MIR221 (microRNA 221)

Gene

• Entrez ID: 407006
• Gene name: MicroRNA 221
• Gene symbol: MIR221
• Synonyms (NCBI Gene): MIRN221, miRNA221, mir-221
• Chromosome: X
• Chromosome location: Xp11.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	18766170
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0006954	Process	Inflammatory response	IDA	20110463
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	23333386
GO:0009749	Process	Response to glucose	IMP	19351599
GO:0010634	Process	Positive regulation of epithelial cell migration	IGI	21673316
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IGI	21673316
GO:0016442	Component	RISC complex	IEA
GO:0032705	Process	Negative regulation of interleukin-21 production	IDA	28798470
GO:0034115	Process	Negative regulation of heterotypic cell-cell adhesion	IDA	20110463
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	16330772, 18413744, 18794255, 19153141, 20018759, 20299489, 20388878, 20516212, 21071579, 23333386, 23390134, 23630541, 23770133, 23770851, 24147153, 24269686, 24324033, 24736554, 25019494, 25910754, 27780851, 28798470
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	21310411, 21673316, 22294051
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IMP	18246122, 19088079, 19351599, 20813046
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	19671867, 20110463
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IMP	19088079
GO:0043065	Process	Positive regulation of apoptotic process	IDA	24147153
GO:0043066	Process	Negative regulation of apoptotic process	IDA	20813046
GO:0043066	Process	Negative regulation of apoptotic process	IMP	19671867
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IMP	19351599
GO:0044828	Process	Host-mediated suppression of viral genome replication	ISS
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IDA	16330772
GO:0046427	Process	Positive regulation of receptor signaling pathway via JAK-STAT	IDA	25019494
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IMP	19088079
GO:0048680	Process	Positive regulation of axon regeneration	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IGI	21310411
GO:0060354	Process	Negative regulation of cell adhesion molecule production	IGI	21310411
GO:0060546	Process	Negative regulation of necroptotic process	IDA	25910754
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IDA	23333386
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IGI	20516212
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IDA	18413744
GO:1900149	Process	Positive regulation of Schwann cell migration	ISS
GO:1902034	Process	Negative regulation of hematopoietic stem cell proliferation	IDA	16330772
GO:1903122	Process	Negative regulation of TRAIL-activated apoptotic signaling pathway	IMP	18246122
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	16330772, 18413744, 18794255, 19153141, 19671867, 20018759, 20110463, 20299489, 20388878, 20516212, 21071579, 23333386, 23390134, 23630541, 23770133, 23770851, 24147153, 24269686, 24324033, 24736554, 25019494, 25910754, 27780851, 28798470
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	21310411, 21673316, 22294051
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IMP	20813046
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IGI	27780851
GO:1903691	Process	Positive regulation of wound healing, spreading of epidermal cells	IDA	24269686
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	19088079
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IMP	19088079
GO:1904995	Process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IGI	21310411
GO:1905046	Process	Positive regulation of Schwann cell proliferation involved in axon regeneration	ISS
GO:1905064	Process	Negative regulation of vascular associated smooth muscle cell differentiation	IMP	18548003, 19088079
GO:1905176	Process	Positive regulation of vascular associated smooth muscle cell dedifferentiation	IMP	19088079
GO:2000780	Process	Negative regulation of double-strand break repair	IDA	24147153

Other IDs

• MIM: 300568
• HGNC: 31601
• e!Ensembl: ENSG00000207870

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer