Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4093
Gene name Gene Name - the full gene name approved by the HGNC.	SMAD family member 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SMAD9
Synonyms (NCBI Gene) Gene synonyms aliases	MADH6, MADH9, PPH2, SMAD8, SMAD8/9, SMAD8A, SMAD8B
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different is

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SNP ID	Visualize variation	Clinical significance	Consequence
rs78249575	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs121918359	G>A,T	Pathogenic	Intron variant, stop gained, synonymous variant, coding sequence variant
rs146583835	G>A,T	Likely-pathogenic	Stop gained, coding sequence variant, synonymous variant
rs397514715	T>C	Pathogenic	Coding sequence variant, missense variant
rs397514716	G>A	Pathogenic	Stop gained, coding sequence variant

Show/Hide all(494)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020446	hsa-miR-106b-5p	Microarray	17242205
MIRT053445	hsa-miR-203a-3p	Microarray	23807165
MIRT550327	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT550326	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT550325	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT550324	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT550323	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT550322	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550321	hsa-miR-5585-3p	HITS-CLIP	21572407
MIRT550320	hsa-miR-653-5p	HITS-CLIP	21572407
MIRT550319	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT625504	hsa-miR-606	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625502	hsa-miR-890	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT625504	hsa-miR-606	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625502	hsa-miR-890	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT550327	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT550326	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550325	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT550324	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT550323	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT550322	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT550321	hsa-miR-5585-3p	PAR-CLIP	21572407
MIRT550320	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT550319	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT732816	hsa-miR-100-5p	Luciferase reporter assay, RNA-seq, qRT-PCR, Western blotting	34256859
MIRT053445	hsa-miR-203a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	31788111
MIRT550327	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT550326	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT550325	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT550324	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT550323	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT550322	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT550321	hsa-miR-5585-3p	HITS-CLIP	21572407
MIRT550320	hsa-miR-653-5p	HITS-CLIP	21572407
MIRT550319	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT625504	hsa-miR-606	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625502	hsa-miR-890	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT625504	hsa-miR-606	HITS-CLIP	23824327
MIRT625503	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT625502	hsa-miR-890	HITS-CLIP	23824327
MIRT625501	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT625500	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT625499	hsa-miR-940	HITS-CLIP	23824327
MIRT625498	hsa-miR-3929	HITS-CLIP	23824327
MIRT625497	hsa-miR-4419b	HITS-CLIP	23824327
MIRT625496	hsa-miR-4478	HITS-CLIP	23824327
MIRT625495	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT625494	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT625493	hsa-miR-1827	HITS-CLIP	23824327
MIRT625492	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT625491	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT625490	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT625489	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT625488	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT625487	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT625486	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT625485	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT625484	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT625483	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT625482	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT625481	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT625480	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT625479	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT625478	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT625477	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT625476	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT625475	hsa-miR-3689c	HITS-CLIP	23824327
MIRT625474	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT625473	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT625472	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT625471	hsa-miR-665	HITS-CLIP	23824327
MIRT550327	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT550326	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT550325	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT550324	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT550323	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT550322	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT550321	hsa-miR-5585-3p	PAR-CLIP	21572407
MIRT550320	hsa-miR-653-5p	PAR-CLIP	21572407
MIRT550319	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT1371190	hsa-miR-1179	CLIP-seq
MIRT1371191	hsa-miR-1268	CLIP-seq
MIRT1371192	hsa-miR-1268b	CLIP-seq
MIRT1371193	hsa-miR-24	CLIP-seq
MIRT1371194	hsa-miR-2467-3p	CLIP-seq
MIRT1371195	hsa-miR-298	CLIP-seq
MIRT1371196	hsa-miR-3125	CLIP-seq
MIRT1371197	hsa-miR-3163	CLIP-seq
MIRT1371198	hsa-miR-3197	CLIP-seq
MIRT1371199	hsa-miR-335	CLIP-seq
MIRT1371200	hsa-miR-34b	CLIP-seq
MIRT1371201	hsa-miR-3612	CLIP-seq
MIRT1371202	hsa-miR-3678-3p	CLIP-seq
MIRT1371203	hsa-miR-3916	CLIP-seq
MIRT1371204	hsa-miR-3974	CLIP-seq
MIRT1371205	hsa-miR-4257	CLIP-seq
MIRT1371206	hsa-miR-4284	CLIP-seq
MIRT1371207	hsa-miR-4457	CLIP-seq
MIRT1371208	hsa-miR-4486	CLIP-seq
MIRT1371209	hsa-miR-4536	CLIP-seq
MIRT1371210	hsa-miR-4684-5p	CLIP-seq
MIRT1371211	hsa-miR-4767	CLIP-seq
MIRT1371212	hsa-miR-4802-3p	CLIP-seq
MIRT1371213	hsa-miR-513b	CLIP-seq
MIRT1371214	hsa-miR-548c-3p	CLIP-seq
MIRT1371215	hsa-miR-548n	CLIP-seq
MIRT1371216	hsa-miR-562	CLIP-seq
MIRT1371217	hsa-miR-585	CLIP-seq
MIRT1371218	hsa-miR-624	CLIP-seq
MIRT1371219	hsa-miR-650	CLIP-seq
MIRT1371220	hsa-miR-653	CLIP-seq
MIRT1371221	hsa-miR-671-5p	CLIP-seq
MIRT1371222	hsa-miR-7	CLIP-seq
MIRT1371223	hsa-miR-181a	CLIP-seq
MIRT1371224	hsa-miR-181b	CLIP-seq
MIRT1371225	hsa-miR-181c	CLIP-seq
MIRT1371226	hsa-miR-181d	CLIP-seq
MIRT1371227	hsa-miR-3122	CLIP-seq
MIRT739579	hsa-miR-3148	CLIP-seq
MIRT1371228	hsa-miR-3176	CLIP-seq
MIRT1371198	hsa-miR-3197	CLIP-seq
MIRT1371199	hsa-miR-335	CLIP-seq
MIRT1371229	hsa-miR-3913-5p	CLIP-seq
MIRT1371230	hsa-miR-3922-3p	CLIP-seq
MIRT1371231	hsa-miR-3924	CLIP-seq
MIRT1371232	hsa-miR-3941	CLIP-seq
MIRT1371204	hsa-miR-3974	CLIP-seq
MIRT739580	hsa-miR-3978	CLIP-seq
MIRT1371233	hsa-miR-4252	CLIP-seq
MIRT1371234	hsa-miR-4262	CLIP-seq
MIRT739583	hsa-miR-4434	CLIP-seq
MIRT1371207	hsa-miR-4457	CLIP-seq
MIRT739584	hsa-miR-4516	CLIP-seq
MIRT739582	hsa-miR-4531	CLIP-seq
MIRT1371235	hsa-miR-4643	CLIP-seq
MIRT1371236	hsa-miR-466	CLIP-seq
MIRT1371237	hsa-miR-4672	CLIP-seq
MIRT1371238	hsa-miR-4699-3p	CLIP-seq
MIRT1371211	hsa-miR-4767	CLIP-seq
MIRT1371239	hsa-miR-4789-3p	CLIP-seq
MIRT1371240	hsa-miR-4793-3p	CLIP-seq
MIRT1371213	hsa-miR-513b	CLIP-seq
MIRT739578	hsa-miR-570	CLIP-seq
MIRT1371218	hsa-miR-624	CLIP-seq
MIRT739581	hsa-miR-944	CLIP-seq
MIRT1371193	hsa-miR-24	CLIP-seq
MIRT1371200	hsa-miR-34b	CLIP-seq
MIRT1371206	hsa-miR-4284	CLIP-seq
MIRT1371194	hsa-miR-2467-3p	CLIP-seq
MIRT2333708	hsa-miR-25	CLIP-seq
MIRT2333709	hsa-miR-3140-3p	CLIP-seq
MIRT1371228	hsa-miR-3176	CLIP-seq
MIRT2333710	hsa-miR-32	CLIP-seq
MIRT1371201	hsa-miR-3612	CLIP-seq
MIRT2333711	hsa-miR-363	CLIP-seq
MIRT2333712	hsa-miR-367	CLIP-seq
MIRT2333713	hsa-miR-370	CLIP-seq
MIRT1371230	hsa-miR-3922-3p	CLIP-seq
MIRT1371233	hsa-miR-4252	CLIP-seq
MIRT1371205	hsa-miR-4257	CLIP-seq
MIRT2333714	hsa-miR-4299	CLIP-seq
MIRT2333715	hsa-miR-4325	CLIP-seq
MIRT2333716	hsa-miR-4705	CLIP-seq
MIRT2333717	hsa-miR-4729	CLIP-seq
MIRT1371240	hsa-miR-4793-3p	CLIP-seq
MIRT2333718	hsa-miR-556-5p	CLIP-seq
MIRT1371219	hsa-miR-650	CLIP-seq
MIRT2333719	hsa-miR-92a	CLIP-seq
MIRT2333720	hsa-miR-92b	CLIP-seq
MIRT2394849	hsa-miR-1245	CLIP-seq
MIRT2394850	hsa-miR-3591-5p	CLIP-seq
MIRT1371191	hsa-miR-1268	CLIP-seq
MIRT1371192	hsa-miR-1268b	CLIP-seq
MIRT1371197	hsa-miR-3163	CLIP-seq
MIRT1371208	hsa-miR-4486	CLIP-seq
MIRT1371210	hsa-miR-4684-5p	CLIP-seq
MIRT1371214	hsa-miR-548c-3p	CLIP-seq
MIRT1371217	hsa-miR-585	CLIP-seq
MIRT2627883	hsa-miR-106a	CLIP-seq
MIRT2627884	hsa-miR-106b	CLIP-seq
MIRT2627885	hsa-miR-1245b-3p	CLIP-seq
MIRT1371191	hsa-miR-1268	CLIP-seq
MIRT1371192	hsa-miR-1268b	CLIP-seq
MIRT2627886	hsa-miR-149	CLIP-seq
MIRT2627887	hsa-miR-150	CLIP-seq
MIRT2627888	hsa-miR-17	CLIP-seq
MIRT2627889	hsa-miR-20a	CLIP-seq
MIRT2627890	hsa-miR-20b	CLIP-seq
MIRT2627891	hsa-miR-2114	CLIP-seq
MIRT1371193	hsa-miR-24	CLIP-seq
MIRT1371194	hsa-miR-2467-3p	CLIP-seq
MIRT2627892	hsa-miR-3064-5p	CLIP-seq
MIRT1371227	hsa-miR-3122	CLIP-seq
MIRT1371197	hsa-miR-3163	CLIP-seq
MIRT2627893	hsa-miR-3190	CLIP-seq
MIRT1371198	hsa-miR-3197	CLIP-seq
MIRT2627894	hsa-miR-320a	CLIP-seq
MIRT2627895	hsa-miR-320b	CLIP-seq
MIRT2627896	hsa-miR-320c	CLIP-seq
MIRT2627897	hsa-miR-320d	CLIP-seq
MIRT2627898	hsa-miR-330-3p	CLIP-seq
MIRT1371199	hsa-miR-335	CLIP-seq
MIRT1371200	hsa-miR-34b	CLIP-seq
MIRT1371201	hsa-miR-3612	CLIP-seq
MIRT2627899	hsa-miR-3663-5p	CLIP-seq
MIRT2627900	hsa-miR-3913-3p	CLIP-seq
MIRT1371229	hsa-miR-3913-5p	CLIP-seq
MIRT2627901	hsa-miR-3914	CLIP-seq
MIRT1371204	hsa-miR-3974	CLIP-seq
MIRT2627902	hsa-miR-3976	CLIP-seq
MIRT739580	hsa-miR-3978	CLIP-seq
MIRT1371205	hsa-miR-4257	CLIP-seq
MIRT2627903	hsa-miR-4258	CLIP-seq
MIRT2627904	hsa-miR-4279	CLIP-seq
MIRT2627905	hsa-miR-4293	CLIP-seq
MIRT2333714	hsa-miR-4299	CLIP-seq
MIRT2627906	hsa-miR-4330	CLIP-seq
MIRT2627907	hsa-miR-4429	CLIP-seq
MIRT2627908	hsa-miR-4437	CLIP-seq
MIRT1371207	hsa-miR-4457	CLIP-seq
MIRT2627909	hsa-miR-4462	CLIP-seq
MIRT1371208	hsa-miR-4486	CLIP-seq
MIRT1371209	hsa-miR-4536	CLIP-seq
MIRT2627910	hsa-miR-4674	CLIP-seq
MIRT1371210	hsa-miR-4684-5p	CLIP-seq
MIRT2627911	hsa-miR-4757-5p	CLIP-seq
MIRT1371211	hsa-miR-4767	CLIP-seq
MIRT2627912	hsa-miR-4786-5p	CLIP-seq
MIRT2627913	hsa-miR-4794	CLIP-seq
MIRT2627914	hsa-miR-489	CLIP-seq
MIRT2627915	hsa-miR-490-3p	CLIP-seq
MIRT2627916	hsa-miR-495	CLIP-seq
MIRT2627917	hsa-miR-5096	CLIP-seq
MIRT1371213	hsa-miR-513b	CLIP-seq
MIRT2627918	hsa-miR-519d	CLIP-seq
MIRT2627919	hsa-miR-520g	CLIP-seq
MIRT2627920	hsa-miR-520h	CLIP-seq
MIRT1371214	hsa-miR-548c-3p	CLIP-seq
MIRT1371217	hsa-miR-585	CLIP-seq
MIRT2627921	hsa-miR-596	CLIP-seq
MIRT1371218	hsa-miR-624	CLIP-seq
MIRT2627922	hsa-miR-634	CLIP-seq
MIRT1371219	hsa-miR-650	CLIP-seq
MIRT2627923	hsa-miR-873	CLIP-seq
MIRT2627924	hsa-miR-93	CLIP-seq
MIRT2627883	hsa-miR-106a	CLIP-seq
MIRT2627884	hsa-miR-106b	CLIP-seq
MIRT2691369	hsa-miR-1205	CLIP-seq
MIRT2691370	hsa-miR-1238	CLIP-seq
MIRT2627885	hsa-miR-1245b-3p	CLIP-seq
MIRT2691371	hsa-miR-1267	CLIP-seq
MIRT1371191	hsa-miR-1268	CLIP-seq
MIRT1371192	hsa-miR-1268b	CLIP-seq
MIRT2691372	hsa-miR-1281	CLIP-seq
MIRT2627886	hsa-miR-149	CLIP-seq
MIRT2627887	hsa-miR-150	CLIP-seq
MIRT2627888	hsa-miR-17	CLIP-seq
MIRT2691373	hsa-miR-188-3p	CLIP-seq
MIRT2691374	hsa-miR-1909	CLIP-seq
MIRT2691375	hsa-miR-200b	CLIP-seq
MIRT2691376	hsa-miR-200c	CLIP-seq
MIRT2627889	hsa-miR-20a	CLIP-seq
MIRT2627890	hsa-miR-20b	CLIP-seq
MIRT2627891	hsa-miR-2114	CLIP-seq
MIRT1371193	hsa-miR-24	CLIP-seq
MIRT2691377	hsa-miR-302a	CLIP-seq
MIRT2691378	hsa-miR-302b	CLIP-seq
MIRT2691379	hsa-miR-302c	CLIP-seq
MIRT2691380	hsa-miR-302d	CLIP-seq
MIRT2691381	hsa-miR-302e	CLIP-seq
MIRT2627892	hsa-miR-3064-5p	CLIP-seq
MIRT1371227	hsa-miR-3122	CLIP-seq
MIRT1371197	hsa-miR-3163	CLIP-seq
MIRT1371198	hsa-miR-3197	CLIP-seq
MIRT2627894	hsa-miR-320a	CLIP-seq
MIRT2627895	hsa-miR-320b	CLIP-seq
MIRT2627896	hsa-miR-320c	CLIP-seq
MIRT2627897	hsa-miR-320d	CLIP-seq
MIRT2627898	hsa-miR-330-3p	CLIP-seq
MIRT1371199	hsa-miR-335	CLIP-seq
MIRT2691382	hsa-miR-338-5p	CLIP-seq
MIRT2691383	hsa-miR-3591-3p	CLIP-seq
MIRT2691384	hsa-miR-3647-3p	CLIP-seq
MIRT2691385	hsa-miR-3671	CLIP-seq
MIRT2691386	hsa-miR-372	CLIP-seq
MIRT2691387	hsa-miR-373	CLIP-seq
MIRT2627900	hsa-miR-3913-3p	CLIP-seq
MIRT1371229	hsa-miR-3913-5p	CLIP-seq
MIRT2691388	hsa-miR-3942-3p	CLIP-seq
MIRT1371204	hsa-miR-3974	CLIP-seq
MIRT2627902	hsa-miR-3976	CLIP-seq
MIRT2627903	hsa-miR-4258	CLIP-seq
MIRT2691389	hsa-miR-4269	CLIP-seq
MIRT2691390	hsa-miR-429	CLIP-seq
MIRT2627905	hsa-miR-4293	CLIP-seq
MIRT2627906	hsa-miR-4330	CLIP-seq
MIRT2691391	hsa-miR-4420	CLIP-seq
MIRT2627907	hsa-miR-4429	CLIP-seq
MIRT2627908	hsa-miR-4437	CLIP-seq
MIRT1371207	hsa-miR-4457	CLIP-seq
MIRT1371208	hsa-miR-4486	CLIP-seq
MIRT2691392	hsa-miR-452	CLIP-seq
MIRT1371209	hsa-miR-4536	CLIP-seq
MIRT2627910	hsa-miR-4674	CLIP-seq
MIRT2691393	hsa-miR-4676-3p	CLIP-seq
MIRT1371210	hsa-miR-4684-5p	CLIP-seq
MIRT2691394	hsa-miR-4686	CLIP-seq
MIRT2691395	hsa-miR-4691-5p	CLIP-seq
MIRT2627911	hsa-miR-4757-5p	CLIP-seq
MIRT1371211	hsa-miR-4767	CLIP-seq
MIRT2627912	hsa-miR-4786-5p	CLIP-seq
MIRT2627913	hsa-miR-4794	CLIP-seq
MIRT2627914	hsa-miR-489	CLIP-seq
MIRT2627916	hsa-miR-495	CLIP-seq
MIRT2627917	hsa-miR-5096	CLIP-seq
MIRT2691396	hsa-miR-512-3p	CLIP-seq
MIRT1371213	hsa-miR-513b	CLIP-seq
MIRT2691397	hsa-miR-513c	CLIP-seq
MIRT2691398	hsa-miR-514b-5p	CLIP-seq
MIRT2627918	hsa-miR-519d	CLIP-seq
MIRT2691399	hsa-miR-520a-3p	CLIP-seq
MIRT2691400	hsa-miR-520b	CLIP-seq
MIRT2691401	hsa-miR-520c-3p	CLIP-seq
MIRT2691402	hsa-miR-520d-3p	CLIP-seq
MIRT2691403	hsa-miR-520e	CLIP-seq
MIRT2627919	hsa-miR-520g	CLIP-seq
MIRT2627920	hsa-miR-520h	CLIP-seq
MIRT2691404	hsa-miR-532-3p	CLIP-seq
MIRT1371214	hsa-miR-548c-3p	CLIP-seq
MIRT1371217	hsa-miR-585	CLIP-seq
MIRT2627921	hsa-miR-596	CLIP-seq
MIRT2691405	hsa-miR-607	CLIP-seq
MIRT1371218	hsa-miR-624	CLIP-seq
MIRT2627924	hsa-miR-93	CLIP-seq

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAS	25534700
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001649	Process	Osteoblast differentiation	IDA	34948289
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	ISS	9389648
GO:0005515	Function	Protein binding	IPI	15231748, 16189514, 23455924, 25502805, 25609649, 25755279, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	TAS	19018011
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006879	Process	Intracellular iron ion homeostasis	IDA	15514116
GO:0006879	Process	Intracellular iron ion homeostasis	IDA	31800957
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0009653	Process	Anatomical structure morphogenesis	IBA
GO:0030154	Process	Cell differentiation	IBA
GO:0030509	Process	BMP signaling pathway	IBA
GO:0030509	Process	BMP signaling pathway	IDA	31800957
GO:0030509	Process	BMP signaling pathway	ISS	8653785
GO:0030509	Process	BMP signaling pathway	TAS	19018011
GO:0032502	Process	Developmental process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS	14687659
GO:0046872	Function	Metal ion binding	IEA
GO:0048863	Process	Stem cell differentiation	ISS
GO:0060395	Process	SMAD protein signal transduction	IBA
GO:0060395	Process	SMAD protein signal transduction	ISS
GO:0060395	Process	SMAD protein signal transduction	NAS	14687659
GO:0070411	Function	I-SMAD binding	IBA
GO:0071141	Component	SMAD protein complex	NAS	14687659
GO:0071144	Component	Heteromeric SMAD protein complex	IBA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071773	Process	Cellular response to BMP stimulus	NAS	14687659
GO:0141091	Process	Transforming growth factor beta receptor superfamily signaling pathway	IEA

MIM	HGNC	e!Ensembl
603295	6774	ENSG00000120693

Protein

UniProt ID

O15198

Protein name

Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)

Protein function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

PDB

6FZT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03165	MH1	34 → 135	MH1 domain	Domain
PF03166	MH2	271 → 443	MH2 domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

Sequence

MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
FQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQ
SGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG
FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSR
NCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVK
GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS

Sequence length

467

Interactions

View interactions

	KEGG		Reactome
	Hormone signaling TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells		Signaling by BMP

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Pulmonary Arterial Hypertension Associated With Congenital Heart Disease	pulmonary arterial hypertension associated with congenital heart disease	rs146583835	N/A
Pulmonary Hypertension	pulmonary hypertension, primary, 2	rs121918359, rs397514716, rs770716081	N/A

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Heritable Pulmonary Arterial Hypertension	heritable pulmonary arterial hypertension	N/A	N/A	GenCC
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS
Pulmonary arterial hypertension	pulmonary arterial hypertension	N/A	N/A	GenCC

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33648465
Adenoma	Associate	18008360
Alzheimer Disease	Associate	36764297
Arteriovenous Malformations	Inhibit	36198763
Autistic Disorder	Associate	12826745
Breast Neoplasms	Associate	39940786
Carcinoma Non Small Cell Lung	Inhibit	32150102
Carcinoma Ovarian Epithelial	Associate	34110955
Chondrosarcoma	Associate	23088614
Colorectal Neoplasms	Associate	31545230, 37373155
Diabetes Mellitus Type 1	Associate	35650387
Esophageal Neoplasms	Inhibit	34725559
Essential Hypertension	Associate	30617053
Familial Primary Pulmonary Hypertension	Associate	21920918, 23590310
Glioblastoma	Associate	25165192
Glioma	Associate	25165192
Hypertension Pulmonary	Associate	26820968
Hypoxia	Inhibit	20336693
Intracranial Arteriovenous Malformations	Associate	36198763
Keratoacanthoma	Associate	19671862
Keratoconus	Associate	25247416
Language Disorders	Associate	12826745
Leukemia Lymphocytic Chronic B Cell	Stimulate	28349818
Multiple Myeloma	Associate	36717825
Myositis Ossificans	Associate	27530160
Neoplasms	Associate	34725559
Neuroblastoma	Associate	36539767
Neurofibrosarcoma	Associate	23423222, 27494873
Osteoarthritis	Associate	37652257
Phenylketonurias	Associate	21920918, 32159364
Prostatic Neoplasms	Associate	18942118
Pulmonary Arterial Hypertension	Associate	23590310, 26820968, 30180189, 35346192
Squamous Cell Carcinoma of Head and Neck	Associate	28035402
Stomach Neoplasms	Associate	18158559
Vascular Calcification	Associate	29895327, 34954251

SMAD9 (SMAD family member 9)