MAGEA6 (MAGE family member A6)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein
Entrez ID 4105
Gene name MAGE family member A6
Gene symbol MAGEA6
Synonyms (NCBI Gene)
CT1.6MAGE-3bMAGE3BMAGE6
Chromosome X
Chromosome location Xq28
Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of thi
miRNA miRNA information provided by mirtarbase database.
11
Gene miRNA Gene ontology Other IDs Protein
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miRTarBase ID miRNA Experiments Reference
MIRT004110 hsa-miR-34a-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 21177782
MIRT004110 hsa-miR-34a-5p ImmunocytochemistryLuciferase reporter assayqRT-PCRWestern blot 21177782
MIRT027491 hsa-miR-98-5p Microarray 19088304
MIRT027491 hsa-miR-98-5p PAR-CLIP 27292025
MIRT027491 hsa-miR-98-5p PAR-CLIP 27292025
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
Gene miRNA Gene ontology Other IDs Protein
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0005515 Function Protein binding IPI 20864041, 21516116, 25416956, 25910212, 26871637, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IBA
GO:0010507 Process Negative regulation of autophagy IDA 31267705
GO:0042826 Function Histone deacetylase binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
300176 6804 ENSG00000197172
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43360
Protein name Melanoma-associated antigen 6 (Cancer/testis antigen 1.6) (CT1.6) (MAGE-6 antigen) (MAGE3B antigen)
Protein function Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:17942928, PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 an
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12440 MAGE_N 5 → 96 Melanoma associated antigen family N terminal Family
PF01454 MAGE 185 → 283 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Sequence
Sequence length 314
Interactions View interactions