1293	CLIP-seq
MIRT2268803	hsa-miR-1324	CLIP-seq
MIRT2568153	hsa-miR-1343	CLIP-seq
MIRT2568154	hsa-miR-1827	CLIP-seq
MIRT1556662	hsa-miR-296-3p	CLIP-seq
MIRT2568155	hsa-miR-296-5p	CLIP-seq
MIRT2568156	hsa-miR-3166	CLIP-seq
MIRT2268804	hsa-miR-329	CLIP-seq
MIRT2268805	hsa-miR-362-3p	CLIP-seq
MIRT2568157	hsa-miR-3674	CLIP-seq
MIRT2568158	hsa-miR-4256	CLIP-seq
MIRT1556663	hsa-miR-4260	CLIP-seq
MIRT2568159	hsa-miR-4319	CLIP-seq
MIRT2568160	hsa-miR-4453	CLIP-seq
MIRT1556665	hsa-miR-4459	CLIP-seq
MIRT1556666	hsa-miR-4483	CLIP-seq
MIRT2568161	hsa-miR-4538	CLIP-seq
MIRT2038833	hsa-miR-4676-5p	CLIP-seq
MIRT2568162	hsa-miR-4709-3p	CLIP-seq
MIRT2568163	hsa-miR-4747-3p	CLIP-seq
MIRT2568164	hsa-miR-4755-3p	CLIP-seq
MIRT2568165	hsa-miR-4768-3p	CLIP-seq
MIRT1556668	hsa-miR-4768-5p	CLIP-seq
MIRT1556669	hsa-miR-4779	CLIP-seq
MIRT2568166	hsa-miR-513a-5p	CLIP-seq
MIRT2038847	hsa-miR-575	CLIP-seq
MIRT2568167	hsa-miR-579	CLIP-seq
MIRT2568168	hsa-miR-587	CLIP-seq
MIRT1556673	hsa-miR-885-3p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
TFAP2A	Repression	20805990

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IDA	23878390
GO:0003094	Process	Glomerular filtration	IEP	20354148
GO:0005055	Function	Laminin receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	36739428
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	NAS	8378324
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	8378324
GO:0009653	Process	Anatomical structure morphogenesis	TAS	8378324
GO:0009897	Component	External side of plasma membrane	IDA	20354148
GO:0016020	Component	Membrane	IEA
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0061042	Process	Vascular wound healing	IEP	20354148

MIM	HGNC	e!Ensembl
155735	6934	ENSG00000076706

Protein

UniProt ID

P43121

Protein name

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)

Protein function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hemat

PDB

6LYN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	30 → 133	Immunoglobulin V-set domain	Domain
PF08205	C2-set_2	139 → 234	CD80-like C2-set immunoglobulin domain	Domain
PF13927	Ig_3	253 → 322		Domain
PF00047	ig	348 → 421	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated

Sequence

MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHV
DWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKR
PRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRP
LKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESRE
VTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTN
DNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSS
LTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRT
QLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRV
LSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPH
TRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITL
PPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH

Sequence length

646

Interactions

View interactions

MCAM (melanoma cell adhesion molecule)