Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	409
Gene name Gene Name - the full gene name approved by the HGNC.	Arrestin beta 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARRB2
Synonyms (NCBI Gene) Gene synonyms aliases	ARB2, ARR2, BARR2
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory si

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045486	hsa-miR-149-5p	CLASH	23622248
MIRT039876	hsa-miR-615-3p	CLASH	23622248
MIRT038258	hsa-miR-330-5p	CLASH	23622248
MIRT481458	hsa-miR-9500	PAR-CLIP	23592263
MIRT481457	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT481456	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT481455	hsa-miR-7515	PAR-CLIP	23592263
MIRT481454	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT481453	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT481452	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT481451	hsa-miR-5194	PAR-CLIP	23592263
MIRT481450	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT481449	hsa-miR-2115-5p	PAR-CLIP	23592263
MIRT481448	hsa-miR-6077	PAR-CLIP	23592263
MIRT481447	hsa-miR-3202	PAR-CLIP	23592263
MIRT481445	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT481446	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT481444	hsa-miR-4271	PAR-CLIP	23592263
MIRT481443	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT481442	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT481441	hsa-miR-4710	PAR-CLIP	23592263
MIRT481440	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT116603	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT728304	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT728303	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT728302	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT728300	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT481458	hsa-miR-9500	PAR-CLIP	23592263
MIRT481457	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT481456	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT481455	hsa-miR-7515	PAR-CLIP	23592263
MIRT481454	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT481453	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT481452	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT481451	hsa-miR-5194	PAR-CLIP	23592263
MIRT481450	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT481449	hsa-miR-2115-5p	PAR-CLIP	23592263
MIRT481448	hsa-miR-6077	PAR-CLIP	23592263
MIRT481447	hsa-miR-3202	PAR-CLIP	23592263
MIRT481445	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT481446	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT481444	hsa-miR-4271	PAR-CLIP	23592263
MIRT481443	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT481442	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT481441	hsa-miR-4710	PAR-CLIP	23592263
MIRT481440	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT116603	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT755378	hsa-miR-365a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	35958620
MIRT800609	hsa-miR-3184	CLIP-seq
MIRT800610	hsa-miR-4492	CLIP-seq
MIRT800611	hsa-miR-4498	CLIP-seq
MIRT800612	hsa-miR-4505	CLIP-seq
MIRT800613	hsa-miR-762	CLIP-seq
MIRT800614	hsa-miR-1208	CLIP-seq
MIRT800615	hsa-miR-155	CLIP-seq
MIRT800616	hsa-miR-181a	CLIP-seq
MIRT800617	hsa-miR-181b	CLIP-seq
MIRT800618	hsa-miR-181c	CLIP-seq
MIRT800619	hsa-miR-181d	CLIP-seq
MIRT800620	hsa-miR-1908	CLIP-seq
MIRT800621	hsa-miR-3127-3p	CLIP-seq
MIRT800622	hsa-miR-3135b	CLIP-seq
MIRT800623	hsa-miR-3180-5p	CLIP-seq
MIRT800624	hsa-miR-3613-3p	CLIP-seq
MIRT800625	hsa-miR-3647-3p	CLIP-seq
MIRT800626	hsa-miR-365	CLIP-seq
MIRT800627	hsa-miR-3652	CLIP-seq
MIRT800628	hsa-miR-4262	CLIP-seq
MIRT800629	hsa-miR-4282	CLIP-seq
MIRT800630	hsa-miR-4291	CLIP-seq
MIRT800631	hsa-miR-4420	CLIP-seq
MIRT800632	hsa-miR-4430	CLIP-seq
MIRT800633	hsa-miR-4434	CLIP-seq
MIRT800610	hsa-miR-4492	CLIP-seq
MIRT800611	hsa-miR-4498	CLIP-seq
MIRT800634	hsa-miR-4508	CLIP-seq
MIRT800635	hsa-miR-4516	CLIP-seq
MIRT800636	hsa-miR-451b	CLIP-seq
MIRT800637	hsa-miR-4531	CLIP-seq
MIRT800638	hsa-miR-520a-5p	CLIP-seq
MIRT800639	hsa-miR-525-5p	CLIP-seq
MIRT800640	hsa-miR-545	CLIP-seq
MIRT800641	hsa-miR-558	CLIP-seq
MIRT800642	hsa-miR-663	CLIP-seq
MIRT800643	hsa-miR-744	CLIP-seq
MIRT800613	hsa-miR-762	CLIP-seq
MIRT800615	hsa-miR-155	CLIP-seq
MIRT800616	hsa-miR-181a	CLIP-seq
MIRT800617	hsa-miR-181b	CLIP-seq
MIRT800618	hsa-miR-181c	CLIP-seq
MIRT800619	hsa-miR-181d	CLIP-seq
MIRT1936492	hsa-miR-1825	CLIP-seq
MIRT1936493	hsa-miR-199a-5p	CLIP-seq
MIRT1936494	hsa-miR-199b-5p	CLIP-seq
MIRT1936495	hsa-miR-2115	CLIP-seq
MIRT800609	hsa-miR-3184	CLIP-seq
MIRT1936496	hsa-miR-3185	CLIP-seq
MIRT800626	hsa-miR-365	CLIP-seq
MIRT800628	hsa-miR-4262	CLIP-seq
MIRT800630	hsa-miR-4291	CLIP-seq
MIRT1936497	hsa-miR-4302	CLIP-seq
MIRT800610	hsa-miR-4492	CLIP-seq
MIRT800611	hsa-miR-4498	CLIP-seq
MIRT800612	hsa-miR-4505	CLIP-seq
MIRT800636	hsa-miR-451b	CLIP-seq
MIRT1936498	hsa-miR-4709-3p	CLIP-seq
MIRT800640	hsa-miR-545	CLIP-seq
MIRT800613	hsa-miR-762	CLIP-seq
MIRT1936495	hsa-miR-2115	CLIP-seq
MIRT800609	hsa-miR-3184	CLIP-seq
MIRT1936496	hsa-miR-3185	CLIP-seq
MIRT800610	hsa-miR-4492	CLIP-seq
MIRT800611	hsa-miR-4498	CLIP-seq
MIRT800612	hsa-miR-4505	CLIP-seq
MIRT800613	hsa-miR-762	CLIP-seq
MIRT1936495	hsa-miR-2115	CLIP-seq
MIRT800609	hsa-miR-3184	CLIP-seq
MIRT1936496	hsa-miR-3185	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001664	Function	G protein-coupled receptor binding	IBA	21873635
GO:0001664	Function	G protein-coupled receptor binding	IPI	10644702
GO:0001933	Process	Negative regulation of protein phosphorylation	IEA
GO:0002031	Process	G protein-coupled receptor internalization	IBA	21873635
GO:0002031	Process	G protein-coupled receptor internalization	IDA	10644702
GO:0002031	Process	G protein-coupled receptor internalization	IMP	12582207
GO:0002031	Process	G protein-coupled receptor internalization	TAS	24157794
GO:0002032	Process	Desensitization of G protein-coupled receptor signaling pathway by arrestin	IMP	12582207
GO:0002092	Process	Positive regulation of receptor internalization	IMP	22457824
GO:0005102	Function	Signaling receptor binding	IPI	18604210
GO:0005515	Function	Protein binding	IPI	12958365, 15125834, 16051150, 16378096, 16524428, 16820410, 17148612, 17620599, 19060904, 19122674, 19202075, 19363159, 19782076, 19955404, 20664520, 20802461, 22190034, 22282525, 22300987, 22457824, 23208550, 23341447, 23809162, 24157794, 25241761, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IDA	16820410
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12958365, 15611106, 16325578, 16820410, 23341447
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	18604210
GO:0005886	Component	Plasma membrane	TAS	21149639
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	16820410
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IDA	12958365
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007212	Process	Dopamine receptor signaling pathway	NAS	21711983
GO:0007420	Process	Brain development	IEA
GO:0007628	Process	Adult walking behavior	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016567	Process	Protein ubiquitination	IMP	15878855
GO:0016579	Process	Protein deubiquitination	TAS
GO:0019899	Function	Enzyme binding	IPI	23382074
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030139	Component	Endocytic vesicle	IDA	23341447
GO:0030168	Process	Platelet activation	TAS
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	16378096
GO:0031410	Component	Cytoplasmic vesicle	IDA	12958365, 15611106
GO:0031623	Process	Receptor internalization	IDA	12958365
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15878855
GO:0031691	Function	Alpha-1A adrenergic receptor binding	IEA
GO:0031692	Function	Alpha-1B adrenergic receptor binding	IEA
GO:0031701	Function	Angiotensin receptor binding	IBA	21873635
GO:0031701	Function	Angiotensin receptor binding	IPI	15611106
GO:0031702	Function	Type 1 angiotensin receptor binding	IEA
GO:0031748	Function	D1 dopamine receptor binding	IEA
GO:0031762	Function	Follicle-stimulating hormone receptor binding	IEA
GO:0031826	Function	Type 2A serotonin receptor binding	IEA
GO:0031859	Function	Platelet activating factor receptor binding	IEA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	15125834, 16378096
GO:0032226	Process	Positive regulation of synaptic transmission, dopaminergic	IEA
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IEA
GO:0032695	Process	Negative regulation of interleukin-12 production	IEA
GO:0032715	Process	Negative regulation of interleukin-6 production	IEA
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IEA
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IEA
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IEA
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IEA
GO:0034260	Process	Negative regulation of GTPase activity	IEA
GO:0034392	Process	Negative regulation of smooth muscle cell apoptotic process	IEA
GO:0042699	Process	Follicle-stimulating hormone signaling pathway	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IMP	15878855
GO:0043197	Component	Dendritic spine	IEA
GO:0043422	Function	Protein kinase B binding	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045953	Process	Negative regulation of natural killer cell mediated cytotoxicity	IMP	18604210
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0051019	Function	Mitogen-activated protein kinase binding	IEA
GO:0051897	Process	Positive regulation of protein kinase B signaling	IEA
GO:0051898	Process	Negative regulation of protein kinase B signaling	NAS	21711983
GO:0051928	Process	Positive regulation of calcium ion transport	IEA
GO:0060071	Process	Wnt signaling pathway, planar cell polarity pathway	TAS
GO:0060079	Process	Excitatory postsynaptic potential	NAS	21711983
GO:0060326	Process	Cell chemotaxis	IMP	15635042
GO:0061024	Process	Membrane organization	TAS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	10644702
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	12582207
GO:0071889	Function	14-3-3 protein binding	IEA
GO:0090201	Process	Negative regulation of release of cytochrome c from mitochondria	IEA
GO:1904037	Process	Positive regulation of epithelial cell apoptotic process	IEA
GO:1990763	Function	Arrestin family protein binding	IEA
GO:2000573	Process	Positive regulation of DNA biosynthetic process	IEA
GO:2000727	Process	Positive regulation of cardiac muscle cell differentiation	IEA

MIM	HGNC	e!Ensembl
107941	712	ENSG00000141480

Protein

UniProt ID

P32121

Protein name

Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)

Protein function

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated rece

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00339	Arrestin_N	19 → 175	Arrestin (or S-antigen), N-terminal domain	Domain
PF02752	Arrestin_C	194 → 349	Arrestin (or S-antigen), C-terminal domain	Domain

Sequence

MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTC
AFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTI
PQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPG
PQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYA
DICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTN
LASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQS
AAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC

Sequence length

409

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Dopaminergic synapse Olfactory transduction Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Morphine addiction Chemical carcinogenesis - receptor activation		G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder		18191226	ClinVar

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	28611418
Autoimmune Diseases	Associate	29272019
Carcinoma Hepatocellular	Associate	22961449
Carcinoma Non Small Cell Lung	Inhibit	37443143
Cardiovascular Diseases	Associate	37100034
Coronary Artery Disease	Associate	28980286
Dyspnea	Associate	25948405
Giant Cell Tumor of Tendon Sheath	Associate	33994368
Heart Failure	Associate	37092838, 37100034
Kidney Failure Chronic	Associate	30212930
Lung Diseases	Associate	33649538
Lung Neoplasms	Associate	37443143, 38066059
Neoplasm Metastasis	Stimulate	36284990
Neoplasms	Associate	33649538, 36284990, 37443143
Prostatic Neoplasms	Associate	15229631, 36284990
Pulmonary Embolism	Associate	24337368
Uterine Cervical Neoplasms	Associate	33829064
Vascular Diseases	Associate	34873055
WHIM syndrome	Associate	18436740

ARRB2 (arrestin beta 2)