MAOB (monoamine oxidase B)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4129
Gene name Gene Name - the full gene name approved by the HGNC.
Monoamine oxidase B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAOB
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp11.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabo
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
miRTarBase ID miRNA Experiments Reference
MIRT536189 hsa-miR-335-5p PAR-CLIP 22012620
MIRT536188 hsa-miR-4426 PAR-CLIP 22012620
MIRT536187 hsa-miR-4647 PAR-CLIP 22012620
MIRT536186 hsa-miR-4662b PAR-CLIP 22012620
MIRT536185 hsa-miR-4786-3p PAR-CLIP 22012620
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
CDCA7L Repression 20980443
EAPP Repression 20980443
RARA Unknown 19401466
SP1 Unknown 11259630;20980443
SP3 Unknown 11259630
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 30021884, 32296183, 32814053
GO:0005739 Component Mitochondrion HDA 20833797
GO:0005740 Component Mitochondrial envelope TAS 7063850
GO:0005741 Component Mitochondrial outer membrane TAS 24252804
GO:0008131 Function Primary amine oxidase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
309860 6834 ENSG00000069535
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P27338
Protein name Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)
Protein function Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of
PDB 1GOS , 1OJ9 , 1OJA , 1OJC , 1OJD , 1S2Q , 1S2Y , 1S3B , 1S3E , 2BK3 , 2BK4 , 2BK5 , 2BYB , 2C64 , 2C65 , 2C66 , 2C67 , 2C70 , 2C72 , 2C73 , 2C75 , 2C76 , 2V5Z , 2V60 , 2V61 , 2VRL , 2VRM , 2VZ2 , 2XCG , 2XFN , 2XFO , 2XFP , 2XFQ , 2XFU , 3PO7 , 3ZYX , 4A79 , 4A7A , 4CRT , 5MRL , 6FVZ , 6FW0 , 6FWC , 6RKB , 6RKP , 6RLE , 6YT2 , 7B0V , 7B0Z , 7P4F , 7P4H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01593 Amino_oxidase 14 → 451 Flavin containing amine oxidoreductase Domain
Sequence
Sequence length 520
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Parkinson disease
Cocaine addiction
Amphetamine addiction
Alcoholism 		  Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (7)
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)		 21075085, 7816197
Anemia Anemia, Megaloblastic rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)		 7430361
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)		 19221690
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 15059925
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 21063030 ClinVar
Huntington disease Huntington Disease, Huntington Disease, Late Onset, Juvenile Huntington Disease 21075085 ClinVar
Mental depression Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder 19268543, 22414661, 19657584, 17640790 ClinVar
Show/Hide Text Mining Associations (68)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 31533842
Adenocarcinoma of Lung Associate 35664356, 37189138
Alcohol Related Disorders Associate 27341797
Alcoholism Associate 23915421
Alzheimer Disease Associate 31771069, 36006974, 36776057
Aphasia Inhibit 22365943
Aphasia Associate 34287249
Asthma Associate 37238670
Astrocytoma Associate 26689994
Attention Deficit and Disruptive Behavior Disorders Associate 18430257