MIR185 (microRNA 185)

Gene

• Entrez ID: 406961
• Gene name: MicroRNA 185
• Gene symbol: MIR185
• Synonyms (NCBI Gene): MIRN185, miR-185
• Chromosome: 22
• Chromosome location: 22q11.21
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IDA	24803541, 26316588, 27906433
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0009968	Process	Negative regulation of signal transduction	IDA	26316588
GO:0010629	Process	Negative regulation of gene expression	IGI	24296663
GO:0010744	Process	Positive regulation of macrophage derived foam cell differentiation	IMP	26523989
GO:0010987	Process	Negative regulation of high-density lipoprotein particle clearance	IDA	23459944
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	26523989
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IGI	24296663
GO:0016442	Component	RISC complex	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IDA	26694763
GO:0030336	Process	Negative regulation of cell migration	IDA	26316588
GO:0030889	Process	Negative regulation of B cell proliferation	IMP	24803541
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IMP	24803541
GO:0034763	Process	Negative regulation of transmembrane transport	IMP	27906433
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	24803541, 26523989, 26694763, 27906433, 28277742
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	24296663
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	23459944, 23951060, 26316588, 29053187
GO:0042632	Process	Cholesterol homeostasis	IDA	26523989
GO:0045541	Process	Negative regulation of cholesterol biosynthetic process	IDA	23951060
GO:0045541	Process	Negative regulation of cholesterol biosynthetic process	IGI	24296663
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	IDA	23951060
GO:0050869	Process	Negative regulation of B cell activation	IMP	24803541
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IDA	28277742
GO:0071397	Process	Cellular response to cholesterol	IGI	24296663
GO:0106108	Process	Negative regulation of (R)-mevalonic acid biosynthetic process	IGI	24296663
GO:0106222	Function	LncRNA binding	IDA	29053187
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	23459944, 23951060, 24803541, 26316588, 26523989, 26694763, 27906433, 28277742, 29053187
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	24296663
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1904706	Process	Negative regulation of vascular associated smooth muscle cell proliferation	IDA	28277742
GO:1905601	Process	Negative regulation of receptor-mediated endocytosis involved in cholesterol transport	IGI	24296663
GO:1905700	Process	Negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane	IMP	27906433
GO:2001024	Process	Negative regulation of response to drug	IMP	27906433

Other IDs

• MIM: 615576
• HGNC: 31556
• e!Ensembl: ENSG00000208023

Interactions View interactions