MAGEA1 (MAGE family member A1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4100
Gene name Gene Name - the full gene name approved by the HGNC.
MAGE family member A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MAGEA1
Synonyms (NCBI Gene) Gene synonyms aliases
CT1.1, MAGE1
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of thi
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT2265993 hsa-miR-141 CLIP-seq
MIRT2265994 hsa-miR-146a CLIP-seq
MIRT2265995 hsa-miR-146b-5p CLIP-seq
MIRT2265996 hsa-miR-200a CLIP-seq
MIRT2265997 hsa-miR-4251 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15316101
GO:0005515 Function Protein binding IPI 15316101, 16189514, 21364888, 25416956, 25910212, 27107012, 30886144, 32296183
GO:0005634 Component Nucleus IDA 15316101
GO:0005737 Component Cytoplasm IDA 15316101
GO:0005886 Component Plasma membrane TAS 1840703
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
300016 6796 ENSG00000198681
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID P43355
Protein name Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)
Protein function May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformatio
PDB 1W72 , 3BO8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12440 MAGE_N 5 → 89 Melanoma associated antigen family N terminal Family
PF01454 MAGE 109 → 276 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymph
Sequence
Sequence length 309
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)		 26640592
Show/Hide Text Mining Associations (30)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 24633336
Arthritis Rheumatoid Stimulate 33088399
Astrocytoma Associate 15367334
Breast Neoplasms Associate 15365776, 21495200, 26510686, 30498011
Carcinoma Hepatocellular Associate 15237429, 15633217, 15661935, 24002931, 32941982, 36211805
Carcinoma Ovarian Epithelial Associate 25101620
Carcinoma Renal Cell Associate 25120790
Cholestasis Intrahepatic Associate 21211023
Colorectal Neoplasms Associate 15756003, 17007017, 33203797
Esophageal Neoplasms Associate 11223546