MIR17 (microRNA 17)

Gene

• Entrez ID: 406952
• Gene name: MicroRNA 17
• Gene symbol: MIR17
• Synonyms (NCBI Gene): MIR17-5p, MIR91, MIRN17, MIRN91, hsa-mir-17, miR-17, miR17-3p, miRNA17, miRNA91
• Chromosome: 13
• Chromosome location: 13q31.3
• Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	ISS
GO:0003151	Process	Outflow tract morphogenesis	ISS
GO:0003730	Function	MRNA 3'-UTR binding	IDA	21982160, 23399447, 24378993, 25785043
GO:0005615	Component	Extracellular space	HDA	26646931
GO:0005739	Component	Mitochondrion	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	23399447
GO:0010629	Process	Negative regulation of gene expression	IDA	22161164
GO:0010629	Process	Negative regulation of gene expression	IMP	23399447
GO:0010666	Process	Positive regulation of cardiac muscle cell apoptotic process	ISS
GO:0010989	Process	Negative regulation of low-density lipoprotein particle clearance	IDA	23285084
GO:0016442	Component	RISC complex	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IDA	21145484
GO:0032682	Process	Negative regulation of chemokine production	IDA	23399447
GO:0032682	Process	Negative regulation of chemokine production	IMP	23399447
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IMP	26041742
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	HDA	18320040
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IDA	20190813, 20299512, 21067317, 21508257, 21982160, 22473208, 23059786, 23285084, 23969726, 24378993, 25200830, 25785043, 26041742, 27640178
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IEA
GO:0035195	Process	MiRNA-mediated post-transcriptional gene silencing	IGI	21145484
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	23399447, 23562609
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IMP	19390056
GO:0042985	Process	Negative regulation of amyloid precursor protein biosynthetic process	IDA	21982160
GO:0045600	Process	Positive regulation of fat cell differentiation	IGI	23399447
GO:0045668	Process	Negative regulation of osteoblast differentiation	IGI	23399447
GO:0045777	Process	Positive regulation of blood pressure	ISS
GO:0048146	Process	Positive regulation of fibroblast proliferation	ISS
GO:0050766	Process	Positive regulation of phagocytosis	ISS
GO:0070062	Component	Extracellular exosome	IDA	31926946
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071456	Process	Cellular response to hypoxia	IMP	27640178
GO:0071874	Process	Cellular response to norepinephrine stimulus	ISS
GO:0090370	Process	Negative regulation of cholesterol efflux	IDA	25785043
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	ISS
GO:1901299	Process	Negative regulation of hydrogen peroxide-mediated programmed cell death	ISS
GO:1901300	Process	Positive regulation of hydrogen peroxide-mediated programmed cell death	ISS
GO:1902109	Process	Negative regulation of mitochondrial membrane permeability involved in apoptotic process	ISS
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	HDA	18320040
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IDA	20190813, 20299512, 21067317, 21982160, 22473208, 23059786, 23285084, 23399447, 23562609, 23969726, 24378993, 25200830, 25785043, 26041742, 27640178
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IGI	21145484
GO:1903231	Function	MRNA base-pairing post-transcriptional repressor activity	IMP	19390056
GO:1903244	Process	Positive regulation of cardiac muscle hypertrophy in response to stress	ISS
GO:1903561	Component	Extracellular vesicle	HDA	28798470
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IDA	20299512
GO:1904046	Process	Negative regulation of vascular endothelial growth factor production	HMP	18320040
GO:1904598	Process	Positive regulation of connective tissue replacement involved in inflammatory response wound healing	ISS
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IDA	22161164
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IMP	27640178
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	ISS
GO:1905101	Process	Negative regulation of apoptosome assembly	ISS
GO:1905111	Process	Positive regulation of pulmonary blood vessel remodeling	ISS
GO:1905149	Process	Positive regulation of smooth muscle hypertrophy	ISS
GO:1905460	Process	Negative regulation of vascular associated smooth muscle cell apoptotic process	IMP	27640178
GO:1905601	Process	Negative regulation of receptor-mediated endocytosis involved in cholesterol transport	IDA	23285084
GO:2000773	Process	Negative regulation of cellular senescence	ISS
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	ISS

Other IDs

• MIM: 609416
• HGNC: 31547
• e!Ensembl: ENSG00000284536

Interactions View interactions

Pathways

KEGG:

MicroRNAs in cancer