Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4074
Gene name Gene Name - the full gene name approved by the HGNC.
Mannose-6-phosphate receptor, cation dependent
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
M6PR
Synonyms (NCBI Gene) Gene synonyms aliases
CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein func
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005835 hsa-miR-204-5p Immunoblot, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21282569
MIRT045509 hsa-miR-149-5p CLASH 23622248
MIRT041910 hsa-miR-484 CLASH 23622248
MIRT054448 hsa-miR-211-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 24039954
MIRT473912 hsa-miR-20b-5p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity TAS 10799489
GO:0005515 Function Protein binding IPI 11387475, 27385586, 32296183, 32814053, 37100772
GO:0005737 Component Cytoplasm IEA
GO:0005764 Component Lysosome IEA
GO:0005765 Component Lysosomal membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
154540 6752 ENSG00000003056
Protein
UniProt ID P20645
Protein name Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)
Protein function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resultin
PDB 1JUQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02157 Man-6-P_recep 24 277 Mannose-6-phosphate receptor Family
Sequence
Sequence length 277
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysosome
Phagosome
Salmonella infection
  Lysosome Vesicle Biogenesis
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
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