Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4134
Gene name Gene Name - the full gene name approved by the HGNC.
Microtubule associated protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAP4
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MA
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025500 hsa-miR-34a-5p Proteomics 21566225
MIRT027147 hsa-miR-103a-3p Sequencing 20371350
MIRT031936 hsa-miR-16-5p Sequencing 20371350
MIRT031936 hsa-miR-16-5p Proteomics 18668040
MIRT052234 hsa-let-7b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
TP53 Repression 19411072
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA 21873635
GO:0000226 Process Microtubule cytoskeleton organization ISS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005198 Function Structural molecule activity TAS 1905296
GO:0005515 Function Protein binding IPI 17474147
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
157132 6862 ENSG00000047849
Protein
UniProt ID P27816
Protein name Microtubule-associated protein 4 (MAP-4)
Protein function Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00418 Tubulin-binding 927 953 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 992 1022 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 1023 1053 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 1054 1085 Tau and MAP protein, tubulin-binding repeat Family
Sequence
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS
ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP
EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP
CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE
IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM
ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI
KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ
ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ
LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM
EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG
ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE
LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ
PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK
APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE
GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST
TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT
EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG
GN
VQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL
PAGGA
VKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA
QTLDSQIQETSI
Sequence length 1152
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Myocardial Infarction Myocardial Infarction GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 36705386
Adenocarcinoma of Lung Associate 29743960
Alzheimer Disease Associate 18842138
Colorectal Neoplasms Associate 35544729
Encephalitis Tick Borne Associate 31122248
Esophageal Squamous Cell Carcinoma Associate 36991467
Hypertension Associate 26866982
Leukemia Associate 12123579
Malformations of Cortical Development Associate 28222113
Melanoma Associate 35871080