MAT2A (methionine adenosyltransferase 2A)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4144
Gene name Gene Name - the full gene name approved by the HGNC.
Methionine adenosyltransferase 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAT2A
Synonyms (NCBI Gene) Gene synonyms aliases
MATA2, MATII, SAMS2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1977)
miRTarBase ID miRNA Experiments Reference
MIRT005213 hsa-miR-30a-5p pSILAC 18668040
MIRT016409 hsa-miR-193b-3p Proteomics 21512034
MIRT005213 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT029216 hsa-miR-26b-5p Sequencing 20371350
MIRT045753 hsa-miR-125a-5p CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
Transcription factor Regulation Reference
JUN Activation 14530285
MYB Activation 11427482
MYB Unknown 11115410
NFKB1 Activation 14530285
RELA Activation 14530285
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0004478 Function Methionine adenosyltransferase activity IBA 21873635
GO:0004478 Function Methionine adenosyltransferase activity IDA 7665609, 10644686, 25075345
GO:0005515 Function Protein binding IPI 10644686, 25075345, 25416956, 28514442, 32296183, 32814053
GO:0005524 Function ATP binding IEA
GO:0005829 Component Cytosol IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601468 6904 ENSG00000168906
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P31153
Protein name S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)
Protein function Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the t
PDB 2P02 , 4KTT , 4KTV , 4NDN , 5A19 , 5A1G , 5A1I , 5UGH , 6FAJ , 6FBN , 6FBO , 6FBP , 6FCB , 6FCD , 6FWB , 6G6R , 6P9V , 6WKB , 7BHR , 7BHS , 7BHT , 7BHU , 7BHV , 7BHW , 7BHX , 7KCC , 7KCE , 7KCF , 7KDA , 7KDB , 7L1A , 7LNH , 7RW5 , 7RW7 , 7RWG , 7RWH , 7RXV , 7RXW , 7RXX , 8AXZ , 8OOG , 8P1T , 8P1V , 8P1W , 8P4H , 8QDY , 8QDZ , 8QE0 , 8QE1 , 8QE2 , 8QE3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00438 S-AdoMet_synt_N 17 → 115 S-adenosylmethionine synthetase, N-terminal domain Domain
PF02772 S-AdoMet_synt_M 129 → 250 S-adenosylmethionine synthetase, central domain Domain
PF02773 S-AdoMet_synt_C 252 → 389 S-adenosylmethionine synthetase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in kidney. {ECO:0000269|PubMed:1426236}.
Sequence
Sequence length 395
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cysteine and methionine metabolism
One carbon pool by folate
Metabolic pathways
Biosynthesis of amino acids
Biosynthesis of cofactors 		  Methylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (7)
Causal
Disease term Disease name dbSNP ID References
Aortic aneurysm Aortic Aneurysm, Abdominal rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953
View all (29 more)
Bicuspid aortic valve Bicuspid aortic valve rs1569484234, rs1569484208
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 30104761
Hypertension Hypertensive disease rs13306026
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Ischemic stroke Ischemic stroke ClinVar
Thoracic Aortic Aneurysm And Aortic Dissection familial thoracic aortic aneurysm and aortic dissection GenCC
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (24)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 22879628
Aphasia Broca Associate 36818472
Astrocytoma Associate 14578171
Breast Neoplasms Associate 26418898, 34065390, 37240447
Carcinogenesis Associate 21247894
Carcinoma Hepatocellular Associate 14530285, 18045590, 21247894, 23588207, 24098708, 37240447
Carcinoma Renal Cell Associate 24636201
Cholangiocarcinoma Associate 35841118
Colorectal Neoplasms Associate 21406062, 23588207, 24636201, 26416353, 27213918
COVID 19 Associate 36818472