DENND6B (DENN domain containing 6B)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
414918
Gene name Gene Name - the full gene name approved by the HGNC.
DENN domain containing 6B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DENND6B
Synonyms (NCBI Gene) Gene synonyms aliases
AFI1B, FAM116B
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.33
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(21)
miRTarBase ID miRNA Experiments Reference
MIRT018860 hsa-miR-335-5p Microarray 18185580
MIRT631217 hsa-miR-500a-5p HITS-CLIP 23824327
MIRT631216 hsa-miR-6850-3p HITS-CLIP 23824327
MIRT631215 hsa-miR-6499-5p HITS-CLIP 23824327
MIRT631214 hsa-miR-214-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005085 Function Guanyl-nucleotide exchange factor activity IDA 22595670
GO:0005085 Function Guanyl-nucleotide exchange factor activity IEA
GO:0005085 Function Guanyl-nucleotide exchange factor activity TAS
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
620562 32690 ENSG00000205593
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways
UniProt ID Q8NEG7
Protein name Protein DENND6B (DENN domain-containing protein 6B)
Protein function Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08616 SPA 248 → 358 Family
Sequence 
MDALLGTGPRRARGCLGAAGPTSSGRAARTPAAPWARFSAWLECVCVVTFDLELGQALEL
VYPNDFRLTDKEKSSICYLSFPDSHSGCLGDTQFSFRMRQCGGQRSPWHADDRHYNSRAP
VALQREPAHYFGYVYFRQVKDSSVKRGYFQKSLVLVSRLPFVRLFQALLSLIAPEYFDKL
APCLEAVCSEIDQWPAPAPGQTLNLPVMGVVVQVRIPSRVDKSESSPPKQFDQENLLPAP
VVLASVHELDLFRCFRPVLTHMQTLWELMLLGEPLLVLAPSPDVSSEMVLALTSCLQPLR
FCCDFRPYFTIHDSEFKEFTTRTQAPPNVVLGVTNPFFIKTLQHWPHILRVGEPKMSGDL
PKQVKLKKPSRLKTLDTKPGLYTAYTAHLHRDKALLKRLLKGVQKKRPSDVQSALLRRHL
LELTQSFIIPLEHYMASLMPLQKSITPWKTPPQIQPFSQDDFLRSLEHAGPQLTCILKGD
WLGLYRRFFKSPHFDGWYRQRHKEMALKLEALHLEAICEANIETWMKDKSEVEVVDLVLK
LREKLVRAQGHQLPVKEATLQRAQLYIETVIGSLPKDLQAVLCPP
Sequence length 585
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways
  Reactome
    RAB GEFs exchange GTP for GDP on RABs
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