MAGEA1 (MAGE family member A1)

Gene

• Entrez ID: 4100
• Gene name: MAGE family member A1
• Gene symbol: MAGEA1
• Synonyms (NCBI Gene): CT1.1, MAGE1
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of thi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2265993	hsa-miR-141	CLIP-seq
MIRT2265994	hsa-miR-146a	CLIP-seq
MIRT2265995	hsa-miR-146b-5p	CLIP-seq
MIRT2265996	hsa-miR-200a	CLIP-seq
MIRT2265997	hsa-miR-4251	CLIP-seq
MIRT2265998	hsa-miR-589	CLIP-seq
MIRT2565294	hsa-miR-3168	CLIP-seq
MIRT2565294	hsa-miR-3168	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	15316101
GO:0005515	Function	Protein binding	IPI	15316101, 16189514, 21364888, 25416956, 25910212, 27107012, 30886144, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15316101
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	15316101
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS	1840703
GO:0042826	Function	Histone deacetylase binding	IBA
GO:0042826	Function	Histone deacetylase binding	IDA	15316101
GO:0045746	Process	Negative regulation of Notch signaling pathway	IDA	15316101

Other IDs

• MIM: 300016
• HGNC: 6796
• e!Ensembl: ENSG00000198681

Protein

• UniProt ID: P43355
• Protein name: Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen)
• Protein function: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformatio
• PDB: 1W72, 3BO8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12440	MAGE_N	5 → 89	Melanoma associated antigen family N terminal	Family
  PF01454	MAGE	109 → 276	MAGE family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymph
• Sequence:

  MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQG
  ASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAR
  EPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYD
  GLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLT
  QDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREA
  ALREEEEGV

• Sequence length: 309