STS (steroid sulfatase)

Gene

• Entrez ID: 412
• Gene name: Steroid sulfatase
• Gene symbol: STS
• Synonyms (NCBI Gene): ARSC, ARSC1, ASC, ES, SSDD, XLI
• Chromosome: X
• Chromosome location: Xp22.31
• Summary: This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cho

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs137853165	T>A	Pathogenic	Coding sequence variant, missense variant
rs137853166	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853167	C>T	Pathogenic	Coding sequence variant, missense variant
rs137853168	G>C	Pathogenic	Coding sequence variant, missense variant
rs137853169	A>G	Pathogenic	Coding sequence variant, missense variant
rs1064795456	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1463414987	G>A,T	Pathogenic	Stop gained, coding sequence variant, missense variant
rs1555956229	G>T	Pathogenic	Stop gained, coding sequence variant
rs1555967260	G>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1601748137	G>T	Pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019334	hsa-miR-148b-3p	Microarray	17612493
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	20371350
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	20371350
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT532547	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	22012620
MIRT462576	hsa-miR-1264	PAR-CLIP	23592263
MIRT462575	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT462574	hsa-miR-4705	PAR-CLIP	23592263
MIRT462573	hsa-miR-3153	PAR-CLIP	23592263
MIRT462572	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462571	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462570	hsa-miR-4271	PAR-CLIP	23592263
MIRT462569	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462568	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462567	hsa-miR-4425	PAR-CLIP	23592263
MIRT462566	hsa-miR-3147	PAR-CLIP	23592263
MIRT462565	hsa-miR-130a-5p	PAR-CLIP	23592263
MIRT462564	hsa-miR-23a-3p	PAR-CLIP	23592263
MIRT462563	hsa-miR-23b-3p	PAR-CLIP	23592263
MIRT462562	hsa-miR-23c	PAR-CLIP	23592263
MIRT462561	hsa-miR-2110	PAR-CLIP	23592263
MIRT462559	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT462560	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT462558	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT462557	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT462556	hsa-miR-6083	PAR-CLIP	23592263
MIRT462555	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT443775	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT443776	hsa-miR-3123	PAR-CLIP	22100165
MIRT443774	hsa-miR-3976	PAR-CLIP	22100165
MIRT443773	hsa-miR-3651	PAR-CLIP	22100165
MIRT443772	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443771	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	20371350
MIRT532547	hsa-miR-545-5p	PAR-CLIP	20371350
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	20371350
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	20371350
MIRT532548	hsa-miR-624-5p	PAR-CLIP	22012620
MIRT532547	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT532546	hsa-miR-6892-3p	PAR-CLIP	22012620
MIRT532545	hsa-miR-7848-3p	PAR-CLIP	22012620
MIRT462576	hsa-miR-1264	PAR-CLIP	23592263
MIRT462575	hsa-miR-3200-5p	PAR-CLIP	23592263
MIRT462574	hsa-miR-4705	PAR-CLIP	23592263
MIRT462573	hsa-miR-3153	PAR-CLIP	23592263
MIRT462572	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT462571	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT462570	hsa-miR-4271	PAR-CLIP	23592263
MIRT462569	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT462568	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT462567	hsa-miR-4425	PAR-CLIP	23592263
MIRT462566	hsa-miR-3147	PAR-CLIP	23592263
MIRT462565	hsa-miR-130a-5p	PAR-CLIP	23592263
MIRT462564	hsa-miR-23a-3p	PAR-CLIP	23592263
MIRT462563	hsa-miR-23b-3p	PAR-CLIP	23592263
MIRT462562	hsa-miR-23c	PAR-CLIP	23592263
MIRT462561	hsa-miR-2110	PAR-CLIP	23592263
MIRT462559	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT462560	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT462558	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT462557	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT462556	hsa-miR-6083	PAR-CLIP	23592263
MIRT462555	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT443775	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT443776	hsa-miR-3123	PAR-CLIP	22100165
MIRT443774	hsa-miR-3976	PAR-CLIP	22100165
MIRT443773	hsa-miR-3651	PAR-CLIP	22100165
MIRT443772	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT443771	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1399857	hsa-miR-1193	CLIP-seq
MIRT1399858	hsa-miR-125a-3p	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT1399860	hsa-miR-145	CLIP-seq
MIRT1399861	hsa-miR-1910	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT1399863	hsa-miR-2355-5p	CLIP-seq
MIRT1399864	hsa-miR-3121-3p	CLIP-seq
MIRT1399865	hsa-miR-3136-3p	CLIP-seq
MIRT1399866	hsa-miR-3150b-3p	CLIP-seq
MIRT1399867	hsa-miR-3154	CLIP-seq
MIRT1399868	hsa-miR-3163	CLIP-seq
MIRT1399869	hsa-miR-3165	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT1399871	hsa-miR-3612	CLIP-seq
MIRT1399872	hsa-miR-3614-3p	CLIP-seq
MIRT1399873	hsa-miR-3662	CLIP-seq
MIRT1399874	hsa-miR-3918	CLIP-seq
MIRT1399875	hsa-miR-3919	CLIP-seq
MIRT1399876	hsa-miR-3929	CLIP-seq
MIRT1399877	hsa-miR-3934	CLIP-seq
MIRT1399878	hsa-miR-4264	CLIP-seq
MIRT1399879	hsa-miR-4293	CLIP-seq
MIRT1399880	hsa-miR-4297	CLIP-seq
MIRT1399881	hsa-miR-4419b	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT1399883	hsa-miR-4434	CLIP-seq
MIRT1399884	hsa-miR-4443	CLIP-seq
MIRT1399885	hsa-miR-4478	CLIP-seq
MIRT1399886	hsa-miR-4516	CLIP-seq
MIRT1399887	hsa-miR-4531	CLIP-seq
MIRT1399888	hsa-miR-455-3p	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT1399892	hsa-miR-4685-5p	CLIP-seq
MIRT1399893	hsa-miR-4689	CLIP-seq
MIRT1399894	hsa-miR-4694-3p	CLIP-seq
MIRT1399895	hsa-miR-4704-3p	CLIP-seq
MIRT1399896	hsa-miR-4717-5p	CLIP-seq
MIRT1399897	hsa-miR-4724-3p	CLIP-seq
MIRT1399898	hsa-miR-4756-3p	CLIP-seq
MIRT1399899	hsa-miR-4784	CLIP-seq
MIRT1399900	hsa-miR-4797-3p	CLIP-seq
MIRT1399901	hsa-miR-485-5p	CLIP-seq
MIRT1399902	hsa-miR-513a-3p	CLIP-seq
MIRT1399903	hsa-miR-645	CLIP-seq
MIRT1399904	hsa-miR-650	CLIP-seq
MIRT1399905	hsa-miR-654-3p	CLIP-seq
MIRT1399906	hsa-miR-659	CLIP-seq
MIRT1399907	hsa-miR-671-5p	CLIP-seq
MIRT1399908	hsa-miR-764	CLIP-seq
MIRT1399909	hsa-miR-942	CLIP-seq
MIRT2119867	hsa-miR-1227	CLIP-seq
MIRT2119868	hsa-miR-185	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT2119869	hsa-miR-2052	CLIP-seq
MIRT2119870	hsa-miR-2277-3p	CLIP-seq
MIRT2119871	hsa-miR-296-3p	CLIP-seq
MIRT2119872	hsa-miR-3132	CLIP-seq
MIRT2119873	hsa-miR-3148	CLIP-seq
MIRT2119874	hsa-miR-3152-5p	CLIP-seq
MIRT2119875	hsa-miR-3189-3p	CLIP-seq
MIRT2119876	hsa-miR-323b-3p	CLIP-seq
MIRT2119877	hsa-miR-3658	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2119879	hsa-miR-3688-3p	CLIP-seq
MIRT2119880	hsa-miR-3692	CLIP-seq
MIRT2119881	hsa-miR-4252	CLIP-seq
MIRT2119882	hsa-miR-4265	CLIP-seq
MIRT2119883	hsa-miR-4296	CLIP-seq
MIRT2119884	hsa-miR-4306	CLIP-seq
MIRT2119885	hsa-miR-4312	CLIP-seq
MIRT2119886	hsa-miR-4322	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT2119887	hsa-miR-4433	CLIP-seq
MIRT2119888	hsa-miR-4459	CLIP-seq
MIRT2119889	hsa-miR-450b-3p	CLIP-seq
MIRT2119890	hsa-miR-4644	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT2119891	hsa-miR-4711-5p	CLIP-seq
MIRT2119892	hsa-miR-4726-3p	CLIP-seq
MIRT2119893	hsa-miR-4768-3p	CLIP-seq
MIRT2119894	hsa-miR-4773	CLIP-seq
MIRT2119895	hsa-miR-4774-3p	CLIP-seq
MIRT2119896	hsa-miR-4795-3p	CLIP-seq
MIRT2119897	hsa-miR-548a-3p	CLIP-seq
MIRT2119898	hsa-miR-548e	CLIP-seq
MIRT2119899	hsa-miR-548f	CLIP-seq
MIRT2119900	hsa-miR-769-3p	CLIP-seq
MIRT2119901	hsa-miR-938	CLIP-seq
MIRT2341933	hsa-miR-103a	CLIP-seq
MIRT2341934	hsa-miR-107	CLIP-seq
MIRT2341935	hsa-miR-1184	CLIP-seq
MIRT1399857	hsa-miR-1193	CLIP-seq
MIRT2341936	hsa-miR-1206	CLIP-seq
MIRT2341937	hsa-miR-1229	CLIP-seq
MIRT2341938	hsa-miR-1238	CLIP-seq
MIRT2341939	hsa-miR-1273e	CLIP-seq
MIRT2341940	hsa-miR-1273f	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT2341941	hsa-miR-137	CLIP-seq
MIRT2341942	hsa-miR-138	CLIP-seq
MIRT2341943	hsa-miR-143	CLIP-seq
MIRT2119868	hsa-miR-185	CLIP-seq
MIRT1399862	hsa-miR-1915	CLIP-seq
MIRT2341944	hsa-miR-2117	CLIP-seq
MIRT2119870	hsa-miR-2277-3p	CLIP-seq
MIRT1399863	hsa-miR-2355-5p	CLIP-seq
MIRT2341945	hsa-miR-2392	CLIP-seq
MIRT2341946	hsa-miR-25	CLIP-seq
MIRT2341947	hsa-miR-3065-5p	CLIP-seq
MIRT2341948	hsa-miR-30a	CLIP-seq
MIRT2341949	hsa-miR-30b	CLIP-seq
MIRT2341950	hsa-miR-30c	CLIP-seq
MIRT2341951	hsa-miR-30d	CLIP-seq
MIRT2341952	hsa-miR-30e	CLIP-seq
MIRT1399864	hsa-miR-3121-3p	CLIP-seq
MIRT2341953	hsa-miR-3124-3p	CLIP-seq
MIRT2341954	hsa-miR-3143	CLIP-seq
MIRT2341955	hsa-miR-3145-5p	CLIP-seq
MIRT2119873	hsa-miR-3148	CLIP-seq
MIRT1399867	hsa-miR-3154	CLIP-seq
MIRT1399869	hsa-miR-3165	CLIP-seq
MIRT2341956	hsa-miR-3182	CLIP-seq
MIRT2341957	hsa-miR-3188	CLIP-seq
MIRT2341958	hsa-miR-32	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT2341959	hsa-miR-33a	CLIP-seq
MIRT2341960	hsa-miR-33b	CLIP-seq
MIRT2341961	hsa-miR-3615	CLIP-seq
MIRT2341962	hsa-miR-363	CLIP-seq
MIRT2341963	hsa-miR-3654	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2341964	hsa-miR-3665	CLIP-seq
MIRT2341965	hsa-miR-367	CLIP-seq
MIRT2341966	hsa-miR-3673	CLIP-seq
MIRT2341967	hsa-miR-3675-5p	CLIP-seq
MIRT2119879	hsa-miR-3688-3p	CLIP-seq
MIRT2341968	hsa-miR-3691-3p	CLIP-seq
MIRT2341969	hsa-miR-3691-5p	CLIP-seq
MIRT2119880	hsa-miR-3692	CLIP-seq
MIRT2341970	hsa-miR-378	CLIP-seq
MIRT2341971	hsa-miR-378b	CLIP-seq
MIRT2341972	hsa-miR-378c	CLIP-seq
MIRT2341973	hsa-miR-378d	CLIP-seq
MIRT2341974	hsa-miR-378e	CLIP-seq
MIRT2341975	hsa-miR-378f	CLIP-seq
MIRT2341976	hsa-miR-378h	CLIP-seq
MIRT2341977	hsa-miR-378i	CLIP-seq
MIRT2341978	hsa-miR-3920	CLIP-seq
MIRT2341979	hsa-miR-3921	CLIP-seq
MIRT2341980	hsa-miR-3941	CLIP-seq
MIRT2341981	hsa-miR-3942-3p	CLIP-seq
MIRT2341982	hsa-miR-422a	CLIP-seq
MIRT2341983	hsa-miR-4266	CLIP-seq
MIRT2341984	hsa-miR-4273	CLIP-seq
MIRT2119884	hsa-miR-4306	CLIP-seq
MIRT2341985	hsa-miR-4310	CLIP-seq
MIRT1399882	hsa-miR-4427	CLIP-seq
MIRT2119887	hsa-miR-4433	CLIP-seq
MIRT2341986	hsa-miR-4450	CLIP-seq
MIRT2119888	hsa-miR-4459	CLIP-seq
MIRT2341987	hsa-miR-4463	CLIP-seq
MIRT2341988	hsa-miR-4464	CLIP-seq
MIRT2341989	hsa-miR-4477a	CLIP-seq
MIRT2341990	hsa-miR-4502	CLIP-seq
MIRT2341991	hsa-miR-4503	CLIP-seq
MIRT2341992	hsa-miR-4525	CLIP-seq
MIRT2119890	hsa-miR-4644	CLIP-seq
MIRT2341993	hsa-miR-4653-5p	CLIP-seq
MIRT1399889	hsa-miR-4659a-3p	CLIP-seq
MIRT1399890	hsa-miR-4659b-3p	CLIP-seq
MIRT2341994	hsa-miR-466	CLIP-seq
MIRT2341995	hsa-miR-4667-5p	CLIP-seq
MIRT2341996	hsa-miR-4672	CLIP-seq
MIRT1399891	hsa-miR-4680-3p	CLIP-seq
MIRT1399894	hsa-miR-4694-3p	CLIP-seq
MIRT2341997	hsa-miR-4695-5p	CLIP-seq
MIRT2341998	hsa-miR-4700-5p	CLIP-seq
MIRT2341999	hsa-miR-4708-5p	CLIP-seq
MIRT2119891	hsa-miR-4711-5p	CLIP-seq
MIRT2342000	hsa-miR-4728-3p	CLIP-seq
MIRT2342001	hsa-miR-4731-3p	CLIP-seq
MIRT2342002	hsa-miR-4748	CLIP-seq
MIRT2342003	hsa-miR-4762-3p	CLIP-seq
MIRT2119893	hsa-miR-4768-3p	CLIP-seq
MIRT2342004	hsa-miR-4768-5p	CLIP-seq
MIRT2342005	hsa-miR-4770	CLIP-seq
MIRT2342006	hsa-miR-4772-3p	CLIP-seq
MIRT2342007	hsa-miR-4776-3p	CLIP-seq
MIRT2342008	hsa-miR-4779	CLIP-seq
MIRT2119896	hsa-miR-4795-3p	CLIP-seq
MIRT2342009	hsa-miR-4801	CLIP-seq
MIRT2342010	hsa-miR-483-3p	CLIP-seq
MIRT2342011	hsa-miR-495	CLIP-seq
MIRT2342012	hsa-miR-500a	CLIP-seq
MIRT2342013	hsa-miR-512-5p	CLIP-seq
MIRT2342014	hsa-miR-532-5p	CLIP-seq
MIRT2119897	hsa-miR-548a-3p	CLIP-seq
MIRT2119898	hsa-miR-548e	CLIP-seq
MIRT2119899	hsa-miR-548f	CLIP-seq
MIRT2342015	hsa-miR-550b	CLIP-seq
MIRT2342016	hsa-miR-577	CLIP-seq
MIRT2342017	hsa-miR-579	CLIP-seq
MIRT2342018	hsa-miR-587	CLIP-seq
MIRT2342019	hsa-miR-596	CLIP-seq
MIRT2342020	hsa-miR-600	CLIP-seq
MIRT2342021	hsa-miR-885-3p	CLIP-seq
MIRT2342022	hsa-miR-92a	CLIP-seq
MIRT2342023	hsa-miR-92b	CLIP-seq
MIRT2119901	hsa-miR-938	CLIP-seq
MIRT1399909	hsa-miR-942	CLIP-seq
MIRT2342024	hsa-miR-943	CLIP-seq
MIRT2341933	hsa-miR-103a	CLIP-seq
MIRT2341934	hsa-miR-107	CLIP-seq
MIRT2341935	hsa-miR-1184	CLIP-seq
MIRT2119878	hsa-miR-3664-3p	CLIP-seq
MIRT2341985	hsa-miR-4310	CLIP-seq
MIRT1399859	hsa-miR-1324	CLIP-seq
MIRT1399870	hsa-miR-323-5p	CLIP-seq
MIRT2692321	hsa-miR-128	CLIP-seq
MIRT2692322	hsa-miR-1322	CLIP-seq
MIRT2692323	hsa-miR-140-3p	CLIP-seq
MIRT2692324	hsa-miR-203	CLIP-seq
MIRT2692325	hsa-miR-3119	CLIP-seq
MIRT2692326	hsa-miR-3611	CLIP-seq
MIRT2692327	hsa-miR-3924	CLIP-seq
MIRT2692328	hsa-miR-4417	CLIP-seq
MIRT2692329	hsa-miR-4720-3p	CLIP-seq
MIRT2692330	hsa-miR-4760-3p	CLIP-seq
MIRT2692331	hsa-miR-4804-3p	CLIP-seq
MIRT2692332	hsa-miR-598	CLIP-seq
MIRT2692333	hsa-miR-7	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
STAT3	Activation	21331591

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004065	Function	Arylsulfatase activity	IBA
GO:0004773	Function	Steryl-sulfatase activity	IEA
GO:0004773	Function	Steryl-sulfatase activity	TAS	2668275
GO:0005764	Component	Lysosome	TAS	2668275
GO:0005768	Component	Endosome	TAS	2668275
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	2668275
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	TAS	2668275
GO:0005886	Component	Plasma membrane	TAS	2668275
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006706	Process	Steroid catabolic process	TAS	6957717
GO:0007565	Process	Female pregnancy	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008484	Function	Sulfuric ester hydrolase activity	IDA	15962010
GO:0008544	Process	Epidermis development	TAS	9252398
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	2668275
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	TAS	6957717
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 300747
• HGNC: 11425
• e!Ensembl: ENSG00000101846

Protein

• UniProt ID: P08842
• Protein name: Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)
• Protein function: Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
• PDB: 1P49, 8EG3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00884	Sulfatase	27 → 413	Sulfatase	Family
  PF14707	Sulfatase_C	437 → 572		Domain

• Sequence:

  MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
  GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
  LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
  GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
  NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
  GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
  NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
  IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
  CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
  LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

• Sequence length: 583

Pathways

KEGG:

Steroid hormone biosynthesis
Metabolic pathways

Reactome:

Glycosphingolipid metabolism
The activation of arylsulfatases

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
STS-related disorder	Likely pathogenic	rs2518726328	RCV003408763
X-linked ichthyosis with steryl-sulfatase deficiency	Likely pathogenic; Pathogenic	rs2147089236, rs1927377513, rs137853165, rs137853166, rs137853169, rs1601748137, rs2518683298, rs1463414987	RCV001783828 RCV002466828 RCV000011298 RCV000011299 RCV000011302 RCV000011303 RCV005220747 RCV000853199

Associations from Text Mining
Disease Name	Relationship Type	References
Acute On Chronic Liver Failure	Associate	34551597
Atherosclerosis	Associate	14507642
Attention Deficit Disorder with Hyperactivity	Associate	20862695, 21255266, 28367959
Auditory Perceptual Disorders	Associate	21255266
Breast Neoplasms	Associate	10574257, 12657638, 17214375, 29563635
Carcinoma Ovarian Epithelial	Associate	34321053
Corneal Dystrophies Hereditary	Associate	28302098
Endometriosis	Associate	16084891
Ichthyosis X Linked	Associate	17468528, 17657246, 26676689, 27711218, 28302098, 31944387, 32005174, 40157041, 9242515
Ichthyosis X Linked	Inhibit	2813406, 30768640, 34675221
Kidney Failure Chronic	Associate	35715831
Multiple Sulfatase Deficiency Disease	Inhibit	6108562
Osteoglophonic dwarfism	Associate	35403328
Ovarian Neoplasms	Associate	15302278
Prostatic Neoplasms	Associate	32928794