MAGEA4 (MAGE family member A4)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein
Entrez ID 4103
Gene name MAGE family member A4
Gene symbol MAGEA4
Synonyms (NCBI Gene)
CT1.4MAGE-41MAGE-X2MAGE4MAGE4AMAGE4B
Chromosome X
Chromosome location Xq28
Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of thi
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Gene ontology Other IDs Protein
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miRTarBase ID miRNA Experiments Reference
MIRT1125608 hsa-miR-2861 CLIP-seq
MIRT1125609 hsa-miR-3120-3p CLIP-seq
MIRT1125610 hsa-miR-3185 CLIP-seq
MIRT1125611 hsa-miR-3942-5p CLIP-seq
MIRT1125612 hsa-miR-4703-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Gene ontology Other IDs Protein
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0005515 Function Protein binding IPI 12525503, 14739298, 16189514, 21044950, 21516116, 28514442, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0042826 Function Histone deacetylase binding IBA
GO:0043066 Process Negative regulation of apoptotic process IMP 22842486
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
300175 6802 ENSG00000147381
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P43358
Protein name Melanoma-associated antigen 4 (Cancer/testis antigen 1.4) (CT1.4) (MAGE-4 antigen) (MAGE-41 antigen) (MAGE-X2 antigen)
Protein function Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486).
PDB 1I4F , 2WA0 , 6TRN , 6TRO , 7UOA , 8ES8 , 8ES9 , 8FJA , 9BD3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12440 MAGE_N 5 → 97 Melanoma associated antigen family N terminal Family
PF01454 MAGE 171 → 284 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
Sequence
Sequence length 317
Interactions View interactions