MIR27A (microRNA 27a)

Gene

• Entrez ID: 407018
• Gene name: MicroRNA 27a
• Gene symbol: MIR27A
• Synonyms (NCBI Gene): MIR27, MIRN27A, mir-27a
• Chromosome: 19
• Chromosome location: 19p13.12
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Transcription factors

Transcription factor	Regulation	Reference
RUNX1	Unknown	23752185

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	26400397, 27910957, 28122350
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0010628	Process	Positive regulation of gene expression	IGI	26400397
GO:0010629	Process	Negative regulation of gene expression	IDA	24608080
GO:0010629	Process	Negative regulation of gene expression	IGI	25327529
GO:0010629	Process	Negative regulation of gene expression	ISS	27910957
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	26318398
GO:0016442	Component	RISC complex	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	23874542, 24244514, 24608080, 24725595, 25327529, 26318398, 27910957, 28791023
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	21536891
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	25327529, 26318398, 28122350
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	25915942, 26400397
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IGI	21536891
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IGI	26400397
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IGI	25327529
GO:0045599	Process	Negative regulation of fat cell differentiation	ISS	27910957
GO:0045669	Process	Positive regulation of osteoblast differentiation	ISS	27910957
GO:0050868	Process	Negative regulation of T cell activation	IDA	24725595
GO:0060392	Process	Negative regulation of SMAD protein signal transduction	IMP	26400397
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IGI	21536891
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0071560	Process	Cellular response to transforming growth factor beta stimulus	IDA	28791023
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	21536891
GO:0090206	Process	Negative regulation of cholesterol metabolic process	IDA	24608080
GO:0090370	Process	Negative regulation of cholesterol efflux	IDA	24608080
GO:1902046	Process	Positive regulation of Fas signaling pathway	IGI	26400397
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	23874542, 24244514, 24608080, 24725595, 25327529, 25915942, 26318398, 26400397, 27910957, 28122350, 28791023
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	21536891
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	21536891
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	IDA	24244514
GO:2000660	Process	Negative regulation of interleukin-1-mediated signaling pathway	IGI	25327529

Other IDs

• MIM: 612153
• HGNC: 31613
• e!Ensembl: ENSG00000207808

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer