Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4082
Gene name Gene Name - the full gene name approved by the HGNC.
Myristoylated alanine rich protein kinase C substrate
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MARCKS
Synonyms (NCBI Gene) Gene synonyms aliases
80K-L, MACS, PKCSL, PRKCSL
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MACS
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q21
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001221 hsa-miR-21-5p Luciferase reporter assay, Western blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assay, Western blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assay, Western blot 19302977
MIRT001221 hsa-miR-21-5p Luciferase reporter assay 19302977
MIRT020762 hsa-miR-155-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005080 Function Protein kinase C binding IEA
GO:0005516 Function Calmodulin binding IEA
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005813 Component Centrosome IEA
GO:0005886 Component Plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
177061 6759 ENSG00000277443
Protein
UniProt ID P29966
Protein name Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Protein function Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:237049
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02063 MARCKS 2 329 MARCKS family Family
Tissue specificity TISSUE SPECIFICITY: Detected in spermatozoa. {ECO:0000269|PubMed:23704996}.
Sequence
Sequence length 332
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Fc gamma R-mediated phagocytosis
MicroRNAs in cancer
  Acetylcholine regulates insulin secretion
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenoid Cystic Carcinoma rs121913530, rs886039394, rs121913474 16762588
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 27935865
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19192274
Unknown
Disease term Disease name Evidence References Source
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adrenocortical Carcinoma Associate 26963385
Amyotrophic Lateral Sclerosis Associate 37328865
Aneuploidy Associate 39735979
Anodontia Associate 19957108
Breast Neoplasms Associate 23876235
Breast Neoplasms Male Associate 31771045
Carcinogenesis Associate 19924305
Carcinoma Stimulate 31771045
Carcinoma Basal Cell Stimulate 23876235
Carcinoma Hepatocellular Associate 26722462