Gene Gene information from NCBI Gene database.
Entrez ID 4082
Gene name Myristoylated alanine rich protein kinase C substrate
Gene symbol MARCKS
Synonyms (NCBI Gene)
80K-LMACSPKCSLPRKCSL
Chromosome 6
Chromosome location 6q21
Summary The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with
miRNA miRNA information provided by mirtarbase database.
1153
miRTarBase ID miRNA Experiments Reference
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assayWestern blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assay 19302977
MIRT020762 hsa-miR-155-5p Proteomics 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005080 Function Protein kinase C binding IEA
GO:0005516 Function Calmodulin binding IEA
GO:0005516 Function Calmodulin binding TAS 1560845
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
177061 6759 ENSG00000277443
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P29966
Protein name Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Protein function Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:237049
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02063 MARCKS 2 329 MARCKS family Family
Tissue specificity TISSUE SPECIFICITY: Detected in spermatozoa. {ECO:0000269|PubMed:23704996}.
Sequence
Sequence length 332
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Fc gamma R-mediated phagocytosis
MicroRNAs in cancer
  Acetylcholine regulates insulin secretion