Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	4129
Gene name	Monoamine oxidase B
Gene symbol	MAOB
Synonyms (NCBI Gene)	-
Chromosome	X
Chromosome location	Xp11.3
Summary	The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT536189	hsa-miR-335-5p	PAR-CLIP	22012620
MIRT536188	hsa-miR-4426	PAR-CLIP	22012620
MIRT536187	hsa-miR-4647	PAR-CLIP	22012620
MIRT536186	hsa-miR-4662b	PAR-CLIP	22012620
MIRT536185	hsa-miR-4786-3p	PAR-CLIP	22012620
MIRT536184	hsa-miR-671-5p	PAR-CLIP	22012620
MIRT536183	hsa-miR-628-5p	PAR-CLIP	22012620
MIRT536189	hsa-miR-335-5p	PAR-CLIP	22012620
MIRT536188	hsa-miR-4426	PAR-CLIP	22012620
MIRT536187	hsa-miR-4647	PAR-CLIP	22012620
MIRT536186	hsa-miR-4662b	PAR-CLIP	22012620
MIRT536185	hsa-miR-4786-3p	PAR-CLIP	22012620
MIRT536184	hsa-miR-671-5p	PAR-CLIP	22012620
MIRT536183	hsa-miR-628-5p	PAR-CLIP	22012620
MIRT1127646	hsa-miR-1185	CLIP-seq
MIRT1127647	hsa-miR-1252	CLIP-seq
MIRT1127648	hsa-miR-2114	CLIP-seq
MIRT1127649	hsa-miR-3173-3p	CLIP-seq
MIRT1127650	hsa-miR-3679-5p	CLIP-seq
MIRT1127651	hsa-miR-4270	CLIP-seq
MIRT1127652	hsa-miR-4441	CLIP-seq
MIRT1127653	hsa-miR-4474-3p	CLIP-seq
MIRT1127654	hsa-miR-599	CLIP-seq
MIRT1127655	hsa-miR-760	CLIP-seq
MIRT2266488	hsa-miR-3650	CLIP-seq
MIRT2438474	hsa-miR-490-5p	CLIP-seq
MIRT2438475	hsa-miR-511	CLIP-seq
MIRT2453644	hsa-miR-3125	CLIP-seq
MIRT2453645	hsa-miR-3613-3p	CLIP-seq
MIRT2453646	hsa-miR-3916	CLIP-seq
MIRT2453647	hsa-miR-4668-3p	CLIP-seq

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Transcription factor	Regulation	Reference
CDCA7L	Repression	20980443
EAPP	Repression	20980443
RARA	Unknown	19401466
SP1	Unknown	11259630;20980443
SP3	Unknown	11259630
SP4	Activation	11259630

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 30021884, 32296183, 32814053, 33961781
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005740	Component	Mitochondrial envelope	TAS	7063850
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS	24252804
GO:0008131	Function	Primary methylamine oxidase activity	IBA
GO:0008131	Function	Primary methylamine oxidase activity	IDA	20493079
GO:0008131	Function	Primary methylamine oxidase activity	IEA
GO:0008131	Function	Primary methylamine oxidase activity	ISS
GO:0009055	Function	Electron transfer activity	TAS	8602220
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0042420	Process	Dopamine catabolic process	IEA
GO:0042420	Process	Dopamine catabolic process	TAS	24252804
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050665	Process	Hydrogen peroxide biosynthetic process	NAS	24252804
GO:0097621	Function	Monoamine oxidase activity	IDA	20493079
GO:0097621	Function	Monoamine oxidase activity	IEA

MIM	HGNC	e!Ensembl
309860	6834	ENSG00000069535

P27338

Protein name

Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)

Protein function

Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of

PDB

1GOS , 1OJ9 , 1OJA , 1OJC , 1OJD , 1S2Q , 1S2Y , 1S3B , 1S3E , 2BK3 , 2BK4 , 2BK5 , 2BYB , 2C64 , 2C65 , 2C66 , 2C67 , 2C70 , 2C72 , 2C73 , 2C75 , 2C76 , 2V5Z , 2V60 , 2V61 , 2VRL , 2VRM , 2VZ2 , 2XCG , 2XFN , 2XFO , 2XFP , 2XFQ , 2XFU , 3PO7 , 3ZYX , 4A79 , 4A7A , 4CRT , 5MRL , 6FVZ , 6FW0 , 6FWC , 6RKB , 6RKP , 6RLE , 6YT2 , 7B0V , 7B0Z , 7P4F , 7P4H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01593	Amino_oxidase	14 → 451	Flavin containing amine oxidoreductase	Domain

Sequence

MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

Sequence length

520

Interactions

View interactions

	KEGG		Reactome
	Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Dopaminergic synapse Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism		Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

MAOB (monoamine oxidase B)