MAGEA3 (MAGE family member A3)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4102
Gene name Gene Name - the full gene name approved by the HGNC.
MAGE family member A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAGEA3
Synonyms (NCBI Gene) Gene synonyms aliases
CT1.3, HIP8, HYPD, MAGE3, MAGEA6
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of thi
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT004111 hsa-miR-34a-5p Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot 21177782
MIRT004111 hsa-miR-34a-5p Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot 21177782
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(6)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20864041, 21277283, 32296183, 32814053
GO:0005783 Component Endoplasmic reticulum IDA 12097332
GO:0010955 Process Negative regulation of protein processing IDA 12097332
GO:0043154 Process Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 12097332
GO:0089720 Function Caspase binding IDA 12097332
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
300174 6801 ENSG00000221867
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID P43357
Protein name Melanoma-associated antigen 3 (Antigen MZ2-D) (Cancer/testis antigen 1.3) (CT1.3) (MAGE-3 antigen)
Protein function Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/T
PDB 1QEW , 4V0P , 5BRZ , 8T9A , 9BD2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12440 MAGE_N 5 → 96 Melanoma associated antigen family N terminal Family
PF01454 MAGE 186 → 283 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukem
Sequence
Sequence length 314
Interactions View interactions