Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4124
Gene name	Mannosidase alpha class 2A member 1
Gene symbol	MAN2A1
Synonyms (NCBI Gene)	AMan IIGOLIM7MANA2MANII
Chromosome	5
Chromosome location	5q21.3
Summary	This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a syste

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002612	hsa-miR-124-3p	Microarray	18668037
MIRT002612	hsa-miR-124-3p	Microarray	15685193
MIRT045458	hsa-miR-149-5p	CLASH	23622248
MIRT044543	hsa-miR-320a	CLASH	23622248
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT621075	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT621074	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT556352	hsa-miR-532-5p	PAR-CLIP	21572407
MIRT556351	hsa-miR-5697	PAR-CLIP	21572407
MIRT556350	hsa-miR-2682-3p	PAR-CLIP	21572407
MIRT556349	hsa-miR-6781-3p	PAR-CLIP	21572407
MIRT556348	hsa-miR-4633-5p	PAR-CLIP	21572407
MIRT556347	hsa-miR-1297	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT556345	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT556344	hsa-miR-4465	PAR-CLIP	21572407
MIRT556343	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT556345	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT727258	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727259	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727257	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT621075	hsa-miR-576-3p	HITS-CLIP	23824327
MIRT621074	hsa-miR-219b-5p	HITS-CLIP	23824327
MIRT621073	hsa-miR-4521	HITS-CLIP	23824327
MIRT556352	hsa-miR-532-5p	PAR-CLIP	21572407
MIRT556351	hsa-miR-5697	PAR-CLIP	21572407
MIRT556350	hsa-miR-2682-3p	PAR-CLIP	21572407
MIRT556349	hsa-miR-6781-3p	PAR-CLIP	21572407
MIRT556348	hsa-miR-4633-5p	PAR-CLIP	21572407
MIRT556347	hsa-miR-1297	PAR-CLIP	21572407
MIRT556346	hsa-miR-26a-5p	PAR-CLIP	21572407
MIRT556345	hsa-miR-26b-5p	PAR-CLIP	21572407
MIRT556344	hsa-miR-4465	PAR-CLIP	21572407
MIRT556343	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1127212	hsa-miR-1193	CLIP-seq
MIRT1127213	hsa-miR-1246	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127215	hsa-miR-1305	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127218	hsa-miR-25	CLIP-seq
MIRT1127219	hsa-miR-3134	CLIP-seq
MIRT1127220	hsa-miR-3163	CLIP-seq
MIRT1127221	hsa-miR-3165	CLIP-seq
MIRT1127222	hsa-miR-32	CLIP-seq
MIRT1127223	hsa-miR-3202	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127225	hsa-miR-335	CLIP-seq
MIRT1127226	hsa-miR-363	CLIP-seq
MIRT1127227	hsa-miR-367	CLIP-seq
MIRT1127228	hsa-miR-3691-5p	CLIP-seq
MIRT1127229	hsa-miR-3692	CLIP-seq
MIRT1127230	hsa-miR-3974	CLIP-seq
MIRT1127231	hsa-miR-421	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT1127233	hsa-miR-4325	CLIP-seq
MIRT1127234	hsa-miR-4428	CLIP-seq
MIRT1127235	hsa-miR-4434	CLIP-seq
MIRT1127236	hsa-miR-4436b-5p	CLIP-seq
MIRT1127237	hsa-miR-4476	CLIP-seq
MIRT1127238	hsa-miR-4490	CLIP-seq
MIRT1127239	hsa-miR-4516	CLIP-seq
MIRT1127240	hsa-miR-4533	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127248	hsa-miR-4747-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127250	hsa-miR-4789-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127254	hsa-miR-493	CLIP-seq
MIRT1127255	hsa-miR-499-3p	CLIP-seq
MIRT1127256	hsa-miR-499a-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT1127258	hsa-miR-548c-3p	CLIP-seq
MIRT1127259	hsa-miR-548m	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq
MIRT1127266	hsa-miR-92a	CLIP-seq
MIRT1127267	hsa-miR-92b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127211	hsa-miR-1183	CLIP-seq
MIRT1921677	hsa-miR-135a	CLIP-seq
MIRT1921678	hsa-miR-135b	CLIP-seq
MIRT1921679	hsa-miR-3119	CLIP-seq
MIRT1127246	hsa-miR-4693-5p	CLIP-seq
MIRT1127260	hsa-miR-550b	CLIP-seq
MIRT1127215	hsa-miR-1305	CLIP-seq
MIRT2036052	hsa-miR-3187-3p	CLIP-seq
MIRT2036053	hsa-miR-3923	CLIP-seq
MIRT1127231	hsa-miR-421	CLIP-seq
MIRT2036054	hsa-miR-4263	CLIP-seq
MIRT2036055	hsa-miR-4435	CLIP-seq
MIRT2036056	hsa-miR-4529-5p	CLIP-seq
MIRT2036057	hsa-miR-4701-5p	CLIP-seq
MIRT2036058	hsa-miR-4775	CLIP-seq
MIRT1127250	hsa-miR-4789-3p	CLIP-seq
MIRT2036059	hsa-miR-548s	CLIP-seq
MIRT2036060	hsa-miR-576-5p	CLIP-seq
MIRT2036061	hsa-miR-588	CLIP-seq
MIRT2036062	hsa-miR-590-3p	CLIP-seq
MIRT2266380	hsa-miR-1229	CLIP-seq
MIRT2266381	hsa-miR-128	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT2266382	hsa-miR-2117	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127218	hsa-miR-25	CLIP-seq
MIRT2266383	hsa-miR-27a	CLIP-seq
MIRT2266384	hsa-miR-27b	CLIP-seq
MIRT1127222	hsa-miR-32	CLIP-seq
MIRT2266385	hsa-miR-342-3p	CLIP-seq
MIRT1127226	hsa-miR-363	CLIP-seq
MIRT1127227	hsa-miR-367	CLIP-seq
MIRT2266386	hsa-miR-4273	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT2266387	hsa-miR-4676-5p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT2266388	hsa-miR-575	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127266	hsa-miR-92a	CLIP-seq
MIRT1127267	hsa-miR-92b	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127216	hsa-miR-137	CLIP-seq
MIRT1127217	hsa-miR-218	CLIP-seq
MIRT1127263	hsa-miR-636	CLIP-seq
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT2565681	hsa-miR-1206	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT2565682	hsa-miR-452	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT2565683	hsa-miR-4676-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT2565684	hsa-miR-4698	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT2565685	hsa-miR-561	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT2565686	hsa-miR-653	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq
MIRT1127210	hsa-miR-1179	CLIP-seq
MIRT2565681	hsa-miR-1206	CLIP-seq
MIRT1127214	hsa-miR-1267	CLIP-seq
MIRT1127224	hsa-miR-323-5p	CLIP-seq
MIRT1127232	hsa-miR-4324	CLIP-seq
MIRT1127241	hsa-miR-4536	CLIP-seq
MIRT1127242	hsa-miR-4659a-3p	CLIP-seq
MIRT1127243	hsa-miR-4659b-3p	CLIP-seq
MIRT1127244	hsa-miR-4666-3p	CLIP-seq
MIRT1127245	hsa-miR-4684-3p	CLIP-seq
MIRT1127247	hsa-miR-4711-5p	CLIP-seq
MIRT1127249	hsa-miR-4760-3p	CLIP-seq
MIRT1127251	hsa-miR-485-3p	CLIP-seq
MIRT1127252	hsa-miR-485-5p	CLIP-seq
MIRT1127253	hsa-miR-490-3p	CLIP-seq
MIRT1127257	hsa-miR-511	CLIP-seq
MIRT1127261	hsa-miR-579	CLIP-seq
MIRT1127262	hsa-miR-626	CLIP-seq
MIRT1127264	hsa-miR-649	CLIP-seq
MIRT1127265	hsa-miR-876-3p	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001701	Process	In utero embryonic development	IEA
GO:0001889	Process	Liver development	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004559	Function	Alpha-mannosidase activity	IBA
GO:0004559	Function	Alpha-mannosidase activity	IEA
GO:0004559	Function	Alpha-mannosidase activity	TAS
GO:0004572	Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA
GO:0004572	Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	TAS	8524845
GO:0005615	Component	Extracellular space	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005797	Component	Golgi medial cisterna	IDA	21525244
GO:0005801	Component	Cis-Golgi network	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006013	Process	Mannose metabolic process	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006491	Process	N-glycan processing	IBA
GO:0006491	Process	N-glycan processing	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007033	Process	Vacuole organization	IEA
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	IEA
GO:0015923	Function	Mannosidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0016799	Function	Hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048286	Process	Lung alveolus development	IEA
GO:0050769	Process	Positive regulation of neurogenesis	IEA
GO:0060042	Process	Retina morphogenesis in camera-type eye	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

MIM	HGNC	e!Ensembl
154582	6824	ENSG00000112893

Q16706

Protein name

Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)

Protein function

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01074	Glyco_hydro_38N	167 → 497	Glycosyl hydrolases family 38 N-terminal domain	Domain
PF09261	Alpha-mann_mid	502 → 606	Alpha mannosidase middle domain	Domain
PF07748	Glyco_hydro_38C	760 → 964	Glycosyl hydrolases family 38 C-terminal domain	Domain

Sequence

MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLER
LLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFAS
QSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGW
LKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIEN
GQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYL
LNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTC
GPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLL
APLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRD
KGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAH
KYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIG
NSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDR
ISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKI
LESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMT
KEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTC
FFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQ
IQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQ
DDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPM
ANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFS
SKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFR
IQLR

Sequence length

1144

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways		Intra-Golgi traffic Reactions specific to the complex N-glycan synthesis pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Anemia Dyserythropoietic Congenital	Associate	19465480	★★★★★ ★☆☆☆☆ Found in Text Mining only
Death	Associate	25238935	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	22545106	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	19465480	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	25238935	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	32723834	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Associate	22545106	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	25238935, 34417538	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	25470275	★★★★★ ★☆☆☆☆ Found in Text Mining only

MAN2A1 (mannosidase alpha class 2A member 1)