Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4139
Gene name Gene Name - the full gene name approved by the HGNC.	Microtubule affinity regulating kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MARK1
Synonyms (NCBI Gene) Gene synonyms aliases	MARK, Par-1c, Par1c
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q41

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT737308	hsa-miR-486-5p	Luciferase reporter assay, Western blotting, qRT-PCR	32547110
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT656421	hsa-miR-1283	HITS-CLIP	23824327
MIRT656420	hsa-miR-3616-5p	HITS-CLIP	23824327
MIRT656419	hsa-miR-573	HITS-CLIP	23824327
MIRT1132532	hsa-miR-101	CLIP-seq
MIRT1132533	hsa-miR-128	CLIP-seq
MIRT1132534	hsa-miR-144	CLIP-seq
MIRT1132535	hsa-miR-221	CLIP-seq
MIRT1132536	hsa-miR-222	CLIP-seq
MIRT1132537	hsa-miR-27a	CLIP-seq
MIRT1132538	hsa-miR-27b	CLIP-seq
MIRT1132539	hsa-miR-300	CLIP-seq
MIRT1132540	hsa-miR-381	CLIP-seq
MIRT1132541	hsa-miR-3922-5p	CLIP-seq
MIRT1132542	hsa-miR-3973	CLIP-seq
MIRT1132543	hsa-miR-4307	CLIP-seq
MIRT1132544	hsa-miR-4503	CLIP-seq
MIRT1132545	hsa-miR-4666-3p	CLIP-seq
MIRT1132546	hsa-miR-4680-3p	CLIP-seq
MIRT1132547	hsa-miR-4724-5p	CLIP-seq
MIRT1132548	hsa-miR-4781-3p	CLIP-seq
MIRT1132549	hsa-miR-499-3p	CLIP-seq
MIRT1132550	hsa-miR-499a-3p	CLIP-seq
MIRT1132551	hsa-miR-513a-3p	CLIP-seq
MIRT1132552	hsa-miR-520g	CLIP-seq
MIRT1132553	hsa-miR-520h	CLIP-seq
MIRT1132554	hsa-miR-567	CLIP-seq
MIRT1132555	hsa-miR-570	CLIP-seq
MIRT1132556	hsa-miR-582-5p	CLIP-seq
MIRT2037758	hsa-miR-1305	CLIP-seq
MIRT2037759	hsa-miR-3671	CLIP-seq
MIRT2037760	hsa-miR-4795-3p	CLIP-seq
MIRT2267825	hsa-miR-3924	CLIP-seq
MIRT2267826	hsa-miR-542-3p	CLIP-seq
MIRT1132532	hsa-miR-101	CLIP-seq
MIRT1132534	hsa-miR-144	CLIP-seq
MIRT2431020	hsa-miR-299-5p	CLIP-seq
MIRT1132551	hsa-miR-513a-3p	CLIP-seq

Show/Hide all(55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	ISS	9108484
GO:0000287	Function	Magnesium ion binding	IDA	14976552
GO:0001764	Process	Neuron migration	ISS
GO:0001786	Function	Phosphatidylserine binding	IDA	21145462
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	14976552
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	NAS	10542369, 28386764
GO:0005515	Function	Protein binding	IPI	23666762, 32296183, 32814053
GO:0005524	Function	ATP binding	IDA	14976552
GO:0005524	Function	ATP binding	IEA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	21145462
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	23666762
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005856	Component	Cytoskeleton	ISS
GO:0005886	Component	Plasma membrane	IDA	21145462
GO:0005886	Component	Plasma membrane	IEA
GO:0006468	Process	Protein phosphorylation	IDA	14976552
GO:0006468	Process	Protein phosphorylation	IMP	23666762
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0008289	Function	Lipid binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	31281935
GO:0010629	Process	Negative regulation of gene expression	IDA	31281935
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IDA	31281935
GO:0010975	Process	Regulation of neuron projection development	IEA
GO:0010975	Process	Regulation of neuron projection development	ISS
GO:0015630	Component	Microtubule cytoskeleton	TAS	9108484
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030425	Component	Dendrite	IDA	23666762
GO:0030425	Component	Dendrite	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	14976552
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0050321	Function	Tau-protein kinase activity	IMP	23666762
GO:0050321	Function	Tau-protein kinase activity	ISS
GO:0050321	Function	Tau-protein kinase activity	NAS	28386764
GO:0050773	Process	Regulation of dendrite development	IEA
GO:0050773	Process	Regulation of dendrite development	ISS
GO:0051654	Process	Establishment of mitochondrion localization	IEA
GO:0051654	Process	Establishment of mitochondrion localization	ISS
GO:0070300	Function	Phosphatidic acid binding	IDA	21145462
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
606511	6896	ENSG00000116141

Protein

UniProt ID

Q9P0L2

Protein name

Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)

Protein function

Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell p

PDB

2HAK , 3OSE , 6C9D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	60 → 311	Protein kinase domain	Domain
PF00627	UBA	331 → 367	UBA/TS-N domain	Domain
PF02149	KA1	751 → 795	Kinase associated domain 1	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. {ECO:0000269|PubMed:9108484}.

Sequence

MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
AFKNIASKIANELKL

Sequence length

795

Interactions

View interactions

MARK1 (microtubule affinity regulating kinase 1)