MIR221 (microRNA 221)

Gene

• Entrez ID: 407006
• Gene name: MicroRNA 221
• Gene symbol: MIR221
• Synonyms (NCBI Gene): MIRN221, miRNA221, mir-221
• Chromosome: X
• Chromosome location: Xp11.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005615	Component	Extracellular space	HDA	18766170
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	23333386
GO:0009749	Process	Response to glucose	IMP	19351599
GO:0010634	Process	Positive regulation of epithelial cell migration	IGI	21673316
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IGI	21673316
GO:0032705	Process	Negative regulation of interleukin-21 production	IDA	28798470
GO:0034115	Process	Negative regulation of heterotypic cell-cell adhesion	IDA	20110463
GO:0035195	Process	Gene silencing by miRNA	IDA	16330772, 18413744, 18794255, 19153141, 19962668, 20018759, 20299489, 20388878, 20516212, 21071579, 23333386, 23390134, 23630541, 23770133, 23770851, 24147153, 24269686, 24324033, 24736554, 25019494, 25910754, 27780851, 28798470
GO:0035195	Process	Gene silencing by miRNA	IEA
GO:0035195	Process	Gene silencing by miRNA	IGI	21310411, 21673316, 22294051
GO:0035195	Process	Gene silencing by miRNA	IMP	18246122, 19088079, 19351599, 20813046
GO:0035278	Process	MiRNA mediated inhibition of translation	IDA	19671867, 19962668, 20110463
GO:0035278	Process	MiRNA mediated inhibition of translation	IMP	19088079
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	25019494
GO:0043065	Process	Positive regulation of apoptotic process	IDA	24147153
GO:0043066	Process	Negative regulation of apoptotic process	IDA	20813046
GO:0043066	Process	Negative regulation of apoptotic process	IMP	19671867
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IMP	19351599
GO:0044828	Process	Negative regulation by host of viral genome replication	ISS
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IDA	16330772
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IDA	25019494
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IMP	19088079
GO:0048680	Process	Positive regulation of axon regeneration	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IGI	21310411
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	19962668
GO:0060354	Process	Negative regulation of cell adhesion molecule production	IGI	21310411
GO:0060546	Process	Negative regulation of necroptotic process	IDA	25910754
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IDA	23333386
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	19962668
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IGI	20516212
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IDA	18413744
GO:1900149	Process	Positive regulation of Schwann cell migration	ISS
GO:1902034	Process	Negative regulation of hematopoietic stem cell proliferation	IDA	16330772
GO:1903122	Process	Negative regulation of TRAIL-activated apoptotic signaling pathway	IDA	19962668
GO:1903122	Process	Negative regulation of TRAIL-activated apoptotic signaling pathway	IMP	18246122
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IDA	16330772, 18413744, 18794255, 19153141, 19671867, 19962668, 20018759, 20110463, 20299489, 20388878, 20516212, 21071579, 23333386, 23390134, 23630541, 23770133, 23770851, 24147153, 24269686, 24324033, 24736554, 25019494, 25910754, 27780851, 28798470
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IGI	21310411, 21673316, 22294051
GO:1903231	Function	MRNA binding involved in posttranscriptional gene silencing	IMP	20813046
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IGI	27780851
GO:1903691	Process	Positive regulation of wound healing, spreading of epidermal cells	IDA	24269686
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	19088079
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IMP	19088079
GO:1904995	Process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IGI	21310411
GO:1905046	Process	Positive regulation of Schwann cell proliferation involved in axon regeneration	ISS
GO:1905064	Process	Negative regulation of vascular associated smooth muscle cell differentiation	IMP	18548003, 19088079
GO:1905176	Process	Positive regulation of vascular associated smooth muscle cell dedifferentiation	IMP	19088079
GO:2000780	Process	Negative regulation of double-strand break repair	IDA	24147153

Other IDs

• MIM: 300568
• HGNC: 31601
• e!Ensembl: ENSG00000207870

Pathways

KEGG:

MicroRNAs in cancer

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	20099276
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	20099276
Cataract	Cataract, Pseudoaphakia	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322, rs121917775, rs121917735, rs121917736, rs137853199, rs137853200, rs121917867, rs121917869, rs121913555, rs104893736, rs121909595, rs121909596, rs121909597, rs28931605, rs121909598, rs104893618, rs1695062782, rs74315486, rs74315487, rs74315490, rs74315489, rs745938679, rs1566402656, rs74315439, rs74315441, rs121912973, rs121917823, rs1593332981, rs121917825, rs121917827, rs113994108, rs387906963, rs387906964, rs1240503246, rs387906965, rs387906966, rs750207077, rs387907336, rs387907337, rs387907342, rs140332366, rs397514703, rs398122937, rs398122378, rs398122392, rs398122944, rs137853924, rs398122947, rs397515623, rs397515624, rs397515625, rs397515626, rs398122948, rs587778872, rs398123066, rs587777601, rs370424081, rs786205221, rs786205222, rs864309684, rs864309688, rs864309701, rs864309689, rs864309690, rs864309681, rs864309686, rs864309696, rs864309693, rs864309687, rs864309691, rs864309692, rs864309695, rs864309678, rs864309685, rs864309700, rs864309698, rs864309683, rs864309682, rs864309679, rs111534978, rs864309680, rs864309702, rs864622780, rs756898971, rs869312732, rs775038545, rs878852983, rs1114167312, rs1114167313, rs1114167314, rs1114167315, rs1114167307, rs886041410, rs886041412, rs1057518738, rs1057517926, rs1057518878, rs1057519616, rs12799308, rs1064793935, rs1064797219, rs1085307126, rs1085307127, rs765628635, rs1114167427, rs1114167433, rs1554744860, rs1554743428, rs747093432, rs1411557416, rs1555179713, rs1481963503, rs1555549755, rs1456161420, rs1555547008, rs1555889308, rs1555888762, rs766522434, rs1264025914, rs1553585262, rs1567671947, rs1337897299, rs764945940, rs1307969607, rs949335475, rs1184095219, rs776129797, rs1569203234, rs1567668570, rs749141857, rs764098604, rs1184398243, rs1578956689, rs1568480054, rs1564745688, rs1564722302, rs1564723150, rs1571175950, rs1569602837, rs1576552712, rs1575369255, rs981126461, rs1570403798, rs200557771, rs1477743112, rs1651879427, rs1651881222, rs1651919374, rs2024441691, rs148284531, rs1246080692	30926320
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28545106
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	20099276

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Associate	25252191
Adenocarcinoma Follicular	Associate	23563786
Adenocarcinoma Mucinous	Stimulate	21757972
Alopecia	Associate	37496996
Alzheimer Disease	Associate	38195609
Amyotrophic Lateral Sclerosis	Associate	28870590
Aneurysm	Associate	28425970
Aortic Aneurysm Abdominal	Associate	28425970
Aortic Aneurysm Thoracic	Associate	28425970
Aortic Aneurysm Thoracic	Stimulate	35563123
Arthritis Rheumatoid	Associate	27834806
Asthma	Associate	23944957, 30654657
Astrocytoma	Associate	26191177
Asymptomatic Infections	Associate	36147570
Atherosclerosis	Associate	26645212, 29695561, 34951407
Behcet Syndrome	Stimulate	31980721
beta Thalassemia	Associate	34398996
Bipolar Disorder	Associate	37761918
Brain Neoplasms	Associate	29110584
Breast Neoplasms	Associate	18708351, 18790736, 19290006, 21057537, 21761362, 23031797, 23776679, 24736554, 24886939, 24905916, 25797271, 26503209, 26551008, 26556862, 28045030, 28191469, 28335433, 29716623, 31150454, 31899608, 32631271, 33919884, 34493366, 34946928, 35805995, 36078129, 36613808, 39766287
Breast Neoplasms	Stimulate	21378318, 23801152, 24129242, 31400480
Breast Neoplasms	Inhibit	26186233
Brugada Syndrome	Associate	35617207
Carcinogenesis	Associate	26883054, 31570425, 36232606, 37896899
Carcinoma	Associate	26106610
Carcinoma Basal Cell	Associate	36833430
Carcinoma Basosquamous	Associate	36833430
Carcinoma Hepatocellular	Associate	19671867, 22396537, 23320393, 24324033, 25019494, 25275448, 26167081, 26231037, 26817861, 27271989, 27983537, 28442344, 29476051, 29534065, 30473536, 31214616, 31698701, 31754293, 32306499, 36232606, 38084140
Carcinoma Hepatocellular	Stimulate	26380927, 29333940, 37798688
Carcinoma Intraductal Noninfiltrating	Associate	28335433
Carcinoma Non Small Cell Lung	Associate	20975375, 21706050, 25421010, 26831656, 27081922, 31173294, 37369478
Carcinoma Non Small Cell Lung	Inhibit	21544802, 25641933
Carcinoma Non Small Cell Lung	Stimulate	28534372
Carcinoma Ovarian Epithelial	Stimulate	23569131
Carcinoma Pancreatic Ductal	Associate	23776656, 25061297, 27230035, 27401251, 31311829, 33730072, 34905088
Carcinoma Papillary	Stimulate	18587330, 39177218
Carcinoma Renal Cell	Associate	24379138, 25279769, 25909813, 26191221
Carcinoma Squamous Cell	Stimulate	30891072, 36833430
Cardiomegaly	Associate	34946964
Cardiomyopathies	Associate	31115025
Cardiomyopathy Hypertrophic	Associate	31868204, 34946964
Cardiomyopathy infantile histiocytoid	Stimulate	24443580
Cardiovascular Diseases	Associate	26211628, 31150454, 31936594
Carotid Stenosis	Associate	26238333
Carotid Stenosis	Stimulate	28779016
Central Nervous System Diseases	Inhibit	25130212
Cerebral Hemorrhage	Associate	30966854
Cerebrovascular Disorders	Associate	19351599
Cholangiocarcinoma	Associate	24147037, 24918778, 27280413
Cholangiocarcinoma	Stimulate	26501139
Chromosome Aberrations	Stimulate	24147153
Colonic Neoplasms	Associate	36246978
Colorectal Neoplasms	Associate	21278784, 22895844, 24409057, 35657974, 38267567
Colorectal Neoplasms	Stimulate	25233396, 34357372, 36332335
Coronary Artery Disease	Associate	38139440
Coronary Disease	Associate	30088484
COVID 19	Associate	36901868
Cysts	Associate	21757972
Death	Associate	24379138, 27423422
Dental Plaque	Stimulate	26238333
Diabetes Gestational	Associate	32244558
Diabetes Mellitus	Associate	23648338
Diabetes Mellitus	Stimulate	25409512
Diabetes Mellitus Type 2	Associate	31754293, 40016689
Diabetic Nephropathies	Stimulate	37831346
Diabetic Retinopathy	Associate	32698791
Drug Related Side Effects and Adverse Reactions	Associate	26503209
Endocrine System Diseases	Associate	26211628
Endplate Acetylcholinesterase Deficiency	Associate	29529124
Epilepsy Familial Mesial Temporal Lobe	Associate	22535415
Epstein Barr Virus Infections	Inhibit	25130212
Fibrosis	Associate	26167081, 27731343, 31868204
Fibrosis	Stimulate	32563236
Gastrointestinal Stromal Tumors	Inhibit	23969726
Gastrointestinal Stromal Tumors	Associate	25898773, 30983504, 39382501
Glioblastoma	Associate	17721077, 21245048, 21895872, 23497354, 24147153, 24412053, 28381184, 29110584, 33082482, 33803955, 34278445, 34641347
Glioblastoma	Stimulate	21378318, 28534372
Glioma	Associate	24147153, 25731730, 26197878, 32777750
Glucocorticoid Receptor Deficiency	Associate	20237425
Goiter Multinodular 2	Associate	24327568, 37737255
Head and Neck Neoplasms	Associate	21637912, 36833430
Heart Diseases	Associate	26645212
Heart Failure	Associate	26211628, 30088484, 30523241
Helicobacter Infections	Stimulate	26364844
Hematologic Neoplasms	Associate	29716623
Hepatitis C	Stimulate	26090579
Hepatitis C	Associate	29534065
Hepatitis C Chronic	Stimulate	25019494
Hepatitis C Chronic	Inhibit	25386083
Hepatitis C Chronic	Associate	29333940
Huntington Disease	Associate	33803955
Hypertrophy	Associate	31868204
Hypoxia	Inhibit	27612459
Hypoxia Brain	Associate	37583428
Idiopathic Noncirrhotic Portal Hypertension	Stimulate	37798688
Infections	Associate	28978468
Inflammation	Associate	23867206, 28870590, 32157304
Inflammation	Inhibit	31565033
Influenza Human	Inhibit	33955508
Insulin Resistance	Associate	23756832, 31828133
Intervertebral Disc Degeneration	Associate	29529124, 30130742
Kidney Neoplasms	Associate	20595629, 26191221
Kidney Neoplasms	Stimulate	32109249
Langer Giedion Syndrome	Associate	23776679
Laryngeal Neoplasms	Associate	32096156
Leiomyosarcoma	Associate	18382364
Leiomyosarcoma	Inhibit	23969726
Leukemia	Associate	26153983, 30926883
Leukemia Lymphocytic Chronic B Cell	Associate	20203269, 34981813
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	21501493
Leukemia Myeloid Acute	Associate	20110180, 20425795, 26496024, 29172404
Leukemia Myeloid Acute	Stimulate	23895238
Leukemia Prolymphocytic T Cell	Stimulate	21378318
Liver Cirrhosis	Associate	27271989, 31754293
Liver Diseases	Associate	37798688
Lung Neoplasms	Associate	25641933, 29876362, 31447008, 35302725, 37283359
Lymphatic Metastasis	Stimulate	22613407, 32316638, 39177218
Lymphatic Metastasis	Associate	26831656, 28453462
Lymphoma B Cell	Associate	25130212
Lymphoma B Cell Marginal Zone	Stimulate	22110251
Lymphoma Follicular	Associate	19413891
Lymphoma Large B Cell Diffuse	Associate	19287466, 26683099
Malformations of Cortical Development Group I	Associate	31115025
Melanoma	Associate	20547861, 21119596
Melanoma Cutaneous Malignant	Stimulate	25430553
Membranous Obstruction of Inferior Vena Cava	Associate	25279769
Mesothelioma Malignant	Associate	34638565
Metabolic Syndrome	Stimulate	24093444
Metabolic Syndrome	Associate	37086927
MINOCA	Associate	38139440
Mouth Neoplasms	Associate	29976158, 33237235
Multiple Myeloma	Associate	26496024
Multiple Myeloma	Stimulate	30765325
Multiple Sclerosis	Associate	32948204
Myelodysplastic Syndromes	Associate	32629683, 34130612
Neoplasm Invasiveness	Associate	33809988
Neoplasm Metastasis	Stimulate	22613407, 23770851, 26501139, 31084400, 31341019, 37369478
Neoplasm Metastasis	Associate	23329235, 24129242, 24379138, 25731730, 25797271, 25928257, 29120535, 31214616, 37283359, 39183060
Neoplasms	Associate	17149698, 17569667, 18382364, 19671867, 20547861, 20975375, 21071579, 22396537, 22466166, 22613407, 23329235, 23372675, 23569131, 23895238, 24129242, 24324033, 24379138, 24736554, 24886939, 25279769, 25731730, 25797271, 25883224, 26106610, 26153983, 26191177, 26209976, 26231037, 26383775, 26831656, 27081922, 27358112, 27852308, 28986522, 29716623, 29843209, 29976158, 30024497, 30891072, 30926883, 31084400, 31214616, 31660895, 31773681, 32777750, 33237235, 33402480, 35562181, 37047300, 37737255
Neoplasms	Inhibit	18413744, 21378318, 23497354, 25641933, 26186233, 26191221, 26325107, 27404381, 31114989, 31570425, 32901864, 32948204, 39382501
Neoplasms	Stimulate	20460378, 21245048, 26950485, 27983537, 28442344, 31899608, 32316638, 33828027
Neoplasms Adipose Tissue	Associate	26211628
Neoplasms Glandular and Epithelial	Associate	35475887
Nerve Degeneration	Associate	30130742
Neuroblastoma	Associate	24885481
Neuroendocrine Tumors	Associate	37047300
Neuroma Acoustic	Associate	23776562
Obesity	Associate	23756832, 23867206, 31828133
Obesity	Stimulate	26211628
Osteoarthritis	Associate	34874225
Osteosarcoma	Associate	23372675, 30024497, 31084400, 33828027
Ovarian Neoplasms	Stimulate	18560586
Pancreatic Cyst	Associate	21757972
Pancreatic Intraductal Neoplasms	Associate	33809988
Pancreatic Neoplasms	Associate	17149698, 20332664, 21757972, 23329235, 23967190, 25955843, 29687843, 30165365, 32957376, 33730072, 35740894
Pancreatic Neoplasms	Stimulate	25883224
Pancreatitis	Associate	17149698
Pancreatitis Chronic	Associate	28074846
Panic Disorder	Associate	37761918
Paroxysmal ventricular fibrillation	Associate	27423422
Personality Disorders	Associate	24886939, 31570425
Plaque Atherosclerotic	Associate	26451018
Polycystic Ovary Syndrome	Associate	36627014
Polycythemia Vera	Associate	17976518
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	20237425, 27358112
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	18173753
Prostatic Hyperplasia	Associate	26831660, 34972164
Prostatic Neoplasms	Associate	19267923, 21378318, 22117988, 22298119, 23353719, 23770851, 24167554, 24191917, 24892674, 25190021, 25252191, 25846647, 26364608, 26484677, 26628405, 30518666, 30537232, 31756185, 32948204, 35887223, 35983819
Prostatic Neoplasms	Stimulate	21071579, 34972164
Prostatic Neoplasms	Inhibit	25761682, 26325107, 31828111, 32901864
Prostatic Neoplasms Castration Resistant	Stimulate	19351832, 23770851
Prostatic Neoplasms Castration Resistant	Associate	22127852, 24760272
Prostatic Neoplasms Castration Resistant	Inhibit	26325107
Prostatitis	Associate	17569667, 21245048, 22864280, 26831660
Pterygium	Associate	25053875, 33299863
Pulmonary Embolism	Stimulate	30485259
Rectal Neoplasms	Associate	26865277
Rectal Neoplasms	Stimulate	30348685
Reperfusion Injury	Associate	31115025
Retinal Dysplasia	Stimulate	22432036
Retinoblastoma	Associate	29843209
Rupture	Inhibit	26451018
Sarcoidosis	Associate	26768132
Sarcoidosis Pulmonary	Associate	26768132
Shoulder Injuries	Associate	26451018
Skin Neoplasms	Associate	36833430
Spondylitis Ankylosing	Stimulate	23607629
Squamous Cell Carcinoma of Head and Neck	Associate	19351747, 20652977, 26788506, 26883054, 28453462, 28677788, 32277655, 33237235, 34098850
Stomach Neoplasms	Associate	22432036, 22613407, 22994734, 26209976, 26364844, 26772615, 31773681
Stomach Neoplasms	Stimulate	28618968
Stroke	Associate	26238333, 28779016, 31565033
Sveinsson Chorioretinal Atrophy	Associate	34493366
Synovitis	Stimulate	23648338
Thrombocythemia Essential	Associate	26990535, 31240987
Thrombosis	Associate	25279769
Thyroid cancer follicular	Associate	24625073
Thyroid Cancer Papillary	Associate	16365291, 21537871, 23783103, 28061868, 32316638, 32899424, 33402480, 39177218, 39273308
Thyroid Cancer Papillary	Stimulate	18587330
Thyroid Carcinoma Anaplastic	Associate	24327568
Thyroid Neoplasms	Associate	18270258, 26106610, 26960768, 35562181, 37737255
Thyroiditis	Associate	16365291, 25924719
Triple Negative Breast Neoplasms	Associate	25797271, 27404381, 31341019, 31929841, 39183060
Urinary Bladder Neoplasms	Associate	25928257, 28770966, 32471285, 35264666, 36047424
Uterine Cervical Neoplasms	Associate	26482612, 27160122, 29789601, 34488676
Uterine Cervical Neoplasms	Stimulate	31114989
Vaginal Discharge	Associate	27423422
Vascular Diseases	Associate	19351599