Gene Gene information from NCBI Gene database.
Entrez ID 4134
Gene name Microtubule associated protein 4
Gene symbol MAP4
Synonyms (NCBI Gene)
-
Chromosome 3
Chromosome location 3p21.31
Summary The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MA
miRNA miRNA information provided by mirtarbase database.
472
miRTarBase ID miRNA Experiments Reference
MIRT025500 hsa-miR-34a-5p Proteomics 21566225
MIRT027147 hsa-miR-103a-3p Sequencing 20371350
MIRT031936 hsa-miR-16-5p Sequencing 20371350
MIRT031936 hsa-miR-16-5p Proteomics 18668040
MIRT052234 hsa-let-7b-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
TP53 Repression 19411072
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0000226 Process Microtubule cytoskeleton organization IDA 34782749
GO:0000226 Process Microtubule cytoskeleton organization ISS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005198 Function Structural molecule activity TAS 1905296
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
157132 6862 ENSG00000047849
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27816
Protein name Microtubule-associated protein 4 (MAP-4)
Protein function Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00418 Tubulin-binding 927 953 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 992 1022 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 1023 1053 Tau and MAP protein, tubulin-binding repeat Family
PF00418 Tubulin-binding 1054 1085 Tau and MAP protein, tubulin-binding repeat Family
Sequence
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNS
ESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWP
EDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSP
CNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALE
IMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDM
ALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPI
KMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQ
ANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQ
LPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEM
EVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKG
ISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSE
LSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ
PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAK
APEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTE
GKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPST
TPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKT
EAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGG
GN
VQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHL
PAGGA
VKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA
QTLDSQIQETSI
Sequence length 1152
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
41
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs182500657 RCV005910482
Cervical cancer Benign rs182500657 RCV005910484
Clear cell carcinoma of kidney Benign rs182500657 RCV005910485
Familial cancer of breast Benign rs182500657 RCV005910481
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 36705386
Adenocarcinoma of Lung Associate 29743960
Alzheimer Disease Associate 18842138
Colorectal Neoplasms Associate 35544729
Encephalitis Tick Borne Associate 31122248
Esophageal Squamous Cell Carcinoma Associate 36991467
Hypertension Associate 26866982
Leukemia Associate 12123579
Malformations of Cortical Development Associate 28222113
Melanoma Associate 35871080