MIR34A (microRNA 34a)

Gene

• Entrez ID: 407040
• Gene name: MicroRNA 34a
• Gene symbol: MIR34A
• Synonyms (NCBI Gene): MIRN34A, miRNA34A, mir-34, mir-34a
• Chromosome: 1
• Chromosome location: 1p36.22|1p36.22
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	24637697, 25355491, 26330104, 28073349, 33229509
GO:0006974	Process	DNA damage response	IDA	30111844
GO:0010628	Process	Positive regulation of gene expression	IDA	27302634
GO:0010629	Process	Negative regulation of gene expression	IMP	26330104
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	IDA	23426265
GO:0010884	Process	Positive regulation of lipid storage	IMP	26330104
GO:0016525	Process	Negative regulation of angiogenesis	IDA	20424141, 24048733
GO:0032682	Process	Negative regulation of chemokine production	IDA	33229509
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IDA	26949937
GO:0034763	Process	Negative regulation of transmembrane transport	IDA	28073349
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	HDA	18320040
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	20424141, 23426265, 23462268, 24637697, 24792364, 25355491, 26330104, 26949937, 27302634, 27780189, 28073349, 28340489, 28348487, 30111844, 33229509
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	23047694
GO:0035359	Process	Negative regulation of peroxisome proliferator activated receptor signaling pathway	IMP	26330104
GO:0042632	Process	Cholesterol homeostasis	ISS
GO:0048678	Process	Response to axon injury	ISS	27780189
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IDA	30111844
GO:0051152	Process	Positive regulation of smooth muscle cell differentiation	IDA	25526086
GO:0051726	Process	Regulation of cell cycle	ISS
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0061044	Process	Negative regulation of vascular wound healing	IDA	26493107
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070328	Process	Triglyceride homeostasis	ISS
GO:0071456	Process	Cellular response to hypoxia	IDA	27302634
GO:0071659	Process	Negative regulation of IP-10 production	IDA	33229509
GO:0071672	Process	Negative regulation of smooth muscle cell chemotaxis	IDA	26493107
GO:0090281	Process	Negative regulation of calcium ion import	IDA	27302634
GO:0097468	Process	Programmed cell death in response to reactive oxygen species	IMP	22651868
GO:0110058	Process	Positive regulation of blood vessel endothelial cell differentiation	IDA	24792364
GO:1900222	Process	Negative regulation of amyloid-beta clearance	ISS
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	HDA	18320040
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	23426265, 23462268, 24637697, 24792364, 25355491, 26330104, 26949937, 27302634, 28073349, 28340489, 28348487, 30111844, 33229509
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IDA	23426265
GO:1903671	Process	Negative regulation of sprouting angiogenesis	ISS
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	24792364, 26493107, 27302634
GO:1904753	Process	Negative regulation of vascular associated smooth muscle cell migration	IDA	26493107, 27302634
GO:1905205	Process	Positive regulation of connective tissue replacement	ISS
GO:1905563	Process	Negative regulation of vascular endothelial cell proliferation	IDA	28276476
GO:2000108	Process	Positive regulation of leukocyte apoptotic process	IMP	22651868
GO:2000774	Process	Positive regulation of cellular senescence	IDA	20424141

Other IDs

• MIM: 611172
• HGNC: 31635
• e!Ensembl: ENSG00000284357

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer