Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	412
Gene name Gene Name - the full gene name approved by the HGNC.	Steroid sulfatase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STS
Synonyms (NCBI Gene) Gene synonyms aliases	ARSC, ARSC1, ASC, ES, SSDD, XLI
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xp22.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cho

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SNP ID	Visualize variation	Clinical significance	Consequence
rs137853165	T>A	Pathogenic	Coding sequence variant, missense variant
rs137853166	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853167	C>T	Pathogenic	Coding sequence variant, missense variant
rs137853168	G>C	Pathogenic	Coding sequence variant, missense variant
rs137853169	A>G	Pathogenic	Coding sequence variant, missense variant
rs1064795456	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1463414987	G>A,T	Pathogenic	Stop gained, coding sequence variant, missense variant
rs1555956229	G>T	Pathogenic	Stop gained, coding sequence variant
rs1555967260	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1601748137	G>T	Pathogenic	Splice donor variant

Show/Hide all(311)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019334	hsa-miR-148b-3p	Microarray	17612493
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	20371350
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	20371350
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT532547	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	22012620
MIRT462576	hsa-miR-1264	PAR-CLIP	23592263
MIRT462575	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT462574	hsa-miR-4705	PAR-CLIP	23592263
MIRT462573	hsa-miR-3153	PAR-CLIP	23592263
MIRT462572	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462571	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462570	hsa-miR-4271	PAR-CLIP	23592263
MIRT462569	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462568	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462567	hsa-miR-4425	PAR-CLIP	23592263
MIRT462566	hsa-miR-3147	PAR-CLIP	23592263
MIRT462565	hsa-miR-130a-5p	PAR-CLIP	23592263
MIRT462564	hsa-miR-23a-3p	PAR-CLIP	23592263
MIRT462563	hsa-miR-23b-3p	PAR-CLIP	23592263
MIRT462562	hsa-miR-23c	PAR-CLIP	23592263
MIRT462561	hsa-miR-2110	PAR-CLIP	23592263
MIRT462559	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT462560	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT462558	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT462557	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT462556	hsa-miR-6083	PAR-CLIP	23592263
MIRT462555	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT443775	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT443776	hsa-miR-3123	PAR-CLIP	22100165
MIRT443774	hsa-miR-3976	PAR-CLIP	22100165
MIRT443773	hsa-miR-3651	PAR-CLIP	22100165
MIRT443772	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443771	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	20371350
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	20371350
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT532547	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	22012620
MIRT462576	hsa-miR-1264	PAR-CLIP	23592263
MIRT462575	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT462574	hsa-miR-4705	PAR-CLIP	23592263
MIRT462573	hsa-miR-3153	PAR-CLIP	23592263
MIRT462572	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462571	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462570	hsa-miR-4271	PAR-CLIP	23592263
MIRT462569	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462568	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462567	hsa-miR-4425	PAR-CLIP	23592263
MIRT462566	hsa-miR-3147	PAR-CLIP	23592263
MIRT462565	hsa-miR-130a-5p	PAR-CLIP	23592263
MIRT462564	hsa-miR-23a-3p	PAR-CLIP	23592263
MIRT462563	hsa-miR-23b-3p	PAR-CLIP	23592263
MIRT462562	hsa-miR-23c	PAR-CLIP	23592263
MIRT462561	hsa-miR-2110	PAR-CLIP	23592263
MIRT462559	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT462560	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT462558	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT462557	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT462556	hsa-miR-6083	PAR-CLIP	23592263
MIRT462555	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT443775	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT443776	hsa-miR-3123	PAR-CLIP	22100165
MIRT443774	hsa-miR-3976	PAR-CLIP	22100165
MIRT443773	hsa-miR-3651	PAR-CLIP	22100165
MIRT443772	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443771	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1399857	hsa-miR-1193	CLIP-seq
MIRT1399858	hsa-miR-125a-3p	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT1399860	hsa-miR-145	CLIP-seq
MIRT1399861	hsa-miR-1910	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT1399863	hsa-miR-2355-5p	CLIP-seq
MIRT1399864	hsa-miR-3121-3p	CLIP-seq
MIRT1399865	hsa-miR-3136-3p	CLIP-seq
MIRT1399866	hsa-miR-3150b-3p	CLIP-seq
MIRT1399867	hsa-miR-3154	CLIP-seq
MIRT1399868	hsa-miR-3163	CLIP-seq
MIRT1399869	hsa-miR-3165	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT1399871	hsa-miR-3612	CLIP-seq
MIRT1399872	hsa-miR-3614-3p	CLIP-seq
MIRT1399873	hsa-miR-3662	CLIP-seq
MIRT1399874	hsa-miR-3918	CLIP-seq
MIRT1399875	hsa-miR-3919	CLIP-seq
MIRT1399876	hsa-miR-3929	CLIP-seq
MIRT1399877	hsa-miR-3934	CLIP-seq
MIRT1399878	hsa-miR-4264	CLIP-seq
MIRT1399879	hsa-miR-4293	CLIP-seq
MIRT1399880	hsa-miR-4297	CLIP-seq
MIRT1399881	hsa-miR-4419b	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT1399883	hsa-miR-4434	CLIP-seq
MIRT1399884	hsa-miR-4443	CLIP-seq
MIRT1399885	hsa-miR-4478	CLIP-seq
MIRT1399886	hsa-miR-4516	CLIP-seq
MIRT1399887	hsa-miR-4531	CLIP-seq
MIRT1399888	hsa-miR-455-3p	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT1399892	hsa-miR-4685-5p	CLIP-seq
MIRT1399893	hsa-miR-4689	CLIP-seq
MIRT1399894	hsa-miR-4694-3p	CLIP-seq
MIRT1399895	hsa-miR-4704-3p	CLIP-seq
MIRT1399896	hsa-miR-4717-5p	CLIP-seq
MIRT1399897	hsa-miR-4724-3p	CLIP-seq
MIRT1399898	hsa-miR-4756-3p	CLIP-seq
MIRT1399899	hsa-miR-4784	CLIP-seq
MIRT1399900	hsa-miR-4797-3p	CLIP-seq
MIRT1399901	hsa-miR-485-5p	CLIP-seq
MIRT1399902	hsa-miR-513a-3p	CLIP-seq
MIRT1399903	hsa-miR-645	CLIP-seq
MIRT1399904	hsa-miR-650	CLIP-seq
MIRT1399905	hsa-miR-654-3p	CLIP-seq
MIRT1399906	hsa-miR-659	CLIP-seq
MIRT1399907	hsa-miR-671-5p	CLIP-seq
MIRT1399908	hsa-miR-764	CLIP-seq
MIRT1399909	hsa-miR-942	CLIP-seq
MIRT2119867	hsa-miR-1227	CLIP-seq
MIRT2119868	hsa-miR-185	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT2119869	hsa-miR-2052	CLIP-seq
MIRT2119870	hsa-miR-2277-3p	CLIP-seq
MIRT2119871	hsa-miR-296-3p	CLIP-seq
MIRT2119872	hsa-miR-3132	CLIP-seq
MIRT2119873	hsa-miR-3148	CLIP-seq
MIRT2119874	hsa-miR-3152-5p	CLIP-seq
MIRT2119875	hsa-miR-3189-3p	CLIP-seq
MIRT2119876	hsa-miR-323b-3p	CLIP-seq
MIRT2119877	hsa-miR-3658	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2119879	hsa-miR-3688-3p	CLIP-seq
MIRT2119880	hsa-miR-3692	CLIP-seq
MIRT2119881	hsa-miR-4252	CLIP-seq
MIRT2119882	hsa-miR-4265	CLIP-seq
MIRT2119883	hsa-miR-4296	CLIP-seq
MIRT2119884	hsa-miR-4306	CLIP-seq
MIRT2119885	hsa-miR-4312	CLIP-seq
MIRT2119886	hsa-miR-4322	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT2119887	hsa-miR-4433	CLIP-seq
MIRT2119888	hsa-miR-4459	CLIP-seq
MIRT2119889	hsa-miR-450b-3p	CLIP-seq
MIRT2119890	hsa-miR-4644	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT2119891	hsa-miR-4711-5p	CLIP-seq
MIRT2119892	hsa-miR-4726-3p	CLIP-seq
MIRT2119893	hsa-miR-4768-3p	CLIP-seq
MIRT2119894	hsa-miR-4773	CLIP-seq
MIRT2119895	hsa-miR-4774-3p	CLIP-seq
MIRT2119896	hsa-miR-4795-3p	CLIP-seq
MIRT2119897	hsa-miR-548a-3p	CLIP-seq
MIRT2119898	hsa-miR-548e	CLIP-seq
MIRT2119899	hsa-miR-548f	CLIP-seq
MIRT2119900	hsa-miR-769-3p	CLIP-seq
MIRT2119901	hsa-miR-938	CLIP-seq
MIRT2341933	hsa-miR-103a	CLIP-seq
MIRT2341934	hsa-miR-107	CLIP-seq
MIRT2341935	hsa-miR-1184	CLIP-seq
MIRT1399857	hsa-miR-1193	CLIP-seq
MIRT2341936	hsa-miR-1206	CLIP-seq
MIRT2341937	hsa-miR-1229	CLIP-seq
MIRT2341938	hsa-miR-1238	CLIP-seq
MIRT2341939	hsa-miR-1273e	CLIP-seq
MIRT2341940	hsa-miR-1273f	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT2341941	hsa-miR-137	CLIP-seq
MIRT2341942	hsa-miR-138	CLIP-seq
MIRT2341943	hsa-miR-143	CLIP-seq
MIRT2119868	hsa-miR-185	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT2341944	hsa-miR-2117	CLIP-seq
MIRT2119870	hsa-miR-2277-3p	CLIP-seq
MIRT1399863	hsa-miR-2355-5p	CLIP-seq
MIRT2341945	hsa-miR-2392	CLIP-seq
MIRT2341946	hsa-miR-25	CLIP-seq
MIRT2341947	hsa-miR-3065-5p	CLIP-seq
MIRT2341948	hsa-miR-30a	CLIP-seq
MIRT2341949	hsa-miR-30b	CLIP-seq
MIRT2341950	hsa-miR-30c	CLIP-seq
MIRT2341951	hsa-miR-30d	CLIP-seq
MIRT2341952	hsa-miR-30e	CLIP-seq
MIRT1399864	hsa-miR-3121-3p	CLIP-seq
MIRT2341953	hsa-miR-3124-3p	CLIP-seq
MIRT2341954	hsa-miR-3143	CLIP-seq
MIRT2341955	hsa-miR-3145-5p	CLIP-seq
MIRT2119873	hsa-miR-3148	CLIP-seq
MIRT1399867	hsa-miR-3154	CLIP-seq
MIRT1399869	hsa-miR-3165	CLIP-seq
MIRT2341956	hsa-miR-3182	CLIP-seq
MIRT2341957	hsa-miR-3188	CLIP-seq
MIRT2341958	hsa-miR-32	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT2341959	hsa-miR-33a	CLIP-seq
MIRT2341960	hsa-miR-33b	CLIP-seq
MIRT2341961	hsa-miR-3615	CLIP-seq
MIRT2341962	hsa-miR-363	CLIP-seq
MIRT2341963	hsa-miR-3654	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2341964	hsa-miR-3665	CLIP-seq
MIRT2341965	hsa-miR-367	CLIP-seq
MIRT2341966	hsa-miR-3673	CLIP-seq
MIRT2341967	hsa-miR-3675-5p	CLIP-seq
MIRT2119879	hsa-miR-3688-3p	CLIP-seq
MIRT2341968	hsa-miR-3691-3p	CLIP-seq
MIRT2341969	hsa-miR-3691-5p	CLIP-seq
MIRT2119880	hsa-miR-3692	CLIP-seq
MIRT2341970	hsa-miR-378	CLIP-seq
MIRT2341971	hsa-miR-378b	CLIP-seq
MIRT2341972	hsa-miR-378c	CLIP-seq
MIRT2341973	hsa-miR-378d	CLIP-seq
MIRT2341974	hsa-miR-378e	CLIP-seq
MIRT2341975	hsa-miR-378f	CLIP-seq
MIRT2341976	hsa-miR-378h	CLIP-seq
MIRT2341977	hsa-miR-378i	CLIP-seq
MIRT2341978	hsa-miR-3920	CLIP-seq
MIRT2341979	hsa-miR-3921	CLIP-seq
MIRT2341980	hsa-miR-3941	CLIP-seq
MIRT2341981	hsa-miR-3942-3p	CLIP-seq
MIRT2341982	hsa-miR-422a	CLIP-seq
MIRT2341983	hsa-miR-4266	CLIP-seq
MIRT2341984	hsa-miR-4273	CLIP-seq
MIRT2119884	hsa-miR-4306	CLIP-seq
MIRT2341985	hsa-miR-4310	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT2119887	hsa-miR-4433	CLIP-seq
MIRT2341986	hsa-miR-4450	CLIP-seq
MIRT2119888	hsa-miR-4459	CLIP-seq
MIRT2341987	hsa-miR-4463	CLIP-seq
MIRT2341988	hsa-miR-4464	CLIP-seq
MIRT2341989	hsa-miR-4477a	CLIP-seq
MIRT2341990	hsa-miR-4502	CLIP-seq
MIRT2341991	hsa-miR-4503	CLIP-seq
MIRT2341992	hsa-miR-4525	CLIP-seq
MIRT2119890	hsa-miR-4644	CLIP-seq
MIRT2341993	hsa-miR-4653-5p	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT2341994	hsa-miR-466	CLIP-seq
MIRT2341995	hsa-miR-4667-5p	CLIP-seq
MIRT2341996	hsa-miR-4672	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT1399894	hsa-miR-4694-3p	CLIP-seq
MIRT2341997	hsa-miR-4695-5p	CLIP-seq
MIRT2341998	hsa-miR-4700-5p	CLIP-seq
MIRT2341999	hsa-miR-4708-5p	CLIP-seq
MIRT2119891	hsa-miR-4711-5p	CLIP-seq
MIRT2342000	hsa-miR-4728-3p	CLIP-seq
MIRT2342001	hsa-miR-4731-3p	CLIP-seq
MIRT2342002	hsa-miR-4748	CLIP-seq
MIRT2342003	hsa-miR-4762-3p	CLIP-seq
MIRT2119893	hsa-miR-4768-3p	CLIP-seq
MIRT2342004	hsa-miR-4768-5p	CLIP-seq
MIRT2342005	hsa-miR-4770	CLIP-seq
MIRT2342006	hsa-miR-4772-3p	CLIP-seq
MIRT2342007	hsa-miR-4776-3p	CLIP-seq
MIRT2342008	hsa-miR-4779	CLIP-seq
MIRT2119896	hsa-miR-4795-3p	CLIP-seq
MIRT2342009	hsa-miR-4801	CLIP-seq
MIRT2342010	hsa-miR-483-3p	CLIP-seq
MIRT2342011	hsa-miR-495	CLIP-seq
MIRT2342012	hsa-miR-500a	CLIP-seq
MIRT2342013	hsa-miR-512-5p	CLIP-seq
MIRT2342014	hsa-miR-532-5p	CLIP-seq
MIRT2119897	hsa-miR-548a-3p	CLIP-seq
MIRT2119898	hsa-miR-548e	CLIP-seq
MIRT2119899	hsa-miR-548f	CLIP-seq
MIRT2342015	hsa-miR-550b	CLIP-seq
MIRT2342016	hsa-miR-577	CLIP-seq
MIRT2342017	hsa-miR-579	CLIP-seq
MIRT2342018	hsa-miR-587	CLIP-seq
MIRT2342019	hsa-miR-596	CLIP-seq
MIRT2342020	hsa-miR-600	CLIP-seq
MIRT2342021	hsa-miR-885-3p	CLIP-seq
MIRT2342022	hsa-miR-92a	CLIP-seq
MIRT2342023	hsa-miR-92b	CLIP-seq
MIRT2119901	hsa-miR-938	CLIP-seq
MIRT1399909	hsa-miR-942	CLIP-seq
MIRT2342024	hsa-miR-943	CLIP-seq
MIRT2341933	hsa-miR-103a	CLIP-seq
MIRT2341934	hsa-miR-107	CLIP-seq
MIRT2341935	hsa-miR-1184	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2341985	hsa-miR-4310	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT2692321	hsa-miR-128	CLIP-seq
MIRT2692322	hsa-miR-1322	CLIP-seq
MIRT2692323	hsa-miR-140-3p	CLIP-seq
MIRT2692324	hsa-miR-203	CLIP-seq
MIRT2692325	hsa-miR-3119	CLIP-seq
MIRT2692326	hsa-miR-3611	CLIP-seq
MIRT2692327	hsa-miR-3924	CLIP-seq
MIRT2692328	hsa-miR-4417	CLIP-seq
MIRT2692329	hsa-miR-4720-3p	CLIP-seq
MIRT2692330	hsa-miR-4760-3p	CLIP-seq
MIRT2692331	hsa-miR-4804-3p	CLIP-seq
MIRT2692332	hsa-miR-598	CLIP-seq
MIRT2692333	hsa-miR-7	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
STAT3	Activation	21331591

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004065	Function	Arylsulfatase activity	IBA
GO:0004773	Function	Steryl-sulfatase activity	IEA
GO:0004773	Function	Steryl-sulfatase activity	TAS	2668275
GO:0005764	Component	Lysosome	TAS	2668275
GO:0005768	Component	Endosome	TAS	2668275
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	2668275
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	TAS	2668275
GO:0005886	Component	Plasma membrane	TAS	2668275
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006706	Process	Steroid catabolic process	TAS	6957717
GO:0007565	Process	Female pregnancy	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008484	Function	Sulfuric ester hydrolase activity	IDA	15962010
GO:0008544	Process	Epidermis development	TAS	9252398
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	2668275
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	6957717
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
300747	11425	ENSG00000101846

Protein

UniProt ID

P08842

Protein name

Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)

Protein function

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.

PDB

1P49 , 8EG3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00884	Sulfatase	27 → 413	Sulfatase	Family
PF14707	Sulfatase_C	437 → 572		Domain

Sequence

MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

Sequence length

583

Interactions

View interactions

	KEGG		Reactome
	Steroid hormone biosynthesis Metabolic pathways		Glycosphingolipid metabolism The activation of arylsulfatases

STS (steroid sulfatase)