MIR27B (microRNA 27b)

Gene

• Entrez ID: 407019
• Gene name: MicroRNA 27b
• Gene symbol: MIR27B
• Synonyms (NCBI Gene): MIR-27b, MIRN27B, miRNA27B
• Chromosome: 9
• Chromosome location: 9q22.32
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	19800867, 22120719, 25795136, 29608331
GO:0003730	Function	MRNA 3'-UTR binding	IMP	20164187
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0006805	Process	Xenobiotic metabolic process	NAS	16982751
GO:0010628	Process	Positive regulation of gene expression	IDA	26520906
GO:0010629	Process	Negative regulation of gene expression	IDA	24608080, 26520906
GO:0010629	Process	Negative regulation of gene expression	IMP	21562928
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IGI	31124343
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	26520906
GO:0016442	Component	RISC complex	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	28095798
GO:0032691	Process	Negative regulation of interleukin-1 beta production	IDA	31124343
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IMP	20164187
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	19800867, 22120719, 24177325, 24608080, 25795136, 26395742, 26520906, 28095798, 28396577, 29608331, 29794473, 31124343
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	21536891
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	20164187
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	16982751, 21562928, 22184411
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	30729664
GO:0035359	Process	Negative regulation of peroxisome proliferator activated receptor signaling pathway	IDA	25795136
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	22184411
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IGI	21536891
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	ISS
GO:0042632	Process	Cholesterol homeostasis	IDA	26520906
GO:0045599	Process	Negative regulation of fat cell differentiation	IDA	29794473
GO:0045599	Process	Negative regulation of fat cell differentiation	IMP	19800867
GO:0045766	Process	Positive regulation of angiogenesis	IMP	24177325
GO:0060354	Process	Negative regulation of cell adhesion molecule production	IDA	28396577
GO:0061766	Process	Positive regulation of lung blood pressure	ISS	25795136
GO:0070062	Component	Extracellular exosome	IDA	28159509
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IGI	21536891
GO:0071864	Process	Positive regulation of cell proliferation in bone marrow	IMP	24177325
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	22184411
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	21536891
GO:0090206	Process	Negative regulation of cholesterol metabolic process	IDA	24608080
GO:0090322	Process	Regulation of superoxide metabolic process	IGI	24177325
GO:0090370	Process	Negative regulation of cholesterol efflux	IDA	24608080, 26520906
GO:0106090	Process	Positive regulation of cell adhesion involved in sprouting angiogenesis	IMP	24177325
GO:1901202	Process	Negative regulation of extracellular matrix assembly	IDA	28095798
GO:1901203	Process	Positive regulation of extracellular matrix assembly	IDA	30729664
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IGI	31124343
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	16982751, 19800867, 22120719, 22184411, 24177325, 24608080, 25795136, 26395742, 26520906, 28095798, 28396577, 29608331, 29794473, 30729664, 31124343
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	21536891
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IMP	20164187
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	22184411
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	21536891
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1904761	Process	Negative regulation of myofibroblast differentiation	IDA	28095798
GO:1905111	Process	Positive regulation of pulmonary blood vessel remodeling	ISS	25795136
GO:1905601	Process	Negative regulation of receptor-mediated endocytosis involved in cholesterol transport	IDA	26520906
GO:1990776	Process	Response to angiotensin	IDA	30729664
GO:2001244	Process	Positive regulation of intrinsic apoptotic signaling pathway	IGI	31124343

Other IDs

• MIM: 610636
• HGNC: 31614
• e!Ensembl: ENSG00000207864

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer