MAN2A2 (mannosidase alpha class 2A member 2)

Gene

• Entrez ID: 4122
• Gene name: Mannosidase alpha class 2A member 2
• Gene symbol: MAN2A2
• Synonyms (NCBI Gene): MANA2X, alpha-MIIx
• Chromosome: 15
• Chromosome location: 15q26.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024425	hsa-miR-215-5p	Microarray	19074876
MIRT026963	hsa-miR-192-5p	Microarray	19074876
MIRT042114	hsa-miR-484	CLASH	23622248
MIRT679229	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT679228	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679227	hsa-miR-8079	HITS-CLIP	23824327
MIRT679226	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679225	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679224	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679223	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679222	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679221	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679220	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679219	hsa-miR-6131	HITS-CLIP	23824327
MIRT679218	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679217	hsa-miR-640	HITS-CLIP	23824327
MIRT679216	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679215	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT569475	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT569474	hsa-miR-6801-3p	PAR-CLIP	20371350
MIRT569473	hsa-miR-6810-3p	PAR-CLIP	20371350
MIRT569472	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT569471	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT569470	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT569469	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT569468	hsa-miR-4715-3p	PAR-CLIP	20371350
MIRT679229	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT679228	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679227	hsa-miR-8079	HITS-CLIP	23824327
MIRT679226	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679225	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT679224	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679223	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679222	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679221	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679220	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679219	hsa-miR-6131	HITS-CLIP	23824327
MIRT679218	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679217	hsa-miR-640	HITS-CLIP	23824327
MIRT679216	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679215	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT569475	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT569474	hsa-miR-6801-3p	PAR-CLIP	20371350
MIRT569473	hsa-miR-6810-3p	PAR-CLIP	20371350
MIRT569472	hsa-miR-6752-3p	PAR-CLIP	20371350
MIRT569471	hsa-miR-4722-3p	PAR-CLIP	20371350
MIRT569470	hsa-miR-6727-3p	PAR-CLIP	20371350
MIRT569469	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT569468	hsa-miR-4715-3p	PAR-CLIP	20371350
MIRT1127268	hsa-let-7a	CLIP-seq
MIRT1127269	hsa-let-7b	CLIP-seq
MIRT1127270	hsa-let-7c	CLIP-seq
MIRT1127271	hsa-let-7d	CLIP-seq
MIRT1127272	hsa-let-7e	CLIP-seq
MIRT1127273	hsa-let-7f	CLIP-seq
MIRT1127274	hsa-let-7g	CLIP-seq
MIRT1127275	hsa-let-7i	CLIP-seq
MIRT1127276	hsa-miR-100	CLIP-seq
MIRT1127277	hsa-miR-106a	CLIP-seq
MIRT1127278	hsa-miR-106b	CLIP-seq
MIRT1127279	hsa-miR-1245	CLIP-seq
MIRT1127280	hsa-miR-1252	CLIP-seq
MIRT1127281	hsa-miR-1294	CLIP-seq
MIRT1127282	hsa-miR-150	CLIP-seq
MIRT1127283	hsa-miR-15a	CLIP-seq
MIRT1127284	hsa-miR-15b	CLIP-seq
MIRT1127285	hsa-miR-16	CLIP-seq
MIRT1127286	hsa-miR-17	CLIP-seq
MIRT1127287	hsa-miR-1827	CLIP-seq
MIRT1127288	hsa-miR-195	CLIP-seq
MIRT1127289	hsa-miR-202	CLIP-seq
MIRT1127290	hsa-miR-20a	CLIP-seq
MIRT1127291	hsa-miR-20b	CLIP-seq
MIRT1127292	hsa-miR-2682	CLIP-seq
MIRT1127293	hsa-miR-297	CLIP-seq
MIRT1127294	hsa-miR-3124-3p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT1127296	hsa-miR-3149	CLIP-seq
MIRT1127297	hsa-miR-3180-5p	CLIP-seq
MIRT1127298	hsa-miR-3188	CLIP-seq
MIRT1127299	hsa-miR-3192	CLIP-seq
MIRT1127300	hsa-miR-3195	CLIP-seq
MIRT1127301	hsa-miR-3612	CLIP-seq
MIRT1127302	hsa-miR-3689a-3p	CLIP-seq
MIRT1127303	hsa-miR-3689c	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT1127305	hsa-miR-374a	CLIP-seq
MIRT1127306	hsa-miR-374b	CLIP-seq
MIRT1127307	hsa-miR-3927	CLIP-seq
MIRT1127308	hsa-miR-3940-5p	CLIP-seq
MIRT1127309	hsa-miR-3942-5p	CLIP-seq
MIRT1127310	hsa-miR-424	CLIP-seq
MIRT1127311	hsa-miR-4265	CLIP-seq
MIRT1127312	hsa-miR-4277	CLIP-seq
MIRT1127313	hsa-miR-4294	CLIP-seq
MIRT1127314	hsa-miR-4296	CLIP-seq
MIRT1127315	hsa-miR-4314	CLIP-seq
MIRT1127316	hsa-miR-4316	CLIP-seq
MIRT1127317	hsa-miR-432	CLIP-seq
MIRT1127318	hsa-miR-4322	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT1127320	hsa-miR-4443	CLIP-seq
MIRT1127321	hsa-miR-4451	CLIP-seq
MIRT1127322	hsa-miR-4458	CLIP-seq
MIRT1127323	hsa-miR-4474-3p	CLIP-seq
MIRT1127324	hsa-miR-449c	CLIP-seq
MIRT1127325	hsa-miR-4500	CLIP-seq
MIRT1127326	hsa-miR-4507	CLIP-seq
MIRT1127327	hsa-miR-4646-5p	CLIP-seq
MIRT1127328	hsa-miR-4677-3p	CLIP-seq
MIRT1127329	hsa-miR-4679	CLIP-seq
MIRT1127330	hsa-miR-4703-5p	CLIP-seq
MIRT1127331	hsa-miR-4728-5p	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT1127333	hsa-miR-497	CLIP-seq
MIRT1127334	hsa-miR-519d	CLIP-seq
MIRT1127335	hsa-miR-520a-5p	CLIP-seq
MIRT1127336	hsa-miR-520g	CLIP-seq
MIRT1127337	hsa-miR-520h	CLIP-seq
MIRT1127338	hsa-miR-525-5p	CLIP-seq
MIRT1127339	hsa-miR-570	CLIP-seq
MIRT1127340	hsa-miR-593	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT1127342	hsa-miR-650	CLIP-seq
MIRT1127343	hsa-miR-924	CLIP-seq
MIRT1127344	hsa-miR-93	CLIP-seq
MIRT1127345	hsa-miR-98	CLIP-seq
MIRT1127346	hsa-miR-99a	CLIP-seq
MIRT1127347	hsa-miR-99b	CLIP-seq
MIRT1127277	hsa-miR-106a	CLIP-seq
MIRT1127278	hsa-miR-106b	CLIP-seq
MIRT2036063	hsa-miR-1207-5p	CLIP-seq
MIRT1127280	hsa-miR-1252	CLIP-seq
MIRT2036064	hsa-miR-128	CLIP-seq
MIRT1127282	hsa-miR-150	CLIP-seq
MIRT1127286	hsa-miR-17	CLIP-seq
MIRT1127290	hsa-miR-20a	CLIP-seq
MIRT1127291	hsa-miR-20b	CLIP-seq
MIRT2036065	hsa-miR-3064-3p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT2036066	hsa-miR-3128	CLIP-seq
MIRT2036067	hsa-miR-3622b-5p	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT1127305	hsa-miR-374a	CLIP-seq
MIRT1127306	hsa-miR-374b	CLIP-seq
MIRT2036068	hsa-miR-3976	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT1127323	hsa-miR-4474-3p	CLIP-seq
MIRT2036069	hsa-miR-4717-5p	CLIP-seq
MIRT2036070	hsa-miR-4720-5p	CLIP-seq
MIRT2036071	hsa-miR-4736	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT2036072	hsa-miR-4763-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2036074	hsa-miR-4799-3p	CLIP-seq
MIRT1127334	hsa-miR-519d	CLIP-seq
MIRT1127336	hsa-miR-520g	CLIP-seq
MIRT1127337	hsa-miR-520h	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT1127344	hsa-miR-93	CLIP-seq
MIRT2036075	hsa-miR-940	CLIP-seq
MIRT2036063	hsa-miR-1207-5p	CLIP-seq
MIRT2266389	hsa-miR-122	CLIP-seq
MIRT2266390	hsa-miR-1244	CLIP-seq
MIRT2266391	hsa-miR-149	CLIP-seq
MIRT2266392	hsa-miR-1909	CLIP-seq
MIRT2266393	hsa-miR-3064-5p	CLIP-seq
MIRT1127295	hsa-miR-3126-3p	CLIP-seq
MIRT2036066	hsa-miR-3128	CLIP-seq
MIRT2266394	hsa-miR-3135b	CLIP-seq
MIRT2036067	hsa-miR-3622b-5p	CLIP-seq
MIRT2266395	hsa-miR-3652	CLIP-seq
MIRT1127304	hsa-miR-371-3p	CLIP-seq
MIRT2266396	hsa-miR-371b-3p	CLIP-seq
MIRT2266397	hsa-miR-411	CLIP-seq
MIRT1127319	hsa-miR-4326	CLIP-seq
MIRT2266398	hsa-miR-4430	CLIP-seq
MIRT2266399	hsa-miR-4684-3p	CLIP-seq
MIRT2266400	hsa-miR-4687-3p	CLIP-seq
MIRT2036070	hsa-miR-4720-5p	CLIP-seq
MIRT2036071	hsa-miR-4736	CLIP-seq
MIRT1127332	hsa-miR-4757-5p	CLIP-seq
MIRT2036072	hsa-miR-4763-3p	CLIP-seq
MIRT2266401	hsa-miR-4794	CLIP-seq
MIRT2036074	hsa-miR-4799-3p	CLIP-seq
MIRT2266402	hsa-miR-515-3p	CLIP-seq
MIRT2266403	hsa-miR-519e	CLIP-seq
MIRT2266404	hsa-miR-587	CLIP-seq
MIRT2266405	hsa-miR-647	CLIP-seq
MIRT2453640	hsa-miR-147	CLIP-seq
MIRT2453641	hsa-miR-3911	CLIP-seq
MIRT1127341	hsa-miR-644	CLIP-seq
MIRT2453642	hsa-miR-663b	CLIP-seq
MIRT2453643	hsa-miR-892a	CLIP-seq
MIRT2565687	hsa-miR-1184	CLIP-seq
MIRT2565688	hsa-miR-1202	CLIP-seq
MIRT2565689	hsa-miR-1205	CLIP-seq
MIRT2565690	hsa-miR-1251	CLIP-seq
MIRT2565691	hsa-miR-1343	CLIP-seq
MIRT2565692	hsa-miR-188-3p	CLIP-seq
MIRT2565693	hsa-miR-193a-5p	CLIP-seq
MIRT2565694	hsa-miR-1972	CLIP-seq
MIRT2565695	hsa-miR-216b	CLIP-seq
MIRT2565696	hsa-miR-3074-5p	CLIP-seq
MIRT1127294	hsa-miR-3124-3p	CLIP-seq
MIRT2565697	hsa-miR-3158-5p	CLIP-seq
MIRT1127297	hsa-miR-3180-5p	CLIP-seq
MIRT2565698	hsa-miR-3667-3p	CLIP-seq
MIRT2565699	hsa-miR-3675-3p	CLIP-seq
MIRT2266396	hsa-miR-371b-3p	CLIP-seq
MIRT2565700	hsa-miR-376c	CLIP-seq
MIRT2565701	hsa-miR-3937	CLIP-seq
MIRT2565702	hsa-miR-3972	CLIP-seq
MIRT2565703	hsa-miR-431	CLIP-seq
MIRT2565704	hsa-miR-4480	CLIP-seq
MIRT2565705	hsa-miR-4662a-5p	CLIP-seq
MIRT2036069	hsa-miR-4717-5p	CLIP-seq
MIRT2565706	hsa-miR-4719	CLIP-seq
MIRT2565707	hsa-miR-4769-3p	CLIP-seq
MIRT2565708	hsa-miR-4775	CLIP-seq
MIRT2565709	hsa-miR-4776-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2266401	hsa-miR-4794	CLIP-seq
MIRT2565710	hsa-miR-494	CLIP-seq
MIRT2565711	hsa-miR-499a-5p	CLIP-seq
MIRT1127335	hsa-miR-520a-5p	CLIP-seq
MIRT1127338	hsa-miR-525-5p	CLIP-seq
MIRT2565712	hsa-miR-544	CLIP-seq
MIRT2565713	hsa-miR-609	CLIP-seq
MIRT2565690	hsa-miR-1251	CLIP-seq
MIRT2565695	hsa-miR-216b	CLIP-seq
MIRT2565699	hsa-miR-3675-3p	CLIP-seq
MIRT2036073	hsa-miR-4777-5p	CLIP-seq
MIRT2565710	hsa-miR-494	CLIP-seq
MIRT2565713	hsa-miR-609	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0003824	Function	Catalytic activity	IEA
GO:0004559	Function	Alpha-mannosidase activity	IBA
GO:0004559	Function	Alpha-mannosidase activity	IEA
GO:0004572	Function	Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006013	Process	Mannose metabolic process	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006491	Process	N-glycan processing	IBA
GO:0015923	Function	Mannosidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0016799	Function	Hydrolase activity, hydrolyzing N-glycosyl compounds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 600988
• HGNC: 6825
• e!Ensembl: ENSG00000196547

Protein

• UniProt ID: P49641
• Protein name: Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)
• Protein function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01074	Glyco_hydro_38N	167 → 497	Glycosyl hydrolases family 38 N-terminal domain	Domain
  PF09261	Alpha-mann_mid	502 → 606	Alpha mannosidase middle domain	Domain
  PF07748	Glyco_hydro_38C	765 → 970	Glycosyl hydrolases family 38 C-terminal domain	Domain

• Sequence:

  MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
  LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
  GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
  IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
  GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
  LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
  GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
  VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
  ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
  RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
  HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
  FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
  QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
  LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF
  FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFT
  DLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVIL
  DRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLN
  APALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKG
  FDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPM
  EIATFRLRLG

• Sequence length: 1150

Pathways

KEGG:

N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways

Reactome:

Intra-Golgi traffic
Reactions specific to the complex N-glycan synthesis pathway

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Aganglionic megacolon	Uncertain significance	rs374688808	RCV000984694
Hepatocellular carcinoma	Uncertain significance	rs551769619	RCV005937557

Associations from Text Mining
Disease Name	Relationship Type	References
Cholangiocarcinoma	Associate	33141432
Chronobiology Disorders	Associate	35163208
Glioma	Associate	17986135
Myocardial Infarction	Associate	33836805