Gene Gene information from NCBI Gene database.
Entrez ID 4076
Gene name Cell cycle associated protein 1
Gene symbol CAPRIN1
Synonyms (NCBI Gene)
CONDCACGPIAP1GPIP137GRIP137M11S1NEDLAADRNG105p137GPI
Chromosome 11
Chromosome location 11p13
miRNA miRNA information provided by mirtarbase database.
833
miRTarBase ID miRNA Experiments Reference
MIRT005086 hsa-miR-16-5p Luciferase reporter assayqRT-PCRWestern blot 19250063
MIRT022856 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT023918 hsa-miR-1-3p Proteomics 18668040
MIRT025338 hsa-miR-34a-5p Proteomics 21566225
MIRT025338 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
50
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IDA 31439799
GO:0000932 Component P-body ISS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601178 6743 ENSG00000135387
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14444
Protein name Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule
Protein function mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, P
PDB 4WBE , 4WBP , 6TA7 , 7XHG , 8TH7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18293 Caprin-1_dimer 132 247 Caprin-1 dimerization domain Domain
PF12287 Caprin-1_C 359 685 Cytoplasmic activation/proliferation-associated protein-1 C term Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:7657653}.
Sequence
Sequence length 709
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
22
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Autism Likely pathogenic rs2496026698 RCV003311577
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Autistic behavior Likely pathogenic rs2496026698 RCV003311577
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
CAPRIN1-related neurodevelopmental disorders Pathogenic rs2134131094 RCV001822993
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Epileptic encephalopathy Likely pathogenic rs1851273791 RCV003224973
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Autism spectrum disorder Likely benign ClinVar
GenCC
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
AUTISM SPECTRUM DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CAPRIN1-associated disorder Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Amyotrophic Lateral Sclerosis Associate 29134320
★☆☆☆☆
Found in Text Mining only
Ataxia Associate 36136249
★☆☆☆☆
Found in Text Mining only
Attention Deficit Disorder with Hyperactivity Associate 40112765
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Associate 23849776, 31332282, 40112765
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
Breast Neoplasms Associate 29037839
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 36855123
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 29037839, 31599409, 35072355
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Stimulate 38082307
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 26036633, 39871215
★☆☆☆☆
Found in Text Mining only
Cell Transformation Neoplastic Stimulate 38082307
★☆☆☆☆
Found in Text Mining only