Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
412
Gene name Gene Name - the full gene name approved by the HGNC.
Steroid sulfatase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STS
Synonyms (NCBI Gene) Gene synonyms aliases
ARSC, ARSC1, ASC, ES, SSDD, XLI
Disease Acronyms (UniProt) Disease acronyms from UniProt database
ES
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp22.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cho
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs137853165 T>A Pathogenic Coding sequence variant, missense variant
rs137853166 G>A Pathogenic Coding sequence variant, missense variant
rs137853167 C>T Pathogenic Coding sequence variant, missense variant
rs137853168 G>C Pathogenic Coding sequence variant, missense variant
rs137853169 A>G Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019334 hsa-miR-148b-3p Microarray 17612493
MIRT532547 hsa-miR-545-5p PAR-CLIP 20371350
MIRT532548 hsa-miR-624-5p PAR-CLIP 20371350
MIRT532547 hsa-miR-545-5p PAR-CLIP 20371350
MIRT532546 hsa-miR-6892-3p PAR-CLIP 20371350
Transcription factors
Transcription factor Regulation Reference
STAT3 Activation 21331591
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004065 Function Arylsulfatase activity IBA 21873635
GO:0004773 Function Steryl-sulfatase activity IEA
GO:0005764 Component Lysosome TAS 2668275
GO:0005768 Component Endosome TAS 2668275
GO:0005783 Component Endoplasmic reticulum TAS 2668275
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300747 11425 ENSG00000101846
Protein
UniProt ID P08842
Protein name Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Estrone sulfatase) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)
Protein function Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
PDB 1P49 , 8EG3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00884 Sulfatase 27 413 Sulfatase Family
PF14707 Sulfatase_C 437 572 Domain
Sequence
Sequence length 583
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Steroid hormone biosynthesis
Metabolic pathways
  Glycosphingolipid metabolism
The activation of arylsulfatases
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Attention deficit hyperactivity disorder Attention Deficit Disorder, Attention deficit hyperactivity disorder rs786205019 18413370
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
22532847
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Associations from Text Mining
Disease Name Relationship Type References
Acute On Chronic Liver Failure Associate 34551597
Atherosclerosis Associate 14507642
Attention Deficit Disorder with Hyperactivity Associate 20862695, 21255266, 28367959
Auditory Perceptual Disorders Associate 21255266
Breast Neoplasms Associate 10574257, 12657638, 17214375, 29563635
Carcinoma Ovarian Epithelial Associate 34321053
Corneal Dystrophies Hereditary Associate 28302098
Endometriosis Associate 16084891
Ichthyosis X Linked Associate 17468528, 17657246, 26676689, 27711218, 28302098, 31944387, 32005174, 40157041, 9242515
Ichthyosis X Linked Inhibit 2813406, 30768640, 34675221